Details for: APP

Gene ID: 351

Symbol: APP

Ensembl ID: ENSG00000142192

Description: amyloid beta precursor protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1048.6982
    Cell Significance Index: -163.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 613.8540
    Cell Significance Index: -155.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 344.4656
    Cell Significance Index: -162.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 327.2804
    Cell Significance Index: -132.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 300.2127
    Cell Significance Index: -154.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 243.0769
    Cell Significance Index: -163.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 139.2103
    Cell Significance Index: -132.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 132.3486
    Cell Significance Index: -163.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 58.4278
    Cell Significance Index: -156.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 45.0793
    Cell Significance Index: -98.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 42.3480
    Cell Significance Index: -130.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 41.1779
    Cell Significance Index: -162.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 7.8786
    Cell Significance Index: 210.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 5.5102
    Cell Significance Index: 287.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.6461
    Cell Significance Index: 1666.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.4861
    Cell Significance Index: 446.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.2468
    Cell Significance Index: 651.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.1885
    Cell Significance Index: 167.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.1844
    Cell Significance Index: 195.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1026
    Cell Significance Index: 84.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.8408
    Cell Significance Index: 1964.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.7769
    Cell Significance Index: 358.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6322
    Cell Significance Index: 123.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5204
    Cell Significance Index: 141.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.5156
    Cell Significance Index: 169.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4625
    Cell Significance Index: 443.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4171
    Cell Significance Index: 1320.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3003
    Cell Significance Index: 315.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2816
    Cell Significance Index: 280.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.2698
    Cell Significance Index: 4186.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.0131
    Cell Significance Index: 3099.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6456
    Cell Significance Index: 72.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4060
    Cell Significance Index: 53.2400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1517
    Cell Significance Index: 27.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0856
    Cell Significance Index: 479.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.0204
    Cell Significance Index: 29.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9528
    Cell Significance Index: 71.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8226
    Cell Significance Index: 23.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7927
    Cell Significance Index: 157.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7816
    Cell Significance Index: 27.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.6290
    Cell Significance Index: 10.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5410
    Cell Significance Index: 1018.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4643
    Cell Significance Index: 35.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4516
    Cell Significance Index: 12.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4113
    Cell Significance Index: 5.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3833
    Cell Significance Index: 37.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3706
    Cell Significance Index: 16.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3619
    Cell Significance Index: 265.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3225
    Cell Significance Index: 55.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2388
    Cell Significance Index: 151.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2119
    Cell Significance Index: 288.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0262
    Cell Significance Index: 1.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0115
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0702
    Cell Significance Index: -52.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0718
    Cell Significance Index: -32.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0877
    Cell Significance Index: -12.7500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1092
    Cell Significance Index: -0.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1249
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1417
    Cell Significance Index: -88.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1571
    Cell Significance Index: -118.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2063
    Cell Significance Index: -21.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2118
    Cell Significance Index: -119.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2812
    Cell Significance Index: -6.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.3022
    Cell Significance Index: -57.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3560
    Cell Significance Index: -74.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4954
    Cell Significance Index: -142.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.5034
    Cell Significance Index: -81.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7224
    Cell Significance Index: -18.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7717
    Cell Significance Index: -88.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8946
    Cell Significance Index: -104.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9907
    Cell Significance Index: -28.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0559
    Cell Significance Index: -54.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1225
    Cell Significance Index: -28.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.1554
    Cell Significance Index: -22.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.1705
    Cell Significance Index: -82.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1875
    Cell Significance Index: -123.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -1.2187
    Cell Significance Index: -132.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.2201
    Cell Significance Index: -21.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2536
    Cell Significance Index: -33.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.3163
    Cell Significance Index: -150.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -1.3234
    Cell Significance Index: -156.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.6525
    Cell Significance Index: -34.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.7413
    Cell Significance Index: -37.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.7463
    Cell Significance Index: -138.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.7726
    Cell Significance Index: -46.6100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.8464
    Cell Significance Index: -28.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.8733
    Cell Significance Index: -60.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.0972
    Cell Significance Index: -145.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.1395
    Cell Significance Index: -29.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.2947
    Cell Significance Index: -48.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -2.3106
    Cell Significance Index: -149.0700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -2.5117
    Cell Significance Index: -31.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.6027
    Cell Significance Index: -159.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.8659
    Cell Significance Index: -180.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.9756
    Cell Significance Index: -97.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -3.0984
    Cell Significance Index: -98.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -3.3100
    Cell Significance Index: -65.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -3.3863
    Cell Significance Index: -71.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -3.4576
    Cell Significance Index: -121.1300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -3.5309
    Cell Significance Index: -44.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: The APP gene encodes for a 750-kDa protein with 17 exons, 16 introns, and a 3' untranslated region (3' UTR). The gene is located on chromosome 21q22.2. 2. **Expression**: APP is predominantly expressed in neurons, particularly in the hippocampus, cerebral cortex, and cerebellum. 3. **Function**: APP plays a dual role in the brain, acting as both a cell adhesion molecule and a precursor to Aβ peptides. 4. **Regulation**: The APP gene is regulated by various transcription factors, including NF-κB, AP-1, and CREB. **Pathways and Functions** 1. **Amyloid Fiber Formation**: The APP gene is involved in the formation of amyloid fibers, which are pathogenic in Alzheimer's disease. 2. **Astrocyte Activation**: APP can activate astrocytes, which are involved in the immune response and the clearance of Aβ peptides. 3. **Cell Adhesion**: APP interacts with NCAM, a cell adhesion molecule, and regulates cell-cell interactions. 4. **Apoptosis**: APP can induce apoptosis in neurons, contributing to neurodegeneration in Alzheimer's disease. 5. **Cytokine Signaling**: APP can modulate cytokine signaling, including the activation of NF-κB, which is involved in immune responses. 6. **Neurodegenerative Diseases**: APP has been implicated in various neurodegenerative diseases, including Alzheimer's disease, frontotemporal dementia, and Parkinson's disease. **Clinical Significance** 1. **Alzheimer's Disease**: The APP gene is a key player in the development of Alzheimer's disease, and its dysregulation is a hallmark of the disease. 2. **Frontotemporal Dementia**: APP has been implicated in frontotemporal dementia, a neurodegenerative disorder characterized by progressive cognitive decline. 3. **Parkinson's Disease**: APP has been linked to Parkinson's disease, a neurodegenerative disorder characterized by motor dysfunction. 4. **Amyloid-Related Disorders**: APP has been implicated in various amyloid-related disorders, including amyloid angiopathy and cerebral amyloid angiopathy. 5. **Immunotherapy**: The APP gene has been a target for immunotherapy in Alzheimer's disease, with several antibodies and vaccines designed to target Aβ peptides and APP. In conclusion, the APP gene is a critical component in the development of Alzheimer's disease and other neurodegenerative disorders. Its dysregulation has been implicated in various cellular processes, including cell adhesion, immune response, and apoptosis. Further research is needed to fully understand the role of APP in disease and to develop effective therapeutic strategies for the treatment of neurodegenerative disorders.

Genular Protein ID: 1420399229

Symbol: A4_HUMAN

Name: ABPP

UniProtKB Accession Codes:

P05067 B2R5V1 B4DII8 D3DSD1 D3DSD2 D3DSD3 P09000 P78438 Q13764 Q13778 Q13793 Q16011 Q16014 Q16019 Q16020 Q6GSC0 Q8WZ99 Q9BT38 Q9UC33 Q9UCA9 Q9UCB6 Q9UCC8 Q9UCD1 Q9UQ58

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 24 DrugCentral 1 ELM 1 EMBL 87 EMDB 38 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 7 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 100 PDBsum 100 PIR 2 PRINTS 3 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 Pumba 1 RNAct 1 Reactome 17 RefSeq 10 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 7 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2881207

Title: The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.

PubMed ID: 2881207

DOI: 10.1038/325733a0

PubMed ID: 2893289

Title: A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.

PubMed ID: 2893289

DOI: 10.1038/331525a0

PubMed ID: 2783775

Title: The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons.

PubMed ID: 2783775

DOI: 10.1093/nar/17.2.517

PubMed ID: 2110105

Title: Genomic organization of the human amyloid beta-protein precursor gene.

PubMed ID: 2110105

DOI: 10.1016/0378-1119(90)90310-n

PubMed ID: 1908403

Title:

PubMed ID: 1908403

DOI: 10.1016/0378-1119(91)90093-q

PubMed ID: 1587857

Title: Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.

PubMed ID: 1587857

DOI: 10.1016/s0021-9258(19)50090-4

PubMed ID: 9108164

Title: A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus.

PubMed ID: 9108164

DOI: 10.1093/nar/25.9.1802

PubMed ID: 12859342

Title: Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639.

PubMed ID: 12859342

DOI: 10.1046/j.1460-9568.2003.02731.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3140222

Title: A cDNA specifying the human amyloid beta precursor protein (ABPP) encodes a 95-kDa polypeptide.

PubMed ID: 3140222

DOI: 10.1093/nar/16.19.9351

PubMed ID: 2538123

Title: Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene.

PubMed ID: 2538123

DOI: 10.1016/0006-291x(89)92437-6

PubMed ID: 3597385

Title: Purification of protease nexin II from human fibroblasts.

PubMed ID: 3597385

DOI: 10.1016/s0021-9258(18)47443-1

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 2893290

Title: Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.

PubMed ID: 2893290

DOI: 10.1038/331528a0

PubMed ID: 2893291

Title: Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity.

PubMed ID: 2893291

DOI: 10.1038/331530a0

PubMed ID: 2893379

Title: Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex.

PubMed ID: 2893379

DOI: 10.1073/pnas.85.3.929

PubMed ID: 8576160

Title: Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.

PubMed ID: 8576160

DOI: 10.1074/jbc.271.3.1613

PubMed ID: 8476439

Title: A system for studying the effect(s) of familial Alzheimer disease mutations on the processing of the beta-amyloid peptide precursor.

PubMed ID: 8476439

DOI: 10.1006/bbrc.1993.1386

PubMed ID: 2675837

Title: Alzheimer's disease amyloid peptide is encoded by two exons and shows similarity to soybean trypsin inhibitor.

PubMed ID: 2675837

DOI: 10.1016/0006-291x(89)91112-1

PubMed ID: 15201367

Title: Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease.

PubMed ID: 15201367

DOI: 10.1136/jnnp.2003.010611

PubMed ID: 3312495

Title: Amyloid angiopathy of Alzheimer's disease: amino acid composition and partial sequence of a 4,200-dalton peptide isolated from cortical microvessels.

PubMed ID: 3312495

DOI: 10.1111/j.1471-4159.1987.tb01005.x

PubMed ID: 1406936

Title: Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids.

PubMed ID: 1406936

DOI: 10.1038/359325a0

PubMed ID: 8229004

Title: Characterization of beta-amyloid peptide from human cerebrospinal fluid.

PubMed ID: 8229004

DOI: 10.1111/j.1471-4159.1993.tb09841.x

PubMed ID: 8248178

Title: Beta-amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

PubMed ID: 8248178

DOI: 10.1073/pnas.90.22.10836

PubMed ID: 8109908

Title: The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient.

PubMed ID: 8109908

DOI: 10.1002/ana.410350223

PubMed ID: 3810169

Title: Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.

PubMed ID: 3810169

DOI: 10.1126/science.3810169

PubMed ID: 2949367

Title: Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

PubMed ID: 2949367

DOI: 10.1126/science.2949367

PubMed ID: 22576872

Title: An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid beta and amyloid precursor protein in human and cat cerebrospinal fluid.

PubMed ID: 22576872

DOI: 10.1002/jms.2987

PubMed ID: 16816112

Title: BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome.

PubMed ID: 16816112

DOI: 10.1096/fj.05-5632com

PubMed ID: 2569763

Title: A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein.

PubMed ID: 2569763

DOI: 10.1126/science.2569763

PubMed ID: 3035574

Title: Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

PubMed ID: 3035574

DOI: 10.1073/pnas.84.12.4190

PubMed ID: 2900137

Title: Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

PubMed ID: 2900137

DOI: 10.1002/j.1460-2075.1988.tb02900.x

PubMed ID: 2649245

Title: Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

PubMed ID: 2649245

DOI: 10.1016/0092-8674(89)90177-3

PubMed ID: 2506449

Title: The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.

PubMed ID: 2506449

DOI: 10.1038/341144a0

PubMed ID: 1969731

Title: Protease-specificity of Kunitz inhibitor domain of Alzheimer's disease amyloid protein precursor.

PubMed ID: 1969731

DOI: 10.1016/0006-291x(90)92084-d

PubMed ID: 8344894

Title: A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.

PubMed ID: 8344894

DOI: 10.1016/s0021-9258(19)85394-2

PubMed ID: 8446172

Title: Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o).

PubMed ID: 8446172

DOI: 10.1038/362075a0

PubMed ID: 8131745

Title: Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein.

PubMed ID: 8131745

DOI: 10.1002/j.1460-2075.1994.tb06360.x

PubMed ID: 7913895

Title: The beta A4 amyloid precursor protein binding to copper.

PubMed ID: 7913895

DOI: 10.1016/0014-5793(94)00658-x

PubMed ID: 8158260

Title: A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth.

PubMed ID: 8158260

DOI: 10.1523/jneurosci.14-04-02117.1994

PubMed ID: 7737970

Title: The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene.

PubMed ID: 7737970

DOI: 10.1074/jbc.270.18.10388

PubMed ID: 8626687

Title: APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein.

PubMed ID: 8626687

DOI: 10.1074/jbc.271.19.11339

PubMed ID: 8887653

Title: The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.

PubMed ID: 8887653

DOI: 10.1128/mcb.16.11.6229

PubMed ID: 8855266

Title: Association of a novel human FE65-like protein with the cytoplasmic domain of the amyloid-beta precursor protein.

PubMed ID: 8855266

DOI: 10.1073/pnas.93.20.10832

PubMed ID: 9168929

Title: Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions.

PubMed ID: 9168929

DOI: 10.1006/bbrc.1997.6547

PubMed ID: 9357988

Title: Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease.

PubMed ID: 9357988

DOI: 10.1016/s0014-5793(97)01146-0

PubMed ID: 9338779

Title: An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.

PubMed ID: 9338779

DOI: 10.1038/39522

PubMed ID: 9585534

Title: Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide.

PubMed ID: 9585534

DOI: 10.1021/bi980022m

PubMed ID: 9843960

Title: PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein.

PubMed ID: 9843960

DOI: 10.1073/pnas.95.25.14745

PubMed ID: 10413512

Title: Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease.

PubMed ID: 10413512

DOI: 10.1021/bi990205o

PubMed ID: 10319819

Title: Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.

PubMed ID: 10319819

DOI: 10.1016/s0092-8674(00)80748-5

PubMed ID: 10535332

Title: Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress.

PubMed ID: 10535332

DOI: 10.1016/s0361-9230(99)00093-3

PubMed ID: 10341243

Title: Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.

PubMed ID: 10341243

DOI: 10.1523/jneurosci.19-11-04421.1999

PubMed ID: 9890987

Title: Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.

PubMed ID: 9890987

DOI: 10.1074/jbc.274.4.2243

PubMed ID: 10383380

Title: Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.

PubMed ID: 10383380

DOI: 10.1074/jbc.274.27.18851

PubMed ID: 10461923

Title: Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein.

PubMed ID: 10461923

DOI: 10.1046/j.1471-4159.1999.0731288.x

PubMed ID: 10656250

Title: Identification of a novel aspartic proteinase (Asp 2) as beta-secretase.

PubMed ID: 10656250

DOI: 10.1006/mcne.1999.0811

PubMed ID: 10081969

Title: Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein.

PubMed ID: 10081969

DOI: 10.1016/s0304-3940(98)00995-1

PubMed ID: 10816430

Title: Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides.

PubMed ID: 10816430

DOI: 10.1042/bj3480359

PubMed ID: 10681545

Title: Beta-amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.

PubMed ID: 10681545

DOI: 10.1074/jbc.275.8.5626

PubMed ID: 12214090

Title: Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

PubMed ID: 12214090

DOI: 10.3233/jad-2000-23-408

PubMed ID: 11775062

Title: Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins.

PubMed ID: 11775062

DOI: 10.1023/a:1012629603390

PubMed ID: 11689470

Title: Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.

PubMed ID: 11689470

DOI: 10.1096/fj.01-0251com

PubMed ID: 11278849

Title: Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module.

PubMed ID: 11278849

DOI: 10.1074/jbc.m011161200

PubMed ID: 11274207

Title: Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered structure containing superoxide dismutase-like subunits.

PubMed ID: 11274207

DOI: 10.1074/jbc.m100175200

PubMed ID: 11438549

Title: Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.

PubMed ID: 11438549

DOI: 10.1074/jbc.m105410200

PubMed ID: 11544248

Title: The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.

PubMed ID: 11544248

DOI: 10.1074/jbc.c100447200

PubMed ID: 11238726

Title: Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function.

PubMed ID: 11238726

DOI: 10.1046/j.1471-4159.2001.00144.x

PubMed ID: 11943163

Title: Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II.

PubMed ID: 11943163

DOI: 10.1016/s0014-5793(02)02376-1

PubMed ID: 11724784

Title: Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

PubMed ID: 11724784

DOI: 10.1074/jbc.m108357200

PubMed ID: 11784781

Title: Contrasting species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.

PubMed ID: 11784781

DOI: 10.1523/jneurosci.22-02-00365.2002

PubMed ID: 12032279

Title: The galvanization of beta-amyloid in Alzheimer's disease.

PubMed ID: 12032279

DOI: 10.1073/pnas.122249699

PubMed ID: 8999878

Title: Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.

PubMed ID: 8999878

DOI: 10.1074/jbc.272.3.1896

PubMed ID: 10806211

Title: Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2.

PubMed ID: 10806211

DOI: 10.1074/jbc.m002850200

PubMed ID: 10742146

Title: A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.

PubMed ID: 10742146

DOI: 10.1038/74656

PubMed ID: 11517218

Title: Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid.

PubMed ID: 11517218

DOI: 10.1074/jbc.m104059200

PubMed ID: 11604391

Title: Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity.

PubMed ID: 11604391

DOI: 10.1074/jbc.m104068200

PubMed ID: 11146006

Title: Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

PubMed ID: 11146006

DOI: 10.1046/j.1471-4159.2001.00102.x

PubMed ID: 11851430

Title: A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.

PubMed ID: 11851430

DOI: 10.1021/bi015794o

PubMed ID: 11877420

Title: Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.

PubMed ID: 11877420

DOI: 10.1074/jbc.m110286200

PubMed ID: 12142279

Title: A cell biological perspective on Alzheimer's disease.

PubMed ID: 12142279

DOI: 10.1146/annurev.cellbio.18.020402.142302

PubMed ID: 14527950

Title: Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.

PubMed ID: 14527950

DOI: 10.1074/jbc.m309561200

PubMed ID: 15084524

Title: Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.

PubMed ID: 15084524

DOI: 10.1096/fj.03-1040fje

PubMed ID: 15347684

Title: Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.

PubMed ID: 15347684

DOI: 10.1074/jbc.m405329200

PubMed ID: 16154999

Title: Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor.

PubMed ID: 16154999

DOI: 10.1074/jbc.m508460200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16174740

Title: Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

PubMed ID: 16174740

DOI: 10.1073/pnas.0503689102

PubMed ID: 16407538

Title: Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.

PubMed ID: 16407538

DOI: 10.1523/jneurosci.3882-05.2006

PubMed ID: 17062754

Title: A peptide zipcode sufficient for anterograde transport within amyloid precursor protein.

PubMed ID: 17062754

DOI: 10.1073/pnas.0607527103

PubMed ID: 17855360

Title: SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.

PubMed ID: 17855360

DOI: 10.1074/jbc.m705073200

PubMed ID: 18468999

Title: Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells.

PubMed ID: 18468999

DOI: 10.1074/jbc.m801827200

PubMed ID: 19366692

Title: BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.

PubMed ID: 19366692

DOI: 10.1074/jbc.m109.006403

PubMed ID: 19225519

Title: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.

PubMed ID: 19225519

DOI: 10.1038/nature07767

PubMed ID: 19901339

Title: RAGE-mediated signaling contributes to intraneuronal transport of amyloid-{beta} and neuronal dysfunction.

PubMed ID: 19901339

DOI: 10.1073/pnas.0905686106

PubMed ID: 20580937

Title: Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol.

PubMed ID: 20580937

DOI: 10.1016/j.bbalip.2010.05.010

PubMed ID: 20811458

Title: Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.

PubMed ID: 20811458

DOI: 10.1038/nature09325

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21712440

Title: Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid.

PubMed ID: 21712440

DOI: 10.1073/pnas.1102664108

Sequence Information:

  • Length: 770
  • Mass: 86943
  • Checksum: A12EE761403740F5
  • Sequence:
    • MLPGLALLLL AAWTARALEV PTDGNAGLLA EPQIAMFCGR LNMHMNVQNG KWDSDPSGTK 
TCIDTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHPH FVIPYRCLVG 
EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR 
GVEFVCCPLA EESDNVDSAD AEEDDSDVWW GGADTDYADG SEDKVVEVAE EEEVAEVEEE 
EADDDEDDED GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC 
RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSAMSQSLL KTTQEPLARD 
PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA 
KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL 
QAVPPRPRHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER 
MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET 
KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN 
IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL 
VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN

Genular Protein ID: 1267942749

Symbol: A0A0A0MRG2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MRG2

Database IDs:

ARBA 35 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 5 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 14 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 3 SMART 1 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 660
  • Mass: 75110
  • Checksum: 7EC5DD46A8729202
  • Sequence:
    • MFCGRLNMHM NVQNGKWDSD PSGTKTCIDT KEGILQYCQE VYPELQITNV VEANQPVTIQ 
NWCKRGRKQC KTHPHFVIPY RCLVGEFVSD ALLVPDKCKF LHQERMDVCE THLHWHTVAK 
ETCSEKSTNL HDYGMLLPCG IDKFRGVEFV CCPLAEESDN VDSADAEEDD SDVWWGGADT 
DYADGSEDKV VEVAEEEEVA EVEEEEADDD EDDEDGDEVE EEAEEPYEEA TERTTSIATT 
TTTTTESVEE VVRVPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM 
REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR 
LALENYITAL QAVPPRPRHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV 
MTHLRVIYER MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN 
DALMPSLTET KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL 
TTRPGSGLTN IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG AIIGLMVGGV 
VIATVIVITL VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN

Genular Protein ID: 2813719217

Symbol: B4DJT9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DJT9

Database IDs:

ARBA 25 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 14 Gene3D 5 InterPro 13 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 RefSeq 1 SAM 3 SMART 1 SMR 1 SUPFAM 3

Sequence Information:

  • Length: 660
  • Mass: 75150
  • Checksum: B6AA0D4BD471A235
  • Sequence:
    • MFCGRLNMHM NVQNGKWDSD PSGTKTCIDT KEGILQYCQE VYPELQITNV VEANQPVTIQ 
NWCKRGRKQC KTHPHFVIPY RCLVGEFVSD ALLVPDKCKF LHQERMDVCE THLHWHTVAK 
ETCSEKSTNL HDYGMLLPCG IDKFRGVEFV CCPLAEESDN VDSADAEEDD SDVWWGGADT 
DYADGSEDKV VEVAEEEEVA EVEEEEADDD EDDEDGDEVE EEAEEPYEEA TERTTSIATT 
TTTTTESVEE VVRVPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM 
REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR 
LALENYITAL QAVPPRPRHV FNMLKKYVRA EQKDRQHTLK HFEHERMVDP KKAAQIRSQV 
MTHLRVIYER MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN 
DALMPSLTET KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL 
TTRPGSGLTN IKTEEISEVK MDAEFRHDPG YEVHHQKLVF FAEDVGSNKG AIIGLMVGGV 
VIATVIVITL VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN

Genular Protein ID: 2577413779

Symbol: B4DGD0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DGD0

Database IDs:

ARBA 48 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 24 Gene3D 6 InterPro 17 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 9 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 RefSeq 2 RuleBase 1 SAM 3 SMART 2 SMR 1 SUPFAM 4

Sequence Information:

  • Length: 714
  • Mass: 80806
  • Checksum: 471EA43FF6B14888
  • Sequence:
    • MLPGLALLLL AAWTARALEV YPELQITNVV EANQPVTIQN WCKRGRKQCK THPHFVIPYR 
CLVGEFVSDA LLVPDKCKFL HQERMDVCET HLHWHTVAKE TCSEKSTNLH DYGMLLPCGI 
DKFRGVEFVC CPLAEESDNV DSADAEEDDS DVWWGGADTD YADGSEDKVV EVAEEEEVAE 
VEEEEADDDE DDEDGDEVEE EAEEPYEEAT ERTTSIATTT TTTTESVEEV VREVCSEQAE 
TGPCRAMISR WYFDVTEGKC APFFYGGCGG NRNNFDTEEY CMAVCGSAMS QSLLKTTQEP 
LARDPVKLPT TAASTPDAVD KYLETPGDES EHAHFQKAKE RLEAKHRERM SQVMREWEEA 
ERQAKNLPKA DKKAVIQHFQ EKVESLEQEA ANERQQLVET HMARVEAMLN DRRRLALENY 
ITALQAVPPR PRHVFNMLKK YVRAEQKDRQ HTLKHFEHVR MVDPKKAAQI RSQVMTHLRV 
IYERMNQSLS LLYNVPAVAE EIQDEVDELL QKEQNYSDDV LANMISEPRI SYGNDALMPS 
LTETKTTVEL LPVNGEFSLD DLQPWHSFGA DSVPANTENE VEPVDARPAA DRGLTTRPGS 
GLTNIKTEEI SEVKMDAEFR HDSGYEVHHQ KLVFFAEDVG SNKGAIIGLM VGGVVIATVI 
VITLVMLKKK QYTSIHHGVV EVDAAVTPEE RHLSKMQQNG YENPTYKFFE QMQN

Genular Protein ID: 852524551

Symbol: E9PG40_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PG40

Database IDs:

ARBA 48 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 6 GeneTree 1 HGNC 1 InterPro 17 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 9 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 6 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 3 SMART 2 SMR 1 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 714
  • Mass: 80833
  • Checksum: 68CC52E6F29B777B
  • Sequence:
    • MLPGLALLLL AAWTARALEV YPELQITNVV EANQPVTIQN WCKRGRKQCK THPHFVIPYR 
CLVGEFVSDA LLVPDKCKFL HQERMDVCET HLHWHTVAKE TCSEKSTNLH DYGMLLPCGI 
DKFRGVEFVC CPLAEESDNV DSADAEEDDS DVWWGGADTD YADGSEDKVV EVAEEEEVAE 
VEEEEADDDE DDEDGDEVEE EAEEPYEEAT ERTTSIATTT TTTTESVEEV VREVCSEQAE 
TGPCRAMISR WYFDVTEGKC APFFYGGCGG NRNNFDTEEY CMAVCGSAMS QSLLKTTQEP 
LARDPVKLPT TAASTPDAVD KYLETPGDEN EHAHFQKAKE RLEAKHRERM SQVMREWEEA 
ERQAKNLPKA DKKAVIQHFQ EKVESLEQEA ANERQQLVET HMARVEAMLN DRRRLALENY 
ITALQAVPPR PRHVFNMLKK YVRAEQKDRQ HTLKHFEHVR MVDPKKAAQI RSQVMTHLRV 
IYERMNQSLS LLYNVPAVAE EIQDEVDELL QKEQNYSDDV LANMISEPRI SYGNDALMPS 
LTETKTTVEL LPVNGEFSLD DLQPWHSFGA DSVPANTENE VEPVDARPAA DRGLTTRPGS 
GLTNIKTEEI SEVKMDAEFR HDSGYEVHHQ KLVFFAEDVG SNKGAIIGLM VGGVVIATVI 
VITLVMLKKK QYTSIHHGVV EVDAAVTPEE RHLSKMQQNG YENPTYKFFE QMQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.