Details for: AQP6

Gene ID: 363

Symbol: AQP6

Ensembl ID: ENSG00000086159

Description: aquaporin 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.22
    Marker Score: 2230
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.17
    Marker Score: 1945
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.04
    Marker Score: 607
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.98
    Marker Score: 520.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.94
    Marker Score: 496
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.67
    Marker Score: 10538
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.64
    Marker Score: 1217
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.63
    Marker Score: 363
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1455
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1212
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 473
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.55
    Marker Score: 609
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.45
    Marker Score: 2975
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.38
    Marker Score: 121
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.32
    Marker Score: 516.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 135
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.29
    Marker Score: 306
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.23
    Marker Score: 61
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 107
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.21
    Marker Score: 186
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.21
    Marker Score: 55
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.19
    Marker Score: 126
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 113
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.19
    Marker Score: 179
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.19
    Marker Score: 467
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.17
    Marker Score: 710
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.14
    Marker Score: 192
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.13
    Marker Score: 55
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.13
    Marker Score: 378
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.13
    Marker Score: 172.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.12
    Marker Score: 227
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.12
    Marker Score: 131
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.11
    Marker Score: 626
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.1
    Marker Score: 236
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.09
    Marker Score: 18
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.09
    Marker Score: 95
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 98
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.08
    Marker Score: 114
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.08
    Marker Score: 152
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 91
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.07
    Marker Score: 515
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.06
    Marker Score: 79
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.06
    Marker Score: 130
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.06
    Marker Score: 1302
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.05
    Marker Score: 101
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.05
    Marker Score: 84
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.05
    Marker Score: 168
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 80
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.05
    Marker Score: 48

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Other Information

**Key characteristics:** - Gene ID: ENSG00000086159 - Ensembl: 200002227 - Protein name: AQP6_HUMAN (Aquaporin-6) - Molecular weight: 80 kDa - Cellular location: Apical plasma membrane - Function: Water and solute transport, including the transport of glucose, amino acids, and other molecules **Pathways and functions:** - Apical plasma membrane: AQP6 is primarily expressed in the plasma membrane of blood vessel endothelial cells, kidney collecting duct intercalated cells, pericytes, and other cell types that are involved in maintaining fluid and solute balance in the body. - Aquaporin-mediated transport: AQP6 is a key player in aquaporin-mediated transport, which is a process by which water and other molecules move down their concentration gradient through selectively permeable channels. AQP6 is responsible for the transport of water across the plasma membrane, facilitating the movement of water into and out of cells. - Carbon dioxide transport: In addition to water, AQP6 is also involved in the transport of carbon dioxide across cell membranes. - Cytoplasmic vesicle membrane: AQP6 is also expressed in cytoplasmic vesicles, where it plays a role in maintaining cellular water balance and preventing the leakage of water into or out of the cell. - Nitrate transmembrane transport: AQP6 is expressed in the plasma membrane of renal cells, where it is involved in the transport of nitrate ions across the cell membrane. - Passive transport by aquaporins: AQP6 is a member of the aquaporin family of water channels, which exhibit passive transport properties. This means that water molecules move down their concentration gradient through the protein without the need for active transport mechanisms. **Clinical significance:** - Mutations in the AQP6 gene have been linked to human diseases, including nephrotic syndrome, which is characterized by the buildup of urea and creatinine in the blood due to impaired water and solute transport in the kidneys. - AQP6 is also involved in the regulation of blood pressure and blood sugar levels. - Dysfunction of AQP6 has been implicated in various diseases, including glaucoma, diabetic retinopathy, and pulmonary edema.

Genular Protein ID: 3813652987

Symbol: AQP6_HUMAN

Name: Aquaporin-6

UniProtKB Accession Codes:

Q13520

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8812490

Title: cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13.

PubMed ID: 8812490

DOI: 10.1006/geno.1996.0396

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 282
  • Mass: 29370
  • Checksum: BDA1B3DFCA5C685E
  • Sequence:
    • MDAVEPGGRG WASMLACRLW KAISRALFAE FLATGLYVFF GVGSVMRWPT ALPSVLQIAI 
TFNLVTAMAV QVTWKASGAH ANPAVTLAFL VGSHISLPRA VAYVAAQLVG ATVGAALLYG 
VMPGDIRETL GINVVRNSVS TGQAVAVELL LTLQLVLCVF ASTDSRQTSG SPATMIGISV 
ALGHLIGIHF TGCSMNPARS FGPAIIIGKF TVHWVFWVGP LMGALLASLI YNFVLFPDTK 
TLAQRLAILT GTVEVGTGAG AGAEPLKKES QPGSGAVEME SV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.