Details for: msl 1

Gene ID: 35121

Symbol: msl 1

Ensembl ID: FBgn0005617

Description: male-specific lethal 1

Associated with

Other Information

Genular Protein ID: 2923715892

Symbol: MSL1_DROME

Name: N/A

UniProtKB Accession Codes:

P50535 Q3ZAP1 Q9VJ66

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CTD 1 ComplexPortal 1 DIP 1 DNASU 1 EMBL 3 EnsemblMetazoa 2 ExpressionAtlas 1 FlyBase 1 GO 13 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PaxDb 1 Pfam 1 PhylomeDB 1 Proteomes 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 7781064

Title: Expression of msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila.

PubMed ID: 7781064

DOI: 10.1016/0092-8674(95)90007-1

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 8325488

Title: The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males.

PubMed ID: 8325488

DOI: 10.1093/genetics/134.2.545

PubMed ID: 10679323

Title: Ordered assembly of roX RNAs into MSL complexes on the dosage-compensated X chromosome in Drosophila.

PubMed ID: 10679323

DOI: 10.1016/s0960-9822(00)00311-0

PubMed ID: 11014199

Title: Chromodomains are protein-RNA interaction modules.

PubMed ID: 11014199

DOI: 10.1038/35030169

PubMed ID: 12653959

Title: Tamo selectively modulates nuclear import in Drosophila.

PubMed ID: 12653959

DOI: 10.1046/j.1365-2443.2002.00634.x

PubMed ID: 16543150

Title: Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila.

PubMed ID: 16543150

DOI: 10.1016/j.molcel.2006.02.007

PubMed ID: 18510926

Title: Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila.

PubMed ID: 18510926

DOI: 10.1016/j.cell.2008.04.036

PubMed ID: 21726816

Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

PubMed ID: 21726816

DOI: 10.1016/j.molcel.2011.05.015

PubMed ID: 23084834

Title: MSL2 combines sensor and effector functions in homeostatic control of the Drosophila dosage compensation machinery.

PubMed ID: 23084834

DOI: 10.1016/j.molcel.2012.09.012

PubMed ID: 27183194

Title: Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.

PubMed ID: 27183194

DOI: 10.1038/nsmb.3233

PubMed ID: 32502394

Title: Intergenerationally maintained histone H4 lysine 16 acetylation is instructive for future gene activation.

PubMed ID: 32502394

DOI: 10.1016/j.cell.2020.05.026

PubMed ID: 34426916

Title: Mutations of phosphorylation sites in MSL1 protein do not affect dosage compensation in Drosophila melanogaster.

PubMed ID: 34426916

DOI: 10.1134/s1607672921040025

Sequence Information:

  • Length: 1039
  • Mass: 117503
  • Checksum: 644C21C0390A2750
  • Sequence:
    • MDKRFKWPPK KRANYLESPY PHIPSRGRQR NLHGHPNQTQ HLHQHPGKIY ERQQYGNGRG 
GHGGGNNNYR KLLHSLPAEH GGGAMAPPSS GGTVCAGADM VKLISENNNL RRMVMLNLNL 
MQEQTDSIAA KDKELDDQSA KMSVVKAQNE ELKQAVAQLE AANQELCKQL RRKNQRRNDN 
DDDDDDPPLP PAAPQQKLIR CHAETQTVFR EREQGTQTID AQPQFANALP RGINMKESPA 
LDHHAGAVTN QPASKRSESK GRGEFNGKKV STFILQRMNQ DFEHHIHEQT EVAEEHEMEA 
HKEQISQEED QLVAEEDHLH MQEVHTEEVV GGDIFHDALE SIEMEVVTEE LVDMEEHGQS 
VDANGHIEED DDEDDEDDEN SDKDDDSEED DYPWMHSDAD VNARTEEELW QNQNYLLELD 
PTEEKTCAPS AHSTPNHQQK SSTQAEIRKE GNQNRITEKL LQLKPEPMVD ALEAPILPKW 
VAFKKKDKEH ESVPESPEVP KQQPHQEDAI VDHNAIKNQL EVPKPDLKPK DQPKDEQRQD 
GQLDVRVEPQ EDVRKVQKET LKRQPEDAPK HLPKAVAPKV TKTSSRESTL PKANTADIKD 
APAQKVIANH QSTKTQTDPV KTQRLQVKIR QYEMHPDMRT GSSAPSDIRK QKNVDPVSTP 
ETKTIKSKSM LVNDKKTTSE TSQSPDQEID VETVRRKLAE HLKKELLSQS HSSQVTLKKI 
RERVATNLIY PPPSAPVSST TITPAPTPST TPTPGSTPQH AVTSSMDQEI SAAKSKSKAA 
EQIATPLTPQ SNSSVSSTTS TIRKTLNNCS PHTYSKATAR SGKLQSRFRT ATFPYSTRTW 
EDQEFHCDNE FFLEEADELL ADNPSLEIPK WRDVPVPPSS DKIDTELLSD ATFERRHQKY 
VKDEVDRKCR DARYMKEQIR LEQLRMRRNQ DEVLVALDPL RASTFYPLPE DIEAIQFVNE 
VTVQAFGENV VNMEARDDFG VPWVDAIEAP TSIARSKALA EPVATLASKK IPTTAAEARH 
QENHSSYVFP KRRKRQKNR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.