mle | FBgn0002774 | NCBI 35523

Details for: mle

Gene ID: 35523

Symbol: mle

Ensembl ID: FBgn0002774

Description: maleless

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-DME-1169410)
Cytokine signaling in immune system
(R-DME-1280215)
Cytosolic sensors of pathogen-associated dna
(R-DME-1834949)
Dex/h-box helicases activate type i ifn and inflammatory cytokines production
(R-DME-3134963)
Immune system
(R-DME-168256)
Innate immune system
(R-DME-168249)
Interferon signaling
(R-DME-913531)
Pkr-mediated signaling
(R-DME-9833482)
Rip-mediated nfkb activation via zbp1
(R-DME-1810476)
Zbp1(dai) mediated induction of type i ifns
(R-DME-1606322)
3'-5' dna/rna helicase activity
(GO:0033679)
3'-5' dna helicase activity
(GO:0043138)
3'-5' rna helicase activity
(GO:0034458)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Axon extension
(GO:0048675)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromosome
(GO:0005694)
Cytosol
(GO:0005829)
Determination of adult lifespan
(GO:0008340)
Dna duplex unwinding
(GO:0032508)
Dna helicase activity
(GO:0003678)
Dosage compensation by hyperactivation of x chromosome
(GO:0009047)
Double-stranded dna binding
(GO:0003690)
Double-stranded rna binding
(GO:0003725)
Helicase activity
(GO:0004386)
Intracellular anatomical structure
(GO:0005622)
Lncrna binding
(GO:0106222)
Male courtship behavior, veined wing generated song production
(GO:0045433)
Msl complex
(GO:0072487)
Nuclear chromosome
(GO:0000228)
Nucleic acid binding
(GO:0003676)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Polytene chromosome
(GO:0005700)
Positive regulation of dna topoisomerase (atp-hydrolyzing) activity
(GO:2000373)
Positive regulation of heterochromatin formation
(GO:0031453)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Regulation of cytoplasmic translation
(GO:2000765)
Regulation of mrna processing
(GO:0050684)
Regulatory region rna binding
(GO:0001069)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Rna helicase activity
(GO:0003724)
Sex-chromosome dosage compensation
(GO:0007549)
X chromosome
(GO:0000805)
X chromosome located dosage compensation complex, transcription activating
(GO:0016456)

Other Information

Proteins

Dosage compensation regulator

Genular Protein ID: 2308505279

Symbol: MLE_DROME

Name: Dosage compensation regulator

UniProtKB Accession Codes:

P24785 Q86NQ4 Q9V9J1

Database IDs:

Citations:

PubMed ID: 1653648

Title: The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila.

PubMed ID: 1653648

DOI: 10.1016/0092-8674(91)90439-6

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 23989663

Title: Topoisomerase II plays a role in dosage compensation in Drosophila.

PubMed ID: 23989663

DOI: 10.4161/trns.26185

Sequence Information:

Length: 1293
Mass: 143661
Checksum: 7667679F069BCAF5
Sequence:

MDIKSFLYQF CAKSQIEPKF DIRQTGPKNR QRFLCEVRVE PNTYIGVGNS TNKKDAEKNA 
CRDFVNYLVR VGKLNTNDVP ADAGASGGGP RTGLEGAGMA GGSGQQKRVF DGQSGPQDLG 
EAYRPLNHDG GDGGNRYSVI DRIQEQRDMN EAEAFDVNAA IHGNWTIENA KERLNIYKQT 
NNIRDDYKYT PVGPEHARSF LAELSIYVPA LNRTVTARES GSNKKSASKS CALSLVRQLF 
HLNVIEPFSG TLKKKKDEQL KPYPVKLSPN LINKIDEVIK GLDLPVVNPR NIKIELDGPP 
IPLIVNLSRI DSSQQDGEKR QESSVIPWAP PQANWNTWHA CNIDEGELAT TSIDDLSMDY 
ERSLRDRRQN DNEYRQFLEF REKLPIAAMR SEILTAINDN PVVIIRGNTG CGKTTQIAQY 
ILDDYICSGQ GGYANIYVTQ PRRISAISVA ERVARERCEQ LGDTVGYSVR FESVFPRPYG 
AILFCTVGVL LRKLEAGLRG VSHIIVDEIH ERDVNSDFLL VILRDMVDTY PDLHVILMSA 
TIDTTKFSKY FGICPVLEVP GRAFPVQQFF LEDIIQMTDF VPSAESRRKR KEVEDEEQLL 
SEDKDEAEIN YNKVCEDKYS QKTRNAMAML SESDVSFELL EALLMHIKSK NIPGAILVFL 
PGWNLIFALM KFLQNTNIFG DTSQYQILPC HSQIPRDEQR KVFEPVPEGV TKIILSTNIA 
ETSITIDDIV FVIDICKARM KLFTSHNNLT SYATVWASKT NLEQRKGRAG RVRPGFCFTL 
CSRARFQALE DNLTPEMFRT PLHEMALTIK LLRLGSIHHF LSKALEPPPV DAVIEAEVLL 
REMRCLDAND ELTPLGRLLA RLPIEPRLGK MMVLGAVFGC ADLMAIMASY SSTFSEVFSL 
DIGQRRLANH QKALSGTKCS DHVAMIVASQ MWRREKQRGE HMEARFCDWK GLQMSTMNVI 
WDAKQQLLDL LQQAGFPEEC MISHEVDERI DGDDPVLDVS LALLCLGLYP NICVHKEKRK 
VLTTESKAAL LHKTSVNCSN LAVTFPYPFF VFGEKIRTRA VSCKQLSMVS PLQVILFGSR 
KIDLAANNIV RVDNWLNFDI EPELAAKIGA LKPALEDLIT VACDNPSDIL RLEEPYAQLV 
KVVKDLCVKS AGDFGLQRES GILPHQSRQF SDGGGPPKRG RFETGRFTNS SFGRRGNGRT 
FGGGYGNNGG GYGNNGGGYG NIGGGYGNNA GGYGNNGGYG NNGGGYRNNG GGYGNNGGGY 
GNKRGGFGDS FESNRGSGGG FRNGDQGGRW GNF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: mle

Associated with

Other Information

The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila. PubMed ID: 1653648

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

Topoisomerase II plays a role in dosage compensation in Drosophila. PubMed ID: 23989663

Database document:

PubMed ID: 1653648

PubMed ID: 10731132

PubMed ID: 12537572

PubMed ID: 23989663