Details for: dpn

Gene ID: 35800

Symbol: dpn

Ensembl ID: FBgn0010109

Description: deadpan

Associated with

  • Adult locomotory behavior
    (GO:0008344)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Larval locomotory behavior
    (GO:0008345)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuroblast development
    (GO:0014019)
  • Nucleus
    (GO:0005634)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of neuroblast proliferation
    (GO:0002052)
  • Protein dimerization activity
    (GO:0046983)
  • R7 cell fate commitment
    (GO:0007465)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of neuroblast proliferation
    (GO:1902692)
  • Regulation of neurogenesis
    (GO:0050767)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Sex-chromosome dosage compensation
    (GO:0007549)
  • Sex determination, establishment of x:a ratio
    (GO:0007540)

Other Information

Genular Protein ID: 3697536896

Symbol: DPN_DROME

Name: Protein deadpan

UniProtKB Accession Codes:

Q26263 Q9V384

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 1 CTD 1 DIP 1 ELM 1 EMBL 3 EnsemblMetazoa 1 FlyBase 1 GO 25 Gene3D 2 GeneTree 1 Genevisible 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1427077

Title: Deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product.

PubMed ID: 1427077

DOI: 10.1101/gad.6.11.2137

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 8001118

Title: Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins.

PubMed ID: 8001118

DOI: 10.1016/0092-8674(94)90070-1

PubMed ID: 7651341

Title: Protein-protein interactions among components of the Drosophila primary sex determination signal.

PubMed ID: 7651341

DOI: 10.1007/bf02190799

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 21262215

Title: The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila.

PubMed ID: 21262215

DOI: 10.1016/j.ydbio.2011.01.019

PubMed ID: 22357926

Title: bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation.

PubMed ID: 22357926

DOI: 10.1242/dev.071779

PubMed ID: 23056424

Title: The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch.

PubMed ID: 23056424

DOI: 10.1371/journal.pone.0046724

PubMed ID: 24618901

Title: The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages.

PubMed ID: 24618901

DOI: 10.7554/elife.01906

PubMed ID: 28899667

Title: bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression.

PubMed ID: 28899667

DOI: 10.1016/j.ydbio.2017.09.011

Sequence Information:

  • Length: 435
  • Mass: 46551
  • Checksum: 9511A6C5F5019A29
  • Sequence:
    • MDYKNDINSD DDFDCSNGYS DSYGSNGRMS NPNGLSKAEL RKTNKPIMEK RRRARINHCL 
NELKSLILEA MKKDPARHTK LEKADILEMT VKHLQSVQRQ QLNMAIQSDP SVVQKFKTGF 
VECAEEVNRY VSQMDGIDTG VRQRLSAHLN QCANSLEQIG SMSNFSNGYR GGLFPATAVT 
AAPTPLFPSL PQDLNNNSRT ESSAPAIQMG GLQLIPSRLP SGEFALIMPN TGSAAPPPGP 
FAWPGSAAGV AAGTASAALA SIANPTHLND YTQSFRMSAF SKPVNTSVPA NLPENLIHTL 
PGQTQLPVKN STSPPLSPIS SISSHCEESR AASPTVDVMS KHSFAGVFST PPPTSAETSF 
NTSGSLNLSA GSHDSSGCSR PLAHLQQQQV SSTSGIAKRD REAEAESSDC SLDEPSSKKF 
LAGAIEKSSS AWRPW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.