Details for: AQP3

Gene ID: 360

Symbol: AQP3

Ensembl ID: ENSG00000165272

Description: aquaporin 3 (Gill blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.08
    Marker Score: 30405
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.76
    Marker Score: 9492
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.42
    Marker Score: 2695
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.31
    Marker Score: 2210
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.25
    Marker Score: 25342
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.06
    Marker Score: 1036
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.04
    Marker Score: 3195
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.02
    Marker Score: 19654
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.01
    Marker Score: 15827
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.01
    Marker Score: 7345
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.94
    Marker Score: 25325
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.79
    Marker Score: 4477
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.6
    Marker Score: 8936
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.52
    Marker Score: 5752
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.49
    Marker Score: 21626.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.47
    Marker Score: 3632
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.41
    Marker Score: 1189
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.38
    Marker Score: 653
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.38
    Marker Score: 574
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.32
    Marker Score: 735
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.22
    Marker Score: 640
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.21
    Marker Score: 2583
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.18
    Marker Score: 1271
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.17
    Marker Score: 9323
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.15
    Marker Score: 1003
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.13
    Marker Score: 3491
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.09
    Marker Score: 13347
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.08
    Marker Score: 1854
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.97
    Marker Score: 1365
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.9
    Marker Score: 430
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.89
    Marker Score: 6992
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.87
    Marker Score: 2640
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.86
    Marker Score: 2873
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.83
    Marker Score: 96836
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.81
    Marker Score: 3444
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.8
    Marker Score: 2545
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.78
    Marker Score: 45617
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.78
    Marker Score: 1211.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.75
    Marker Score: 2264
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.72
    Marker Score: 379
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.61
    Marker Score: 324
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.56
    Marker Score: 1142
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.56
    Marker Score: 1301
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.53
    Marker Score: 542
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.49
    Marker Score: 2563
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.47
    Marker Score: 375
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.46
    Marker Score: 2660
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.44
    Marker Score: 2829
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.42
    Marker Score: 1607
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4
    Marker Score: 22542
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.4
    Marker Score: 666
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.39
    Marker Score: 581
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.39
    Marker Score: 1297
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.38
    Marker Score: 1831
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.31
    Marker Score: 1645
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.31
    Marker Score: 1160
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.31
    Marker Score: 802
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.29
    Marker Score: 357
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.24
    Marker Score: 1974
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.22
    Marker Score: 12106
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.19
    Marker Score: 1137
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.17
    Marker Score: 406
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.16
    Marker Score: 13514
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.16
    Marker Score: 4478
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.15
    Marker Score: 1245
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.14
    Marker Score: 1890
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.14
    Marker Score: 569
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.14
    Marker Score: 1015
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.14
    Marker Score: 345
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.12
    Marker Score: 392
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.11
    Marker Score: 217
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.1
    Marker Score: 849
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.08
    Marker Score: 6577
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.07
    Marker Score: 1038
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.07
    Marker Score: 398
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.06
    Marker Score: 907
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.04
    Marker Score: 273
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.02
    Marker Score: 443
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.01
    Marker Score: 619
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71725
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47952
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.99
    Marker Score: 4768
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.98
    Marker Score: 428
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.98
    Marker Score: 576
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.97
    Marker Score: 435
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.95
    Marker Score: 695
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.93
    Marker Score: 257
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.93
    Marker Score: 237
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.91
    Marker Score: 1001
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.9
    Marker Score: 2053
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.89
    Marker Score: 2298
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.89
    Marker Score: 878
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.88
    Marker Score: 978
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5252

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Other Information

**Key characteristics:** - AQP3 is a transmembrane protein with a single transmembrane domain and a hydrophilic extracellular domain. - It is expressed in high levels in epithelial cells, where it is thought to be involved in maintaining water balance and preventing the leakage of fluid and solute across the cell membrane. - AQP3 is a key regulator of renal water homeostasis, and its expression is regulated by various factors, including angiotensin II, vasopressin, and other hormones. **Pathways and functions:** - AQP3 is involved in a variety of cellular processes, including: - Aquaporin-mediated transport of water and small molecules across cell membranes - Glycerol channel activity, which is involved in the transport of glycerol between cells and tissues - Glycerol transmembrane transport, which is involved in the transport of glycerol between blood and cells - Identical protein binding, which is involved in the binding of specific proteins to aquaporins - Passive transport by aquaporins, which is a non-specific mechanism for the transport of water across cell membranes - Positive regulation of immune system process, which is involved in the regulation of immune responses - Protein binding, which is involved in the binding of proteins to aquaporins - Renal water homeostasis, which is the regulation of water balance in the body - Response to ischemia, which is the regulation of water balance in the brain and other organs during periods of ischemia **Clinical significance:** - Mutations in the AQP3 gene have been linked to a number of human diseases, including: - Renal failure - Diabetes - Hypertension - Hypertension-induced heart failure - Stroke - Eye diseases - Skin diseases - Cancer AQP3 is a promising target for the treatment of a variety of human diseases. By targeting AQP3, it may be possible to inhibit water loss and improve tissue function in diseases that are characterized by fluid and solute leakage.

Genular Protein ID: 2367226337

Symbol: AQP3_HUMAN

Name: Aquaporin-3

UniProtKB Accession Codes:

Q92482 A8K843 B2RE16 D3DRL3 O00108 Q6FGT2 Q6FGW6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 12 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7558005

Title: Structure and chromosomal localization of a human water channel (AQP3) gene.

PubMed ID: 7558005

DOI: 10.1006/geno.1995.1055

PubMed ID: 12239222

Title: AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL.

PubMed ID: 12239222

DOI: 10.1074/jbc.m208999200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18495115

Title: Regulation of aquaporin 3 expression by magnesium ion.

PubMed ID: 18495115

DOI: 10.1016/j.ejphar.2008.03.063

PubMed ID: 30420639

Title: Human adipose glycerol flux is regulated by a pH gate in AQP10.

PubMed ID: 30420639

DOI: 10.1038/s41467-018-07176-z

Sequence Information:

  • Length: 292
  • Mass: 31544
  • Checksum: A9555E9576EABA9C
  • Sequence:
    • MGRQKELVSR CGEMLHIRYR LLRQALAECL GTLILVMFGC GSVAQVVLSR GTHGGFLTIN 
LAFGFAVTLG ILIAGQVSGA HLNPAVTFAM CFLAREPWIK LPIYTLAQTL GAFLGAGIVF 
GLYYDAIWHF ADNQLFVSGP NGTAGIFATY PSGHLDMING FFDQFIGTAS LIVCVLAIVD 
PYNNPVPRGL EAFTVGLVVL VIGTSMGFNS GYAVNPARDF GPRLFTALAG WGSAVFTTGQ 
HWWWVPIVSP LLGSIAGVFV YQLMIGCHLE QPPPSNEEEN VKLAHVKHKE QI

Genular Protein ID: 420479881

Symbol: A0A2R8Y2R4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8Y2R4

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 2 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

Sequence Information:

  • Length: 237
  • Mass: 25080
  • Checksum: D3BBE3A803F1D29F
  • Sequence:
    • MGRQKELVSR CGEMLHIRYR LLRQALAECL GTLILVMFGC GSVAQVVLSR GTHGGFLTIN 
LAFGFAVTLG ILIAGQVSGA HLNPAVTFAM CFLAREPWIK LPIYTLAQTL GAFLGAGIVF 
GLYYDAIWHF ADNQLFVSGP NGTAGIFATY PSGHLDMING FFDQDRPALV VGAHRVPTPG 
LHCGCLRVPA DDRLPPGAAP TLQRGRECEA GPCEAQGADL SGQGPSPHSA ALALSIH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.