Gene AQP5 - ENSG00000161798 | NCBI Gene ID: 362

Details for: AQP5

Gene ID: 362

Symbol: AQP5

Ensembl ID: ENSG00000161798

Description: aquaporin 5

Associated with

Aquaporin-mediated transport
(R-HSA-445717)
Passive transport by aquaporins
(R-HSA-432047)
Transport of small molecules
(R-HSA-382551)
Apical plasma membrane
(GO:0016324)
Basal plasma membrane
(GO:0009925)
Camera-type eye morphogenesis
(GO:0048593)
Carbon dioxide transport
(GO:0015670)
Cellular hypotonic response
(GO:0071476)
Cytoplasmic vesicle membrane
(GO:0030659)
Endoplasmic reticulum
(GO:0005783)
Extracellular exosome
(GO:0070062)
Identical protein binding
(GO:0042802)
Microvillus
(GO:0005902)
Odontogenesis
(GO:0042476)
Pancreatic juice secretion
(GO:0030157)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein homotetramerization
(GO:0051289)
Saliva secretion
(GO:0046541)
Transmembrane transport
(GO:0055085)
Water channel activity
(GO:0015250)
Water transport
(GO:0006833)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.6
Marker Score: 8195
Cell Name: serous secreting cell (CL0000313)
Fold Change: 3.36
Marker Score: 1343
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.16
Marker Score: 23547
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 3
Marker Score: 2005
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.68
Marker Score: 1324
Cell Name: progenitor cell (CL0011026)
Fold Change: 2.63
Marker Score: 16959.5
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 2.43
Marker Score: 667
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.4
Marker Score: 2528
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.05
Marker Score: 4661
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.95
Marker Score: 564
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.87
Marker Score: 1096
Cell Name: tracheobronchial serous cell (CL0019001)
Fold Change: 1.78
Marker Score: 651
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.75
Marker Score: 556
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.53
Marker Score: 1041
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.49
Marker Score: 695
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 868
Cell Name: secretory cell (CL0000151)
Fold Change: 1.28
Marker Score: 2329
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.23
Marker Score: 312
Cell Name: acinar cell (CL0000622)
Fold Change: 1.12
Marker Score: 793
Cell Name: club cell (CL0000158)
Fold Change: 1.1
Marker Score: 1288
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.1
Marker Score: 38058
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.05
Marker Score: 5511
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 1.03
Marker Score: 3016
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71813
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48038
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5345
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5283
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.86
Marker Score: 7295
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.83
Marker Score: 632
Cell Name: peptic cell (CL0000155)
Fold Change: 0.81
Marker Score: 339
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.76
Marker Score: 4512
Cell Name: basal cell (CL0000646)
Fold Change: 0.75
Marker Score: 973
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.7
Marker Score: 842
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.65
Marker Score: 792
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.62
Marker Score: 178
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.6
Marker Score: 394
Cell Name: malignant cell (CL0001064)
Fold Change: 0.58
Marker Score: 7766
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.57
Marker Score: 455
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 232
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.55
Marker Score: 4742
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.53
Marker Score: 589
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.53
Marker Score: 572
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.52
Marker Score: 701
Cell Name: melanocyte (CL0000148)
Fold Change: 0.5
Marker Score: 202
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.5
Marker Score: 443
Cell Name: male germ cell (CL0000015)
Fold Change: 0.47
Marker Score: 134
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 277
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.46
Marker Score: 7233
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.44
Marker Score: 907
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.43
Marker Score: 246
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.43
Marker Score: 1472
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.42
Marker Score: 672
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.41
Marker Score: 131
Cell Name: Unknown (CL0000003)
Fold Change: 0.41
Marker Score: 1258
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.39
Marker Score: 742
Cell Name: germ cell (CL0000586)
Fold Change: 0.39
Marker Score: 680
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.38
Marker Score: 234
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.38
Marker Score: 131
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.37
Marker Score: 114
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.36
Marker Score: 571
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.34
Marker Score: 470.5
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.33
Marker Score: 123
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.33
Marker Score: 183
Cell Name: ionocyte (CL0005006)
Fold Change: 0.33
Marker Score: 100
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.31
Marker Score: 722
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.31
Marker Score: 869
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.3
Marker Score: 73172
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.29
Marker Score: 541
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.28
Marker Score: 255
Cell Name: myoepithelial cell (CL0000185)
Fold Change: 0.27
Marker Score: 76
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.27
Marker Score: 98.5
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.27
Marker Score: 119
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.27
Marker Score: 78
Cell Name: stem cell (CL0000034)
Fold Change: 0.26
Marker Score: 624
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.26
Marker Score: 69
Cell Name: mast cell (CL0000097)
Fold Change: 0.25
Marker Score: 147
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.25
Marker Score: 510
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.25
Marker Score: 309
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.25
Marker Score: 353
Cell Name: brush cell of trachebronchial tree (CL0002075)
Fold Change: 0.24
Marker Score: 75
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.23
Marker Score: 413
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.23
Marker Score: 548
Cell Name: keratocyte (CL0002363)
Fold Change: 0.23
Marker Score: 53
Cell Name: macrophage (CL0000235)
Fold Change: 0.23
Marker Score: 255
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.23
Marker Score: 72
Cell Name: neural cell (CL0002319)
Fold Change: 0.22
Marker Score: 106
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.21
Marker Score: 101
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.21
Marker Score: 46
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.21
Marker Score: 518
Cell Name: goblet cell (CL0000160)
Fold Change: 0.2
Marker Score: 1341
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.2
Marker Score: 283
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.2
Marker Score: 80

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**Key characteristics**: - AQP5 is a transmembrane protein with a molecular weight of approximately 45 kDa. - It is a member of the Aquaporin family of water channels. - It is expressed in high levels in the plasma membrane of cells in tissues that are involved in water transport, such as salivary gland, serous secreting cells, and epithelial cells of the respiratory tract. - It is also expressed in epithelial cells of the eye, where it is involved in the regulation of intraocular fluid balance. **Pathways and functions**: - AQP5 is involved in the regulation of water and solute transport across cell membranes. - It is a key regulator of water balance in various tissues, including the lungs, kidney, and eye. - It is involved in the regulation of the salivary gland, where it helps to maintain proper hydration and prevent desiccation. - It is also involved in the regulation of the tear film, the fluid that is produced by the eyes to keep them moist. - It is involved in the regulation of the gastrointestinal tract, where it helps to maintain water and electrolyte balance. - It is also involved in the regulation of the kidney, where it helps to regulate water and solute balance. **Clinical significance**: - Mutations in AQP5 have been linked to a number of human diseases, including kidney disease, eye diseases, and cancer. - AQP5 is a potential therapeutic target for a variety of diseases, including kidney disease, eye diseases, and cancer. - Development of drugs that target AQP5 could provide a new treatment for these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Aquaporin-5

Genular Protein ID: 3202073419

Symbol: AQP5_HUMAN

Name: Aquaporin-5

UniProtKB Accession Codes:

P55064 Q6FGW8

Database IDs:

Citations:

PubMed ID: 8621489

Title: The human aquaporin-5 gene. Molecular characterization and chromosomal localization.

PubMed ID: 8621489

DOI: 10.1074/jbc.271.15.8599

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16571723

Title: A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.

PubMed ID: 16571723

DOI: 10.1074/jbc.m600549200

PubMed ID: 23473857

Title: Immunolocalization and translocation of aquaporin-5 water channel in sweat glands.

PubMed ID: 23473857

DOI: 10.1016/j.jdermsci.2013.01.013

PubMed ID: 18768791

Title: High-resolution X-ray structure of human aquaporin 5.

PubMed ID: 18768791

DOI: 10.1073/pnas.0801466105

PubMed ID: 26569106

Title: Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways.

PubMed ID: 26569106

DOI: 10.1371/journal.pone.0143027

PubMed ID: 23830519

Title: Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma.

PubMed ID: 23830519

DOI: 10.1016/j.ajhg.2013.06.008

Sequence Information:

Length: 265
Mass: 28292
Checksum: 053C10E6A17EAFDA
Sequence:

MKKEVCSVAF LKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQIALAFG LAIGTLAQAL 
GPVSGGHINP AITLALLVGN QISLLRAFFY VAAQLVGAIA GAGILYGVAP LNARGNLAVN 
ALNNNTTQGQ AMVVELILTF QLALCIFAST DSRRTSPVGS PALSIGLSVT LGHLVGIYFT 
GCSMNPARSF GPAVVMNRFS PAHWVFWVGP IVGAVLAAIL YFYLLFPNSL SLSERVAIIK 
GTYEPDEDWE EQREERKKTM ELTTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: AQP5

Associated with

Cells (max top 100)

Other Information

The human aquaporin-5 gene. Molecular characterization and chromosomal localization. PubMed ID: 8621489

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. PubMed ID: 16571723

Immunolocalization and translocation of aquaporin-5 water channel in sweat glands. PubMed ID: 23473857

High-resolution X-ray structure of human aquaporin 5. PubMed ID: 18768791

Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways. PubMed ID: 26569106

Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma. PubMed ID: 23830519