Top2 | FBgn0284220 | NCBI 35225

Details for: Top2

Gene ID: 35225

Symbol: Top2

Ensembl ID: FBgn0284220

Description: Topoisomerase 2

Associated with

Metabolism of proteins
(R-DME-392499)
Post-translational protein modification
(R-DME-597592)
Sumo e3 ligases sumoylate target proteins
(R-DME-3108232)
Sumoylation
(R-DME-2990846)
Sumoylation of dna replication proteins
(R-DME-4615885)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Chromatin binding
(GO:0003682)
Chromosome
(GO:0005694)
Chromosome condensation
(GO:0030261)
Condensed chromosome
(GO:0000793)
Dna binding
(GO:0003677)
Dna metabolic process
(GO:0006259)
Dna topoisomerase type ii (double strand cut, atp-hydrolyzing) activity
(GO:0003918)
Dna topological change
(GO:0006265)
Four-way junction dna binding
(GO:0000400)
Heterochromatin formation
(GO:0031507)
Male meiosis chromosome segregation
(GO:0007060)
Meiotic cell cycle
(GO:0051321)
Metaphase chromosome alignment
(GO:0051310)
Mitotic cell cycle
(GO:0000278)
Mitotic chromosome condensation
(GO:0007076)
Mitotic sister chromatid segregation
(GO:0000070)
Mrna binding
(GO:0003729)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Rdna binding
(GO:0000182)
Resolution of meiotic recombination intermediates
(GO:0000712)
Satellite dna binding
(GO:0003696)
Sister chromatid segregation
(GO:0000819)

Other Information

Proteins

TOP2_DROME

Genular Protein ID: 3662620266

Symbol: TOP2_DROME

Name: N/A

UniProtKB Accession Codes:

P15348 M9PDQ1 Q6NR40 Q9VIW2

Database IDs:

Citations:

PubMed ID: 2538621

Title: Structure of the Drosophila DNA topoisomerase II gene. Nucleotide sequence and homology among topoisomerases II.

PubMed ID: 2538621

DOI: 10.1016/0022-2836(89)90361-6

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 6308011

Title: DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.

PubMed ID: 6308011

DOI: 10.1016/s0021-9258(17)44700-4

PubMed ID: 2547764

Title: Single strand DNA cleavage reaction of duplex DNA by Drosophila topoisomerase II.

PubMed ID: 2547764

DOI: 10.1016/s0021-9258(18)80026-6

PubMed ID: 1328202

Title: Effect of casein kinase II-mediated phosphorylation on the catalytic cycle of topoisomerase II. Regulation of enzyme activity by enhancement of ATP hydrolysis.

PubMed ID: 1328202

DOI: 10.1016/s0021-9258(19)88732-x

PubMed ID: 8383533

Title: Protein kinase C modulates the catalytic activity of topoisomerase II by enhancing the rate of ATP hydrolysis: evidence for a common mechanism of regulation by phosphorylation.

PubMed ID: 8383533

DOI: 10.1021/bi00059a029

PubMed ID: 8978614

Title: Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II.

PubMed ID: 8978614

DOI: 10.1016/s0092-8674(00)81804-8

PubMed ID: 9545289

Title: Identifying Lys359 as a critical residue for the ATP-dependent reactions of Drosophila DNA topoisomerase II.

PubMed ID: 9545289

DOI: 10.1074/jbc.273.16.9586

PubMed ID: 10885744

Title: Essential functions of DNA topoisomerase I in Drosophila melanogaster.

PubMed ID: 10885744

DOI: 10.1006/dbio.2000.9704

PubMed ID: 10751154

Title: During both interphase and mitosis, DNA topoisomerase II interacts with DNA as well as RNA through the protein's C-terminal domain.

PubMed ID: 10751154

DOI: 10.1242/jcs.113.9.1635

PubMed ID: 10786800

Title: Single-molecule analysis of DNA uncoiling by a type II topoisomerase.

PubMed ID: 10786800

DOI: 10.1038/35009144

PubMed ID: 11172718

Title: Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing.

PubMed ID: 11172718

DOI: 10.1016/s1097-2765(01)00161-7

PubMed ID: 14600258

Title: RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate.

PubMed ID: 14600258

DOI: 10.1242/jcs.00797

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 18752348

Title: Dual role of topoisomerase II in centromere resolution and aurora B activity.

PubMed ID: 18752348

DOI: 10.1371/journal.pbio.0060207

PubMed ID: 21304601

Title: DNA topoisomerase II modulates insulator function in Drosophila.

PubMed ID: 21304601

DOI: 10.1371/journal.pone.0016562

PubMed ID: 23989663

Title: Topoisomerase II plays a role in dosage compensation in Drosophila.

PubMed ID: 23989663

DOI: 10.4161/trns.26185

PubMed ID: 25340780

Title: Topoisomerase II is required for the proper separation of heterochromatic regions during Drosophila melanogaster female meiosis.

PubMed ID: 25340780

DOI: 10.1371/journal.pgen.1004650

Sequence Information:

Length: 1447
Mass: 164396
Checksum: 63B5D2814AD06419
Sequence:

MENGNKALSI EQMYQKKSQL EHILLRPDSY IGSVEFTKEL MWVYDNSQNR MVQKEISFVP 
GLYKIFDEIL VNAADNKQRD KSMNTIKIDI DPERNMVSVW NNGQGIPVTM HKEQKMYVPT 
MIFGHLLTSS NYNDDEKKVT GGRNGYGAKL CNIFSTSFTV ETATREYKKS FKQTWGNNMG 
KASDVQIKDF NGTDYTRITF SPDLAKFKMD RLDEDIVALM SRRAYDVAAS SKGVSVFLNG 
NKLGVRNFKD YIDLHIKNTD DDSGPPIKIV HEVANERWEV ACCPSDRGFQ QVSFVNSIAT 
YKGGRHVDHV VDNLIKQLLE VLKKKNKGGI NIKPFQVRNH LWVFVNCLIE NPTFDSQTKE 
NMTLQQKGFG SKCTLSEKFI NNMSKSGIVE SVLAWAKFKA QNDIAKTGGR KSSKIKGIPK 
LEDANEAGGK NSIKCTLILT EGDSAKSLAV SGLGVIGRDL YGVFPLRGKL LNVREANFKQ 
LSENAEINNL CKIIGLQYKK KYLTEDDLKT LRYGKVMIMT DQDQDGSHIK GLLINFIHTN 
WPELLRLPFL EEFITPIVKA TKKNEELSFY SLPEFEEWKN DTANHHTYNI KYYKGLGTST 
SKEAKEYFQD MDRHRILFKY DGSVDDESIV MAFSKKHIES RKVWLTNHMD EVKRRKELGL 
PERYLYTKGT KSITYADFIN LELVLFSNAD NERSIPSLVD GLKPGQRKVM FTCFKRNDKR 
EVKVAQLSGS VAEMSAYHHG EVSLQMTIVN LAQNFVGANN INLLEPRGQF GTRLSGGKDC 
ASARYIFTIM SPLTRLIYHP LDDPLLDYQV DDGQKIEPLW YLPIIPMVLV NGAEGIGTGW 
STKISNYNPR EIMKNLRKMI NGQEPSVMHP WYKNFLGRME YVSDGRYIQT GNIQILSGNR 
LEISELPVGV WTQNYKENVL EPLSNGTEKV KGIISEYREY HTDTTVRFVI SFAPGEFERI 
HAEEGGFYRV FKLTTTLSTN QMHAFDQNNC LRRFPTAIDI LKEYYKLRRE YYARRRDFLV 
GQLTAQADRL SDQARFILEK CEKKLVVENK QRKAMCDELL KRGYRPDPVK EWQRRIKMED 
AEQADEEDEE EEEAAPSVSS KAKKEKEVDP EKAFKKLTDV KKFDYLLGMS MWMLTEEKKN 
ELLKQRDTKL SELESLRKKT PEMLWLDDLD ALESKLNEVE EKERAEEQGI NLKTAKALKG 
QKSASAKGRK VKSMGGGAGA GDVFPDPDGE PVEFKITEEI IKKMAAAAKV AQAAKEPKKP 
KEPKEPKVKK EPKGKQIKAE PDASGDEVDE FDAMVEGGSK TSPKAKKAVV KKEPGEKKPR 
QKKENGGGLK QSKIDFSKAK AKKSDDDVEE VTPRAERPGR RQASKKIDYS SLFSDEEEDG 
GNVGSDDDGN ASDDDSPKRP AKRGREDESS GGAKKKAPPK KRRAVIESDD DDIEIDEDDD 
DDSDFNC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Top2

Associated with

Other Information

Structure of the Drosophila DNA topoisomerase II gene. Nucleotide sequence and homology among topoisomerases II. PubMed ID: 2538621

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA. PubMed ID: 6308011

Single strand DNA cleavage reaction of duplex DNA by Drosophila topoisomerase II. PubMed ID: 2547764

Effect of casein kinase II-mediated phosphorylation on the catalytic cycle of topoisomerase II. Regulation of enzyme activity by enhancement of ATP hydrolysis. PubMed ID: 1328202

Protein kinase C modulates the catalytic activity of topoisomerase II by enhancing the rate of ATP hydrolysis: evidence for a common mechanism of regulation by phosphorylation. PubMed ID: 8383533

Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II. PubMed ID: 8978614

Identifying Lys359 as a critical residue for the ATP-dependent reactions of Drosophila DNA topoisomerase II. PubMed ID: 9545289

Essential functions of DNA topoisomerase I in Drosophila melanogaster. PubMed ID: 10885744

During both interphase and mitosis, DNA topoisomerase II interacts with DNA as well as RNA through the protein's C-terminal domain. PubMed ID: 10751154

Single-molecule analysis of DNA uncoiling by a type II topoisomerase. PubMed ID: 10786800

Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing. PubMed ID: 11172718

RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate. PubMed ID: 14600258

Phosphoproteome analysis of Drosophila melanogaster embryos. PubMed ID: 18327897

Dual role of topoisomerase II in centromere resolution and aurora B activity. PubMed ID: 18752348

DNA topoisomerase II modulates insulator function in Drosophila. PubMed ID: 21304601

Topoisomerase II plays a role in dosage compensation in Drosophila. PubMed ID: 23989663

Topoisomerase II is required for the proper separation of heterochromatic regions during Drosophila melanogaster female meiosis. PubMed ID: 25340780