Details for: AQP1

Gene ID: 358

Symbol: AQP1

Ensembl ID: ENSG00000240583

Description: aquaporin 1 (Colton blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.7
    Marker Score: 6800
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.64
    Marker Score: 11795
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 4.22
    Marker Score: 8726
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.08
    Marker Score: 2649
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.54
    Marker Score: 9002.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.45
    Marker Score: 4887
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.43
    Marker Score: 3906
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.32
    Marker Score: 744
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.26
    Marker Score: 3288
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.2
    Marker Score: 2285
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 2.16
    Marker Score: 459
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.06
    Marker Score: 3489
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.84
    Marker Score: 12012
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.76
    Marker Score: 422
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.72
    Marker Score: 1859
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.61
    Marker Score: 1518
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.6
    Marker Score: 623
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.53
    Marker Score: 611
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.48
    Marker Score: 663
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168570
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.37
    Marker Score: 3231
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.35
    Marker Score: 765
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.26
    Marker Score: 1141
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.25
    Marker Score: 317
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.22
    Marker Score: 1223
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.21
    Marker Score: 1457
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.12
    Marker Score: 2117
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.11
    Marker Score: 17354
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.08
    Marker Score: 328
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 788
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.01
    Marker Score: 630
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71790
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48014
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.99
    Marker Score: 889
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.99
    Marker Score: 230
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.98
    Marker Score: 368
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.97
    Marker Score: 2313
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.95
    Marker Score: 5010
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.94
    Marker Score: 616
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5323
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.91
    Marker Score: 871
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.9
    Marker Score: 827
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5277
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.87
    Marker Score: 190.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.86
    Marker Score: 927
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.86
    Marker Score: 408
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.83
    Marker Score: 229
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.82
    Marker Score: 192
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.82
    Marker Score: 241
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.8
    Marker Score: 220
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.79
    Marker Score: 1216
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.79
    Marker Score: 1517
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.79
    Marker Score: 518
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.77
    Marker Score: 5102
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 676
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.74
    Marker Score: 217
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.74
    Marker Score: 660
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.73
    Marker Score: 1549
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.73
    Marker Score: 274
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.7
    Marker Score: 603
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2797
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.64
    Marker Score: 13728
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.63
    Marker Score: 315
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1264
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.6
    Marker Score: 153
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.6
    Marker Score: 248
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.59
    Marker Score: 442
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 371
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.54
    Marker Score: 224
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.53
    Marker Score: 2221
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.53
    Marker Score: 150
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.53
    Marker Score: 211
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.51
    Marker Score: 143
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5
    Marker Score: 603
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.5
    Marker Score: 184
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.49
    Marker Score: 810
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 153
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.48
    Marker Score: 1303
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.48
    Marker Score: 338
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.47
    Marker Score: 301
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.47
    Marker Score: 634
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.46
    Marker Score: 133
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.46
    Marker Score: 626
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 273
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 119
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.45
    Marker Score: 5980
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.44
    Marker Score: 237
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.44
    Marker Score: 127

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Other Information

**Key characteristics:** - AQP1 is a water channel protein that is found in the plasma membrane of endothelial cells. - It is a type of aquaporin, a family of transmembrane proteins that are responsible for the transport of water and other molecules across cell membranes. - AQP1 is expressed in high levels in the lungs, kidneys, and salivary glands. **Pathways and functions:** - AQP1 is involved in the transport of water across cell membranes. - It is a key player in the regulation of water balance in the body. - AQP1 is involved in the regulation of blood pressure. - It is also involved in the transport of ions, such as sodium and potassium. **Clinical significance:** - Mutations in the AQP1 gene have been linked to several human diseases, including kidney disease, diabetes, and hypertension. - AQP1 is a potential therapeutic target for these diseases. **Additional information:** - The AQP1 gene is located on chromosome 19p13.1. - It is a highly conserved protein, with a sequence that is similar in humans, rodents, and birds. - AQP1 is a highly important protein that plays a vital role in maintaining water balance and blood pressure in the body.

Genular Protein ID: 2140981811

Symbol: AQP1_HUMAN

Name: Aquaporin-CHIP

UniProtKB Accession Codes:

P29972 B5BU39 E7EM69 E9PC21 F5GY19 Q8TBI5 Q8TDC1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 13 EMDB 3 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 81 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 8 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1722319

Title: Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.

PubMed ID: 1722319

DOI: 10.1073/pnas.88.24.11110

PubMed ID: 8340403

Title: The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization.

PubMed ID: 8340403

DOI: 10.1016/s0021-9258(18)82322-5

PubMed ID: 8703970

Title: Characterization of the 3' UTR sequence encoded by the AQP-1 gene in human retinal pigment epithelium.

PubMed ID: 8703970

DOI: 10.1016/0005-2736(96)00076-4

PubMed ID: 7517253

Title: The water channel gene in human uterus.

PubMed ID: 7517253

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2007592

Title: Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins.

PubMed ID: 2007592

DOI: 10.1016/s0021-9258(18)38133-x

PubMed ID: 1373524

Title: Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein.

PubMed ID: 1373524

DOI: 10.1126/science.256.5055.385

PubMed ID: 7677994

Title: The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel.

PubMed ID: 7677994

DOI: 10.1016/s0021-9258(18)54108-9

PubMed ID: 7507481

Title: Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis.

PubMed ID: 7507481

DOI: 10.1016/s0021-9258(17)42079-5

PubMed ID: 23219802

Title: Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains.

PubMed ID: 23219802

DOI: 10.1016/j.bbamem.2012.11.030

PubMed ID: 7518771

Title: The three-dimensional structure of human erythrocyte aquaporin CHIP.

PubMed ID: 7518771

DOI: 10.1002/j.1460-2075.1994.tb06597.x

PubMed ID: 9177353

Title: The three-dimensional structure of aquaporin-1.

PubMed ID: 9177353

DOI: 10.1038/42512

PubMed ID: 11034202

Title: Structural determinants of water permeation through aquaporin-1.

PubMed ID: 11034202

DOI: 10.1038/35036519

PubMed ID: 11532455

Title: A refined structure of human aquaporin-1.

PubMed ID: 11532455

DOI: 10.1016/s0014-5793(01)02743-0

PubMed ID: 11171962

Title: Visualization of a water-selective pore by electron crystallography in vitreous ice.

PubMed ID: 11171962

DOI: 10.1073/pnas.98.4.1398

PubMed ID: 35835865

Title: Architecture of the human erythrocyte ankyrin-1 complex.

PubMed ID: 35835865

DOI: 10.1038/s41594-022-00792-w

PubMed ID: 7521882

Title: Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens.

PubMed ID: 7521882

DOI: 10.1172/jci117418

PubMed ID: 7521540

Title: Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels.

PubMed ID: 7521540

DOI: 10.1126/science.7521540

Sequence Information:

  • Length: 269
  • Mass: 28526
  • Checksum: BA204D82FB26352E
  • Sequence:
    • MASEFKKKLF WRAVVAEFLA TTLFVFISIG SALGFKYPVG NNQTAVQDNV KVSLAFGLSI 
ATLAQSVGHI SGAHLNPAVT LGLLLSCQIS IFRALMYIIA QCVGAIVATA ILSGITSSLT 
GNSLGRNDLA DGVNSGQGLG IEIIGTLQLV LCVLATTDRR RRDLGGSAPL AIGLSVALGH 
LLAIDYTGCG INPARSFGSA VITHNFSNHW IFWVGPFIGG ALAVLIYDFI LAPRSSDLTD 
RVKVWTSGQV EEYDLDADDI NSRVEMKPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.