AQP1 | ENSG00000240583 | NCBI 358

Details for: AQP1

Gene ID: 358

Symbol: AQP1

Ensembl ID: ENSG00000240583

Description: aquaporin 1 (Colton blood group)

Associated with

Aquaporin-mediated transport
(R-HSA-445717)
Erythrocytes take up carbon dioxide and release oxygen
(R-HSA-1237044)
Erythrocytes take up oxygen and release carbon dioxide
(R-HSA-1247673)
O2/co2 exchange in erythrocytes
(R-HSA-1480926)
Passive transport by aquaporins
(R-HSA-432047)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Ammonium transmembrane transport
(GO:0072488)
Ammonium transmembrane transporter activity
(GO:0008519)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
Axon
(GO:0030424)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Brush border
(GO:0005903)
Brush border membrane
(GO:0031526)
Camera-type eye morphogenesis
(GO:0048593)
Carbon dioxide transmembrane transport
(GO:0035378)
Carbon dioxide transmembrane transporter activity
(GO:0035379)
Carbon dioxide transport
(GO:0015670)
Cellular homeostasis
(GO:0019725)
Cellular hyperosmotic response
(GO:0071474)
Cellular response to camp
(GO:0071320)
Cellular response to copper ion
(GO:0071280)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to hypoxia
(GO:0071456)
Cellular response to inorganic substance
(GO:0071241)
Cellular response to mechanical stimulus
(GO:0071260)
Cellular response to mercury ion
(GO:0071288)
Cellular response to nitric oxide
(GO:0071732)
Cellular response to retinoic acid
(GO:0071300)
Cellular response to salt stress
(GO:0071472)
Cellular response to uv
(GO:0034644)
Cell volume homeostasis
(GO:0006884)
Cerebrospinal fluid secretion
(GO:0033326)
Cgmp-mediated signaling
(GO:0019934)
Corticotropin secretion
(GO:0051458)
Cytoplasm
(GO:0005737)
Defense response to gram-negative bacterium
(GO:0050829)
Ephrin receptor binding
(GO:0046875)
Establishment of localization in cell
(GO:0051649)
Establishment or maintenance of actin cytoskeleton polarity
(GO:0030950)
Fibroblast migration
(GO:0010761)
Glomerular filtration
(GO:0003094)
Glycerol transmembrane transport
(GO:0015793)
Glycerol transmembrane transporter activity
(GO:0015168)
Hyperosmotic response
(GO:0006972)
Identical protein binding
(GO:0042802)
Intracellular cgmp-activated cation channel activity
(GO:0005223)
Intracellular water homeostasis
(GO:0009992)
Lateral ventricle development
(GO:0021670)
Lipid digestion
(GO:0044241)
Metanephric descending thin limb development
(GO:0072220)
Metanephric glomerulus vasculature development
(GO:0072239)
Metanephric proximal convoluted tubule segment 2 development
(GO:0072232)
Metanephric proximal straight tubule development
(GO:0072230)
Multicellular organismal-level water homeostasis
(GO:0050891)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Nitric oxide transmembrane transporter activity
(GO:0030184)
Nitric oxide transport
(GO:0030185)
Nuclear membrane
(GO:0031965)
Nucleus
(GO:0005634)
Odontogenesis
(GO:0042476)
Pancreatic juice secretion
(GO:0030157)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of fibroblast migration
(GO:0010763)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of saliva secretion
(GO:0046878)
Potassium channel activity
(GO:0005267)
Potassium ion transmembrane transport
(GO:0071805)
Potassium ion transmembrane transporter activity
(GO:0015079)
Potassium ion transport
(GO:0006813)
Protein binding
(GO:0005515)
Renal water absorption
(GO:0070295)
Renal water homeostasis
(GO:0003091)
Renal water transport
(GO:0003097)
Sarcolemma
(GO:0042383)
Secretory granule organization
(GO:0033363)
Sensory perception of pain
(GO:0019233)
Transepithelial water transport
(GO:0035377)
Transmembrane transporter activity
(GO:0022857)
Water channel activity
(GO:0015250)
Water transmembrane transporter activity
(GO:0005372)
Water transport
(GO:0006833)
Wound healing
(GO:0042060)

Other Information

Proteins

Aquaporin-CHIP

Genular Protein ID: 2140981811

Symbol: AQP1_HUMAN

Name: Aquaporin-CHIP

UniProtKB Accession Codes:

P29972 B5BU39 E7EM69 E9PC21 F5GY19 Q8TBI5 Q8TDC1

Database IDs:

Citations:

PubMed ID: 1722319

Title: Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.

PubMed ID: 1722319

DOI: 10.1073/pnas.88.24.11110

PubMed ID: 8340403

Title: The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization.

PubMed ID: 8340403

DOI: 10.1016/s0021-9258(18)82322-5

PubMed ID: 8703970

Title: Characterization of the 3' UTR sequence encoded by the AQP-1 gene in human retinal pigment epithelium.

PubMed ID: 8703970

DOI: 10.1016/0005-2736(96)00076-4

PubMed ID: 7517253

Title: The water channel gene in human uterus.

PubMed ID: 7517253

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2007592

Title: Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins.

PubMed ID: 2007592

DOI: 10.1016/s0021-9258(18)38133-x

PubMed ID: 1373524

Title: Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein.

PubMed ID: 1373524

DOI: 10.1126/science.256.5055.385

PubMed ID: 7677994

Title: The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel.

PubMed ID: 7677994

DOI: 10.1016/s0021-9258(18)54108-9

PubMed ID: 7507481

Title: Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis.

PubMed ID: 7507481

DOI: 10.1016/s0021-9258(17)42079-5

PubMed ID: 23219802

Title: Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains.

PubMed ID: 23219802

DOI: 10.1016/j.bbamem.2012.11.030

PubMed ID: 7518771

Title: The three-dimensional structure of human erythrocyte aquaporin CHIP.

PubMed ID: 7518771

DOI: 10.1002/j.1460-2075.1994.tb06597.x

PubMed ID: 9177353

Title: The three-dimensional structure of aquaporin-1.

PubMed ID: 9177353

DOI: 10.1038/42512

PubMed ID: 11034202

Title: Structural determinants of water permeation through aquaporin-1.

PubMed ID: 11034202

DOI: 10.1038/35036519

PubMed ID: 11532455

Title: A refined structure of human aquaporin-1.

PubMed ID: 11532455

DOI: 10.1016/s0014-5793(01)02743-0

PubMed ID: 11171962

Title: Visualization of a water-selective pore by electron crystallography in vitreous ice.

PubMed ID: 11171962

DOI: 10.1073/pnas.98.4.1398

PubMed ID: 35835865

Title: Architecture of the human erythrocyte ankyrin-1 complex.

PubMed ID: 35835865

DOI: 10.1038/s41594-022-00792-w

PubMed ID: 7521882

Title: Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens.

PubMed ID: 7521882

DOI: 10.1172/jci117418

PubMed ID: 7521540

Title: Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels.

PubMed ID: 7521540

DOI: 10.1126/science.7521540

Sequence Information:

Length: 269
Mass: 28526
Checksum: BA204D82FB26352E
Sequence:

MASEFKKKLF WRAVVAEFLA TTLFVFISIG SALGFKYPVG NNQTAVQDNV KVSLAFGLSI 
ATLAQSVGHI SGAHLNPAVT LGLLLSCQIS IFRALMYIIA QCVGAIVATA ILSGITSSLT 
GNSLGRNDLA DGVNSGQGLG IEIIGTLQLV LCVLATTDRR RRDLGGSAPL AIGLSVALGH 
LLAIDYTGCG INPARSFGSA VITHNFSNHW IFWVGPFIGG ALAVLIYDFI LAPRSSDLTD 
RVKVWTSGQV EEYDLDADDI NSRVEMKPK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AQP1

Associated with

Other Information

Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family. PubMed ID: 1722319

The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization. PubMed ID: 8340403

Characterization of the 3' UTR sequence encoded by the AQP-1 gene in human retinal pigment epithelium. PubMed ID: 8703970

The water channel gene in human uterus. PubMed ID: 7517253

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins. PubMed ID: 2007592

Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. PubMed ID: 1373524

The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel. PubMed ID: 7677994

Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis. PubMed ID: 7507481

Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains. PubMed ID: 23219802

The three-dimensional structure of human erythrocyte aquaporin CHIP. PubMed ID: 7518771

The three-dimensional structure of aquaporin-1. PubMed ID: 9177353

Structural determinants of water permeation through aquaporin-1. PubMed ID: 11034202

A refined structure of human aquaporin-1. PubMed ID: 11532455

Visualization of a water-selective pore by electron crystallography in vitreous ice. PubMed ID: 11171962

Architecture of the human erythrocyte ankyrin-1 complex. PubMed ID: 35835865

Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens. PubMed ID: 7521882

Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels. PubMed ID: 7521540