Details for: ACADSB

Gene ID: 36

Symbol: ACADSB

Ensembl ID: ENSG00000196177

Description: acyl-CoA dehydrogenase short/branched chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: cell (CL0000000)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.99
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ACADSB is a mitochondrial enzyme that belongs to the acyl-CoA dehydrogenase family. It is a short-chain dehydrogenase that specifically catalyzes the oxidation of 2-methylbutyryl-CoA and 2-methylpropanoyl-CoA, two key intermediates in the catabolism of branched-chain amino acids. The enzyme requires flavin adenine dinucleotide (FAD) as a cofactor and is sensitive to the redox state of the cell. ACADSB is highly expressed in tissues involved in energy metabolism, such as the liver, brain, and skeletal muscle. **Pathways and Functions** ACADSB is involved in several metabolic pathways, including: 1. **Branched-chain amino acid catabolism**: ACADSB is a key enzyme in the oxidation of 2-methylbutyryl-CoA and 2-methylpropanoyl-CoA, which are derived from the catabolism of leucine, isoleucine, and valine, respectively. 2. **Fatty acid metabolism**: ACADSB is involved in the oxidation of fatty acids, which is essential for energy production and lipid metabolism. 3. **Mitochondrial matrix**: ACADSB is a mitochondrial enzyme that operates within the mitochondrial matrix, where it contributes to the regulation of energy metabolism. **Clinical Significance** Dysregulation of ACADSB has been implicated in various diseases, including: 1. **Neurological disorders**: Mutations in the ACADSB gene have been linked to neurological disorders, such as epilepsy and neurodegenerative diseases, which are characterized by impaired energy metabolism and mitochondrial dysfunction. 2. **Metabolic disorders**: ACADSB dysfunction has been associated with metabolic disorders, such as metabolic syndrome, insulin resistance, and type 2 diabetes. 3. **Cancer**: ACADSB has been implicated in the development and progression of cancer, particularly in tissues with high energy demands, such as the liver and brain. In conclusion, ACADSB is a critical enzyme that plays a pivotal role in the regulation of branched-chain amino acid catabolism and fatty acid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in maintaining energy homeostasis and overall health. Further research is needed to fully elucidate the mechanisms by which ACADSB regulates metabolic pathways and to develop therapeutic strategies for the treatment of diseases associated with ACADSB dysfunction.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.