FASLG | ENSG00000117560 | NCBI 356

Details for: FASLG

Gene ID: 356

Symbol: FASLG

Ensembl ID: ENSG00000117560

Description: Fas ligand

Associated with

Apoptosis
(R-HSA-109581)
Casp8 activity is inhibited
(R-HSA-5218900)
Caspase activation via death receptors in the presence of ligand
(R-HSA-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-HSA-5357769)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Defective intrinsic pathway for apoptosis
(R-HSA-9734009)
Deregulated cdk5 triggers multiple neurodegenerative pathways in alzheimer's disease models
(R-HSA-8862803)
Dimerization of procaspase-8
(R-HSA-69416)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Fasl/ cd95l signaling
(R-HSA-75157)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell death genes
(R-HSA-9614657)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Neurodegenerative diseases
(R-HSA-8863678)
Programmed cell death
(R-HSA-5357801)
Regulated necrosis
(R-HSA-5218859)
Regulation by c-flip
(R-HSA-3371378)
Regulation of necroptotic cell death
(R-HSA-5675482)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by interleukins
(R-HSA-449147)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Tnfs bind their physiological receptors
(R-HSA-5669034)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
Caveola
(GO:0005901)
Cell-cell signaling
(GO:0007267)
Cellular response to type ii interferon
(GO:0071346)
Cytokine activity
(GO:0005125)
Cytoplasmic vesicle lumen
(GO:0060205)
Death receptor binding
(GO:0005123)
Endosomal lumen acidification
(GO:0048388)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Inflammatory cell apoptotic process
(GO:0006925)
Intracellular chloride ion homeostasis
(GO:0030644)
Lysosomal lumen
(GO:0043202)
Necroptotic process
(GO:0070266)
Necroptotic signaling pathway
(GO:0097527)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell apoptotic process
(GO:2000353)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of phosphatidylserine exposure on apoptotic cell surface
(GO:1905782)
Protein binding
(GO:0005515)
Release of sequestered calcium ion into cytosol by endoplasmic reticulum
(GO:1903514)
Response to growth factor
(GO:0070848)
Response to lipopolysaccharide
(GO:0032496)
Retinal cell programmed cell death
(GO:0046666)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
T cell apoptotic process
(GO:0070231)
Tumor necrosis factor receptor binding
(GO:0005164)

Other Information

Proteins

Tumor necrosis factor ligand superfamily member 6

Genular Protein ID: 2394215145

Symbol: TNFL6_HUMAN

Name: Tumor necrosis factor ligand superfamily member 6

UniProtKB Accession Codes:

P48023 Q9BZP9

Database IDs:

Citations:

PubMed ID: 7528780

Title: Fas ligand mediates activation-induced cell death in human T lymphocytes.

PubMed ID: 7528780

DOI: 10.1084/jem.181.1.71

PubMed ID: 7826947

Title: Human Fas ligand: gene structure, chromosomal location and species specificity.

PubMed ID: 7826947

DOI: 10.1093/intimm/6.10.1567

PubMed ID: 7980502

Title: Role of Fas ligand in apoptosis induced by hepatitis C virus infection.

PubMed ID: 7980502

DOI: 10.1006/bbrc.1994.2483

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8787672

Title: Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.

PubMed ID: 8787672

DOI: 10.1172/jci118892

PubMed ID: 9228058

Title: Characterization of Fas (Apo-1, CD95)-Fas ligand interaction.

PubMed ID: 9228058

DOI: 10.1074/jbc.272.30.18827

PubMed ID: 9427603

Title: Downregulation of Fas ligand by shedding.

PubMed ID: 9427603

DOI: 10.1038/nm0198-031

PubMed ID: 17557115

Title: The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells.

PubMed ID: 17557115

DOI: 10.1038/sj.cdd.4402175

PubMed ID: 17164290

Title: Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation.

PubMed ID: 17164290

DOI: 10.1242/jcs.03315

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 27806260

Title: Crystal structure of the complex of human FasL and its decoy receptor DcR3.

PubMed ID: 27806260

DOI: 10.1016/j.str.2016.09.009

PubMed ID: 26334989

Title: Decreased activation-induced cell death by EBV-transformed B-cells from a patient with autoimmune lymphoproliferative syndrome caused by a novel FASLG mutation.

PubMed ID: 26334989

DOI: 10.1038/pr.2015.170

Sequence Information:

Length: 281
Mass: 31485
Checksum: A8A6EB358246E9BB
Sequence:

MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP PPPLPPPPPP 
PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG MFQLFHLQKE LAELRESTSQ 
MHTASSLEKQ IGHPSPPPEK KELRKVAHLT GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG 
LVINETGLYF VYSKVYFRGQ SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA 
RSSYLGAVFN LTSADHLYVN VSELSLVNFE ESQTFFGLYK L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FASLG

Associated with

Other Information

Fas ligand mediates activation-induced cell death in human T lymphocytes. PubMed ID: 7528780

Human Fas ligand: gene structure, chromosomal location and species specificity. PubMed ID: 7826947

Role of Fas ligand in apoptosis induced by hepatitis C virus infection. PubMed ID: 7980502

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. PubMed ID: 8787672

Characterization of Fas (Apo-1, CD95)-Fas ligand interaction. PubMed ID: 9228058

Downregulation of Fas ligand by shedding. PubMed ID: 9427603

The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. PubMed ID: 17557115

Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation. PubMed ID: 17164290

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

Crystal structure of the complex of human FasL and its decoy receptor DcR3. PubMed ID: 27806260

Decreased activation-induced cell death by EBV-transformed B-cells from a patient with autoimmune lymphoproliferative syndrome caused by a novel FASLG mutation. PubMed ID: 26334989