Details for: FAS

Gene ID: 355

Symbol: FAS

Ensembl ID: ENSG00000026103

Description: Fas cell surface death receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.5343
    Cell Significance Index: -13.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.7188
    Cell Significance Index: -14.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 38.0145
    Cell Significance Index: -15.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 32.4704
    Cell Significance Index: -15.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.4635
    Cell Significance Index: -15.6700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 22.8308
    Cell Significance Index: -15.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.6387
    Cell Significance Index: -14.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3628
    Cell Significance Index: -13.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8139
    Cell Significance Index: -15.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.7628
    Cell Significance Index: -10.0800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.4061
    Cell Significance Index: 54.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2385
    Cell Significance Index: 60.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.0041
    Cell Significance Index: 57.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5626
    Cell Significance Index: 21.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.5619
    Cell Significance Index: 33.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4657
    Cell Significance Index: 144.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4199
    Cell Significance Index: 41.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0596
    Cell Significance Index: 20.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8090
    Cell Significance Index: 88.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7558
    Cell Significance Index: 122.9200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.7553
    Cell Significance Index: 6.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7297
    Cell Significance Index: 43.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4209
    Cell Significance Index: 380.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4160
    Cell Significance Index: 57.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3738
    Cell Significance Index: 18.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3268
    Cell Significance Index: 15.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2849
    Cell Significance Index: 36.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2571
    Cell Significance Index: 140.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2394
    Cell Significance Index: 28.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2369
    Cell Significance Index: 10.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1879
    Cell Significance Index: 4.3400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.1753
    Cell Significance Index: 1.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1509
    Cell Significance Index: 18.5600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1473
    Cell Significance Index: 2.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1315
    Cell Significance Index: 58.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1299
    Cell Significance Index: 26.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1250
    Cell Significance Index: 14.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1240
    Cell Significance Index: 8.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1216
    Cell Significance Index: 23.1400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1033
    Cell Significance Index: 1.4700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0991
    Cell Significance Index: 0.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0737
    Cell Significance Index: 2.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0648
    Cell Significance Index: 11.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0618
    Cell Significance Index: 12.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0579
    Cell Significance Index: 108.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0578
    Cell Significance Index: 1.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0543
    Cell Significance Index: 1.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0448
    Cell Significance Index: 1.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0223
    Cell Significance Index: 2.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0152
    Cell Significance Index: 0.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0076
    Cell Significance Index: 0.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0074
    Cell Significance Index: 5.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0074
    Cell Significance Index: -0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0082
    Cell Significance Index: -15.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0093
    Cell Significance Index: -7.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0096
    Cell Significance Index: -14.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0115
    Cell Significance Index: -15.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0168
    Cell Significance Index: -10.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0190
    Cell Significance Index: -13.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0212
    Cell Significance Index: -15.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0224
    Cell Significance Index: -8.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0256
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0261
    Cell Significance Index: -16.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0263
    Cell Significance Index: -2.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0266
    Cell Significance Index: -15.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0288
    Cell Significance Index: -8.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0299
    Cell Significance Index: -13.5800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0508
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0698
    Cell Significance Index: -11.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0748
    Cell Significance Index: -15.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0778
    Cell Significance Index: -11.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0923
    Cell Significance Index: -1.9200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0939
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1017
    Cell Significance Index: -11.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1048
    Cell Significance Index: -0.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1265
    Cell Significance Index: -3.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1291
    Cell Significance Index: -6.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1332
    Cell Significance Index: -13.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1382
    Cell Significance Index: -10.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1553
    Cell Significance Index: -9.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1631
    Cell Significance Index: -2.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1757
    Cell Significance Index: -2.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1775
    Cell Significance Index: -11.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1778
    Cell Significance Index: -13.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1823
    Cell Significance Index: -12.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1903
    Cell Significance Index: -15.0800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2030
    Cell Significance Index: -2.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2316
    Cell Significance Index: -14.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2356
    Cell Significance Index: -14.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2465
    Cell Significance Index: -13.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2472
    Cell Significance Index: -8.5900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2601
    Cell Significance Index: -3.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2789
    Cell Significance Index: -14.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2858
    Cell Significance Index: -10.4900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2882
    Cell Significance Index: -2.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2910
    Cell Significance Index: -11.9200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2996
    Cell Significance Index: -1.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3081
    Cell Significance Index: -6.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3249
    Cell Significance Index: -14.3700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3277
    Cell Significance Index: -5.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell surface death receptor**: FAS is a transmembrane receptor that binds to its ligand, FasL, triggering a signaling cascade that leads to apoptosis. 2. **Apoptosis regulator**: FAS is a key regulator of apoptosis, and its dysregulation can lead to uncontrolled cell growth and tumorigenesis. 3. **Immune system component**: FAS is expressed on various immune cells, including T cells, and plays a critical role in regulating immune responses. 4. **Tight regulation**: FAS expression is tightly regulated by transcription factors, such as TP53, to ensure proper cell death and prevent excessive apoptosis. 5. **Diverse ligands**: FAS can bind to several ligands, including FasL, TRAIL (TNF-related apoptosis-inducing ligand), and CD95L (CD95 ligand), leading to different signaling outcomes. **Pathways and Functions** 1. **Apoptosis signaling pathway**: FAS activation leads to the activation of caspases, including caspase-8, which activates downstream caspases, resulting in apoptosis. 2. **Extrinsic apoptotic signaling pathway**: FAS binding to FasL triggers the activation of caspase-8, which activates downstream caspases, resulting in apoptosis. 3. **Intrinsic apoptotic signaling pathway**: FAS binding to FasL also activates the intrinsic apoptotic pathway, involving the activation of caspase-9 and caspase-3. 4. **Immune response regulation**: FAS is involved in regulating immune responses, including the activation of T cells and the elimination of self-reactive T cells. 5. **Cancer progression**: FAS dysregulation has been implicated in cancer progression, including the development of tumors and the evasion of immune surveillance. **Clinical Significance** 1. **Cancer therapy**: FAS inhibition has been explored as a potential therapeutic strategy for cancer treatment, including the use of FAS ligand antagonists. 2. **Autoimmune disorders**: FAS dysregulation has been implicated in various autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. 3. **Inflammatory conditions**: FAS has been implicated in the regulation of inflammatory responses, including the development of inflammatory bowel disease and rheumatoid arthritis. 4. **Immunotherapy**: FAS has been targeted as a potential target for immunotherapy, including the use of FAS-targeting antibodies and small molecules. 5. **Regulatory T cell function**: FAS has been implicated in the regulation of regulatory T cell function, which is critical for maintaining immune tolerance and preventing autoimmune disease. In conclusion, the FAS gene plays a critical role in regulating programmed cell death and is involved in various immune and inflammatory processes. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions, highlighting the importance of FAS in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 3288833186

Symbol: TNR6_HUMAN

Name: Tumor necrosis factor receptor superfamily member 6

UniProtKB Accession Codes:

P25445 A9UJX4 B6VNV4 Q14292 Q14293 Q14294 Q14295 Q16652 Q5T9P1 Q5T9P2 Q5T9P3 Q6SSE9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 20 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 4 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 7 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1713127

Title: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.

PubMed ID: 1713127

DOI: 10.1016/0092-8674(91)90614-5

PubMed ID: 1375228

Title: Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

PubMed ID: 1375228

DOI: 10.1016/s0021-9258(19)50076-x

PubMed ID: 7575433

Title: Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation.

PubMed ID: 7575433

DOI: 10.1042/bj3100957

PubMed ID: 7533181

Title: Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing.

PubMed ID: 7533181

PubMed ID: 8598453

Title: Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis.

PubMed ID: 8598453

PubMed ID: 8648105

Title: An N-terminal domain shared by Fas/Apo-1 (CD95) soluble variants prevents cell death in vitro.

PubMed ID: 8648105

PubMed ID: 17336828

Title: Autoimmune lymphoproliferative syndrome (ALPS) in a patient with a new germline Fas gene mutation.

PubMed ID: 17336828

DOI: 10.1016/j.imbio.2006.12.003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7538908

Title: RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death.

PubMed ID: 7538908

DOI: 10.1016/0092-8674(95)90072-1

PubMed ID: 9184224

Title: FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

PubMed ID: 9184224

DOI: 10.1093/emboj/16.10.2794

PubMed ID: 10542291

Title: F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis.

PubMed ID: 10542291

DOI: 10.1074/jbc.274.45.32461

PubMed ID: 10535980

Title: LFG: an anti-apoptotic gene that provides protection from fas-mediated cell death.

PubMed ID: 10535980

DOI: 10.1073/pnas.96.22.12667

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15465831

Title: A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway.

PubMed ID: 15465831

DOI: 10.1074/jbc.m408678200

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21109225

Title: Whole-exome-sequencing-based discovery of human FADD deficiency.

PubMed ID: 21109225

DOI: 10.1016/j.ajhg.2010.10.028

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23955153

Title: Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.

PubMed ID: 23955153

DOI: 10.1038/nature12436

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25301068

Title: Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability.

PubMed ID: 25301068

DOI: 10.1038/cdd.2014.153

PubMed ID: 30979585

Title: Structural and functional insights into host death domains inactivation by the bacterial arginine GlcNAcyltransferase effector.

PubMed ID: 30979585

DOI: 10.1016/j.molcel.2019.03.028

PubMed ID: 8967952

Title: NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain.

PubMed ID: 8967952

DOI: 10.1038/384638a0

PubMed ID: 19118384

Title: The Fas-FADD death domain complex structure unravels signalling by receptor clustering.

PubMed ID: 19118384

DOI: 10.1038/nature07606

PubMed ID: 24914971

Title: Structural insights into the mechanism of calmodulin binding to death receptors.

PubMed ID: 24914971

DOI: 10.1107/s1399004714006919

PubMed ID: 7540117

Title: Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome.

PubMed ID: 7540117

DOI: 10.1016/0092-8674(95)90013-6

PubMed ID: 8929361

Title: Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity.

PubMed ID: 8929361

DOI: 10.1056/nejm199611283352204

PubMed ID: 9028321

Title: Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis.

PubMed ID: 9028321

PubMed ID: 9028957

Title: Clinical, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis.

PubMed ID: 9028957

PubMed ID: 9322534

Title: Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis.

PubMed ID: 9322534

DOI: 10.1053/gast.1997.v113.pm9322534

PubMed ID: 9787134

Title: Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity.

PubMed ID: 9787134

PubMed ID: 9821419

Title: The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis.

PubMed ID: 9821419

DOI: 10.1016/s0022-3476(98)70102-7

PubMed ID: 10090885

Title: Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance.

PubMed ID: 10090885

DOI: 10.1086/302333

PubMed ID: 10515860

Title: Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations.

PubMed ID: 10515860

PubMed ID: 10340403

Title: Defective apoptosis due to a point mutation in the death domain of CD95 associated with autoimmune lymphoproliferative syndrome, T-cell lymphoma, and Hodgkin's disease.

PubMed ID: 10340403

DOI: 10.1016/s0301-472x(99)00033-8

PubMed ID: 9927496

Title: The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations.

PubMed ID: 9927496

DOI: 10.1172/jci5121

PubMed ID: 10620127

Title: Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar.

PubMed ID: 10620127

DOI: 10.1046/j.1523-1747.2000.00819.x

PubMed ID: 11418480

Title: The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis.

PubMed ID: 11418480

DOI: 10.1182/blood.v98.1.194

PubMed ID: 20935634

Title: The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations.

PubMed ID: 20935634

DOI: 10.1038/nsmb.1920

Sequence Information:

  • Length: 335
  • Mass: 37732
  • Checksum: 0139942535111410
  • Sequence:
    • MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE GLHHDGQFCH 
KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK CRRCRLCDEG HGLEVEINCT 
RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE HGIIKECTLT SNTKCKEEGS RSNLGWLCLL 
LLPIPLIVWV KRKEVQKTCR KHRKENQGSH ESPTLNPETV AINLSDVDLS KYITTIAGVM 
TLSQVKGFVR KNGVNEAKID EIKNDNVQDT AEQKVQLLRN WHQLHGKKEA YDTLIKDLKK 
ANLCTLAEKI QTIILKDITS DSENSNFRNE IQSLV

Genular Protein ID: 2968375444

Symbol: K9J972_HUMAN

Name: N/A

UniProtKB Accession Codes:

K9J972

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 9 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 197
  • Mass: 21955
  • Checksum: 343DA9D7F00C3B8A
  • Sequence:
    • MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE GLHHDGQFCH 
KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK CRRCRLCDEG HGLEVEINCT 
RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE HGIIKECTLT SNTKCKEEGS RSNLGWLCLL 
LLPIPLIVWG NSGNKFI

Genular Protein ID: 1211796270

Symbol: Q59FU8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FU8

Database IDs:

ARBA 14 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 11 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 2 SMART 2 SUPFAM 2

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 362
  • Mass: 40494
  • Checksum: F4FB186BFD5D8EE2
  • Sequence:
    • MLRVCAQGWH AQGLPHGTNS LLKGGTETSL STPTRLVVLT SVARLSSKSV NAQVTDINSK 
GLELRKTVTT VETQNLEGLH HDGQFCHKPC PPGERKARDC TVNGDEPDCV PCQEGKEYTD 
KAHFSSKCRR CRLCDEGHGL EVEINCTRTQ NTKCRCKPNF FCNSTVCEHC DPCTKCEHGI 
IKECTLTSNT KCKEEGSRSN LGWLCLLLLP IPLIVWVKRK EVQKTCRKHR KENQGSHESP 
TLNPETVAIN LSDVDLSKYI TTIAGVMTLS QVKGFVRKNG VNEAKIDEIK NDNVQDTAEQ 
KVQLLRNWHQ LHGKKEAYDT LIKDLKKANL CTLAEKIQTI ILKDITSDSE NSNFRNEIQS 
LV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.