tra2 | FBgn0003742 | NCBI 36619

Details for: tra2

Gene ID: 36619

Symbol: tra2

Ensembl ID: FBgn0003742

Description: transformer 2

Associated with

Metabolism of rna
(R-DME-8953854)
Mrna splicing
(R-DME-72172)
Mrna splicing - major pathway
(R-DME-72163)
Processing of capped intron-containing pre-mrna
(R-DME-72203)
Rhobtb1 gtpase cycle
(R-DME-9013422)
Rhobtb2 gtpase cycle
(R-DME-9013418)
Rhobtb gtpase cycle
(R-DME-9706574)
Rho gtpase cycle
(R-DME-9012999)
Signaling by rho gtpases
(R-DME-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-DME-9716542)
Signal transduction
(R-DME-162582)
Female sex determination
(GO:0030237)
Female somatic sex determination
(GO:0019101)
Identical protein binding
(GO:0042802)
Male somatic sex determination
(GO:0019102)
Mrna binding
(GO:0003729)
Mrna processing
(GO:0006397)
Mrna splicing, via spliceosome
(GO:0000398)
Positive regulation of mrna splicing, via spliceosome
(GO:0048026)
Pre-mrna binding
(GO:0036002)
Precatalytic spliceosome
(GO:0071011)
Protein binding
(GO:0005515)
Regulation of alternative mrna splicing, via spliceosome
(GO:0000381)
Reproductive process
(GO:0022414)
Rna binding
(GO:0003723)
Sex determination
(GO:0007530)
Spermatogenesis
(GO:0007283)
Spliceosomal complex
(GO:0005681)
Spliceosomal complex assembly
(GO:0000245)

Other Information

Proteins

Transformer-2 sex-determining protein

Genular Protein ID: 3554667038

Symbol: TRA2_DROME

Name: Transformer-2 sex-determining protein

UniProtKB Accession Codes:

P19018 A4UZH1 Q0E977 Q9V734

Database IDs:

Citations:

PubMed ID: 3144434

Title: The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein.

PubMed ID: 3144434

DOI: 10.1016/0092-8674(88)90247-4

PubMed ID: 2120049

Title: Alternatively spliced transcripts of the sex-determining gene tra-2 of Drosophila encode functional proteins of different size.

PubMed ID: 2120049

DOI: 10.1002/j.1460-2075.1990.tb07573.x

PubMed ID: 2116360

Title: Alternative splicing of the sex determination gene transformer-2 is sex-specific in the germ line but not in the soma.

PubMed ID: 2116360

DOI: 10.1101/gad.4.5.789

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 2493992

Title: The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins.

PubMed ID: 2493992

DOI: 10.1016/0092-8674(89)90634-x

PubMed ID: 1674449

Title: Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro.

PubMed ID: 1674449

DOI: 10.1016/0092-8674(91)90090-l

PubMed ID: 8334698

Title: A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA.

PubMed ID: 8334698

DOI: 10.1016/0092-8674(93)90298-5

PubMed ID: 8124712

Title: The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2.

PubMed ID: 8124712

DOI: 10.1016/0092-8674(94)90512-6

PubMed ID: 7867927

Title: Synergistic interactions between two distinct elements of a regulated splicing enhancer.

PubMed ID: 7867927

DOI: 10.1101/gad.9.3.284

PubMed ID: 9418892

Title: Regulation of sex-specific selection of fruitless 5' splice sites by transformer and transformer-2.

PubMed ID: 9418892

DOI: 10.1128/mcb.18.1.450

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

Sequence Information:

Length: 264
Mass: 31031
Checksum: 3BECBD694B0817B3
Sequence:

MDREPLSSGR LHCSARYKHK RSASSSSAGT TSSGHKDRRS DYDYCGSRRH QRSSSRRRSR 
SRSSSESPPP EPRHRSGRSS RDRERMHKSR EHPQASRCIG VFGLNTNTSQ HKVRELFNKY 
GPIERIQMVI DAQTQRSRGF CFIYFEKLSD ARAAKDSCSG IEVDGRRIRV DFSITQRAHT 
PTPGVYLGRQ PRGKAPRSFS PRRGRRVYHD RSASPYDNYR DRYDYRNDRY DRNLRRSPSR 
NRYTRNRSYS RSRSPQLRRT SSRY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: tra2

Associated with

Other Information

The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein. PubMed ID: 3144434

Alternatively spliced transcripts of the sex-determining gene tra-2 of Drosophila encode functional proteins of different size. PubMed ID: 2120049

Alternative splicing of the sex determination gene transformer-2 is sex-specific in the germ line but not in the soma. PubMed ID: 2116360

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins. PubMed ID: 2493992

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. PubMed ID: 1674449

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. PubMed ID: 8334698

The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2. PubMed ID: 8124712

Synergistic interactions between two distinct elements of a regulated splicing enhancer. PubMed ID: 7867927

Regulation of sex-specific selection of fruitless 5' splice sites by transformer and transformer-2. PubMed ID: 9418892

Phosphoproteome analysis of Drosophila melanogaster embryos. PubMed ID: 18327897