Details for: AQP3

Gene ID: 360

Symbol: AQP3

Ensembl ID: ENSG00000165272

Description: aquaporin 3 (Gill blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.2415
    Cell Significance Index: -13.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 84.6464
    Cell Significance Index: -21.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.3960
    Cell Significance Index: -20.8800
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 46.2809
    Cell Significance Index: 137.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 31.8022
    Cell Significance Index: -21.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.8645
    Cell Significance Index: -20.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.0265
    Cell Significance Index: -19.7600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 14.9702
    Cell Significance Index: 33.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6189
    Cell Significance Index: -20.4100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 7.0894
    Cell Significance Index: 43.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.9088
    Cell Significance Index: -21.2200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 6.6668
    Cell Significance Index: 139.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 6.1024
    Cell Significance Index: 317.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4738
    Cell Significance Index: -21.6000
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 5.2461
    Cell Significance Index: 29.2000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 5.0392
    Cell Significance Index: 31.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.9072
    Cell Significance Index: 144.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.6542
    Cell Significance Index: 217.0000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 4.2256
    Cell Significance Index: 16.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5594
    Cell Significance Index: -7.7900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.5319
    Cell Significance Index: 30.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.1002
    Cell Significance Index: 558.8700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.5201
    Cell Significance Index: 26.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.4833
    Cell Significance Index: 69.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.1053
    Cell Significance Index: 148.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9802
    Cell Significance Index: 18.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9427
    Cell Significance Index: 238.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9084
    Cell Significance Index: 843.7500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.5580
    Cell Significance Index: 13.8300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.4582
    Cell Significance Index: 12.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4183
    Cell Significance Index: 105.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2790
    Cell Significance Index: 1154.8000
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.2337
    Cell Significance Index: 3.7600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.2006
    Cell Significance Index: 12.3900
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.0634
    Cell Significance Index: 8.7900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.0379
    Cell Significance Index: 14.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0364
    Cell Significance Index: 28.2100
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.9839
    Cell Significance Index: 6.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9354
    Cell Significance Index: 56.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.8710
    Cell Significance Index: 14.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8453
    Cell Significance Index: 91.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7923
    Cell Significance Index: 78.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7697
    Cell Significance Index: 36.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7115
    Cell Significance Index: 115.7200
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.5832
    Cell Significance Index: 2.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.5459
    Cell Significance Index: 62.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5369
    Cell Significance Index: 37.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5253
    Cell Significance Index: 397.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4979
    Cell Significance Index: 64.3300
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.4545
    Cell Significance Index: 3.9100
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.3789
    Cell Significance Index: 4.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2565
    Cell Significance Index: 140.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2177
    Cell Significance Index: 41.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1752
    Cell Significance Index: 2.6400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.1668
    Cell Significance Index: 2.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1239
    Cell Significance Index: 24.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1239
    Cell Significance Index: 17.0200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1182
    Cell Significance Index: 0.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1122
    Cell Significance Index: 19.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0830
    Cell Significance Index: 2.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0795
    Cell Significance Index: 2.2900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0707
    Cell Significance Index: 0.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0221
    Cell Significance Index: 1.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0132
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0025
    Cell Significance Index: -1.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0060
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0114
    Cell Significance Index: -21.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0125
    Cell Significance Index: -0.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0130
    Cell Significance Index: -23.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0155
    Cell Significance Index: -23.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0176
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0176
    Cell Significance Index: -3.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0177
    Cell Significance Index: -24.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0191
    Cell Significance Index: -10.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0269
    Cell Significance Index: -19.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0284
    Cell Significance Index: -2.9000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0336
    Cell Significance Index: -0.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0338
    Cell Significance Index: -21.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0348
    Cell Significance Index: -10.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0499
    Cell Significance Index: -22.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0557
    Cell Significance Index: -19.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0625
    Cell Significance Index: -7.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0661
    Cell Significance Index: -8.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0843
    Cell Significance Index: -16.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0948
    Cell Significance Index: -2.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1118
    Cell Significance Index: -13.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1132
    Cell Significance Index: -12.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1326
    Cell Significance Index: -3.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1475
    Cell Significance Index: -21.4400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1514
    Cell Significance Index: -2.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1912
    Cell Significance Index: -11.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2053
    Cell Significance Index: -2.1300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2091
    Cell Significance Index: -1.4500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2188
    Cell Significance Index: -1.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2325
    Cell Significance Index: -15.6400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.2513
    Cell Significance Index: -2.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2644
    Cell Significance Index: -20.9400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2697
    Cell Significance Index: -1.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2790
    Cell Significance Index: -21.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** AQP3 is a type of aquaporin protein, which is a family of membrane proteins that facilitate the transport of water and small molecules across cell membranes. The unique characteristic of AQP3 is its ability to transport glycerol, in addition to water, and its expression in epithelial cells, which suggests a role in cell-cell communication and differentiation. AQP3 is also regulated by various factors, including calcium ions, retinoic acid, and vitamin D, which suggests a complex regulatory network. **Pathways and Functions** AQP3 is involved in several physiological pathways, including: 1. **Water transport**: AQP3 plays a crucial role in water absorption in the kidney collecting duct, which is essential for maintaining renal water homeostasis. 2. **Glycerol transport**: AQP3 is responsible for glycerol transport across cell membranes, which is essential for maintaining glycerol homeostasis in the body. 3. **Cell-cell communication**: AQP3 is expressed in epithelial cells, which suggests a role in cell-cell communication and differentiation. 4. **Immune response**: AQP3 has been implicated in the regulation of immune response, particularly in the context of kidney function and immune cell trafficking. 5. **Renal function**: AQP3 is involved in the regulation of renal function, including the regulation of sodium and water reabsorption. **Clinical Significance** AQP3 has been implicated in several diseases and disorders, including: 1. **Nephrogenic diabetes insipidus**: AQP3 deficiency has been associated with nephrogenic diabetes insipidus, a disorder characterized by the inability to concentrate urine. 2. **Kidney disease**: AQP3 has been implicated in the pathogenesis of kidney disease, including chronic kidney disease and acute kidney injury. 3. **Immune disorders**: AQP3 has been implicated in the regulation of immune response, particularly in the context of kidney function and immune cell trafficking. 4. **Cancer**: AQP3 has been implicated in the regulation of cancer cell growth and differentiation, particularly in the context of epithelial cell differentiation. In conclusion, AQP3 is a critical protein involved in various physiological processes, including water transport, glycerol transport, and cell-cell communication. Its dysregulation has been implicated in several diseases and disorders, including nephrogenic diabetes insipidus, kidney disease, and immune disorders. Further research is necessary to fully understand the role of AQP3 in human health and disease.

Genular Protein ID: 2367226337

Symbol: AQP3_HUMAN

Name: Aquaporin-3

UniProtKB Accession Codes:

Q92482 A8K843 B2RE16 D3DRL3 O00108 Q6FGT2 Q6FGW6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 12 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7558005

Title: Structure and chromosomal localization of a human water channel (AQP3) gene.

PubMed ID: 7558005

DOI: 10.1006/geno.1995.1055

PubMed ID: 12239222

Title: AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL.

PubMed ID: 12239222

DOI: 10.1074/jbc.m208999200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18495115

Title: Regulation of aquaporin 3 expression by magnesium ion.

PubMed ID: 18495115

DOI: 10.1016/j.ejphar.2008.03.063

PubMed ID: 30420639

Title: Human adipose glycerol flux is regulated by a pH gate in AQP10.

PubMed ID: 30420639

DOI: 10.1038/s41467-018-07176-z

Sequence Information:

  • Length: 292
  • Mass: 31544
  • Checksum: A9555E9576EABA9C
  • Sequence:
    • MGRQKELVSR CGEMLHIRYR LLRQALAECL GTLILVMFGC GSVAQVVLSR GTHGGFLTIN 
LAFGFAVTLG ILIAGQVSGA HLNPAVTFAM CFLAREPWIK LPIYTLAQTL GAFLGAGIVF 
GLYYDAIWHF ADNQLFVSGP NGTAGIFATY PSGHLDMING FFDQFIGTAS LIVCVLAIVD 
PYNNPVPRGL EAFTVGLVVL VIGTSMGFNS GYAVNPARDF GPRLFTALAG WGSAVFTTGQ 
HWWWVPIVSP LLGSIAGVFV YQLMIGCHLE QPPPSNEEEN VKLAHVKHKE QI

Genular Protein ID: 420479881

Symbol: A0A2R8Y2R4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8Y2R4

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 2 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 237
  • Mass: 25080
  • Checksum: D3BBE3A803F1D29F
  • Sequence:
    • MGRQKELVSR CGEMLHIRYR LLRQALAECL GTLILVMFGC GSVAQVVLSR GTHGGFLTIN 
LAFGFAVTLG ILIAGQVSGA HLNPAVTFAM CFLAREPWIK LPIYTLAQTL GAFLGAGIVF 
GLYYDAIWHF ADNQLFVSGP NGTAGIFATY PSGHLDMING FFDQDRPALV VGAHRVPTPG 
LHCGCLRVPA DDRLPPGAAP TLQRGRECEA GPCEAQGADL SGQGPSPHSA ALALSIH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.