Details for: AQP9

Gene ID: 366

Symbol: AQP9

Ensembl ID: ENSG00000103569

Description: aquaporin 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 32.3828
    Cell Significance Index: -13.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 4.7577
    Cell Significance Index: 69.0800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.8118
    Cell Significance Index: 64.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0786
    Cell Significance Index: 214.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.0621
    Cell Significance Index: 19.6300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3568
    Cell Significance Index: 5.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3006
    Cell Significance Index: 20.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2561
    Cell Significance Index: 3.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2415
    Cell Significance Index: 6.4600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.2353
    Cell Significance Index: 1.3600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0836
    Cell Significance Index: 0.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0521
    Cell Significance Index: 10.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0072
    Cell Significance Index: -13.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0087
    Cell Significance Index: -13.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0097
    Cell Significance Index: -6.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0103
    Cell Significance Index: -14.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0105
    Cell Significance Index: -7.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0159
    Cell Significance Index: -11.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0170
    Cell Significance Index: -10.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0230
    Cell Significance Index: -10.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0232
    Cell Significance Index: -8.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0241
    Cell Significance Index: -13.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0271
    Cell Significance Index: -7.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0272
    Cell Significance Index: -4.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0563
    Cell Significance Index: -11.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0603
    Cell Significance Index: -6.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0619
    Cell Significance Index: -3.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0627
    Cell Significance Index: -7.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0630
    Cell Significance Index: -8.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0644
    Cell Significance Index: -9.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0728
    Cell Significance Index: -12.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0810
    Cell Significance Index: -10.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0885
    Cell Significance Index: -10.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0901
    Cell Significance Index: -9.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0932
    Cell Significance Index: -12.8000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0938
    Cell Significance Index: -0.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0971
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1166
    Cell Significance Index: -13.3600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1171
    Cell Significance Index: -0.9600
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: -0.1195
    Cell Significance Index: -1.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1268
    Cell Significance Index: -9.7300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1355
    Cell Significance Index: -2.6500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1426
    Cell Significance Index: -6.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1429
    Cell Significance Index: -10.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1438
    Cell Significance Index: -4.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1454
    Cell Significance Index: -4.7600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1706
    Cell Significance Index: -2.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1717
    Cell Significance Index: -11.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1732
    Cell Significance Index: -7.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1744
    Cell Significance Index: -10.7200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1757
    Cell Significance Index: -2.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1781
    Cell Significance Index: -6.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1830
    Cell Significance Index: -10.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1958
    Cell Significance Index: -10.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1962
    Cell Significance Index: -9.2200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2078
    Cell Significance Index: -3.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2105
    Cell Significance Index: -5.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2106
    Cell Significance Index: -10.9400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2122
    Cell Significance Index: -2.8200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2159
    Cell Significance Index: -2.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2214
    Cell Significance Index: -3.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2310
    Cell Significance Index: -6.4600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2315
    Cell Significance Index: -2.0400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2344
    Cell Significance Index: -2.7700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2398
    Cell Significance Index: -3.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2451
    Cell Significance Index: -9.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2460
    Cell Significance Index: -6.3200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2575
    Cell Significance Index: -3.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2632
    Cell Significance Index: -4.5100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2654
    Cell Significance Index: -4.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2847
    Cell Significance Index: -10.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3088
    Cell Significance Index: -7.4800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3147
    Cell Significance Index: -7.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3157
    Cell Significance Index: -8.4300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3275
    Cell Significance Index: -4.5400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3340
    Cell Significance Index: -8.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3372
    Cell Significance Index: -7.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3458
    Cell Significance Index: -10.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3602
    Cell Significance Index: -10.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3611
    Cell Significance Index: -10.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3639
    Cell Significance Index: -9.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3676
    Cell Significance Index: -17.1400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.3680
    Cell Significance Index: -3.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3857
    Cell Significance Index: -8.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3868
    Cell Significance Index: -11.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3868
    Cell Significance Index: -8.2100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3992
    Cell Significance Index: -9.9700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4100
    Cell Significance Index: -10.4500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4111
    Cell Significance Index: -5.7700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4167
    Cell Significance Index: -8.2400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4207
    Cell Significance Index: -8.5600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4364
    Cell Significance Index: -7.3400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4385
    Cell Significance Index: -8.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4400
    Cell Significance Index: -9.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4403
    Cell Significance Index: -8.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4457
    Cell Significance Index: -10.6900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.4471
    Cell Significance Index: -5.2600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4476
    Cell Significance Index: -9.6700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4589
    Cell Significance Index: -5.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AQP9 is a transmembrane protein with 9 transmembrane alpha-helices, characterized by a unique N-terminal domain and a hydrophobic C-terminal domain. It is expressed in various tissues, including the liver, adipose tissue, and immune cells, such as macrophages and lymphocytes. AQP9 has a high degree of sequence homology with other aquaporins, but its distinct N-terminal domain confers unique properties, including increased water permeability and glycerol transport. **Pathways and Functions:** AQP9 plays a crucial role in several cellular pathways, including: 1. **Water and glycerol transport:** AQP9 facilitates the transport of water and glycerol across cell membranes, regulating cellular hydration and lipid metabolism. 2. **Immune responses:** AQP9 is expressed in immune cells, where it modulates the transport of glycerol and other small molecules, influencing immune cell function and cytokine production. 3. **Metabolic regulation:** AQP9 is involved in the regulation of lipid metabolism, glycerol metabolism, and glucose homeostasis, highlighting its role in energy balance and metabolic health. 4. **Cellular response to camp:** AQP9 responds to cyclic adenosine monophosphate (cAMP) signaling, a key regulator of cellular metabolism and immune responses. **Clinical Significance:** AQP9's expression in various tissues and its involvement in multiple cellular pathways make it a valuable target for therapeutic interventions in diseases associated with metabolic dysregulation, immune dysfunction, and cellular dehydration. Some potential clinical applications of AQP9 include: 1. **Diabetes management:** AQP9's role in glycerol metabolism and glucose homeostasis suggests its potential as a therapeutic target for managing diabetes. 2. **Immune disorders:** AQP9's expression in immune cells and its involvement in immune responses make it a promising target for the treatment of autoimmune diseases. 3. **Liver disease:** AQP9's expression in hepatocytes and its role in glycerol metabolism and bile acid transport suggest its potential as a therapeutic target for liver diseases. In conclusion, AQP9 is a multifaceted water channel with significant implications for our understanding of immune and metabolic processes. Further research on AQP9's role in various cellular pathways and its potential clinical applications will provide valuable insights into the development of novel therapeutic strategies for diseases associated with metabolic dysregulation and immune dysfunction.

Genular Protein ID: 3171020758

Symbol: AQP9_HUMAN

Name: Aquaporin-9

UniProtKB Accession Codes:

O43315 Q9NP32

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9514918

Title: Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol.

PubMed ID: 9514918

DOI: 10.1006/bbrc.1998.8252

PubMed ID: 10564231

Title: Functional and molecular characterization of the human neutral solute channel aquaporin-9.

PubMed ID: 10564231

DOI: 10.1152/ajprenal.1999.277.5.f685

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 30420639

Title: Human adipose glycerol flux is regulated by a pH gate in AQP10.

PubMed ID: 30420639

DOI: 10.1038/s41467-018-07176-z

Sequence Information:

  • Length: 295
  • Mass: 31431
  • Checksum: B3B416CD9F1F9CAF
  • Sequence:
    • MQPEGAEKGK SFKQRLVLKS SLAKETLSEF LGTFILIVLG CGCVAQAILS RGRFGGVITI 
NVGFSMAVAM AIYVAGGVSG GHINPAVSLA MCLFGRMKWF KLPFYVGAQF LGAFVGAATV 
FGIYYDGLMS FAGGKLLIVG ENATAHIFAT YPAPYLSLAN AFADQVVATM ILLIIVFAIF 
DSRNLGAPRG LEPIAIGLLI IVIASSLGLN SGCAMNPARD LSPRLFTALA GWGFEVFRAG 
NNFWWIPVVG PLVGAVIGGL IYVLVIEIHH PEPDSVFKTE QSEDKPEKYE LSVIM

Genular Protein ID: 3434742404

Symbol: H0YK62_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YK62

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 230
  • Mass: 24546
  • Checksum: 8CAD0CA08EC56EFC
  • Sequence:
    • MAVAMAIYVA GGVSGGHINP AVSLAMCLFG RMKWFKLPFY VGAQFLGAFV GAATVFGIYY 
DGLMSFAGGK LLIVGENATA HIFATYPAPY LSLANAFADQ VVATMILLII VFAIFDSRNL 
GAPRGLEPIA IGLLIIVIAS SLGLNSGCAM NPARDLSPRL FTALAGWGFE VFRAGNNFWW 
IPVVGPLVGA VIGGLIYVLV IEIHHPEPDS VFKTEQSEDK PEKYELSVIM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.