Details for: AQP6

Gene ID: 363

Symbol: AQP6

Ensembl ID: ENSG00000086159

Description: aquaporin 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.7955
    Cell Significance Index: -1.4700
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 4.9726
    Cell Significance Index: 19.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6271
    Cell Significance Index: 22.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1896
    Cell Significance Index: 28.8200
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.9704
    Cell Significance Index: 0.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4843
    Cell Significance Index: 6.9400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3870
    Cell Significance Index: 6.1400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3307
    Cell Significance Index: 2.6400
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.1121
    Cell Significance Index: 1.0800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0871
    Cell Significance Index: 0.7400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0678
    Cell Significance Index: 1.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0663
    Cell Significance Index: 13.1600
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.0641
    Cell Significance Index: 0.6100
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.0401
    Cell Significance Index: 0.3200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0350
    Cell Significance Index: 0.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0285
    Cell Significance Index: 1.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0179
    Cell Significance Index: 0.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0096
    Cell Significance Index: 5.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0096
    Cell Significance Index: 18.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0024
    Cell Significance Index: 3.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0023
    Cell Significance Index: 0.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0018
    Cell Significance Index: 3.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0002
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0019
    Cell Significance Index: -1.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0020
    Cell Significance Index: -1.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0021
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0026
    Cell Significance Index: -0.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0030
    Cell Significance Index: -1.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0032
    Cell Significance Index: -0.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0041
    Cell Significance Index: -0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0042
    Cell Significance Index: -0.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0044
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0065
    Cell Significance Index: -1.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0075
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0075
    Cell Significance Index: -1.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0089
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0097
    Cell Significance Index: -1.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0104
    Cell Significance Index: -1.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0115
    Cell Significance Index: -1.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0115
    Cell Significance Index: -0.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0140
    Cell Significance Index: -1.4600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0145
    Cell Significance Index: -0.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0147
    Cell Significance Index: -0.6900
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0148
    Cell Significance Index: -0.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0150
    Cell Significance Index: -0.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0188
    Cell Significance Index: -1.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0189
    Cell Significance Index: -1.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0199
    Cell Significance Index: -1.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0216
    Cell Significance Index: -1.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0226
    Cell Significance Index: -1.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0255
    Cell Significance Index: -1.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0272
    Cell Significance Index: -1.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0278
    Cell Significance Index: -0.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0297
    Cell Significance Index: -1.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0310
    Cell Significance Index: -1.3700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0316
    Cell Significance Index: -0.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0317
    Cell Significance Index: -1.1700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0318
    Cell Significance Index: -0.3300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0324
    Cell Significance Index: -0.5600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0331
    Cell Significance Index: -0.4200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0331
    Cell Significance Index: -0.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0344
    Cell Significance Index: -0.9400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0349
    Cell Significance Index: -0.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0365
    Cell Significance Index: -1.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0376
    Cell Significance Index: -1.4300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0383
    Cell Significance Index: -1.2100
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.0386
    Cell Significance Index: -0.3600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0398
    Cell Significance Index: -0.6700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0410
    Cell Significance Index: -0.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0422
    Cell Significance Index: -1.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0425
    Cell Significance Index: -1.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0427
    Cell Significance Index: -0.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0449
    Cell Significance Index: -1.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0478
    Cell Significance Index: -0.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0498
    Cell Significance Index: -1.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0501
    Cell Significance Index: -1.4400
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0527
    Cell Significance Index: -0.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0530
    Cell Significance Index: -1.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0549
    Cell Significance Index: -1.3700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0557
    Cell Significance Index: -0.4400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0561
    Cell Significance Index: -1.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0563
    Cell Significance Index: -1.3500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0564
    Cell Significance Index: -0.7800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0565
    Cell Significance Index: -1.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0571
    Cell Significance Index: -1.3200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0575
    Cell Significance Index: -1.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0575
    Cell Significance Index: -1.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0608
    Cell Significance Index: -1.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0625
    Cell Significance Index: -1.3500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0653
    Cell Significance Index: -0.5400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0655
    Cell Significance Index: -0.9200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0671
    Cell Significance Index: -1.3200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0674
    Cell Significance Index: -0.9100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0676
    Cell Significance Index: -1.4100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0681
    Cell Significance Index: -0.7300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0682
    Cell Significance Index: -1.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue Distribution:** AQP6 is widely expressed in various tissues, including blood vessels, kidney collecting ducts, cerebral cortex, and intestinal crypts. 2. **Water Channel Activity:** AQP6 is a water channel protein that facilitates the transport of water and small molecules across cell membranes. 3. **Regulation of Cellular Metabolism:** AQP6 has been shown to regulate cellular metabolism by controlling the transport of glucose, amino acids, and other nutrients. 4. **Cell Signaling:** AQP6 can interact with signaling molecules, influencing cell growth, differentiation, and survival. 5. **Neuroprotective Effects:** AQP6 has been implicated in neuroprotection, particularly in the context of cerebral ischemia and neurodegenerative diseases. **Pathways and Functions:** 1. **Aquaporin-Mediated Transport:** AQP6 is involved in the transport of water and small molecules across cell membranes, regulating cellular hydration and ion balance. 2. **Renal Water Transport:** AQP6 plays a critical role in maintaining proper renal water transport, influencing blood pressure regulation and electrolyte balance. 3. **Carbon Dioxide Transport:** AQP6 has been shown to facilitate the transport of carbon dioxide across cell membranes, influencing cellular respiration and metabolic processes. 4. **Nitrate Transmembrane Transport:** AQP6 can regulate nitrate transmembrane transport, impacting cardiovascular function and angiogenesis. 5. **Cell Signaling and Metabolism:** AQP6 interacts with signaling molecules, influencing cell growth, differentiation, and metabolism. **Clinical Significance:** 1. **Renal Disorders:** AQP6 dysregulation has been implicated in various renal disorders, including nephrotic syndrome, nephritic syndrome, and renal fibrosis. 2. **Neurological Disorders:** AQP6 has been linked to neurodegenerative diseases, such as Alzheimer's, Parkinson's, and multiple sclerosis, where its dysregulation may contribute to disease progression. 3. **Cardiovascular Diseases:** AQP6 may play a role in cardiovascular diseases, including hypertension, atherosclerosis, and cardiac dysfunction. 4. **Gastrointestinal Disorders:** AQP6 dysregulation has been implicated in gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease. 5. **Cancer:** AQP6 has been shown to be overexpressed in certain types of cancer, including breast, lung, and colon cancer, where its dysregulation may contribute to tumor progression and metastasis. In conclusion, AQP6 is a multifunctional protein with far-reaching implications in various physiological and pathological processes. Further research is necessary to fully elucidate its role in human health and disease, and to explore potential therapeutic strategies targeting AQP6 for the treatment of related disorders.

Genular Protein ID: 3813652987

Symbol: AQP6_HUMAN

Name: Aquaporin-6

UniProtKB Accession Codes:

Q13520

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8812490

Title: cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13.

PubMed ID: 8812490

DOI: 10.1006/geno.1996.0396

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 282
  • Mass: 29370
  • Checksum: BDA1B3DFCA5C685E
  • Sequence:
    • MDAVEPGGRG WASMLACRLW KAISRALFAE FLATGLYVFF GVGSVMRWPT ALPSVLQIAI 
TFNLVTAMAV QVTWKASGAH ANPAVTLAFL VGSHISLPRA VAYVAAQLVG ATVGAALLYG 
VMPGDIRETL GINVVRNSVS TGQAVAVELL LTLQLVLCVF ASTDSRQTSG SPATMIGISV 
ALGHLIGIHF TGCSMNPARS FGPAIIIGKF TVHWVFWVGP LMGALLASLI YNFVLFPDTK 
TLAQRLAILT GTVEVGTGAG AGAEPLKKES QPGSGAVEME SV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.