Details for: BubR1

Gene ID: 35522

Symbol: BubR1

Ensembl ID: FBgn0263855

Description: Bub1-related kinase

Associated with

  • Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
    (R-DME-176814)
  • Apc-cdc20 mediated degradation of nek2a
    (R-DME-179409)
  • Apc/c-mediated degradation of cell cycle proteins
    (R-DME-174143)
  • Apc/c:cdc20 mediated degradation of mitotic proteins
    (R-DME-176409)
  • Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
    (R-DME-179419)
  • Cdc20:phospho-apc/c mediated degradation of cyclin a
    (R-DME-174184)
  • Cell cycle
    (R-DME-1640170)
  • Cell cycle, mitotic
    (R-DME-69278)
  • Cell cycle checkpoints
    (R-DME-69620)
  • Inactivation of apc/c via direct inhibition of the apc/c complex
    (R-DME-141430)
  • Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
    (R-DME-141405)
  • Mitotic spindle checkpoint
    (R-DME-69618)
  • Regulation of apc/c activators between g1/s and early anaphase
    (R-DME-176408)
  • Regulation of mitotic cell cycle
    (R-DME-453276)
  • Atp binding
    (GO:0005524)
  • Cytoplasm
    (GO:0005737)
  • Female meiosis sister chromatid cohesion
    (GO:0007066)
  • Heterochromatin formation
    (GO:0031507)
  • Kinetochore
    (GO:0000776)
  • Male meiosis sister chromatid cohesion
    (GO:0007065)
  • Meiotic sister chromatid cohesion, centromeric
    (GO:0051754)
  • Mitotic spindle assembly checkpoint signaling
    (GO:0007094)
  • Nucleus
    (GO:0005634)
  • Protein kinase activity
    (GO:0004672)
  • Regulation of exit from mitosis
    (GO:0007096)
  • Regulation of mitotic sister chromatid separation
    (GO:0010965)
  • Synaptonemal complex organization
    (GO:0070193)

Other Information

Genular Protein ID: 3372542786

Symbol: A1Z6I7_DROME

Name: N/A

UniProtKB Accession Codes:

A1Z6I7

Database IDs:

AGR 1 ARBA 2 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 EMBL 2 EnsemblMetazoa 1 ExpressionAtlas 1 FlyBase 2 GO 14 Gene3D 2 Genevisible 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PROSITE 6 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhylomeDB 1 Proteomes 2 Reactome 4 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

PubMed ID: 31201382

Title: BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules.

PubMed ID: 31201382

DOI: 10.1038/s41422-019-0178-z

Sequence Information:

  • Length: 1460
  • Mass: 165061
  • Checksum: 9DB083868A77263B
  • Sequence:
    • MDFDNAKENI QPLASGRNVS LLQASLSQDS THGQELLAQR KQMEEEVRTY KGADPLGAWY 
TFICWIEQSY PAGGSGSGLQ TVLHQCLTKF EDDERYRQDK RLIKLFIKFM EKQKDKIEFY 
QQMYNNGIGT MLADFYIAWA YSYDLSGNMR KADEIFRLGL ECRAEPLEDL KEAHHHFGYT 
VGQRMLYSTG EEANAVNQEL NERRLALQSL HGRRQQISNS ITVGSIRTGA AVKSGLPGVV 
QVEPSTTTSR RNVGRNVEVF NDENSEGNIP ISNSETEVKS SLRSIIDSAC SQENIKEPVA 
WNKANAKRHK HGKIFGSNAS PDLGFDIHVD EQAMPPITNY ERRLEQPFRF PTNFVAKNRP 
QEPWVTPVTI EDEPNASGLP CYNKCLLYPR PNIEFSPEEY RAYSFLKHRN PQHPFIHRND 
DWWGTGRVIR GIRCYPNFAR YSKPQDLDEL DKFWKPPLVP GLQVVFDKIY NEVEQKEYQP 
EELLAAKWME KRNVTVHGDF DMEETVCLPG NKMPRRKSFF PSSFRKSIMP RRVSSVQEED 
EKKEDEATLI VKDIPSQVAP KIPESPCDQI DEPKIKIFED SGSPRDNFAV PAVPVPKIEI 
YEDSEEPQPT PKTRPFYDGD ETCSTQMFNM FIKSQAVSTP KGTQKQAPSR QFGTVLKELP 
LPEEAAHSVE SPVETRSPTL RKQLSTILET SEHGTQSLAT SGTTTKSTIT STSSPGSNAV 
SKLGSKIEEN TPGQMRLQRV ISAGVSAVLS EPEKPGGDNF LRRELWEPNA PSVPMLKSLR 
FQEDKTETIP RPLACFQEDK TETLPQMPIA LPENSMDHGS LGAENCFSAP QLPTLEDESD 
LCGLFGKTPP KTNIFGSPKR NFDPTSQLFK STQGDRRSFA VTGNKLEAAP SISNLQDSFM 
CDLSFVPETQ PEAVAKSGAI QKFDIFLDDT QPKLTKSKPV ALMVSSFDLD CTLPETQQVA 
IKEPGTQQEN IGHSHMIASF MKDCTEIGSC PSQMPASVVK TNISSTSNKI KFSNDSMSES 
SRKAPVNENV GISKQPDEFF ELNAATEMFA TNISMIKNST LLIPNAKVAE ASELSIYYKT 
TPLTPKQSHR SWSQSDLETP PRENFVHPTS NGDQTVLNET LADANKNPFN VELISSLLES 
IDFSMYIEKL PHCQLVGHVK RLHPNTHLEV HNEKFEVSKM IGKGAYGSVY VGKHLKSGKK 
VALKQERPTN YWEFYICLEI HSRLTSEQMI PSYAHIDYAL VGNNSSVYIS EFSDYGSLIG 
VCNKVKSVTN RNMDEYVVMH LSCQMLDIVD HLHAMGIIHA DIKPDNFLLM KPICADPNEV 
SLQLIDFGVS IDMKLFPDNQ TFNYVHHDDL FKCIEMRTGR PWTYQLDLYG LVSVMHVLLF 
GRYMEVVQRS PSTIWMPKTN VPRYFQRTMW ENIFRTLLNI RDCRTMPNLQ QLRTQLKCAL 
AEKEKYVAEA ISKFNTILQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.