Details for: AQP5

Gene ID: 362

Symbol: AQP5

Ensembl ID: ENSG00000161798

Description: aquaporin 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 34.9385
    Cell Significance Index: 24.9700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 16.1110
    Cell Significance Index: 336.0100
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 14.3477
    Cell Significance Index: 79.8600
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 5.2264
    Cell Significance Index: 34.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.7249
    Cell Significance Index: 173.6700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.9897
    Cell Significance Index: 30.8400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.9976
    Cell Significance Index: 25.2400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.6262
    Cell Significance Index: 22.8100
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.5579
    Cell Significance Index: 15.5900
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.5321
    Cell Significance Index: 11.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0758
    Cell Significance Index: 587.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7001
    Cell Significance Index: 90.4500
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 0.6840
    Cell Significance Index: 4.8000
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.5437
    Cell Significance Index: 2.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5107
    Cell Significance Index: 13.6900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3094
    Cell Significance Index: 7.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2698
    Cell Significance Index: 12.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1714
    Cell Significance Index: 233.0700
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.1669
    Cell Significance Index: 1.3800
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.1209
    Cell Significance Index: 1.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0733
    Cell Significance Index: 1.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0293
    Cell Significance Index: 45.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0234
    Cell Significance Index: 1.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0181
    Cell Significance Index: 33.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0015
    Cell Significance Index: 1.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0080
    Cell Significance Index: -15.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0081
    Cell Significance Index: -0.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0115
    Cell Significance Index: -1.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0125
    Cell Significance Index: -2.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0149
    Cell Significance Index: -10.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0165
    Cell Significance Index: -10.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0181
    Cell Significance Index: -13.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0226
    Cell Significance Index: -12.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0239
    Cell Significance Index: -1.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0249
    Cell Significance Index: -8.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0255
    Cell Significance Index: -11.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0307
    Cell Significance Index: -1.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0387
    Cell Significance Index: -1.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0527
    Cell Significance Index: -10.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0578
    Cell Significance Index: -8.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0632
    Cell Significance Index: -7.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0661
    Cell Significance Index: -19.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0860
    Cell Significance Index: -17.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0912
    Cell Significance Index: -10.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0916
    Cell Significance Index: -15.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1081
    Cell Significance Index: -11.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1183
    Cell Significance Index: -8.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1196
    Cell Significance Index: -1.3600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1247
    Cell Significance Index: -1.9300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1268
    Cell Significance Index: -1.3900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1382
    Cell Significance Index: -1.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1389
    Cell Significance Index: -11.0000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1475
    Cell Significance Index: -2.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1487
    Cell Significance Index: -20.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1586
    Cell Significance Index: -10.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1586
    Cell Significance Index: -16.5100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1961
    Cell Significance Index: -0.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2015
    Cell Significance Index: -12.7000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2025
    Cell Significance Index: -6.4100
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2099
    Cell Significance Index: -1.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2238
    Cell Significance Index: -15.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2618
    Cell Significance Index: -16.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2738
    Cell Significance Index: -10.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2907
    Cell Significance Index: -10.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2946
    Cell Significance Index: -22.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3304
    Cell Significance Index: -18.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3585
    Cell Significance Index: -10.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3870
    Cell Significance Index: -9.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4051
    Cell Significance Index: -21.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4291
    Cell Significance Index: -12.3000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4607
    Cell Significance Index: -4.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4753
    Cell Significance Index: -15.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4781
    Cell Significance Index: -24.8400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.4878
    Cell Significance Index: -7.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4934
    Cell Significance Index: -9.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5091
    Cell Significance Index: -17.8400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.5215
    Cell Significance Index: -5.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5277
    Cell Significance Index: -15.0600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5440
    Cell Significance Index: -6.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5592
    Cell Significance Index: -17.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5594
    Cell Significance Index: -24.7500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5599
    Cell Significance Index: -12.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5619
    Cell Significance Index: -15.0300
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.5705
    Cell Significance Index: -6.1100
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.5779
    Cell Significance Index: -4.4000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.5799
    Cell Significance Index: -6.1600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.5849
    Cell Significance Index: -5.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5985
    Cell Significance Index: -15.9800
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.6051
    Cell Significance Index: -5.9400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.6135
    Cell Significance Index: -7.9000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.6236
    Cell Significance Index: -5.3000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.6269
    Cell Significance Index: -6.8300
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.6322
    Cell Significance Index: -7.3200
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.6475
    Cell Significance Index: -3.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6521
    Cell Significance Index: -24.7000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6526
    Cell Significance Index: -16.2800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.6579
    Cell Significance Index: -6.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6666
    Cell Significance Index: -11.7800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.6697
    Cell Significance Index: -13.6300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6774
    Cell Significance Index: -17.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AQP5 is a type II transmembrane protein composed of six transmembrane domains and a hydrophilic pore. Its structure allows it to facilitate the movement of water and small solutes, such as urea, glycerol, and ions, across cell membranes. AQP5 is highly glycosylated, with 11 N-linked glycosylation sites, which are thought to play a role in its stability and function. The gene is ubiquitously expressed in various tissues, but its expression is significantly higher in salivary glands and trachea. **Pathways and Functions:** AQP5 is involved in several cellular processes, including: 1. **Water transport**: AQP5 facilitates the movement of water across cell membranes, which is essential for maintaining proper hydration and secretion in various tissues. 2. **Mucus secretion**: AQP5 is involved in the regulation of mucus secretion in the respiratory and gastrointestinal tracts, where it helps to maintain the integrity of epithelial barriers. 3. **Immune response**: AQP5 has been implicated in the regulation of immune responses, particularly in the secretion of mucus and the maintenance of epithelial barrier function. 4. **Endocytosis and exocytosis**: AQP5 is involved in the regulation of endocytosis and exocytosis, which are critical processes for maintaining cellular homeostasis. **Clinical Significance:** Dysregulation of AQP5 has been implicated in various diseases, including: 1. **Cystic fibrosis**: AQP5 has been shown to play a critical role in the regulation of mucus secretion in cystic fibrosis, a genetic disorder characterized by abnormal mucus production. 2. **Respiratory diseases**: AQP5 has been implicated in the regulation of mucus secretion in respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. 3. **Gastrointestinal disorders**: AQP5 has been implicated in the regulation of mucus secretion in gastrointestinal disorders, such as inflammatory bowel disease (IBD). 4. **Cancer**: AQP5 has been implicated in the regulation of tumor progression and metastasis in various cancers. In conclusion, AQP5 is a critical protein involved in water transport, mucus secretion, and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of AQP5 in human health and disease.

Genular Protein ID: 3202073419

Symbol: AQP5_HUMAN

Name: Aquaporin-5

UniProtKB Accession Codes:

P55064 Q6FGW8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8621489

Title: The human aquaporin-5 gene. Molecular characterization and chromosomal localization.

PubMed ID: 8621489

DOI: 10.1074/jbc.271.15.8599

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16571723

Title: A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.

PubMed ID: 16571723

DOI: 10.1074/jbc.m600549200

PubMed ID: 23473857

Title: Immunolocalization and translocation of aquaporin-5 water channel in sweat glands.

PubMed ID: 23473857

DOI: 10.1016/j.jdermsci.2013.01.013

PubMed ID: 18768791

Title: High-resolution X-ray structure of human aquaporin 5.

PubMed ID: 18768791

DOI: 10.1073/pnas.0801466105

PubMed ID: 26569106

Title: Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways.

PubMed ID: 26569106

DOI: 10.1371/journal.pone.0143027

PubMed ID: 23830519

Title: Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma.

PubMed ID: 23830519

DOI: 10.1016/j.ajhg.2013.06.008

PubMed ID: 23867895

Title: Mutation in AQP5, encoding aquaporin 5, causes palmoplantar keratoderma Bothnia type.

PubMed ID: 23867895

DOI: 10.1038/jid.2013.302

Sequence Information:

  • Length: 265
  • Mass: 28292
  • Checksum: 053C10E6A17EAFDA
  • Sequence:
    • MKKEVCSVAF LKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQIALAFG LAIGTLAQAL 
GPVSGGHINP AITLALLVGN QISLLRAFFY VAAQLVGAIA GAGILYGVAP LNARGNLAVN 
ALNNNTTQGQ AMVVELILTF QLALCIFAST DSRRTSPVGS PALSIGLSVT LGHLVGIYFT 
GCSMNPARSF GPAVVMNRFS PAHWVFWVGP IVGAVLAAIL YFYLLFPNSL SLSERVAIIK 
GTYEPDEDWE EQREERKKTM ELTTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.