FASLG | ENSG00000117560 | NCBI 356

Details for: FASLG

Gene ID: 356

Symbol: FASLG

Ensembl ID: ENSG00000117560

Description: Fas ligand

Associated with

Apoptosis
(R-HSA-109581)
Casp8 activity is inhibited
(R-HSA-5218900)
Caspase activation via death receptors in the presence of ligand
(R-HSA-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-HSA-5357769)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Defective intrinsic pathway for apoptosis
(R-HSA-9734009)
Deregulated cdk5 triggers multiple neurodegenerative pathways in alzheimer's disease models
(R-HSA-8862803)
Dimerization of procaspase-8
(R-HSA-69416)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Fasl/ cd95l signaling
(R-HSA-75157)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell death genes
(R-HSA-9614657)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Neurodegenerative diseases
(R-HSA-8863678)
Programmed cell death
(R-HSA-5357801)
Regulated necrosis
(R-HSA-5218859)
Regulation by c-flip
(R-HSA-3371378)
Regulation of necroptotic cell death
(R-HSA-5675482)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by interleukins
(R-HSA-449147)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Tnfs bind their physiological receptors
(R-HSA-5669034)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
Caveola
(GO:0005901)
Cell-cell signaling
(GO:0007267)
Cellular response to type ii interferon
(GO:0071346)
Cytokine activity
(GO:0005125)
Cytoplasmic vesicle lumen
(GO:0060205)
Death receptor binding
(GO:0005123)
Endosomal lumen acidification
(GO:0048388)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Inflammatory cell apoptotic process
(GO:0006925)
Intracellular chloride ion homeostasis
(GO:0030644)
Lysosomal lumen
(GO:0043202)
Necroptotic process
(GO:0070266)
Necroptotic signaling pathway
(GO:0097527)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell apoptotic process
(GO:2000353)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of extrinsic apoptotic signaling pathway
(GO:2001238)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of phosphatidylserine exposure on apoptotic cell surface
(GO:1905782)
Protein binding
(GO:0005515)
Release of sequestered calcium ion into cytosol by endoplasmic reticulum
(GO:1903514)
Response to growth factor
(GO:0070848)
Response to lipopolysaccharide
(GO:0032496)
Retinal cell programmed cell death
(GO:0046666)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
T cell apoptotic process
(GO:0070231)
Tumor necrosis factor receptor binding
(GO:0005164)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: medium spiny neuron (CL1001474)
Fold Change: 4.6830
Cell Significance Index: 63.2000
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 2.8015
Cell Significance Index: 7.5100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 1.4130
Cell Significance Index: -4.3400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.6638
Cell Significance Index: 10.2700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1147
Cell Significance Index: 79.3200
Cell Name: ependymal cell (CL0000065)
Fold Change: -0.0008
Cell Significance Index: -0.0100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0026
Cell Significance Index: -0.1300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0047
Cell Significance Index: -0.1300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0052
Cell Significance Index: -3.8200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0092
Cell Significance Index: -0.3800
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0188
Cell Significance Index: -0.8200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0208
Cell Significance Index: -15.7500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0277
Cell Significance Index: -15.6200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0291
Cell Significance Index: -3.5800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0311
Cell Significance Index: -14.1300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0625
Cell Significance Index: -11.2600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0681
Cell Significance Index: -13.6600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0803
Cell Significance Index: -15.9400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0998
Cell Significance Index: -13.7000
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1037
Cell Significance Index: -13.4000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1084
Cell Significance Index: -12.7800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1096
Cell Significance Index: -5.1100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1171
Cell Significance Index: -11.9600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1204
Cell Significance Index: -20.5600
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1561
Cell Significance Index: -3.7800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1693
Cell Significance Index: -12.9900
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.1759
Cell Significance Index: -2.2200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1798
Cell Significance Index: -13.4000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1881
Cell Significance Index: -8.8400
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1951
Cell Significance Index: -12.5900
Cell Name: mature T cell (CL0002419)
Fold Change: -0.2015
Cell Significance Index: -1.4500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2227
Cell Significance Index: -13.6900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2414
Cell Significance Index: -16.2300
Cell Name: microglial cell (CL0000129)
Fold Change: -0.2483
Cell Significance Index: -2.9200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2508
Cell Significance Index: -13.0300
Cell Name: astrocyte (CL0000127)
Fold Change: -0.2560
Cell Significance Index: -2.9300
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.3244
Cell Significance Index: -3.2100
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.3328
Cell Significance Index: -3.7200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3344
Cell Significance Index: -9.8200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3482
Cell Significance Index: -15.4000
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.3601
Cell Significance Index: -3.4200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3620
Cell Significance Index: -13.2900
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.3621
Cell Significance Index: -9.0300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3870
Cell Significance Index: -12.6700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4037
Cell Significance Index: -11.8900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4096
Cell Significance Index: -15.5100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4159
Cell Significance Index: -13.3200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4270
Cell Significance Index: -13.6000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.4384
Cell Significance Index: -12.6300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4390
Cell Significance Index: -11.9500
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4412
Cell Significance Index: -11.0200
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.4569
Cell Significance Index: -5.4000
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.4667
Cell Significance Index: -3.9200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4668
Cell Significance Index: -13.3800
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.4743
Cell Significance Index: -12.0900
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5005
Cell Significance Index: -12.4900
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.5032
Cell Significance Index: -6.9000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5108
Cell Significance Index: -13.6400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5355
Cell Significance Index: -13.6800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.5506
Cell Significance Index: -6.2600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5680
Cell Significance Index: -16.2100
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5689
Cell Significance Index: -14.9600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5788
Cell Significance Index: -12.5400
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5838
Cell Significance Index: -14.0000
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.5857
Cell Significance Index: -12.8300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5911
Cell Significance Index: -15.8400
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.5926
Cell Significance Index: -10.1300
Cell Name: activated type II NK T cell (CL0000931)
Fold Change: -0.5957
Cell Significance Index: -1.5300
Cell Name: peg cell (CL4033014)
Fold Change: -0.5986
Cell Significance Index: -13.8300
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5991
Cell Significance Index: -12.7200
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.6255
Cell Significance Index: -12.2300
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.6337
Cell Significance Index: -8.2000
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.6480
Cell Significance Index: -13.0100
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.6539
Cell Significance Index: -10.5900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.6693
Cell Significance Index: -12.3700
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.6915
Cell Significance Index: -14.9400
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.6973
Cell Significance Index: -12.0200
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.6984
Cell Significance Index: -13.8100
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.7026
Cell Significance Index: -24.6200
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.7088
Cell Significance Index: -6.3100
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.7248
Cell Significance Index: -12.2100
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.7258
Cell Significance Index: -12.5500
Cell Name: monocyte (CL0000576)
Fold Change: -0.7430
Cell Significance Index: -8.5500
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.7435
Cell Significance Index: -8.1000
Cell Name: decidual cell (CL2000002)
Fold Change: -0.7511
Cell Significance Index: -12.0500
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.7568
Cell Significance Index: -10.3000
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.7578
Cell Significance Index: -14.7900
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.7710
Cell Significance Index: -8.2900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.7959
Cell Significance Index: -13.3200
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.8031
Cell Significance Index: -8.9000
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.8101
Cell Significance Index: -12.1200
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.8149
Cell Significance Index: -8.6700
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: -0.8203
Cell Significance Index: -5.2200
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.8219
Cell Significance Index: -8.3400
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.8417
Cell Significance Index: -7.9800
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.8430
Cell Significance Index: -9.5000
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.8433
Cell Significance Index: -8.2200
Cell Name: glial cell (CL0000125)
Fold Change: -0.8461
Cell Significance Index: -9.2700
Cell Name: leukocyte (CL0000738)
Fold Change: -0.8490
Cell Significance Index: -14.4200
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.8491
Cell Significance Index: -9.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Transmembrane protein**: FASLG is a type II transmembrane protein, consisting of an extracellular ligand domain, a transmembrane domain, and an intracellular death domain. 2. **Apoptotic ligand**: FASLG induces apoptosis in cells that express the Fas receptor, making it a key player in regulating cell death and tissue homeostasis. 3. **Immune system regulation**: FASLG is involved in the regulation of immune responses, including the elimination of autoreactive T cells and the maintenance of immune tolerance. 4. **Tissue-specific expression**: FASLG is expressed in various tissues, including the brain, immune cells, and epithelial cells, highlighting its broad role in maintaining tissue homeostasis. **Pathways and Functions** 1. **Apoptotic pathway**: FASLG binds to Fas, triggering a cascade of intracellular signaling events that ultimately lead to apoptosis, mediated by caspases, including caspase-8 and caspase-3. 2. **Immune response regulation**: FASLG is involved in the regulation of immune responses, including the elimination of autoreactive T cells, the maintenance of immune tolerance, and the regulation of cytokine production. 3. **Inflammation regulation**: FASLG can also modulate inflammatory responses by regulating the production of pro-inflammatory cytokines and the activation of immune cells. 4. **Neuroprotection**: FASLG has been implicated in neuroprotection, with studies suggesting that it may play a role in the regulation of neuronal apoptosis and the maintenance of neural tissue homeostasis. **Clinical Significance** 1. **Cancer therapy**: FASLG is a target for cancer therapy, with several cancer treatments, including Fas-FasL immunotoxins and Fas-FasL agonists, designed to induce apoptosis in cancer cells. 2. **Autoimmune diseases**: FASLG has been implicated in the pathogenesis of autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis, highlighting its role in maintaining immune tolerance. 3. **Neurodegenerative diseases**: FASLG may play a role in the regulation of neuronal apoptosis, with studies suggesting that dysregulation of FASLG may contribute to the pathogenesis of neurodegenerative diseases, including Alzheimer's disease. 4. **Infectious diseases**: FASLG has been implicated in the regulation of immune responses during infectious diseases, highlighting its role in maintaining immune homeostasis. In conclusion, the Fas Ligand (FASLG) gene is a critical regulator of apoptosis, immune response, and inflammation, with significant implications for cancer therapy, autoimmune diseases, neurodegenerative diseases, and infectious diseases. Further research is needed to fully elucidate the complex roles of FASLG in maintaining tissue homeostasis and regulating the immune response.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Tumor necrosis factor ligand superfamily member 6

Genular Protein ID: 2394215145

Symbol: TNFL6_HUMAN

Name: Tumor necrosis factor ligand superfamily member 6

UniProtKB Accession Codes:

P48023 Q9BZP9

Database IDs:

Citations:

PubMed ID: 7528780

Title: Fas ligand mediates activation-induced cell death in human T lymphocytes.

PubMed ID: 7528780

DOI: 10.1084/jem.181.1.71

PubMed ID: 7826947

Title: Human Fas ligand: gene structure, chromosomal location and species specificity.

PubMed ID: 7826947

DOI: 10.1093/intimm/6.10.1567

PubMed ID: 7980502

Title: Role of Fas ligand in apoptosis induced by hepatitis C virus infection.

PubMed ID: 7980502

DOI: 10.1006/bbrc.1994.2483

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8787672

Title: Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.

PubMed ID: 8787672

DOI: 10.1172/jci118892

PubMed ID: 9228058

Title: Characterization of Fas (Apo-1, CD95)-Fas ligand interaction.

PubMed ID: 9228058

DOI: 10.1074/jbc.272.30.18827

PubMed ID: 9427603

Title: Downregulation of Fas ligand by shedding.

PubMed ID: 9427603

DOI: 10.1038/nm0198-031

PubMed ID: 17557115

Title: The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells.

PubMed ID: 17557115

DOI: 10.1038/sj.cdd.4402175

PubMed ID: 17164290

Title: Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation.

PubMed ID: 17164290

DOI: 10.1242/jcs.03315

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 27806260

Title: Crystal structure of the complex of human FasL and its decoy receptor DcR3.

PubMed ID: 27806260

DOI: 10.1016/j.str.2016.09.009

PubMed ID: 26334989

Title: Decreased activation-induced cell death by EBV-transformed B-cells from a patient with autoimmune lymphoproliferative syndrome caused by a novel FASLG mutation.

PubMed ID: 26334989

DOI: 10.1038/pr.2015.170

Sequence Information:

Length: 281
Mass: 31485
Checksum: A8A6EB358246E9BB
Sequence:

MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP PPPLPPPPPP 
PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG MFQLFHLQKE LAELRESTSQ 
MHTASSLEKQ IGHPSPPPEK KELRKVAHLT GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG 
LVINETGLYF VYSKVYFRGQ SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA 
RSSYLGAVFN LTSADHLYVN VSELSLVNFE ESQTFFGLYK L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FASLG

Associated with

Cells (max top 100)

Other Information

Fas ligand mediates activation-induced cell death in human T lymphocytes. PubMed ID: 7528780

Human Fas ligand: gene structure, chromosomal location and species specificity. PubMed ID: 7826947

Role of Fas ligand in apoptosis induced by hepatitis C virus infection. PubMed ID: 7980502

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. PubMed ID: 8787672

Characterization of Fas (Apo-1, CD95)-Fas ligand interaction. PubMed ID: 9228058

Downregulation of Fas ligand by shedding. PubMed ID: 9427603

The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. PubMed ID: 17557115

Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation. PubMed ID: 17164290

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

Crystal structure of the complex of human FasL and its decoy receptor DcR3. PubMed ID: 27806260

Decreased activation-induced cell death by EBV-transformed B-cells from a patient with autoimmune lymphoproliferative syndrome caused by a novel FASLG mutation. PubMed ID: 26334989