Details for: Cul1

Gene ID: 35742

Symbol: Cul1

Ensembl ID: FBgn0015509

Description: Cullin 1

Associated with

  • Cullin-ring ubiquitin ligase complex
    (GO:0031461)
  • Molecular adaptor activity
    (GO:0060090)
  • Negative regulation of antimicrobial peptide production
    (GO:0002785)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of hippo signaling
    (GO:0035331)
  • Negative regulation of insulin receptor signaling pathway
    (GO:0046627)
  • Negative regulation of peptidoglycan recognition protein signaling pathway
    (GO:0061060)
  • Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051898)
  • Negative regulation of smoothened signaling pathway
    (GO:0045879)
  • Nucleus
    (GO:0005634)
  • Positive regulation of neuron remodeling
    (GO:1904801)
  • Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
    (GO:0032436)
  • Positive regulation of protein ubiquitination
    (GO:0031398)
  • Positive regulation of synaptonemal complex assembly
    (GO:1905088)
  • Protein-macromolecule adaptor activity
    (GO:0030674)
  • Protein binding
    (GO:0005515)
  • Protein catabolic process
    (GO:0030163)
  • Protein k11-linked ubiquitination
    (GO:0070979)
  • Protein ubiquitination
    (GO:0016567)
  • Scf-dependent proteasomal ubiquitin-dependent protein catabolic process
    (GO:0031146)
  • Scf ubiquitin ligase complex
    (GO:0019005)
  • Ubiquitin-dependent protein catabolic process
    (GO:0006511)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 2381869669

Symbol: CUL1_DROME

Name: Cullin homolog 1

UniProtKB Accession Codes:

Q24311 A4UZ78 Q0E9G0 Q9V312

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CTD 1 ComplexPortal 1 DIP 1 DNASU 1 EMBL 6 EnsemblMetazoa 4 ExpressionAtlas 1 FlyBase 1 GO 22 Gene3D 2 GeneTree 1 Genevisible 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 Reactome 24 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 11500045

Title: Occurrence of a putative SCF ubiquitin ligase complex in Drosophila.

PubMed ID: 11500045

DOI: 10.1006/bbrc.2001.5394

PubMed ID: 12183637

Title: Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

PubMed ID: 12183637

DOI: 10.1126/science.1075901

PubMed ID: 18493598

Title: The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.

PubMed ID: 18493598

DOI: 10.1371/journal.pone.0002239

PubMed ID: 20392747

Title: A novel F-box protein is required for caspase activation during cellular remodeling in Drosophila.

PubMed ID: 20392747

DOI: 10.1242/dev.050088

PubMed ID: 20123973

Title: Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors.

PubMed ID: 20123973

DOI: 10.1128/mcb.01100-09

PubMed ID: 24068890

Title: A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning.

PubMed ID: 24068890

DOI: 10.1371/journal.pbio.1001657

PubMed ID: 24413555

Title: The SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth.

PubMed ID: 24413555

DOI: 10.1002/embr.201337966

PubMed ID: 27331610

Title: The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.

PubMed ID: 27331610

DOI: 10.7554/elife.15258

PubMed ID: 27692068

Title: The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs.

PubMed ID: 27692068

DOI: 10.7554/elife.16624

PubMed ID: 27824307

Title:

PubMed ID: 27824307

DOI: 10.7554/elife.22672

Sequence Information:

  • Length: 774
  • Mass: 89511
  • Checksum: 1AF0D035DE85363C
  • Sequence:
    • MNRSGNSQTT QKLVNLDDIW SELVEGIMQV FEHEKSLTRS QYMRFYTHVY DYCTSVSAAP 
SGRSSGKTGG AQLVGKKLYD RLEQFLKSYL SELLTKFKAI SGEEVLLSRY TKQWKSYQFS 
STVLDGICNY LNRNWVKREC EEGQKGIYKI YRLALVAWKG HLFQVLNEPV TKAVLKSIEE 
ERQGKLINRS LVRDVIECYV ELSFNEEDTD AEQQKLSVYK QNFENKFIAD TSAFYEKESD 
AFLSTNTVTE YLKHVENRLE EETQRVRGFN SKNGLSYLHE TTADVLKSTC EEVLIEKHLK 
IFHTEFQNLL NADRNDDLKR MYSLVALSSK NLTDLKSILE NHILHQGTEA IAKCCTTDAA 
NDPKTYVQTI LDVHKKYNAL VLTAFNNDNG FVAALDKACG KFINSNVVTI ANSASKSPEL 
LAKYCDLLLK KSSKNPEDKE LEDNLNQVMV VFKYIEDKDV FQKYYSKMLA KRLVNHTSAS 
DDAEAMMISK LKQTCGYEYT VKLQRMFQDI GVSKDLNSYF KQYLAEKNLT MEIDFGIEVL 
SSGSWPFQLS NNFLLPSELE RSVRQFNEFY AARHSGRKLN WLYQMCKGEL IMNVNRNNSS 
TYTLQASTFQ MSVLLQFNDQ LSFTVQQLQD NTQTQQENLI QVLQILLKAK VLTSSDNENS 
LTPESTVELF LDYKNKKRRI NINQPLKTEL KVEQETVHKH IEEDRKLLIQ AAIVRIMKMR 
KRLNHTNLIS EVLNQLSTRF KPKVPVIKKC IDILIEKEYL ERMEGHKDTY SYLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.