Details for: KLK3

Gene ID: 354

Symbol: KLK3

Ensembl ID: ENSG00000142515

Description: kallikrein related peptidase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 72.9110
    Cell Significance Index: 881.2400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 10.5222
    Cell Significance Index: 108.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.4394
    Cell Significance Index: 210.8700
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.5236
    Cell Significance Index: 15.5700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.8796
    Cell Significance Index: 32.1300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.5208
    Cell Significance Index: 13.5000
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.3544
    Cell Significance Index: 6.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9453
    Cell Significance Index: 179.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9086
    Cell Significance Index: 92.8100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.8981
    Cell Significance Index: 6.4500
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.6366
    Cell Significance Index: 1.4700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.5884
    Cell Significance Index: 9.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5549
    Cell Significance Index: 11.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5324
    Cell Significance Index: 480.6800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.4946
    Cell Significance Index: 5.3600
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.3970
    Cell Significance Index: 2.2100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.3967
    Cell Significance Index: 2.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3620
    Cell Significance Index: 39.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3299
    Cell Significance Index: 53.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3057
    Cell Significance Index: 18.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2155
    Cell Significance Index: 14.9100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1758
    Cell Significance Index: 2.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1743
    Cell Significance Index: 17.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.1433
    Cell Significance Index: -0.3100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.1164
    Cell Significance Index: 1.2700
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.1034
    Cell Significance Index: 0.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0549
    Cell Significance Index: 1.4700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.0471
    Cell Significance Index: 0.5200
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.0406
    Cell Significance Index: 0.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0389
    Cell Significance Index: 7.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0334
    Cell Significance Index: 0.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0274
    Cell Significance Index: 2.0400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.0216
    Cell Significance Index: 0.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0174
    Cell Significance Index: 0.7900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0166
    Cell Significance Index: 0.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0145
    Cell Significance Index: 2.0000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0145
    Cell Significance Index: 0.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0118
    Cell Significance Index: 1.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0114
    Cell Significance Index: 0.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0111
    Cell Significance Index: 0.3200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0079
    Cell Significance Index: 0.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0059
    Cell Significance Index: 0.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0034
    Cell Significance Index: 0.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0016
    Cell Significance Index: 0.2000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0004
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0004
    Cell Significance Index: -0.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0014
    Cell Significance Index: -1.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0016
    Cell Significance Index: -0.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0022
    Cell Significance Index: -1.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0028
    Cell Significance Index: -0.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0031
    Cell Significance Index: -0.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0045
    Cell Significance Index: -0.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0046
    Cell Significance Index: -0.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0050
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0059
    Cell Significance Index: -0.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0067
    Cell Significance Index: -0.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0069
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0071
    Cell Significance Index: -0.8200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0077
    Cell Significance Index: -0.1000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0085
    Cell Significance Index: -0.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0097
    Cell Significance Index: -0.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0100
    Cell Significance Index: -0.3200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0103
    Cell Significance Index: -0.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0124
    Cell Significance Index: -0.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0125
    Cell Significance Index: -0.8400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0133
    Cell Significance Index: -0.2000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0146
    Cell Significance Index: -0.0900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0153
    Cell Significance Index: -0.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0154
    Cell Significance Index: -1.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0162
    Cell Significance Index: -0.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0167
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0174
    Cell Significance Index: -0.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0192
    Cell Significance Index: -1.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0193
    Cell Significance Index: -0.9000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0193
    Cell Significance Index: -0.6100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0206
    Cell Significance Index: -0.2500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0212
    Cell Significance Index: -0.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0220
    Cell Significance Index: -0.9000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0225
    Cell Significance Index: -0.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0226
    Cell Significance Index: -1.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0245
    Cell Significance Index: -0.8600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0245
    Cell Significance Index: -0.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0247
    Cell Significance Index: -0.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0270
    Cell Significance Index: -0.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0273
    Cell Significance Index: -0.8700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.0286
    Cell Significance Index: -0.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0292
    Cell Significance Index: -1.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0297
    Cell Significance Index: -0.5300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0299
    Cell Significance Index: -0.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0309
    Cell Significance Index: -0.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Protein Metabolism:** KLK3 is involved in the proteolytic processing of various proteins, including insulin-like growth factor (IGF) binding proteins (IGFBPs), which regulates IGF transport and uptake. 2. **Angiogenesis:** KLK3 negatively regulates angiogenesis, a process crucial for tumor growth and metastasis. 3. **Immune Regulation:** KLK3 is involved in the production of antibacterial peptides and the regulation of immune responses. 4. **Cellular Localization:** KLK3 is expressed in various cell types, including prostate epithelial cells, plasma cells, and hematopoietic stem cells. **Pathways and Functions:** 1. **Activated PKN1 Stimulates Transcription of AR-Regulated Genes:** KLK3 is upregulated by activated protein kinase N1 (PKN1), which stimulates the transcription of androgen receptor (AR)-regulated genes KLK2 and KLK3. 2. **Endopeptidase Activity:** KLK3 is a serine-type endopeptidase that hydrolyzes various peptides, including IGFBPs and other growth factors. 3. **Extracellular Exosome:** KLK3 is secreted into the extracellular space, where it can interact with other proteins and cells. 4. **Regulation of IGF Transport and Uptake:** KLK3 regulates the transport and uptake of IGFs by IGFBPs, which is crucial for cell growth and differentiation. **Clinical Significance:** 1. **Prostate Cancer:** KLK3 is overexpressed in prostate cancer, making it a potential biomarker for early detection and diagnosis. 2. **Angiogenesis and Metastasis:** KLK3's negative regulation of angiogenesis may contribute to the suppression of tumor growth and metastasis. 3. **Immune System:** KLK3's involvement in immune regulation may have implications for the treatment of autoimmune diseases and cancer. 4. **IGF-Related Disorders:** KLK3's regulation of IGF transport and uptake may be relevant to the treatment of IGF-related disorders, such as IGF-1 deficiency. In conclusion, KLK3 is a multifaceted gene with significant implications in protein metabolism, angiogenesis, and immune regulation. Further research is needed to fully understand the functions and clinical significance of KLK3, but its role in various diseases makes it an exciting area of investigation.

Genular Protein ID: 3101474173

Symbol: KLK3_HUMAN

Name: Prostate-specific antigen

UniProtKB Accession Codes:

P07288 C9JXH3 G3V0H4 G3XAE3 Q15096 Q16272 Q86TG8 Q8IXI4

Database IDs:

ABCD 1 AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 26 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2436946

Title: Molecular cloning of human prostate specific antigen cDNA.

PubMed ID: 2436946

DOI: 10.1016/0014-5793(87)80078-9

PubMed ID: 2467258

Title: Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1.

PubMed ID: 2467258

DOI: 10.1093/nar/17.5.2137

PubMed ID: 2471958

Title: Genomic sequence of human prostate specific antigen (PSA).

PubMed ID: 2471958

DOI: 10.1093/nar/17.10.3981

PubMed ID: 2472789

Title: Characterization of the gene for prostate-specific antigen, a human glandular kallikrein.

PubMed ID: 2472789

DOI: 10.1016/0006-291x(89)91362-4

PubMed ID: 2470373

Title: cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes.

PubMed ID: 2470373

DOI: 10.1016/0006-291x(89)92520-5

PubMed ID: 2466464

Title: Characterization of the prostate-specific antigen gene: a novel human kallikrein-like gene.

PubMed ID: 2466464

DOI: 10.1016/0006-291x(89)92409-1

PubMed ID: 8677566

Title: A comparative analysis of prostate-specific antigen gene sequence in benign and malignant prostate tissue.

PubMed ID: 8677566

DOI: 10.1016/s0090-4295(96)00060-x

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7527295

Title: Molecular characterization of prostate-specific antigen messenger RNA expressed in breast tumors.

PubMed ID: 7527295

PubMed ID: 2456523

Title: Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence.

PubMed ID: 2456523

DOI: 10.1093/nar/16.13.6226

PubMed ID: 2422647

Title: Human prostate-specific antigen: structural and functional similarity with serine proteases.

PubMed ID: 2422647

DOI: 10.1073/pnas.83.10.3166

PubMed ID: 3691515

Title: Isolation, characterization and amino-acid sequence of gamma-seminoprotein, a glycoprotein from human seminal plasma.

PubMed ID: 3691515

DOI: 10.1111/j.1432-1033.1987.tb13674.x

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 23842001

Title: Identification of a novel proteoform of prostate specific antigen (SNP-L132I) in clinical samples by multiple reaction monitoring.

PubMed ID: 23842001

DOI: 10.1074/mcp.m113.028365

PubMed ID: 1725227

Title: Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen.

PubMed ID: 1725227

DOI: 10.1016/0049-3848(91)90002-e

PubMed ID: 7535613

Title: A structural model for the prostate disease marker, human prostate-specific antigen.

PubMed ID: 7535613

DOI: 10.1002/pro.5560031116

PubMed ID: 9751643

Title: Substrate specificity of prostate-specific antigen (PSA).

PubMed ID: 9751643

DOI: 10.1016/s1074-5521(98)90004-7

PubMed ID: 18187150

Title: Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody.

PubMed ID: 18187150

DOI: 10.1016/j.jmb.2007.11.052

Sequence Information:

  • Length: 261
  • Mass: 28741
  • Checksum: AE9E732AF872141A
  • Sequence:
    • MWVPVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC GGVLVHPQWV 
LTAAHCIRNK SVILLGRHSL FHPEDTGQVF QVSHSFPHPL YDMSLLKNRF LRPGDDSSHD 
LMLLRLSEPA ELTDAVKVMD LPTQEPALGT TCYASGWGSI EPEEFLTPKK LQCVDLHVIS 
NDVCAQVHPQ KVTKFMLCAG RWTGGKSTCS GDSGGPLVCN GVLQGITSWG SEPCALPERP 
SLYTKVVHYR KWIKDTIVAN P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.