egr | FBgn0033483 | NCBI 36054

Details for: egr

Gene ID: 36054

Symbol: egr

Ensembl ID: FBgn0033483

Description: eiger

Associated with

Hur (elavl1) binds and stabilizes mrna
(R-DME-450520)
Metabolism of rna
(R-DME-8953854)
Regulation of mrna stability by proteins that bind au-rich elements
(R-DME-450531)
Apical protein localization
(GO:0045176)
Apoptotic process
(GO:0006915)
Asymmetric protein localization involved in cell fate determination
(GO:0045167)
Cellular response to amino acid starvation
(GO:0034198)
Defense response to gram-negative bacterium
(GO:0050829)
Engulfment of apoptotic cell
(GO:0043652)
Extracellular space
(GO:0005615)
Glial cell proliferation
(GO:0014009)
Immune response
(GO:0006955)
Innate immune response
(GO:0045087)
Melanization defense response
(GO:0035006)
Membrane
(GO:0016020)
Negative regulation of multicellular organism growth
(GO:0040015)
Negative regulation of neuromuscular synaptic transmission
(GO:1900074)
Negative regulation of reactive oxygen species biosynthetic process
(GO:1903427)
Neuron cellular homeostasis
(GO:0070050)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of programmed cell death
(GO:0043068)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Positive regulation of sensory perception of pain
(GO:1904058)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Response to tumor cell
(GO:0002347)
Signaling receptor binding
(GO:0005102)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Tumor necrosis factor receptor binding
(GO:0005164)
Tumor necrosis factor receptor superfamily binding
(GO:0032813)
Wound healing
(GO:0042060)

Other Information

Proteins

EIGER_DROME

Genular Protein ID: 2424227050

Symbol: EIGER_DROME

Name: N/A

UniProtKB Accession Codes:

Q8MUJ1 Q8IGD3 Q8MRW2 Q8MY88

Database IDs:

Citations:

PubMed ID: 12176339

Title: Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily.

PubMed ID: 12176339

DOI: 10.1016/s0960-9822(02)00954-5

PubMed ID: 12065414

Title: Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway.

PubMed ID: 12065414

DOI: 10.1093/emboj/cdf306

PubMed ID: 12894227

Title: Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila.

PubMed ID: 12894227

DOI: 10.1038/sj.onc.1206715

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 17356067

Title: Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger.

PubMed ID: 17356067

DOI: 10.1242/jcs.03420

PubMed ID: 17381241

Title: Drosophila eiger mutants are sensitive to extracellular pathogens.

PubMed ID: 17381241

DOI: 10.1371/journal.ppat.0030041

PubMed ID: 19375319

Title: Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae.

PubMed ID: 19375319

DOI: 10.1016/j.cub.2009.03.062

PubMed ID: 19289090

Title: Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila.

PubMed ID: 19289090

DOI: 10.1016/j.devcel.2009.01.002

PubMed ID: 19019992

Title: Neuronal programmed cell death induces glial cell division in the adult Drosophila brain.

PubMed ID: 19019992

DOI: 10.1242/dev.023366

PubMed ID: 20505310

Title: The Drosophila TNF ortholog eiger is required in the fat body for a robust immune response.

PubMed ID: 20505310

DOI: 10.1159/000315050

PubMed ID: 24066226

Title: Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway.

PubMed ID: 24066226

DOI: 10.7554/elife.01004

PubMed ID: 25754009

Title: The role of Drosophila TNF Eiger in developmental and damage-induced neuronal apoptosis.

PubMed ID: 25754009

DOI: 10.1016/j.febslet.2015.02.032

PubMed ID: 25874673

Title: The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth.

PubMed ID: 25874673

DOI: 10.1038/nature14298

Sequence Information:

Length: 415
Mass: 46918
Checksum: E087A26DE222D2BF
Sequence:

MTAETLKPFI TPTSANDDGF PAKATSTATA QRRTRQLIPL VLGFIGLGLV VAILALTIWQ 
TTRVSHLDKE LKSLKRVVDN LQQRLGINYL DEFDEFQKEY ENALIDYPKK VDGLTDEEDD 
DDGDGLDSIA DDEDDDVSYS SVDDVGADYE DYTDMLNKLN NAHTGTTPTS ETTAEGEGET 
DSASSASNDD NVFDDFTSYN AHKKKQERKS RSIADVRNEE QNIQGNHTEL QEKSSNEATS 
KESPAPLHHR RRMHSRHRHL LVRKGESLLS ARSEDSRPAA HFHLSSRRRH QGSMGYHGDM 
YIGNDNERNS YQGHFQTRDG VLTVTNTGLY YVYAQICYNN SHDQNGFIVF QGDTPFLQCL 
NTVPTNMPHK VHTCHTSGLI HLERNERIHL KDIHNDRNAV LREGNNRSYF GIFKV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: egr

Associated with

Other Information

Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. PubMed ID: 12176339

Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. PubMed ID: 12065414

Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila. PubMed ID: 12894227

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger. PubMed ID: 17356067

Drosophila eiger mutants are sensitive to extracellular pathogens. PubMed ID: 17381241

Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae. PubMed ID: 19375319

Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. PubMed ID: 19289090

Neuronal programmed cell death induces glial cell division in the adult Drosophila brain. PubMed ID: 19019992

The Drosophila TNF ortholog eiger is required in the fat body for a robust immune response. PubMed ID: 20505310

Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway. PubMed ID: 24066226

The role of Drosophila TNF Eiger in developmental and damage-induced neuronal apoptosis. PubMed ID: 25754009

The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth. PubMed ID: 25874673