Details for: APP

Gene ID: 351

Symbol: APP

Ensembl ID: ENSG00000142192

Description: amyloid beta precursor protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 6.15
    Marker Score: 32255
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.86
    Marker Score: 103955
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.92
    Marker Score: 4253
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 4.89
    Marker Score: 4017
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.79
    Marker Score: 36097
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.73
    Marker Score: 25388
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.36
    Marker Score: 6306
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.14
    Marker Score: 5832
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.12
    Marker Score: 17190.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.07
    Marker Score: 9346
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4.04
    Marker Score: 5431
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.97
    Marker Score: 3787
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.94
    Marker Score: 10567
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.91
    Marker Score: 18073
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.9
    Marker Score: 9342
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.86
    Marker Score: 5616
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.76
    Marker Score: 9565
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.72
    Marker Score: 4499
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.71
    Marker Score: 2099
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.71
    Marker Score: 9345
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.67
    Marker Score: 32242
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.61
    Marker Score: 12115
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.35
    Marker Score: 113224
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.33
    Marker Score: 1936
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.32
    Marker Score: 3524
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.28
    Marker Score: 2570
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.18
    Marker Score: 3840
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.13
    Marker Score: 2772
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 3.11
    Marker Score: 1029
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.07
    Marker Score: 3282
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.07
    Marker Score: 1589
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.07
    Marker Score: 3113
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.06
    Marker Score: 5890
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.05
    Marker Score: 6093
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.01
    Marker Score: 2591
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3
    Marker Score: 1746
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.99
    Marker Score: 696
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.94
    Marker Score: 2775
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.92
    Marker Score: 2027
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.91
    Marker Score: 21681
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.89
    Marker Score: 1620
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.85
    Marker Score: 4036
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.82
    Marker Score: 2006
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.82
    Marker Score: 4622.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.81
    Marker Score: 37037
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.78
    Marker Score: 1661
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.78
    Marker Score: 2140
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.77
    Marker Score: 2977
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.77
    Marker Score: 55031
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.74
    Marker Score: 20989
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.74
    Marker Score: 11454
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.73
    Marker Score: 94655
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.72
    Marker Score: 40708
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.71
    Marker Score: 3122
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.71
    Marker Score: 3371
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.66
    Marker Score: 90542
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.66
    Marker Score: 101005
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.66
    Marker Score: 2383
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.63
    Marker Score: 3282
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.63
    Marker Score: 3245.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.61
    Marker Score: 1628
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.61
    Marker Score: 1838
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.57
    Marker Score: 4697
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.56
    Marker Score: 2765
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.54
    Marker Score: 16501
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.52
    Marker Score: 7897.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.51
    Marker Score: 10417
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.51
    Marker Score: 1238
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.51
    Marker Score: 794
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.5
    Marker Score: 2636
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.5
    Marker Score: 2674.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.48
    Marker Score: 3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.48
    Marker Score: 6047
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.47
    Marker Score: 7057.5
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.47
    Marker Score: 1186
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.47
    Marker Score: 4089
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.46
    Marker Score: 5146
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.46
    Marker Score: 4360
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.46
    Marker Score: 2316
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.45
    Marker Score: 2750
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.44
    Marker Score: 8678
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.44
    Marker Score: 1608
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.44
    Marker Score: 10506
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.43
    Marker Score: 2351
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.43
    Marker Score: 1297.5
  • Cell Name: glial cell (CL0000125)
    Fold Change: 2.43
    Marker Score: 2671
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.43
    Marker Score: 3368
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.42
    Marker Score: 11897
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.4
    Marker Score: 1006
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.4
    Marker Score: 88385
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.4
    Marker Score: 4501
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.37
    Marker Score: 3974
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.36
    Marker Score: 2924
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.35
    Marker Score: 4774
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.35
    Marker Score: 1768
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.32
    Marker Score: 1458
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.32
    Marker Score: 1661
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.31
    Marker Score: 2613
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.3
    Marker Score: 2168
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.3
    Marker Score: 895

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - APP is a glycoprotein that is approximately 45 kDa in size. - It is expressed in high levels in neurons of the brain and other tissues. - APP is a precursor protein for a number of other amyloid proteins, including amyloid-beta (Aβ). - APP is cleaved into a number of different peptides by a variety of proteases. - The C-terminal fragment of APP is responsible for the characteristic amyloid plaques and neurofibrillary tangles in AD. **Pathways and functions:** - APP is a key player in the formation of amyloid plaques and neurofibrillary tangles in AD. - APP is a precursor for a number of other amyloid proteins, including Aβ. - APP is cleaved into a number of different peptides by a variety of proteases. - The C-terminal fragment of APP is responsible for the characteristic amyloid plaques and neurofibrillary tangles in AD. - APP also plays a role in the regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps). **Clinical significance:** - APP is a promising target for the treatment of AD. - Drugs that target APP are currently being tested in clinical trials for the treatment of AD. - These drugs aim to reduce the levels of APP in the brain and slow the progression of the disease.

Genular Protein ID: 1420399229

Symbol: A4_HUMAN

Name: ABPP

UniProtKB Accession Codes:

P05067 B2R5V1 B4DII8 D3DSD1 D3DSD2 D3DSD3 P09000 P78438 Q13764 Q13778 Q13793 Q16011 Q16014 Q16019 Q16020 Q6GSC0 Q8WZ99 Q9BT38 Q9UC33 Q9UCA9 Q9UCB6 Q9UCC8 Q9UCD1 Q9UQ58

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 24 DrugCentral 1 ELM 1 EMBL 87 EMDB 14 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 7 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 100 PDBsum 100 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 Pumba 1 RNAct 1 Reactome 16 RefSeq 10 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 9 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2881207

Title: The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.

PubMed ID: 2881207

DOI: 10.1038/325733a0

PubMed ID: 2893289

Title: A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.

PubMed ID: 2893289

DOI: 10.1038/331525a0

PubMed ID: 2783775

Title: The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons.

PubMed ID: 2783775

DOI: 10.1093/nar/17.2.517

PubMed ID: 2110105

Title: Genomic organization of the human amyloid beta-protein precursor gene.

PubMed ID: 2110105

DOI: 10.1016/0378-1119(90)90310-n

PubMed ID: 1908403

Title:

PubMed ID: 1908403

DOI: 10.1016/0378-1119(91)90093-q

PubMed ID: 1587857

Title: Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.

PubMed ID: 1587857

DOI: 10.1016/s0021-9258(19)50090-4

PubMed ID: 9108164

Title: A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus.

PubMed ID: 9108164

DOI: 10.1093/nar/25.9.1802

PubMed ID: 12859342

Title: Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639.

PubMed ID: 12859342

DOI: 10.1046/j.1460-9568.2003.02731.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3140222

Title: A cDNA specifying the human amyloid beta precursor protein (ABPP) encodes a 95-kDa polypeptide.

PubMed ID: 3140222

DOI: 10.1093/nar/16.19.9351

PubMed ID: 2538123

Title: Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene.

PubMed ID: 2538123

DOI: 10.1016/0006-291x(89)92437-6

PubMed ID: 3597385

Title: Purification of protease nexin II from human fibroblasts.

PubMed ID: 3597385

DOI: 10.1016/s0021-9258(18)47443-1

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 2893290

Title: Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.

PubMed ID: 2893290

DOI: 10.1038/331528a0

PubMed ID: 2893291

Title: Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity.

PubMed ID: 2893291

DOI: 10.1038/331530a0

PubMed ID: 2893379

Title: Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex.

PubMed ID: 2893379

DOI: 10.1073/pnas.85.3.929

PubMed ID: 8576160

Title: Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.

PubMed ID: 8576160

DOI: 10.1074/jbc.271.3.1613

PubMed ID: 8476439

Title: A system for studying the effect(s) of familial Alzheimer disease mutations on the processing of the beta-amyloid peptide precursor.

PubMed ID: 8476439

DOI: 10.1006/bbrc.1993.1386

PubMed ID: 2675837

Title: Alzheimer's disease amyloid peptide is encoded by two exons and shows similarity to soybean trypsin inhibitor.

PubMed ID: 2675837

DOI: 10.1016/0006-291x(89)91112-1

PubMed ID: 15201367

Title: Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease.

PubMed ID: 15201367

DOI: 10.1136/jnnp.2003.010611

PubMed ID: 3312495

Title: Amyloid angiopathy of Alzheimer's disease: amino acid composition and partial sequence of a 4,200-dalton peptide isolated from cortical microvessels.

PubMed ID: 3312495

DOI: 10.1111/j.1471-4159.1987.tb01005.x

PubMed ID: 1406936

Title: Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids.

PubMed ID: 1406936

DOI: 10.1038/359325a0

PubMed ID: 8229004

Title: Characterization of beta-amyloid peptide from human cerebrospinal fluid.

PubMed ID: 8229004

DOI: 10.1111/j.1471-4159.1993.tb09841.x

PubMed ID: 8248178

Title: Beta-amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

PubMed ID: 8248178

DOI: 10.1073/pnas.90.22.10836

PubMed ID: 8109908

Title: The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient.

PubMed ID: 8109908

DOI: 10.1002/ana.410350223

PubMed ID: 3810169

Title: Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.

PubMed ID: 3810169

DOI: 10.1126/science.3810169

PubMed ID: 2949367

Title: Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

PubMed ID: 2949367

DOI: 10.1126/science.2949367

PubMed ID: 22576872

Title: An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid beta and amyloid precursor protein in human and cat cerebrospinal fluid.

PubMed ID: 22576872

DOI: 10.1002/jms.2987

PubMed ID: 16816112

Title: BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome.

PubMed ID: 16816112

DOI: 10.1096/fj.05-5632com

PubMed ID: 2569763

Title: A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein.

PubMed ID: 2569763

DOI: 10.1126/science.2569763

PubMed ID: 3035574

Title: Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

PubMed ID: 3035574

DOI: 10.1073/pnas.84.12.4190

PubMed ID: 2900137

Title: Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

PubMed ID: 2900137

DOI: 10.1002/j.1460-2075.1988.tb02900.x

PubMed ID: 2649245

Title: Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

PubMed ID: 2649245

DOI: 10.1016/0092-8674(89)90177-3

PubMed ID: 2506449

Title: The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.

PubMed ID: 2506449

DOI: 10.1038/341144a0

PubMed ID: 1969731

Title: Protease-specificity of Kunitz inhibitor domain of Alzheimer's disease amyloid protein precursor.

PubMed ID: 1969731

DOI: 10.1016/0006-291x(90)92084-d

PubMed ID: 8344894

Title: A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.

PubMed ID: 8344894

DOI: 10.1016/s0021-9258(19)85394-2

PubMed ID: 8446172

Title: Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o).

PubMed ID: 8446172

DOI: 10.1038/362075a0

PubMed ID: 8131745

Title: Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein.

PubMed ID: 8131745

DOI: 10.1002/j.1460-2075.1994.tb06360.x

PubMed ID: 7913895

Title: The beta A4 amyloid precursor protein binding to copper.

PubMed ID: 7913895

DOI: 10.1016/0014-5793(94)00658-x

PubMed ID: 8158260

Title: A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth.

PubMed ID: 8158260

DOI: 10.1523/jneurosci.14-04-02117.1994

PubMed ID: 7737970

Title: The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene.

PubMed ID: 7737970

DOI: 10.1074/jbc.270.18.10388

PubMed ID: 8626687

Title: APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein.

PubMed ID: 8626687

DOI: 10.1074/jbc.271.19.11339

PubMed ID: 8887653

Title: The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.

PubMed ID: 8887653

DOI: 10.1128/mcb.16.11.6229

PubMed ID: 8855266

Title: Association of a novel human FE65-like protein with the cytoplasmic domain of the amyloid-beta precursor protein.

PubMed ID: 8855266

DOI: 10.1073/pnas.93.20.10832

PubMed ID: 9168929

Title: Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions.

PubMed ID: 9168929

DOI: 10.1006/bbrc.1997.6547

PubMed ID: 9357988

Title: Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease.

PubMed ID: 9357988

DOI: 10.1016/s0014-5793(97)01146-0

PubMed ID: 9338779

Title: An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.

PubMed ID: 9338779

DOI: 10.1038/39522

PubMed ID: 9585534

Title: Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide.

PubMed ID: 9585534

DOI: 10.1021/bi980022m

PubMed ID: 9843960

Title: PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein.

PubMed ID: 9843960

DOI: 10.1073/pnas.95.25.14745

PubMed ID: 10413512

Title: Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease.

PubMed ID: 10413512

DOI: 10.1021/bi990205o

PubMed ID: 10319819

Title: Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.

PubMed ID: 10319819

DOI: 10.1016/s0092-8674(00)80748-5

PubMed ID: 10535332

Title: Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress.

PubMed ID: 10535332

DOI: 10.1016/s0361-9230(99)00093-3

PubMed ID: 10341243

Title: Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.

PubMed ID: 10341243

DOI: 10.1523/jneurosci.19-11-04421.1999

PubMed ID: 9890987

Title: Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.

PubMed ID: 9890987

DOI: 10.1074/jbc.274.4.2243

PubMed ID: 10383380

Title: Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.

PubMed ID: 10383380

DOI: 10.1074/jbc.274.27.18851

PubMed ID: 10461923

Title: Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein.

PubMed ID: 10461923

DOI: 10.1046/j.1471-4159.1999.0731288.x

PubMed ID: 10656250

Title: Identification of a novel aspartic proteinase (Asp 2) as beta-secretase.

PubMed ID: 10656250

DOI: 10.1006/mcne.1999.0811

PubMed ID: 10081969

Title: Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein.

PubMed ID: 10081969

DOI: 10.1016/s0304-3940(98)00995-1

PubMed ID: 10816430

Title: Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides.

PubMed ID: 10816430

DOI: 10.1042/bj3480359

PubMed ID: 10681545

Title: Beta-amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.

PubMed ID: 10681545

DOI: 10.1074/jbc.275.8.5626

PubMed ID: 12214090

Title: Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

PubMed ID: 12214090

DOI: 10.3233/jad-2000-23-408

PubMed ID: 11775062

Title: Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins.

PubMed ID: 11775062

DOI: 10.1023/a:1012629603390

PubMed ID: 11689470

Title: Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.

PubMed ID: 11689470

DOI: 10.1096/fj.01-0251com

PubMed ID: 11278849

Title: Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module.

PubMed ID: 11278849

DOI: 10.1074/jbc.m011161200

PubMed ID: 11274207

Title: Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered structure containing superoxide dismutase-like subunits.

PubMed ID: 11274207

DOI: 10.1074/jbc.m100175200

PubMed ID: 11438549

Title: Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.

PubMed ID: 11438549

DOI: 10.1074/jbc.m105410200

PubMed ID: 11544248

Title: The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.

PubMed ID: 11544248

DOI: 10.1074/jbc.c100447200

PubMed ID: 11238726

Title: Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function.

PubMed ID: 11238726

DOI: 10.1046/j.1471-4159.2001.00144.x

PubMed ID: 11943163

Title: Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II.

PubMed ID: 11943163

DOI: 10.1016/s0014-5793(02)02376-1

PubMed ID: 11724784

Title: Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

PubMed ID: 11724784

DOI: 10.1074/jbc.m108357200

PubMed ID: 11784781

Title: Contrasting species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.

PubMed ID: 11784781

DOI: 10.1523/jneurosci.22-02-00365.2002

PubMed ID: 12032279

Title: The galvanization of beta-amyloid in Alzheimer's disease.

PubMed ID: 12032279

DOI: 10.1073/pnas.122249699

PubMed ID: 8999878

Title: Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.

PubMed ID: 8999878

DOI: 10.1074/jbc.272.3.1896

PubMed ID: 10806211

Title: Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2.

PubMed ID: 10806211

DOI: 10.1074/jbc.m002850200

PubMed ID: 10742146

Title: A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.

PubMed ID: 10742146

DOI: 10.1038/74656

PubMed ID: 11517218

Title: Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid.

PubMed ID: 11517218

DOI: 10.1074/jbc.m104059200

PubMed ID: 11604391

Title: Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity.

PubMed ID: 11604391

DOI: 10.1074/jbc.m104068200

PubMed ID: 11146006

Title: Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

PubMed ID: 11146006

DOI: 10.1046/j.1471-4159.2001.00102.x

PubMed ID: 11851430

Title: A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.

PubMed ID: 11851430

DOI: 10.1021/bi015794o

PubMed ID: 11877420

Title: Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.

PubMed ID: 11877420

DOI: 10.1074/jbc.m110286200

PubMed ID: 12142279

Title: A cell biological perspective on Alzheimer's disease.

PubMed ID: 12142279

DOI: 10.1146/annurev.cellbio.18.020402.142302

PubMed ID: 14527950

Title: Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.

PubMed ID: 14527950

DOI: 10.1074/jbc.m309561200

PubMed ID: 15084524

Title: Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.

PubMed ID: 15084524

DOI: 10.1096/fj.03-1040fje

PubMed ID: 15347684

Title: Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.

PubMed ID: 15347684

DOI: 10.1074/jbc.m405329200

PubMed ID: 16154999

Title: Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor.

PubMed ID: 16154999

DOI: 10.1074/jbc.m508460200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16174740

Title: Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

PubMed ID: 16174740

DOI: 10.1073/pnas.0503689102

PubMed ID: 16407538

Title: Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.

PubMed ID: 16407538

DOI: 10.1523/jneurosci.3882-05.2006

PubMed ID: 17062754

Title: A peptide zipcode sufficient for anterograde transport within amyloid precursor protein.

PubMed ID: 17062754

DOI: 10.1073/pnas.0607527103

PubMed ID: 17855360

Title: SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.

PubMed ID: 17855360

DOI: 10.1074/jbc.m705073200

PubMed ID: 18468999

Title: Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells.

PubMed ID: 18468999

DOI: 10.1074/jbc.m801827200

PubMed ID: 19366692

Title: BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.

PubMed ID: 19366692

DOI: 10.1074/jbc.m109.006403

PubMed ID: 19225519

Title: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.

PubMed ID: 19225519

DOI: 10.1038/nature07767

PubMed ID: 19901339

Title: RAGE-mediated signaling contributes to intraneuronal transport of amyloid-{beta} and neuronal dysfunction.

PubMed ID: 19901339

DOI: 10.1073/pnas.0905686106

PubMed ID: 20580937

Title: Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol.

PubMed ID: 20580937

DOI: 10.1016/j.bbalip.2010.05.010

PubMed ID: 20811458

Title: Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.

PubMed ID: 20811458

DOI: 10.1038/nature09325

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21712440

Title: Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid.

PubMed ID: 21712440

DOI: 10.1073/pnas.1102664108

Sequence Information:

  • Length: 770
  • Mass: 86943
  • Checksum: A12EE761403740F5
  • Sequence:
    • MLPGLALLLL AAWTARALEV PTDGNAGLLA EPQIAMFCGR LNMHMNVQNG KWDSDPSGTK 
TCIDTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHPH FVIPYRCLVG 
EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR 
GVEFVCCPLA EESDNVDSAD AEEDDSDVWW GGADTDYADG SEDKVVEVAE EEEVAEVEEE 
EADDDEDDED GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC 
RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSAMSQSLL KTTQEPLARD 
PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA 
KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL 
QAVPPRPRHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER 
MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET 
KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN 
IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL 
VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN

Genular Protein ID: 2813719217

Symbol: B4DJT9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DJT9

Database IDs:

ARBA 23 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 9 Gene3D 5 GenomeRNAi 1 InterPro 13 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SUPFAM 3

Sequence Information:

  • Length: 660
  • Mass: 75150
  • Checksum: B6AA0D4BD471A235
  • Sequence:
    • MFCGRLNMHM NVQNGKWDSD PSGTKTCIDT KEGILQYCQE VYPELQITNV VEANQPVTIQ 
NWCKRGRKQC KTHPHFVIPY RCLVGEFVSD ALLVPDKCKF LHQERMDVCE THLHWHTVAK 
ETCSEKSTNL HDYGMLLPCG IDKFRGVEFV CCPLAEESDN VDSADAEEDD SDVWWGGADT 
DYADGSEDKV VEVAEEEEVA EVEEEEADDD EDDEDGDEVE EEAEEPYEEA TERTTSIATT 
TTTTTESVEE VVRVPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM 
REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR 
LALENYITAL QAVPPRPRHV FNMLKKYVRA EQKDRQHTLK HFEHERMVDP KKAAQIRSQV 
MTHLRVIYER MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN 
DALMPSLTET KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL 
TTRPGSGLTN IKTEEISEVK MDAEFRHDPG YEVHHQKLVF FAEDVGSNKG AIIGLMVGGV 
VIATVIVITL VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN

Genular Protein ID: 2577413779

Symbol: B4DGD0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DGD0

Database IDs:

ARBA 46 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 17 Gene3D 6 Genevisible 1 GenomeRNAi 1 InterPro 17 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 9 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 RefSeq 2 RuleBase 1 SAM 3 SMART 2 SMR 1 SUPFAM 4

Sequence Information:

  • Length: 714
  • Mass: 80806
  • Checksum: 471EA43FF6B14888
  • Sequence:
    • MLPGLALLLL AAWTARALEV YPELQITNVV EANQPVTIQN WCKRGRKQCK THPHFVIPYR 
CLVGEFVSDA LLVPDKCKFL HQERMDVCET HLHWHTVAKE TCSEKSTNLH DYGMLLPCGI 
DKFRGVEFVC CPLAEESDNV DSADAEEDDS DVWWGGADTD YADGSEDKVV EVAEEEEVAE 
VEEEEADDDE DDEDGDEVEE EAEEPYEEAT ERTTSIATTT TTTTESVEEV VREVCSEQAE 
TGPCRAMISR WYFDVTEGKC APFFYGGCGG NRNNFDTEEY CMAVCGSAMS QSLLKTTQEP 
LARDPVKLPT TAASTPDAVD KYLETPGDES EHAHFQKAKE RLEAKHRERM SQVMREWEEA 
ERQAKNLPKA DKKAVIQHFQ EKVESLEQEA ANERQQLVET HMARVEAMLN DRRRLALENY 
ITALQAVPPR PRHVFNMLKK YVRAEQKDRQ HTLKHFEHVR MVDPKKAAQI RSQVMTHLRV 
IYERMNQSLS LLYNVPAVAE EIQDEVDELL QKEQNYSDDV LANMISEPRI SYGNDALMPS 
LTETKTTVEL LPVNGEFSLD DLQPWHSFGA DSVPANTENE VEPVDARPAA DRGLTTRPGS 
GLTNIKTEEI SEVKMDAEFR HDSGYEVHHQ KLVFFAEDVG SNKGAIIGLM VGGVVIATVI 
VITLVMLKKK QYTSIHHGVV EVDAAVTPEE RHLSKMQQNG YENPTYKFFE QMQN

Genular Protein ID: 1267942749

Symbol: A0A0A0MRG2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MRG2

Database IDs:

ARBA 34 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 5 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 14 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NIAGADS 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 Proteomes 2 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 660
  • Mass: 75110
  • Checksum: 7EC5DD46A8729202
  • Sequence:
    • MFCGRLNMHM NVQNGKWDSD PSGTKTCIDT KEGILQYCQE VYPELQITNV VEANQPVTIQ 
NWCKRGRKQC KTHPHFVIPY RCLVGEFVSD ALLVPDKCKF LHQERMDVCE THLHWHTVAK 
ETCSEKSTNL HDYGMLLPCG IDKFRGVEFV CCPLAEESDN VDSADAEEDD SDVWWGGADT 
DYADGSEDKV VEVAEEEEVA EVEEEEADDD EDDEDGDEVE EEAEEPYEEA TERTTSIATT 
TTTTTESVEE VVRVPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM 
REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR 
LALENYITAL QAVPPRPRHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV 
MTHLRVIYER MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN 
DALMPSLTET KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL 
TTRPGSGLTN IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG AIIGLMVGGV 
VIATVIVITL VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN

Genular Protein ID: 852524551

Symbol: E9PG40_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PG40

Database IDs:

ARBA 46 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 6 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 InterPro 17 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 NIAGADS 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 9 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 3 SMART 2 SMR 1 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 714
  • Mass: 80833
  • Checksum: 68CC52E6F29B777B
  • Sequence:
    • MLPGLALLLL AAWTARALEV YPELQITNVV EANQPVTIQN WCKRGRKQCK THPHFVIPYR 
CLVGEFVSDA LLVPDKCKFL HQERMDVCET HLHWHTVAKE TCSEKSTNLH DYGMLLPCGI 
DKFRGVEFVC CPLAEESDNV DSADAEEDDS DVWWGGADTD YADGSEDKVV EVAEEEEVAE 
VEEEEADDDE DDEDGDEVEE EAEEPYEEAT ERTTSIATTT TTTTESVEEV VREVCSEQAE 
TGPCRAMISR WYFDVTEGKC APFFYGGCGG NRNNFDTEEY CMAVCGSAMS QSLLKTTQEP 
LARDPVKLPT TAASTPDAVD KYLETPGDEN EHAHFQKAKE RLEAKHRERM SQVMREWEEA 
ERQAKNLPKA DKKAVIQHFQ EKVESLEQEA ANERQQLVET HMARVEAMLN DRRRLALENY 
ITALQAVPPR PRHVFNMLKK YVRAEQKDRQ HTLKHFEHVR MVDPKKAAQI RSQVMTHLRV 
IYERMNQSLS LLYNVPAVAE EIQDEVDELL QKEQNYSDDV LANMISEPRI SYGNDALMPS 
LTETKTTVEL LPVNGEFSLD DLQPWHSFGA DSVPANTENE VEPVDARPAA DRGLTTRPGS 
GLTNIKTEEI SEVKMDAEFR HDSGYEVHHQ KLVFFAEDVG SNKGAIIGLM VGGVVIATVI 
VITLVMLKKK QYTSIHHGVV EVDAAVTPEE RHLSKMQQNG YENPTYKFFE QMQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.