Details for: AQP1

Gene ID: 358

Symbol: AQP1

Ensembl ID: ENSG00000240583

Description: aquaporin 1 (Colton blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.7075
    Cell Significance Index: -27.4800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 10.4676
    Cell Significance Index: 184.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.3262
    Cell Significance Index: 117.3100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6168
    Cell Significance Index: -16.6700
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 5.5219
    Cell Significance Index: 20.5800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.8474
    Cell Significance Index: 20.4500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 1.9630
    Cell Significance Index: 26.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.9256
    Cell Significance Index: 27.7000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.5747
    Cell Significance Index: 22.0200
  • Cell Name: vein endothelial cell of respiratory system (CL4033008)
    Fold Change: 1.4347
    Cell Significance Index: 9.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2766
    Cell Significance Index: 76.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1994
    Cell Significance Index: 1082.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1881
    Cell Significance Index: 129.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.0693
    Cell Significance Index: 122.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8003
    Cell Significance Index: 79.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5734
    Cell Significance Index: 39.6600
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.5079
    Cell Significance Index: 3.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4775
    Cell Significance Index: 77.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3408
    Cell Significance Index: 257.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3013
    Cell Significance Index: 4.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2775
    Cell Significance Index: 8.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2709
    Cell Significance Index: 51.5600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1806
    Cell Significance Index: 0.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1542
    Cell Significance Index: 3.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1446
    Cell Significance Index: 3.0800
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.1179
    Cell Significance Index: 0.4100
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.0898
    Cell Significance Index: 0.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0799
    Cell Significance Index: 3.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0738
    Cell Significance Index: 14.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0712
    Cell Significance Index: 12.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0650
    Cell Significance Index: 41.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0243
    Cell Significance Index: 45.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0149
    Cell Significance Index: 0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0090
    Cell Significance Index: 13.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0069
    Cell Significance Index: 12.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0057
    Cell Significance Index: 0.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0097
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0183
    Cell Significance Index: -11.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0227
    Cell Significance Index: -12.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0255
    Cell Significance Index: -18.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0266
    Cell Significance Index: -14.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0276
    Cell Significance Index: -37.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0387
    Cell Significance Index: -17.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0406
    Cell Significance Index: -14.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0407
    Cell Significance Index: -7.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0436
    Cell Significance Index: -8.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0442
    Cell Significance Index: -5.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0458
    Cell Significance Index: -20.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0637
    Cell Significance Index: -13.4100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0890
    Cell Significance Index: -0.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0980
    Cell Significance Index: -12.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1074
    Cell Significance Index: -13.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1143
    Cell Significance Index: -5.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1244
    Cell Significance Index: -12.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1274
    Cell Significance Index: -9.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1439
    Cell Significance Index: -20.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1517
    Cell Significance Index: -4.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1539
    Cell Significance Index: -21.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1729
    Cell Significance Index: -19.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1902
    Cell Significance Index: -22.1700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2116
    Cell Significance Index: -1.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2126
    Cell Significance Index: -16.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2245
    Cell Significance Index: -16.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2310
    Cell Significance Index: -24.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2699
    Cell Significance Index: -16.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3086
    Cell Significance Index: -20.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3212
    Cell Significance Index: -22.7200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3470
    Cell Significance Index: -3.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3570
    Cell Significance Index: -23.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3703
    Cell Significance Index: -43.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3914
    Cell Significance Index: -16.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3946
    Cell Significance Index: -18.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4289
    Cell Significance Index: -24.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4444
    Cell Significance Index: -28.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4507
    Cell Significance Index: -27.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4782
    Cell Significance Index: -21.1500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4851
    Cell Significance Index: -11.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5110
    Cell Significance Index: -26.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5425
    Cell Significance Index: -28.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5438
    Cell Significance Index: -11.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5581
    Cell Significance Index: -19.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5794
    Cell Significance Index: -21.9400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.5801
    Cell Significance Index: -7.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6241
    Cell Significance Index: -10.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6361
    Cell Significance Index: -23.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6414
    Cell Significance Index: -29.9100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6651
    Cell Significance Index: -28.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6852
    Cell Significance Index: -23.8100
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: -0.6950
    Cell Significance Index: -5.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6978
    Cell Significance Index: -13.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7169
    Cell Significance Index: -23.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7282
    Cell Significance Index: -20.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7369
    Cell Significance Index: -23.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7369
    Cell Significance Index: -6.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7676
    Cell Significance Index: -22.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8002
    Cell Significance Index: -20.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8112
    Cell Significance Index: -22.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8187
    Cell Significance Index: -23.4700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.8416
    Cell Significance Index: -9.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Water channel function**: AQP1 is a transmembrane protein that forms water channels, allowing water and small molecules to pass through the cell membrane. 2. **High expression in various tissues**: AQP1 is highly expressed in the kidney, lung, pancreas, and placenta, indicating its importance in different physiological processes. 3. **Regulation by hormones and signaling pathways**: AQP1 expression and activity are regulated by various hormones, such as vasopressin, and signaling pathways, including cGMP-mediated signaling. 4. **Diverse cellular functions**: AQP1 is involved in various cellular processes, including cell volume regulation, ion transport, and cellular homeostasis. **Pathways and Functions** 1. **Aquaporin-mediated transport**: AQP1 facilitates the transport of water and small molecules across cell membranes, regulating cellular homeostasis and cell volume. 2. **Ion transport**: AQP1 also transports ions, such as potassium and sodium, across cell membranes, influencing cellular signaling and homeostasis. 3. **Cellular homeostasis**: AQP1 plays a crucial role in maintaining cellular homeostasis, regulating water and ion balance, and responding to changes in cellular environment. 4. **Kidney function**: AQP1 is essential for kidney function, regulating water reabsorption, and ion transport in the renal tubules. 5. **Respiratory function**: AQP1 is involved in respiratory function, regulating water and ion transport in the lung tissue. **Clinical Significance** 1. **Kidney disorders**: Dysregulation of AQP1 has been implicated in various kidney disorders, including nephrogenic diabetes insipidus and kidney damage. 2. **Respiratory diseases**: AQP1 dysfunction has been linked to respiratory diseases, such as pulmonary edema and chronic obstructive pulmonary disease (COPD). 3. **Cancer**: AQP1 has been implicated in cancer progression and metastasis, particularly in lung, breast, and colon cancers. 4. **Water balance disorders**: AQP1 dysfunction can lead to water balance disorders, such as hyponatremia and hypernatremia. 5. **Vasopressin regulation**: AQP1 is regulated by vasopressin, a hormone involved in water reabsorption and blood pressure regulation. In conclusion, AQP1 is a crucial water channel protein involved in various physiological processes, including water transport, ion transport, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of AQP1 in maintaining cellular and tissue homeostasis. Further research is necessary to fully understand the mechanisms of AQP1 regulation and its role in disease pathogenesis.

Genular Protein ID: 2140981811

Symbol: AQP1_HUMAN

Name: Aquaporin-CHIP

UniProtKB Accession Codes:

P29972 B5BU39 E7EM69 E9PC21 F5GY19 Q8TBI5 Q8TDC1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 13 EMDB 3 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 80 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1722319

Title: Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.

PubMed ID: 1722319

DOI: 10.1073/pnas.88.24.11110

PubMed ID: 8340403

Title: The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization.

PubMed ID: 8340403

DOI: 10.1016/s0021-9258(18)82322-5

PubMed ID: 8703970

Title: Characterization of the 3' UTR sequence encoded by the AQP-1 gene in human retinal pigment epithelium.

PubMed ID: 8703970

DOI: 10.1016/0005-2736(96)00076-4

PubMed ID: 7517253

Title: The water channel gene in human uterus.

PubMed ID: 7517253

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2007592

Title: Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins.

PubMed ID: 2007592

DOI: 10.1016/s0021-9258(18)38133-x

PubMed ID: 1373524

Title: Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein.

PubMed ID: 1373524

DOI: 10.1126/science.256.5055.385

PubMed ID: 7677994

Title: The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel.

PubMed ID: 7677994

DOI: 10.1016/s0021-9258(18)54108-9

PubMed ID: 7507481

Title: Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis.

PubMed ID: 7507481

DOI: 10.1016/s0021-9258(17)42079-5

PubMed ID: 23219802

Title: Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains.

PubMed ID: 23219802

DOI: 10.1016/j.bbamem.2012.11.030

PubMed ID: 7518771

Title: The three-dimensional structure of human erythrocyte aquaporin CHIP.

PubMed ID: 7518771

DOI: 10.1002/j.1460-2075.1994.tb06597.x

PubMed ID: 9177353

Title: The three-dimensional structure of aquaporin-1.

PubMed ID: 9177353

DOI: 10.1038/42512

PubMed ID: 11034202

Title: Structural determinants of water permeation through aquaporin-1.

PubMed ID: 11034202

DOI: 10.1038/35036519

PubMed ID: 11532455

Title: A refined structure of human aquaporin-1.

PubMed ID: 11532455

DOI: 10.1016/s0014-5793(01)02743-0

PubMed ID: 11171962

Title: Visualization of a water-selective pore by electron crystallography in vitreous ice.

PubMed ID: 11171962

DOI: 10.1073/pnas.98.4.1398

PubMed ID: 35835865

Title: Architecture of the human erythrocyte ankyrin-1 complex.

PubMed ID: 35835865

DOI: 10.1038/s41594-022-00792-w

PubMed ID: 7521882

Title: Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens.

PubMed ID: 7521882

DOI: 10.1172/jci117418

PubMed ID: 7521540

Title: Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels.

PubMed ID: 7521540

DOI: 10.1126/science.7521540

Sequence Information:

  • Length: 269
  • Mass: 28526
  • Checksum: BA204D82FB26352E
  • Sequence:
    • MASEFKKKLF WRAVVAEFLA TTLFVFISIG SALGFKYPVG NNQTAVQDNV KVSLAFGLSI 
ATLAQSVGHI SGAHLNPAVT LGLLLSCQIS IFRALMYIIA QCVGAIVATA ILSGITSSLT 
GNSLGRNDLA DGVNSGQGLG IEIIGTLQLV LCVLATTDRR RRDLGGSAPL AIGLSVALGH 
LLAIDYTGCG INPARSFGSA VITHNFSNHW IFWVGPFIGG ALAVLIYDFI LAPRSSDLTD 
RVKVWTSGQV EEYDLDADDI NSRVEMKPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.