Details for: Vps25

Gene ID: 35847

Symbol: Vps25

Description: Vacuolar protein sorting 25

Associated with

  • Autophagosome maturation
    (GO:0097352)
  • Bicoid mrna localization
    (GO:0045450)
  • Endosomal transport
    (GO:0016197)
  • Endosome transport via multivesicular body sorting pathway
    (GO:0032509)
  • Epithelial structure maintenance
    (GO:0010669)
  • Escrt ii complex
    (GO:0000814)
  • Imaginal disc-derived male genitalia morphogenesis
    (GO:0048803)
  • Maintenance of epithelial cell apical/basal polarity
    (GO:0045199)
  • Multivesicular body sorting pathway
    (GO:0071985)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein localization
    (GO:0008104)
  • Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
    (GO:0043328)
  • Regulation of apoptotic process
    (GO:0042981)
  • Structural molecule activity
    (GO:0005198)
  • Ubiquitin-dependent endocytosis
    (GO:0070086)
  • Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
    (GO:0043162)

Other Information

Genular Protein ID: 1326612285

Symbol: VPS25_DROME

Name: Vacuolar protein-sorting-associated protein 25

UniProtKB Accession Codes:

Q7JXV9

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CTD 1 ComplexPortal 1 DNASU 1 EMBL 2 EnsemblMetazoa 1 FlyBase 1 GO 16 Gene3D 2 GeneTree 1 Genevisible 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 Pfam 1 PhylomeDB 1 Proteomes 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 14605208

Title: A protein interaction map of Drosophila melanogaster.

PubMed ID: 14605208

DOI: 10.1126/science.1090289

PubMed ID: 16256743

Title: The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking.

PubMed ID: 16256743

DOI: 10.1016/j.devcel.2005.09.019

PubMed ID: 16256745

Title: Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila.

PubMed ID: 16256745

DOI: 10.1016/j.devcel.2005.09.020

PubMed ID: 17088062

Title: Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis.

PubMed ID: 17088062

DOI: 10.1016/j.cub.2006.09.031

PubMed ID: 16611691

Title: vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis.

PubMed ID: 16611691

DOI: 10.1242/dev.02356

PubMed ID: 17935992

Title: ESCRTs and Fab1 regulate distinct steps of autophagy.

PubMed ID: 17935992

DOI: 10.1016/j.cub.2007.09.032

PubMed ID: 17268469

Title: bicoid RNA localization requires specific binding of an endosomal sorting complex.

PubMed ID: 17268469

DOI: 10.1038/nature05503

PubMed ID: 19132102

Title: Common and distinct genetic properties of ESCRT-II components in Drosophila.

PubMed ID: 19132102

DOI: 10.1371/journal.pone.0004165

Sequence Information:

  • Length: 174
  • Mass: 20608
  • Checksum: 0711584CC2727233
  • Sequence:
    • MAEFQWPWEY TFPPFFTLQP HEETRQQQLK VWTDLFLKYL RHTNRFTLSI GDQNSPLFHN 
EALKRRLSPE LVLAILGELE RSGHANPLDK RRQEWQVYWF TLEEYGNMVY DWVQETGQTN 
TICTLYEIAS GENTSHLDFY GVDEAVLLSA LRLLEEKGRC ELIEMDGSHG VKFF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.