Mmp2 | FBgn0033438 | NCBI 35997

Details for: Mmp2

Gene ID: 35997

Symbol: Mmp2

Ensembl ID: FBgn0033438

Description: Matrix metalloproteinase 2

Associated with

Activation of matrix metalloproteinases
(R-DME-1592389)
Axon guidance
(R-DME-422475)
Basigin interactions
(R-DME-210991)
Binding and uptake of ligands by scavenger receptors
(R-DME-2173782)
Cell surface interactions at the vascular wall
(R-DME-202733)
Collagen degradation
(R-DME-1442490)
Degradation of the extracellular matrix
(R-DME-1474228)
Developmental biology
(R-DME-1266738)
Egfr transactivation by gastrin
(R-DME-2179392)
Eph-ephrin mediated repulsion of cells
(R-DME-3928665)
Eph-ephrin signaling
(R-DME-2682334)
G alpha (q) signalling events
(R-DME-416476)
Gastrin-creb signalling pathway via pkc and mapk
(R-DME-881907)
Gpcr downstream signalling
(R-DME-388396)
Hemostasis
(R-DME-109582)
Immune system
(R-DME-168256)
Innate immune system
(R-DME-168249)
Nervous system development
(R-DME-9675108)
Neutrophil degranulation
(R-DME-6798695)
Scavenging of heme from plasma
(R-DME-2168880)
Signaling by gpcr
(R-DME-372790)
Signal transduction
(R-DME-162582)
Vesicle-mediated transport
(R-DME-5653656)
Activation of innate immune response
(GO:0002218)
Adult fat body development
(GO:0007505)
Basement membrane disassembly
(GO:0034769)
Basement membrane organization
(GO:0071711)
Cardioblast migration to the midline involved in heart rudiment formation
(GO:0003319)
Cell-cell junction organization
(GO:0045216)
Collagen catabolic process
(GO:0030574)
Dendrite
(GO:0030425)
Embryonic heart tube formation
(GO:0003144)
Endopeptidase activity
(GO:0004175)
External side of plasma membrane
(GO:0009897)
Extracellular matrix
(GO:0031012)
Extracellular matrix organization
(GO:0030198)
Extracellular space
(GO:0005615)
Fasciculation of motor neuron axon
(GO:0097156)
Imaginal disc eversion
(GO:0007561)
Imaginal disc fusion, thorax closure
(GO:0046529)
Lateral inhibition
(GO:0046331)
Metalloendopeptidase activity
(GO:0004222)
Metallopeptidase activity
(GO:0008237)
Motor neuron axon guidance
(GO:0008045)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of extracellular matrix assembly
(GO:1901202)
Negative regulation of fibroblast growth factor receptor signaling pathway
(GO:0040037)
Negative regulation of stem cell proliferation
(GO:2000647)
Open tracheal system development
(GO:0007424)
Ovulation
(GO:0030728)
Plasma membrane
(GO:0005886)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Substrate-dependent cell migration
(GO:0006929)
Tracheal outgrowth, open tracheal system
(GO:0007426)
Tracheal pit formation in open tracheal system
(GO:0035202)
Ventral cord development
(GO:0007419)
Wound healing
(GO:0042060)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

D2MP_DROME

Genular Protein ID: 3284652779

Symbol: D2MP_DROME

Name: N/A

UniProtKB Accession Codes:

Q8MPP3 A0A0B4KFG9 A0A0C4DHC9 Q5BIL2

Database IDs:

Citations:

PubMed ID: 11967260

Title: Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression.

PubMed ID: 11967260

DOI: 10.1074/jbc.m200121200

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12530966

Title: Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development.

PubMed ID: 12530966

DOI: 10.1016/s1534-5807(02)00400-8

PubMed ID: 18045838

Title: Matrix metalloproteinases promote motor axon fasciculation in the Drosophila embryo.

PubMed ID: 18045838

DOI: 10.1242/dev.011072

PubMed ID: 19751719

Title: Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis.

PubMed ID: 19751719

DOI: 10.1016/j.ydbio.2009.09.005

PubMed ID: 20412776

Title: Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase-mediated modification of the basement membranes.

PubMed ID: 20412776

DOI: 10.1016/j.devcel.2010.02.010

PubMed ID: 21471368

Title: Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.

PubMed ID: 21471368

DOI: 10.1523/jneurosci.4811-10.2011

PubMed ID: 22262460

Title: A secreted MMP is required for reepithelialization during wound healing.

PubMed ID: 22262460

DOI: 10.1091/mbc.e11-09-0745

PubMed ID: 25267296

Title: A matrix metalloproteinase mediates long-distance attenuation of stem cell proliferation.

PubMed ID: 25267296

DOI: 10.1083/jcb.201403084

PubMed ID: 25520167

Title: Mmp1 and Mmp2 cooperatively induce Drosophila fat body cell dissociation with distinct roles.

PubMed ID: 25520167

DOI: 10.1038/srep07535

PubMed ID: 25695427

Title: Matrix metalloproteinase 2 is required for ovulation and corpus luteum formation in Drosophila.

PubMed ID: 25695427

DOI: 10.1371/journal.pgen.1004989

Sequence Information:

Length: 758
Mass: 89137
Checksum: 0F06C262A5F4CB4A
Sequence:

MFSKYVLATL LALFAQSMCI QELSLPPEGS HSTAATRSKK AKTAISEDIM YNYLMQFDYL 
PKSDLETGAL RTEDQLKEAI RSLQSFGNIT VTGEIDSATA RLIQKPRCGV GDRRSADSFS 
PDNLYHEIGS NVRVRRFALQ GPKWSRTDLT WSMVNRSMPD ASKVERMVQT ALDVWANHSK 
LTFREVYSDQ ADIQILFARR AHGDGYKFDG PGQVLAHAFY PGEGRGGDAH FDADETWNFD 
GESDDSHGTN FLNVALHELG HSLGLAHSAI PDAVMFPWYQ NNEVAGNLPD DDRYGIQQLY 
GTKEKTWGPY KPQTTTTTTT TTTMRAMIYR ADKPAYWPWN NPSNNPNNDR NRARERQEEE 
RRRQEKERRR QEEERRHQEE ERRRQVEERQ RQEEERWRQE QERQEEENRR RKIEHKSQWE 
RNPSKERNRP RERQEMERRR QEQERQEQER QEQEDRRRER ERDRQLEWER RNRNGAREPV 
TPTANTTPRP TNKPYPTVHR QHHHHNKPRK PKPDSCMTYY DAISIIRGEL FIFRGPYLWR 
IGTSGLYNGY PTEIRRHWSA LPENLTKVDA VYENKQRQIV FFIGREYYVF NSVMLAPGFP 
KPLASLGLPP TLTHIDASFV WGHNNRTYMT SGTLYWRIDD YTGQVELDYP RDMSIWSGVG 
YNIDAAFQYL DGKTYFFKNL GYWEFNDDRM KVAHARAKLS ARRWMQCARS ANEVDDEQRW 
TASLVSEGEE TGRSGSRELR INHFILSILL LAIANWRS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mmp2

Associated with

Other Information

Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression. PubMed ID: 11967260

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. PubMed ID: 12530966

Matrix metalloproteinases promote motor axon fasciculation in the Drosophila embryo. PubMed ID: 18045838

Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis. PubMed ID: 19751719

Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase-mediated modification of the basement membranes. PubMed ID: 20412776

Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila. PubMed ID: 21471368

A secreted MMP is required for reepithelialization during wound healing. PubMed ID: 22262460

A matrix metalloproteinase mediates long-distance attenuation of stem cell proliferation. PubMed ID: 25267296

Mmp1 and Mmp2 cooperatively induce Drosophila fat body cell dissociation with distinct roles. PubMed ID: 25520167

Matrix metalloproteinase 2 is required for ovulation and corpus luteum formation in Drosophila. PubMed ID: 25695427