drk | FBgn0004638 | NCBI 36497

Details for: drk

Gene ID: 36497

Symbol: drk

Ensembl ID: FBgn0004638

Description: downstream of receptor kinase

Associated with

Adaptive immune system
(R-DME-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-DME-983695)
Axon guidance
(R-DME-422475)
Cargo recognition for clathrin-mediated endocytosis
(R-DME-8856825)
Clathrin-mediated endocytosis
(R-DME-8856828)
Cytokine signaling in immune system
(R-DME-1280215)
Dap12 interactions
(R-DME-2172127)
Dap12 signaling
(R-DME-2424491)
Developmental biology
(R-DME-1266738)
Downstream signaling of activated fgfr1
(R-DME-5654687)
Downstream signaling of activated fgfr2
(R-DME-5654696)
Downstream signaling of activated fgfr3
(R-DME-5654708)
Downstream signaling of activated fgfr4
(R-DME-5654716)
Downstream signal transduction
(R-DME-186763)
Egfr downregulation
(R-DME-182971)
Egfr transactivation by gastrin
(R-DME-2179392)
Erythropoietin activates ras
(R-DME-9027284)
Fc epsilon receptor (fceri) signaling
(R-DME-2454202)
Fceri mediated ca+2 mobilization
(R-DME-2871809)
Fceri mediated mapk activation
(R-DME-2871796)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-DME-2029480)
Flt3 signaling
(R-DME-9607240)
Frs-mediated fgfr1 signaling
(R-DME-5654693)
Frs-mediated fgfr2 signaling
(R-DME-5654700)
Frs-mediated fgfr3 signaling
(R-DME-5654706)
Gab1 signalosome
(R-DME-180292)
G alpha (q) signalling events
(R-DME-416476)
Gastrin-creb signalling pathway via pkc and mapk
(R-DME-881907)
Generation of second messenger molecules
(R-DME-202433)
Gpcr downstream signalling
(R-DME-388396)
Grb2 events in egfr signaling
(R-DME-179812)
Grb2 events in erbb2 signaling
(R-DME-1963640)
Igf1r signaling cascade
(R-DME-2428924)
Immune system
(R-DME-168256)
Innate immune system
(R-DME-168249)
Insulin receptor signalling cascade
(R-DME-74751)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-DME-512988)
Intracellular signaling by second messengers
(R-DME-9006925)
Irs-mediated signalling
(R-DME-112399)
Irs-related events triggered by igf1r
(R-DME-2428928)
Mapk1/mapk3 signaling
(R-DME-5684996)
Mapk family signaling cascades
(R-DME-5683057)
Membrane trafficking
(R-DME-199991)
Ncam signaling for neurite out-growth
(R-DME-375165)
Negative regulation of fgfr1 signaling
(R-DME-5654726)
Negative regulation of fgfr2 signaling
(R-DME-5654727)
Negative regulation of fgfr3 signaling
(R-DME-5654732)
Negative regulation of fgfr4 signaling
(R-DME-5654733)
Negative regulation of the pi3k/akt network
(R-DME-199418)
Nervous system development
(R-DME-9675108)
Pi-3k cascade:fgfr1
(R-DME-5654689)
Pi-3k cascade:fgfr2
(R-DME-5654695)
Pi3k events in erbb2 signaling
(R-DME-1963642)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-DME-6811558)
Pip3 activates akt signaling
(R-DME-1257604)
Raf/map kinase cascade
(R-DME-5673001)
Regulation of actin dynamics for phagocytic cup formation
(R-DME-2029482)
Regulation of kit signaling
(R-DME-1433559)
Regulation of signaling by cbl
(R-DME-912631)
Ret signaling
(R-DME-8853659)
Rho gtpase cycle
(R-DME-9012999)
Rho gtpase effectors
(R-DME-195258)
Rho gtpases activate wasps and waves
(R-DME-5663213)
Rhou gtpase cycle
(R-DME-9013420)
Role of lat2/ntal/lab on calcium mobilization
(R-DME-2730905)
Shc-mediated cascade:fgfr1
(R-DME-5654688)
Shc-mediated cascade:fgfr2
(R-DME-5654699)
Shc-mediated cascade:fgfr3
(R-DME-5654704)
Shc-related events triggered by igf1r
(R-DME-2428933)
Shc1 events in egfr signaling
(R-DME-180336)
Shc1 events in erbb4 signaling
(R-DME-1250347)
Signal attenuation
(R-DME-74749)
Signaling by csf3 (g-csf)
(R-DME-9674555)
Signaling by egfr
(R-DME-177929)
Signaling by erbb2
(R-DME-1227986)
Signaling by erbb4
(R-DME-1236394)
Signaling by erythropoietin
(R-DME-9006335)
Signaling by fgfr
(R-DME-190236)
Signaling by fgfr1
(R-DME-5654736)
Signaling by fgfr2
(R-DME-5654738)
Signaling by fgfr3
(R-DME-5654741)
Signaling by fgfr4
(R-DME-5654743)
Signaling by gpcr
(R-DME-372790)
Signaling by insulin receptor
(R-DME-74752)
Signaling by interleukins
(R-DME-449147)
Signaling by ntrk1 (trka)
(R-DME-187037)
Signaling by ntrks
(R-DME-166520)
Signaling by pdgf
(R-DME-186797)
Signaling by receptor tyrosine kinases
(R-DME-9006934)
Signaling by rho gtpases
(R-DME-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-DME-9716542)
Signaling by scf-kit
(R-DME-1433557)
Signaling by the b cell receptor (bcr)
(R-DME-983705)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-DME-2404192)
Signalling to erks
(R-DME-187687)
Signalling to ras
(R-DME-167044)
Signal transduction
(R-DME-162582)
Spry regulation of fgf signaling
(R-DME-1295596)
Tcr signaling
(R-DME-202403)
Vesicle-mediated transport
(R-DME-5653656)

Other Information

Proteins

GRAP_DROME

Genular Protein ID: 3328995268

Symbol: GRAP_DROME

Name: N/A

UniProtKB Accession Codes:

Q08012 A4UZF9 Q0E989 Q9V6Q5

Database IDs:

Citations:

PubMed ID: 8462097

Title: An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro.

PubMed ID: 8462097

DOI: 10.1016/0092-8674(93)90169-q

PubMed ID: 8462098

Title: A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

PubMed ID: 8462098

DOI: 10.1016/0092-8674(93)90170-u

PubMed ID: 12694293

Title: Contrasting selection pressures on components of the Ras-mediated signal transduction pathway in Drosophila.

PubMed ID: 12694293

DOI: 10.1046/j.1365-294x.2003.01741.x

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 9671493

Title: Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase.

PubMed ID: 9671493

DOI: 10.1128/mcb.18.8.4844

PubMed ID: 12128212

Title: SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases.

PubMed ID: 12128212

DOI: 10.1016/s0925-4773(02)00147-8

PubMed ID: 22615583

Title: Drosophila activated Cdc42 kinase has an anti-apoptotic function.

PubMed ID: 22615583

DOI: 10.1371/journal.pgen.1002725

PubMed ID: 30610177

Title: Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss.

PubMed ID: 30610177

DOI: 10.1073/pnas.1810951116

PubMed ID: 16300404

Title: Structural comparison of the unstable drkN SH3 domain and a stable mutant.

PubMed ID: 16300404

DOI: 10.1021/bi0512795

Sequence Information:

Length: 211
Mass: 24435
Checksum: A1D0614AF358F3C0
Sequence:

MEAIAKHDFS ATADDELSFR KTQILKILNM EDDSNWYRAE LDGKEGLIPS NYIEMKNHDW 
YYGRITRADA EKLLSNKHEG AFLIRISESS PGDFSLSVKC PDGVQHFKVL RDAQSKFFLW 
VVKFNSLNEL VEYHRTASVS RSQDVKLRDM IPEEMLVQAL YDFVPQESGE LDFRRGDVIT 
VTDRSDENWW NGEIGNRKGI FPATYVTPYH S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: drk

Associated with

Other Information

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro. PubMed ID: 8462097

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. PubMed ID: 8462098

Contrasting selection pressures on components of the Ras-mediated signal transduction pathway in Drosophila. PubMed ID: 12694293

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase. PubMed ID: 9671493

SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases. PubMed ID: 12128212

Drosophila activated Cdc42 kinase has an anti-apoptotic function. PubMed ID: 22615583

Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss. PubMed ID: 30610177

Structural comparison of the unstable drkN SH3 domain and a stable mutant. PubMed ID: 16300404