KLK3 | ENSG00000142515 | NCBI 354

Details for: KLK3

Gene ID: 354

Symbol: KLK3

Ensembl ID: ENSG00000142515

Description: kallikrein related peptidase 3

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Metabolism of proteins
(R-HSA-392499)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Endopeptidase activity
(GO:0004175)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
(GO:0016811)
Negative regulation of angiogenesis
(GO:0016525)
Nucleus
(GO:0005634)
Positive regulation of antibacterial peptide production
(GO:0002803)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein metabolic process
(GO:0019538)
Proteolysis
(GO:0006508)
Secretory granule
(GO:0030141)
Serine-type endopeptidase activity
(GO:0004252)
Serine-type peptidase activity
(GO:0008236)

Other Information

Proteins

Prostate-specific antigen

Genular Protein ID: 3101474173

Symbol: KLK3_HUMAN

Name: Prostate-specific antigen

UniProtKB Accession Codes:

P07288 C9JXH3 G3V0H4 G3XAE3 Q15096 Q16272 Q86TG8 Q8IXI4

Database IDs:

Citations:

PubMed ID: 2436946

Title: Molecular cloning of human prostate specific antigen cDNA.

PubMed ID: 2436946

DOI: 10.1016/0014-5793(87)80078-9

PubMed ID: 2467258

Title: Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1.

PubMed ID: 2467258

DOI: 10.1093/nar/17.5.2137

PubMed ID: 2471958

Title: Genomic sequence of human prostate specific antigen (PSA).

PubMed ID: 2471958

DOI: 10.1093/nar/17.10.3981

PubMed ID: 2472789

Title: Characterization of the gene for prostate-specific antigen, a human glandular kallikrein.

PubMed ID: 2472789

DOI: 10.1016/0006-291x(89)91362-4

PubMed ID: 2470373

Title: cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes.

PubMed ID: 2470373

DOI: 10.1016/0006-291x(89)92520-5

PubMed ID: 2466464

Title: Characterization of the prostate-specific antigen gene: a novel human kallikrein-like gene.

PubMed ID: 2466464

DOI: 10.1016/0006-291x(89)92409-1

PubMed ID: 8677566

Title: A comparative analysis of prostate-specific antigen gene sequence in benign and malignant prostate tissue.

PubMed ID: 8677566

DOI: 10.1016/s0090-4295(96)00060-x

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7527295

Title: Molecular characterization of prostate-specific antigen messenger RNA expressed in breast tumors.

PubMed ID: 7527295

PubMed ID: 2456523

Title: Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence.

PubMed ID: 2456523

DOI: 10.1093/nar/16.13.6226

PubMed ID: 2422647

Title: Human prostate-specific antigen: structural and functional similarity with serine proteases.

PubMed ID: 2422647

DOI: 10.1073/pnas.83.10.3166

PubMed ID: 3691515

Title: Isolation, characterization and amino-acid sequence of gamma-seminoprotein, a glycoprotein from human seminal plasma.

PubMed ID: 3691515

DOI: 10.1111/j.1432-1033.1987.tb13674.x

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 23842001

Title: Identification of a novel proteoform of prostate specific antigen (SNP-L132I) in clinical samples by multiple reaction monitoring.

PubMed ID: 23842001

DOI: 10.1074/mcp.m113.028365

PubMed ID: 1725227

Title: Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen.

PubMed ID: 1725227

DOI: 10.1016/0049-3848(91)90002-e

PubMed ID: 7535613

Title: A structural model for the prostate disease marker, human prostate-specific antigen.

PubMed ID: 7535613

DOI: 10.1002/pro.5560031116

PubMed ID: 9751643

Title: Substrate specificity of prostate-specific antigen (PSA).

PubMed ID: 9751643

DOI: 10.1016/s1074-5521(98)90004-7

PubMed ID: 18187150

Title: Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody.

PubMed ID: 18187150

DOI: 10.1016/j.jmb.2007.11.052

Sequence Information:

Length: 261
Mass: 28741
Checksum: AE9E732AF872141A
Sequence:

MWVPVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC GGVLVHPQWV 
LTAAHCIRNK SVILLGRHSL FHPEDTGQVF QVSHSFPHPL YDMSLLKNRF LRPGDDSSHD 
LMLLRLSEPA ELTDAVKVMD LPTQEPALGT TCYASGWGSI EPEEFLTPKK LQCVDLHVIS 
NDVCAQVHPQ KVTKFMLCAG RWTGGKSTCS GDSGGPLVCN GVLQGITSWG SEPCALPERP 
SLYTKVVHYR KWIKDTIVAN P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: KLK3

Associated with

Other Information

Molecular cloning of human prostate specific antigen cDNA. PubMed ID: 2436946

Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1. PubMed ID: 2467258

Genomic sequence of human prostate specific antigen (PSA). PubMed ID: 2471958

Characterization of the gene for prostate-specific antigen, a human glandular kallikrein. PubMed ID: 2472789

cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes. PubMed ID: 2470373

Characterization of the prostate-specific antigen gene: a novel human kallikrein-like gene. PubMed ID: 2466464

A comparative analysis of prostate-specific antigen gene sequence in benign and malignant prostate tissue. PubMed ID: 8677566

Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. PubMed ID: 11054574

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular characterization of prostate-specific antigen messenger RNA expressed in breast tumors. PubMed ID: 7527295

Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence. PubMed ID: 2456523

Human prostate-specific antigen: structural and functional similarity with serine proteases. PubMed ID: 2422647

Isolation, characterization and amino-acid sequence of gamma-seminoprotein, a glycoprotein from human seminal plasma. PubMed ID: 3691515

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Identification of a novel proteoform of prostate specific antigen (SNP-L132I) in clinical samples by multiple reaction monitoring. PubMed ID: 23842001

Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen. PubMed ID: 1725227

A structural model for the prostate disease marker, human prostate-specific antigen. PubMed ID: 7535613

Substrate specificity of prostate-specific antigen (PSA). PubMed ID: 9751643

Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody. PubMed ID: 18187150