Details for: AQP4

Gene ID: 361

Symbol: AQP4

Ensembl ID: ENSG00000171885

Description: aquaporin 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.81
    Marker Score: 4327
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 4.63
    Marker Score: 3045
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.67
    Marker Score: 4424
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.05
    Marker Score: 1730.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.99
    Marker Score: 63772
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.25
    Marker Score: 9392.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.2
    Marker Score: 1906
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.18
    Marker Score: 3010.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.15
    Marker Score: 3461
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.99
    Marker Score: 12969
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.98
    Marker Score: 890
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.68
    Marker Score: 6505
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.56
    Marker Score: 25047
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.43
    Marker Score: 752
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.34
    Marker Score: 545
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.32
    Marker Score: 552
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.26
    Marker Score: 6607
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.18
    Marker Score: 652
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.95
    Marker Score: 1805
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.84
    Marker Score: 1164
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12888
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.82
    Marker Score: 1068
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1557
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 444
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.67
    Marker Score: 615
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.61
    Marker Score: 4028
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.6
    Marker Score: 1096
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 478
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.51
    Marker Score: 634
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 305
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.5
    Marker Score: 227
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.49
    Marker Score: 204
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.44
    Marker Score: 511
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.42
    Marker Score: 188
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.42
    Marker Score: 106
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.41
    Marker Score: 123
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.34
    Marker Score: 266
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 162
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.34
    Marker Score: 1152
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.32
    Marker Score: 617
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.31
    Marker Score: 115
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.31
    Marker Score: 1260
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.3
    Marker Score: 485
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3
    Marker Score: 664.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.3
    Marker Score: 330
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 131
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.3
    Marker Score: 844
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.29
    Marker Score: 446
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.28
    Marker Score: 107
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.27
    Marker Score: 2371
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.27
    Marker Score: 468
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.27
    Marker Score: 449
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.27
    Marker Score: 77
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.27
    Marker Score: 126
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.26
    Marker Score: 131
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.26
    Marker Score: 234
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.26
    Marker Score: 94
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 75
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 149
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.24
    Marker Score: 150
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.24
    Marker Score: 85
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.23
    Marker Score: 3110
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.23
    Marker Score: 103
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.23
    Marker Score: 413
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.22
    Marker Score: 596
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.22
    Marker Score: 225
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.22
    Marker Score: 2069
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.21
    Marker Score: 13099
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.21
    Marker Score: 502
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.21
    Marker Score: 207
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.2
    Marker Score: 260
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.2
    Marker Score: 612
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 190
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.19
    Marker Score: 243
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.19
    Marker Score: 70
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.19
    Marker Score: 398
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.19
    Marker Score: 111
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.19
    Marker Score: 42.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.19
    Marker Score: 41.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.18
    Marker Score: 58
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.18
    Marker Score: 40.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.18
    Marker Score: 82
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.18
    Marker Score: 417
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.17
    Marker Score: 37
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.17
    Marker Score: 1493
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.17
    Marker Score: 41.5
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.17
    Marker Score: 41.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.17
    Marker Score: 69

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Other Information

**Key characteristics:** - AQP4 is a water channel protein that is expressed in the plasma membrane of cells. - It is a member of the aquaporin family of water channels. - AQP4 is responsible for the transport of water across cell membranes, and it is involved in maintaining water balance and the transport of small molecules. - It is also involved in the regulation of inflammation and the development of cancer. **Pathways and functions:** - AQP4 is involved in the regulation of water balance in the body. - It is expressed in cells throughout the body, including erythrocytes, astrocytes, and pneumocytes. - In erythrocytes, AQP4 is involved in the regulation of water and solute transport. - In astrocytes, AQP4 is involved in the regulation of water balance and the production of cerebrospinal fluid. - In pneumocytes, AQP4 is involved in the regulation of water and solute transport in the lungs. **Clinical significance:** - Mutations in the AQP4 gene have been linked to a number of human diseases, including kidney disease, stroke, and cancer. - AQP4 is a potential therapeutic target for these diseases. - By understanding the role of AQP4 in water balance and inflammation, it may be possible to develop new treatments for these diseases. **Additional information:** - The AQP4 gene is located on chromosome 1q21.1. - It is a large gene, encoding a protein of approximately 1350 amino acids. - AQP4 is a highly conserved protein, with a similar sequence found in organisms from flies to humans. - It is a key protein in the human body, and its dysfunction is associated with a number of diseases.

Genular Protein ID: 66468414

Symbol: AQP4_HUMAN

Name: Aquaporin-4

UniProtKB Accession Codes:

P55087 P78564

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7559426

Title: cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units.

PubMed ID: 7559426

DOI: 10.1074/jbc.270.39.22907

PubMed ID: 8601457

Title: A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach.

PubMed ID: 8601457

DOI: 10.1016/0014-5793(96)00092-0

PubMed ID: 8855281

Title: The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain.

PubMed ID: 8855281

DOI: 10.1073/pnas.93.20.10908

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22328087

Title: Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations.

PubMed ID: 22328087

DOI: 10.1093/hmg/dds032

PubMed ID: 29055082

Title: Supramolecular aggregation of aquaporin-4 is different in muscle and brain: correlation with tissue susceptibility in neuromyelitis optica.

PubMed ID: 29055082

DOI: 10.1111/jcmm.13401

PubMed ID: 19383790

Title: Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance.

PubMed ID: 19383790

DOI: 10.1073/pnas.0902725106

Sequence Information:

  • Length: 323
  • Mass: 34830
  • Checksum: 1A1600CF0DC11052
  • Sequence:
    • MSDRPTARRW GKCGPLCTRE NIMVAFKGVW TQAFWKAVTA EFLAMLIFVL LSLGSTINWG 
GTEKPLPVDM VLISLCFGLS IATMVQCFGH ISGGHINPAV TVAMVCTRKI SIAKSVFYIA 
AQCLGAIIGA GILYLVTPPS VVGGLGVTMV HGNLTAGHGL LVELIITFQL VFTIFASCDS 
KRTDVTGSIA LAIGFSVAIG HLFAINYTGA SMNPARSFGP AVIMGNWENH WIYWVGPIIG 
AVLAGGLYEY VFCPDVEFKR RFKEAFSKAA QQTKGSYMEV EDNRSQVETD DLILKPGVVH 
VIDVDRGEEK KGKDQSGEVL SSV

Genular Protein ID: 880965122

Symbol: V9PBN7_HUMAN

Name: N/A

UniProtKB Accession Codes:

V9PBN7

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 24356448

Title: A novel human aquaporin-4 splice variant exhibits a dominant-negative activity: a new mechanism to regulate water permeability.

PubMed ID: 24356448

DOI: 10.1091/mbc.E13-06-0331

Sequence Information:

  • Length: 296
  • Mass: 31826
  • Checksum: 9FFD0614CC3183A2
  • Sequence:
    • MSDRPTARRW GKCGPLCTRE NIMVAFKGVW TQAFWKAVTA EFLAMLIFVL LSLGSTINWG 
GTEKPLPVDM VLISLCFGLS IATMVQCFGH ISGGHINPAV TVAMVCTRKI SIAKSVFYIA 
AQCLGAIIGA GILYLVTPPS VVGGLGVTMV HGNLTAGHGL LVELIITFQL VFTIFASCDS 
KRTDVTGSIA LAIGFSVAIG HLFAIYWVGP IIGAVLAGGL YEYVFCPDVE FKRRFKEAFS 
KAAQQTKGSY MEVEDNRSQV ETDDLILKPG VVHVIDVDRG EEKKGKDQSG EVLSSV

Genular Protein ID: 3695548233

Symbol: A0A5F9ZHR4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A5F9ZHR4

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 2 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 352
  • Mass: 38171
  • Checksum: 155A62B8AA624EF4
  • Sequence:
    • MSDRPTARRW GKCGPLCTRE NIMVAFKGVW TQAFWKAVTA EFLAMLIFVL LSLGSTINWG 
GTEKPLPVDM VLISLCFGLS IATMVQCFGH ISGGHINPAV TVAMVCTRKI SIAKSVFYIA 
AQCLGAIIGA GILYLVTPPS VVGGLGVTMV HGNLTAGHGL LVELIITFQL VFTIFASCDS 
KRTDVTGSIA LAIGFSVAIG HLFAINYTGA SMNPARSFGP AVIMGNWENH WIYWVGPIIG 
AVLAGGLYEY VFCPDVEFKR RFKEAFSKAA QQTKGSYMEV EDNRSQVETD DLILKPGVVH 
VIDVDRGEEK KGKDQSGEVL SSVXLEDRTE SRQDSLELSS DFLPPIKETD LL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.