Details for: en

Gene ID: 36240

Symbol: en

Ensembl ID: FBgn0000577

Description: engrailed

Associated with

  • Analia development
    (GO:0007487)
  • Anterior/posterior lineage restriction, imaginal disc
    (GO:0048099)
  • Anterior head segmentation
    (GO:0035288)
  • Axon guidance
    (GO:0007411)
  • Compartment pattern specification
    (GO:0007386)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Genital disc anterior/posterior pattern formation
    (GO:0035224)
  • Genital disc development
    (GO:0035215)
  • Gonad development
    (GO:0008406)
  • Imaginal disc-derived wing vein specification
    (GO:0007474)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuroblast fate determination
    (GO:0007400)
  • Neuron differentiation
    (GO:0030182)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Posterior compartment specification
    (GO:0007388)
  • Posterior head segmentation
    (GO:0035289)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Segment polarity determination
    (GO:0007367)
  • Sequence-specific dna binding
    (GO:0043565)
  • Spiracle morphogenesis, open tracheal system
    (GO:0035277)
  • Trunk segmentation
    (GO:0035290)
  • Ventral midline development
    (GO:0007418)
  • Wing disc anterior/posterior pattern formation
    (GO:0048100)
  • Wing disc morphogenesis
    (GO:0007472)

Other Information

Genular Protein ID: 3353021152

Symbol: HMEN_DROME

Name: Segmentation polarity homeobox protein engrailed

UniProtKB Accession Codes:

P02836 P02837 Q0E9C0 Q24356 Q9V601

Database IDs:

AGR 1 AlphaFoldDB 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 ELM 1 EMBL 6 EnsemblMetazoa 2 EvolutionaryTrace 1 ExpressionAtlas 1 FlyBase 1 GO 31 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 14 PIR 1 PRINTS 3 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 3917855

Title: The engrailed locus of Drosophila: structural analysis of an embryonic transcript.

PubMed ID: 3917855

DOI: 10.1016/0092-8674(85)90306-x

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 2481829

Title: Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts.

PubMed ID: 2481829

DOI: 10.1038/313284a0

PubMed ID: 8334991

Title: Functional domains of the Drosophila Engrailed protein.

PubMed ID: 8334991

DOI: 10.1002/j.1460-2075.1993.tb05934.x

PubMed ID: 2899884

Title: The Drosophila engrailed protein is phosphorylated by a serine-specific protein kinase.

PubMed ID: 2899884

DOI: 10.1093/nar/16.14.6637

PubMed ID: 3935318

Title: Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein.

PubMed ID: 3935318

DOI: 10.1016/0092-8674(85)90012-1

PubMed ID: 1335365

Title: wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate.

PubMed ID: 1335365

DOI: 10.1016/s0092-8674(05)80065-0

PubMed ID: 1977522

Title: Crystal structure of an engrailed homeodomain-DNA complex at 2.8-A resolution: a framework for understanding homeodomain-DNA interactions.

PubMed ID: 1977522

DOI: 10.1016/0092-8674(90)90453-l

PubMed ID: 9309220

Title: Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9-A resolution: structural basis for enhanced affinity and altered specificity.

PubMed ID: 9309220

DOI: 10.1016/s0969-2126(97)00256-6

PubMed ID: 9813123

Title: Engrailed homeodomain-DNA complex at 2.2-A resolution: a detailed view of the interface and comparison with other engrailed structures.

PubMed ID: 9813123

DOI: 10.1006/jmbi.1998.2147

PubMed ID: 10889025

Title: Exploring the role of glutamine 50 in the homeodomain-DNA interface: crystal structure of engrailed (Gln50 --> Ala) complex at 2.0 A.

PubMed ID: 10889025

DOI: 10.1021/bi000071a

Sequence Information:

  • Length: 552
  • Mass: 59411
  • Checksum: 92A94C14AA85C527
  • Sequence:
    • MALEDRCSPQ SAPSPITLQM QHLHHQQQQQ QQQQQQMQHL HQLQQLQQLH QQQLAAGVFH 
HPAMAFDAAA AAAAAAAAAA AHAHAAALQQ RLSGSGSPAS CSTPASSTPL TIKEEESDSV 
IGDMSFHNQT HTTNEEEEAE EDDDIDVDVD DTSAGGRLPP PAHQQQSTAK PSLAFSISNI 
LSDRFGDVQK PGKSMENQAS IFRPFEASRS QTATPSAFTR VDLLEFSRQQ QAAAAAATAA 
MMLERANFLN CFNPAAYPRI HEEIVQSRLR RSAANAVIPP PMSSKMSDAN PEKSALGSLC 
KAVSQIGQPA APTMTQPPLS SSASSLASPP PASNASTISS TSSVATSSSS SSSGCSSAAS 
SLNSSPSSRL GASGSGVNAS SPQPQPIPPP SAVSRDSGME SSDDTRSETG STTTEGGKNE 
MWPAWVYCTR YSDRPSSGPR YRRPKQPKDK TNDEKRPRTA FSSEQLARLK REFNENRYLT 
ERRRQQLSSE LGLNEAQIKI WFQNKRAKIK KSTGSKNPLA LQLMAQGLYN HTTVPLTKEE 
EELEMRMNGQ IP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.