Details for: FAS

Gene ID: 355

Symbol: FAS

Ensembl ID: ENSG00000026103

Description: Fas cell surface death receptor

Associated with

Other Information

Genular Protein ID: 3288833186

Symbol: TNR6_HUMAN

Name: Tumor necrosis factor receptor superfamily member 6

UniProtKB Accession Codes:

P25445 A9UJX4 B6VNV4 Q14292 Q14293 Q14294 Q14295 Q16652 Q5T9P1 Q5T9P2 Q5T9P3 Q6SSE9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 20 EPD 1 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 6 PIR 4 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 7 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1713127

Title: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.

PubMed ID: 1713127

DOI: 10.1016/0092-8674(91)90614-5

PubMed ID: 1375228

Title: Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

PubMed ID: 1375228

DOI: 10.1016/s0021-9258(19)50076-x

PubMed ID: 7575433

Title: Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation.

PubMed ID: 7575433

DOI: 10.1042/bj3100957

PubMed ID: 7533181

Title: Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing.

PubMed ID: 7533181

PubMed ID: 8598453

Title: Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis.

PubMed ID: 8598453

PubMed ID: 8648105

Title: An N-terminal domain shared by Fas/Apo-1 (CD95) soluble variants prevents cell death in vitro.

PubMed ID: 8648105

PubMed ID: 17336828

Title: Autoimmune lymphoproliferative syndrome (ALPS) in a patient with a new germline Fas gene mutation.

PubMed ID: 17336828

DOI: 10.1016/j.imbio.2006.12.003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7538908

Title: RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death.

PubMed ID: 7538908

DOI: 10.1016/0092-8674(95)90072-1

PubMed ID: 10542291

Title: F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis.

PubMed ID: 10542291

DOI: 10.1074/jbc.274.45.32461

PubMed ID: 10535980

Title: LFG: an anti-apoptotic gene that provides protection from fas-mediated cell death.

PubMed ID: 10535980

DOI: 10.1073/pnas.96.22.12667

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15465831

Title: A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway.

PubMed ID: 15465831

DOI: 10.1074/jbc.m408678200

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21109225

Title: Whole-exome-sequencing-based discovery of human FADD deficiency.

PubMed ID: 21109225

DOI: 10.1016/j.ajhg.2010.10.028

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23955153

Title: Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.

PubMed ID: 23955153

DOI: 10.1038/nature12436

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25301068

Title: Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability.

PubMed ID: 25301068

DOI: 10.1038/cdd.2014.153

PubMed ID: 30979585

Title: Structural and functional insights into host death domains inactivation by the bacterial arginine GlcNAcyltransferase effector.

PubMed ID: 30979585

DOI: 10.1016/j.molcel.2019.03.028

PubMed ID: 8967952

Title: NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain.

PubMed ID: 8967952

DOI: 10.1038/384638a0

PubMed ID: 19118384

Title: The Fas-FADD death domain complex structure unravels signalling by receptor clustering.

PubMed ID: 19118384

DOI: 10.1038/nature07606

PubMed ID: 24914971

Title: Structural insights into the mechanism of calmodulin binding to death receptors.

PubMed ID: 24914971

DOI: 10.1107/s1399004714006919

PubMed ID: 7540117

Title: Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome.

PubMed ID: 7540117

DOI: 10.1016/0092-8674(95)90013-6

PubMed ID: 8929361

Title: Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity.

PubMed ID: 8929361

DOI: 10.1056/nejm199611283352204

PubMed ID: 9028321

Title: Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis.

PubMed ID: 9028321

PubMed ID: 9028957

Title: Clinical, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis.

PubMed ID: 9028957

PubMed ID: 9322534

Title: Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis.

PubMed ID: 9322534

DOI: 10.1053/gast.1997.v113.pm9322534

PubMed ID: 9787134

Title: Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity.

PubMed ID: 9787134

PubMed ID: 9821419

Title: The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis.

PubMed ID: 9821419

DOI: 10.1016/s0022-3476(98)70102-7

PubMed ID: 10090885

Title: Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance.

PubMed ID: 10090885

DOI: 10.1086/302333

PubMed ID: 10515860

Title: Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations.

PubMed ID: 10515860

PubMed ID: 10340403

Title: Defective apoptosis due to a point mutation in the death domain of CD95 associated with autoimmune lymphoproliferative syndrome, T-cell lymphoma, and Hodgkin's disease.

PubMed ID: 10340403

DOI: 10.1016/s0301-472x(99)00033-8

PubMed ID: 9927496

Title: The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations.

PubMed ID: 9927496

DOI: 10.1172/jci5121

PubMed ID: 10620127

Title: Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar.

PubMed ID: 10620127

DOI: 10.1046/j.1523-1747.2000.00819.x

PubMed ID: 11418480

Title: The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis.

PubMed ID: 11418480

DOI: 10.1182/blood.v98.1.194

PubMed ID: 20935634

Title: The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations.

PubMed ID: 20935634

DOI: 10.1038/nsmb.1920

Sequence Information:

  • Length: 335
  • Mass: 37732
  • Checksum: 0139942535111410
  • Sequence:
    • MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE GLHHDGQFCH 
KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK CRRCRLCDEG HGLEVEINCT 
RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE HGIIKECTLT SNTKCKEEGS RSNLGWLCLL 
LLPIPLIVWV KRKEVQKTCR KHRKENQGSH ESPTLNPETV AINLSDVDLS KYITTIAGVM 
TLSQVKGFVR KNGVNEAKID EIKNDNVQDT AEQKVQLLRN WHQLHGKKEA YDTLIKDLKK 
ANLCTLAEKI QTIILKDITS DSENSNFRNE IQSLV

Genular Protein ID: 1211796270

Symbol: Q59FU8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FU8

Database IDs:

ARBA 16 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 9 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 6 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 2 Proteomes 2 RefSeq 2 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 362
  • Mass: 40494
  • Checksum: F4FB186BFD5D8EE2
  • Sequence:
    • MLRVCAQGWH AQGLPHGTNS LLKGGTETSL STPTRLVVLT SVARLSSKSV NAQVTDINSK 
GLELRKTVTT VETQNLEGLH HDGQFCHKPC PPGERKARDC TVNGDEPDCV PCQEGKEYTD 
KAHFSSKCRR CRLCDEGHGL EVEINCTRTQ NTKCRCKPNF FCNSTVCEHC DPCTKCEHGI 
IKECTLTSNT KCKEEGSRSN LGWLCLLLLP IPLIVWVKRK EVQKTCRKHR KENQGSHESP 
TLNPETVAIN LSDVDLSKYI TTIAGVMTLS QVKGFVRKNG VNEAKIDEIK NDNVQDTAEQ 
KVQLLRNWHQ LHGKKEAYDT LIKDLKKANL CTLAEKIQTI ILKDITSDSE NSNFRNEIQS 
LV

Genular Protein ID: 2968375444

Symbol: K9J972_HUMAN

Name: N/A

UniProtKB Accession Codes:

K9J972

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 7 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PROSITE-ProRule 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 197
  • Mass: 21955
  • Checksum: 343DA9D7F00C3B8A
  • Sequence:
    • MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE GLHHDGQFCH 
KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK CRRCRLCDEG HGLEVEINCT 
RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE HGIIKECTLT SNTKCKEEGS RSNLGWLCLL 
LLPIPLIVWG NSGNKFI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.