APP | ENSG00000142192 | NCBI 351

Details for: APP

Gene ID: 351

Symbol: APP

Ensembl ID: ENSG00000142192

Description: amyloid beta precursor protein

Associated with

Advanced glycosylation endproduct receptor signaling
(R-HSA-879415)
Amyloid fiber formation
(R-HSA-977225)
Cell recruitment (pro-inflammatory response)
(R-HSA-9664424)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Cytokine signaling in immune system
(R-HSA-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Defective intrinsic pathway for apoptosis
(R-HSA-9734009)
Deregulated cdk5 triggers multiple neurodegenerative pathways in alzheimer's disease models
(R-HSA-8862803)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Ecm proteoglycans
(R-HSA-3000178)
Extracellular matrix organization
(R-HSA-1474244)
Formyl peptide receptors bind formyl peptides and many other ligands
(R-HSA-444473)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Inflammasomes
(R-HSA-622312)
Innate immune system
(R-HSA-168249)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
(R-HSA-9609523)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Leishmania infection
(R-HSA-9658195)
Lysosome vesicle biogenesis
(R-HSA-432720)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mitochondrial protein degradation
(R-HSA-9837999)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Neurodegenerative diseases
(R-HSA-8863678)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Parasitic infection pathways
(R-HSA-9824443)
Peptide ligand-binding receptors
(R-HSA-375276)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Protein localization
(R-HSA-9609507)
Purinergic signaling in leishmaniasis infection
(R-HSA-9660826)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Signaling by gpcr
(R-HSA-372790)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
The nlrp3 inflammasome
(R-HSA-844456)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6 mediated nf-kb activation
(R-HSA-933542)
Trans-golgi network vesicle budding
(R-HSA-199992)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Vesicle-mediated transport
(R-HSA-5653656)
Astrocyte activation involved in immune response
(GO:0002265)
Axonogenesis
(GO:0007409)
Cell adhesion
(GO:0007155)
Central nervous system development
(GO:0007417)
Dna binding
(GO:0003677)
Endocytosis
(GO:0006897)
Enzyme binding
(GO:0019899)
G2/m transition of mitotic cell cycle
(GO:0000086)
Heparin binding
(GO:0008201)
Identical protein binding
(GO:0042802)
Intracellular copper ion homeostasis
(GO:0006878)
Learning
(GO:0007612)
Learning or memory
(GO:0007611)
Mating behavior
(GO:0007617)
Microglial cell activation
(GO:0001774)
Mrna polyadenylation
(GO:0006378)
Notch signaling pathway
(GO:0007219)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Ptb domain binding
(GO:0051425)
Receptor ligand activity
(GO:0048018)
Regulation of epidermal growth factor-activated receptor activity
(GO:0007176)
Regulation of translation
(GO:0006417)
Response to oxidative stress
(GO:0006979)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Serine-type endopeptidase inhibitor activity
(GO:0004867)
Signaling receptor activator activity
(GO:0030546)
Signaling receptor binding
(GO:0005102)
Suckling behavior
(GO:0001967)
Transition metal ion binding
(GO:0046914)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 6.15