Details for: AR
Gene ID: 367
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: AR
Ensembl ID: ENSG00000169083
Description: androgen receptor
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 8.51rCSI 19.98%PRS 81.87
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CSI 6.64rCSI 12.07%PRS 90.93
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CSI 5.42rCSI 17.63%PRS 79.95
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CSI 5rCSI 4.81%PRS 81.57
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CSI 4.18rCSI 7.48%PRS 81.45
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CSI 3.83rCSI 4.67%PRS 88
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CSI 3.71rCSI 3.87%PRS 81.46
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CSI 3.59rCSI 3.16%PRS 71.74
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CSI 3.15rCSI 4.05%PRS 72.51
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CSI 3.11rCSI 3.33%PRS 83.58
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CSI 3.1rCSI 2.52%PRS 81.62
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CSI 3.04rCSI 11.81%PRS 81.27
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CSI 2.99rCSI 7.14%PRS 85.75
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CSI 2.98rCSI 2.57%PRS 82.76
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CSI 2.93rCSI 2.32%PRS 71.69
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CSI 2.92rCSI 3.2%PRS 84.01
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CSI 2.86rCSI 3.97%PRS 79.15
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CSI 2.59rCSI 9.71%PRS 74.99
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CSI 2.52rCSI 1.95%PRS 85.73
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CSI 2.36rCSI 5.66%PRS 85.31
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CSI 2.28rCSI 2.84%PRS 62.66
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CSI 2.11rCSI 5.5%PRS 80.42
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CSI 2.03rCSI 5.03%PRS 82.2
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CSI 1.94rCSI 3.09%PRS 75.53
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CSI 1.91rCSI 9.15%PRS 78.56
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CSI 1.89rCSI 3.84%PRS 61.19
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CSI 1.86rCSI 4.54%PRS 74.64
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CSI 1.78rCSI 3.46%PRS 85.04
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CSI 1.72rCSI 5.58%PRS 80.2
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CSI 1.7rCSI 1.76%PRS 85.67
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CSI 1.61rCSI 2.54%PRS 83.59
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CSI 1.6rCSI 4.51%PRS 77.32
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CSI 1.59rCSI 4.37%PRS 77.57
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CSI 1.54rCSI 2.19%PRS 79.02
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CSI 1.53rCSI 8.55%PRS 84.85
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CSI 1.51rCSI 2.17%PRS 72.27
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CSI 1.37rCSI 3.07%PRS 65.64
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CSI 1.33rCSI 4.27%PRS 78.96
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CSI 1.31rCSI 3.6%PRS 88.21
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CSI 1.2rCSI 3.21%PRS 74.36
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CSI 1.15rCSI 6.75%PRS 65.35
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CSI 1.1rCSI 2.64%PRS 84.84
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CSI 0.92rCSI 7.51%PRS 76.85
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CSI 0.91rCSI 3.84%PRS 86.59
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CSI 0.88rCSI 2.54%PRS 81.6
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CSI 0.79rCSI 4.94%PRS 74.1
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CSI 0.72rCSI 3.88%PRS 88.92
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CSI 0.64rCSI 1.99%PRS 66.48
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CSI 0.28rCSI 6.61%PRS 62.77
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CSI 0.19rCSI 2.05%PRS 86.94
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3111552214
Symbol: ANDR_HUMAN
Name: Androgen receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3216866
Title: The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate.
PubMed ID: 3216866
PubMed ID: 3174628
Title: Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.
PubMed ID: 3174628
PubMed ID: 2911578
Title: Characterization and expression of a cDNA encoding the human androgen receptor.
PubMed ID: 2911578
PubMed ID: 2594783
Title: Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity.
PubMed ID: 2594783
PubMed ID: 2342476
Title: Specific region in hormone binding domain is essential for hormone binding and trans-activation by human androgen receptor.
PubMed ID: 2342476
DOI: 10.1210/mend-4-3-417
PubMed ID: 2293020
Title: Definition of the human androgen receptor gene structure permits the identification of mutations that cause androgen resistance: premature termination of the receptor protein at amino acid residue 588 causes complete androgen resistance.
PubMed ID: 2293020
PubMed ID: 15634333
Title: Androgen receptor function is modulated by the tissue-specific AR45 variant.
PubMed ID: 15634333
PubMed ID: 19244107
Title: A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.
PubMed ID: 19244107
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2917688
Title: The N-terminal domain of the human androgen receptor is encoded by one, large exon.
PubMed ID: 2917688
PubMed ID: 3353726
Title: Molecular cloning of human and rat complementary DNA encoding androgen receptors.
PubMed ID: 3353726
PubMed ID: 3377788
Title: Cloning, structure and expression of a cDNA encoding the human androgen receptor.
PubMed ID: 3377788
PubMed ID: 2546571
Title: Structural organization of the human androgen receptor gene.
PubMed ID: 2546571
PubMed ID: 8413310
Title: A point mutation in the second zinc finger of the DNA-binding domain of the androgen receptor gene causes complete androgen insensitivity in two siblings with receptor-positive androgen resistance.
PubMed ID: 8413310
PubMed ID: 3353727
Title: Cloning of human androgen receptor complementary DNA and localization to the X chromosome.
PubMed ID: 3353727
PubMed ID: 1775137
Title: Substitution of aspartic acid-686 by histidine or asparagine in the human androgen receptor leads to a functionally inactive protein with altered hormone-binding characteristics.
PubMed ID: 1775137
PubMed ID: 1561105
Title: Trinucleotide repeat polymorphism in the androgen receptor gene (AR).
PubMed ID: 1561105
PubMed ID: 8643607
Title: Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.
PubMed ID: 8643607
PubMed ID: 9096391
Title: The CAG repeat within the androgen receptor gene and its relationship to prostate cancer.
PubMed ID: 9096391
PubMed ID: 10332029
Title: PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival.
PubMed ID: 10332029
DOI: 10.1093/hmg/8.6.977
PubMed ID: 10075738
Title: Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate.
PubMed ID: 10075738
PubMed ID: 10383460
Title: Ubc9 interacts with the androgen receptor and activates receptor-dependent transcription.
PubMed ID: 10383460
PubMed ID: 10400640
Title: The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator.
PubMed ID: 10400640
PubMed ID: 10625666
Title: PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression.
PubMed ID: 10625666
PubMed ID: 10930412
Title: Androgen receptor interacts with a novel MYST protein, HBO1.
PubMed ID: 10930412
PubMed ID: 11121022
Title: Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1).
PubMed ID: 11121022
PubMed ID: 12361945
Title: RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor.
PubMed ID: 12361945
PubMed ID: 12039962
Title: Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor.
PubMed ID: 12039962
PubMed ID: 12415108
Title: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.
PubMed ID: 12415108
PubMed ID: 19666546
PubMed ID: 14609956
Title: hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci.
PubMed ID: 14609956
DOI: 10.1093/emboj/cdg585
PubMed ID: 12958311
Title: The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway.
PubMed ID: 12958311
PubMed ID: 14664718
Title: The retinoblastoma protein-associated transcription repressor RBaK interacts with the androgen receptor and enhances its transcriptional activity.
PubMed ID: 14664718
PubMed ID: 12612053
Title: DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.
PubMed ID: 12612053
PubMed ID: 14573606
Title: Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.
PubMed ID: 14573606
PubMed ID: 16027218
Title: Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.
PubMed ID: 16027218
PubMed ID: 16051670
Title: hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes.
PubMed ID: 16051670
DOI: 10.1210/me.2005-0097
PubMed ID: 17045208
Title: Regulation of androgen receptor activity by tyrosine phosphorylation.
PubMed ID: 17045208
PubMed ID: 16951154
Title: Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.
PubMed ID: 16951154
PubMed ID: 17587566
Title: PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.
PubMed ID: 17587566
PubMed ID: 17550981
Title: The zinc finger protein Ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer.
PubMed ID: 17550981
DOI: 10.1210/me.2006-0503
PubMed ID: 18222118
Title: RanBP10 acts as a novel coactivator for the androgen receptor.
PubMed ID: 18222118
PubMed ID: 17494760
Title: Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.
PubMed ID: 17494760
PubMed ID: 18451177
Title: TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.
PubMed ID: 18451177
PubMed ID: 18451096
Title: Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells.
PubMed ID: 18451096
DOI: 10.1210/me.2006-0546
PubMed ID: 18084323
Title: ZIP kinase plays a crucial role in androgen receptor-mediated transcription.
PubMed ID: 18084323
PubMed ID: 19909775
Title: TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells.
PubMed ID: 19909775
PubMed ID: 19345326
Title: Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination.
PubMed ID: 19345326
PubMed ID: 19022849
Title: The single-macro domain protein LRP16 is an essential cofactor of androgen receptor.
PubMed ID: 19022849
DOI: 10.1677/erc-08-0150
PubMed ID: 20980437
Title: CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation.
PubMed ID: 20980437
DOI: 10.1210/me.2010-0238
PubMed ID: 20501646
Title: The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling.
PubMed ID: 20501646
PubMed ID: 20623637
Title: Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity.
PubMed ID: 20623637
DOI: 10.1002/pros.21163
PubMed ID: 21512132
Title: MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling.
PubMed ID: 21512132
PubMed ID: 20812024
Title: FBI-1 functions as a novel AR co-repressor in prostate cancer cells.
PubMed ID: 20812024
PubMed ID: 22170608
Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.
PubMed ID: 22170608
DOI: 10.1038/nature10700
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22031296
Title: DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.
PubMed ID: 22031296
PubMed ID: 23887938
Title: CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2.
PubMed ID: 23887938
DOI: 10.1093/nar/gkt644
PubMed ID: 23487765
Title: ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways.
PubMed ID: 23487765
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 10840043
Title: Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations.
PubMed ID: 10840043
PubMed ID: 11906285
Title: Structural basis for the glucocorticoid response in a mutant human androgen receptor (AR(ccr)) derived from an androgen-independent prostate cancer.
PubMed ID: 11906285
DOI: 10.1021/jm011072j
PubMed ID: 15525515
Title: Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance.
PubMed ID: 15525515
PubMed ID: 15563469
Title: The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor.
PubMed ID: 15563469
PubMed ID: 16129672
Title: Structural basis for accommodation of nonsteroidal ligands in the androgen receptor.
PubMed ID: 16129672
PubMed ID: 16641486
Title: Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
PubMed ID: 16641486
DOI: 10.1110/ps.051905906
PubMed ID: 18007036
Title: Interaction between the androgen receptor and a segment of its corepressor SHP.
PubMed ID: 18007036
PubMed ID: 17311914
Title: Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design.
PubMed ID: 17311914
PubMed ID: 17591767
Title: Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone.
PubMed ID: 17591767
PubMed ID: 17711855
Title: Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12.
PubMed ID: 17711855
PubMed ID: 17911242
Title: A surface on the androgen receptor that allosterically regulates coactivator binding.
PubMed ID: 17911242
PubMed ID: 25091737
Title: Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis.
PubMed ID: 25091737
PubMed ID: 1458719
Title: Androgen resistance due to mutation of the androgen receptor.
PubMed ID: 1458719
PubMed ID: 8339746
Title: Molecular genetics of human androgen insensitivity.
PubMed ID: 8339746
DOI: 10.1007/bf02125442
PubMed ID: 8240973
Title: Mutations of androgen receptor gene in androgen insensitivity syndromes.
PubMed ID: 8240973
PubMed ID: 7937057
Title: The androgen receptor gene mutations database.
PubMed ID: 7937057
PubMed ID: 7626493
PubMed ID: 9016528
PubMed ID: 22334387
Title: The androgen receptor gene mutations database: 2012 update.
PubMed ID: 22334387
DOI: 10.1002/humu.22046
PubMed ID: 2260966
Title: A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens.
PubMed ID: 2260966
PubMed ID: 2082179
Title: Functional characterization of naturally occurring mutant androgen receptors from subjects with complete androgen insensitivity.
PubMed ID: 2082179
PubMed ID: 1856263
Title: Androgen resistance associated with a mutation of the androgen receptor at amino acid 772 (Arg-->Cys) results from a combination of decreased messenger ribonucleic acid levels and impairment of receptor function.
PubMed ID: 1856263
PubMed ID: 1999491
Title: A mutation in the DNA-binding domain of the androgen receptor gene causes complete testicular feminization in a patient with receptor-positive androgen resistance.
PubMed ID: 1999491
DOI: 10.1172/jci115076
PubMed ID: 2010552
Title: Molecular basis of androgen resistance in a family with a qualitative abnormality of the androgen receptor and responsive to high-dose androgen therapy.
PubMed ID: 2010552
DOI: 10.1172/jci115147
PubMed ID: 2062380
Title: Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy.
PubMed ID: 2062380
DOI: 10.1038/352077a0
PubMed ID: 1609793
Title: Replacement of arginine 773 by cysteine or histidine in the human androgen receptor causes complete androgen insensitivity with different receptor phenotypes.
PubMed ID: 1609793
PubMed ID: 1424203
Title: Point mutations detected in the androgen receptor gene of three men with partial androgen insensitivity syndrome.
PubMed ID: 1424203
PubMed ID: 1426313
Title: A unique point mutation in the androgen receptor gene in a family with complete androgen insensitivity syndrome.
PubMed ID: 1426313
PubMed ID: 1487249
Title: Point mutation in the steroid-binding domain of the androgen receptor gene in a family with complete androgen insensitivity syndrome (CAIS).
PubMed ID: 1487249
DOI: 10.1007/bf00220088
PubMed ID: 1307250
Title: Androgen receptor gene mutations identified by SSCP in fourteen subjects with androgen insensitivity syndrome.
PubMed ID: 1307250
DOI: 10.1093/hmg/1.7.497
PubMed ID: 1569163
Title: A single amino acid substitution (Met-786-->Val) in the steroid-binding domain of human androgen receptor leads to complete androgen insensitivity syndrome.
PubMed ID: 1569163
PubMed ID: 1464650
Title: Immunoreactive androgen receptor expression in subjects with androgen resistance.
PubMed ID: 1464650
PubMed ID: 1430233
Title: Mutations in the ligand-binding domain of the androgen receptor gene cluster in two regions of the gene.
PubMed ID: 1430233
DOI: 10.1172/jci116093
PubMed ID: 1562539
Title: The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens.
PubMed ID: 1562539
PubMed ID: 1316540
Title: Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance.
PubMed ID: 1316540
PubMed ID: 1480178
Title: Single base mutations in the human androgen receptor gene causing complete androgen insensitivity: rapid detection by a modified denaturing gradient gel electrophoresis technique.
PubMed ID: 1480178
PubMed ID: 1303262
Title: A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome.
PubMed ID: 1303262
DOI: 10.1038/ng1092-132
PubMed ID: 1631125
Title: Androgen receptor gene mutations in human prostate cancer.
PubMed ID: 1631125
PubMed ID: 8213813
Title: Sequence variation in the androgen receptor gene is not a common determinant of male sexual orientation.
PubMed ID: 8213813
PubMed ID: 8224266
Title: A new mutation within the deoxyribonucleic acid-binding domain of the androgen receptor gene in a family with complete androgen insensitivity syndrome.
PubMed ID: 8224266
PubMed ID: 8103398
Title: An exonic point mutation creates a MaeIII site in the androgen receptor gene of a family with complete androgen insensitivity syndrome.
PubMed ID: 8103398
DOI: 10.1093/hmg/2.7.1041
PubMed ID: 8281139
Title: Androgen receptor gene mutation in male breast cancer.
PubMed ID: 8281139
PubMed ID: 8281140
Title: A single-base substitution in exon 6 of the androgen receptor gene causing complete androgen insensitivity: the mutated receptor fails to transactivate but binds to DNA in vitro.
PubMed ID: 8281140
PubMed ID: 8325932
Title: A single amino acid substitution (Gly743 --> Val) in the steroid-binding domain of the human androgen receptor leads to Reifenstein syndrome.
PubMed ID: 8325932
PubMed ID: 8325950
Title: Single strand conformation polymorphism analysis of androgen receptor gene mutations in patients with androgen insensitivity syndromes: application for diagnosis, genetic counseling, and therapy.
PubMed ID: 8325950
PubMed ID: 8097257
Title: Mutations of the androgen receptor gene identified in perineal hypospadias.
PubMed ID: 8097257
DOI: 10.1136/jmg.30.3.198
PubMed ID: 8096390
Title: Complete androgen insensitivity syndrome associated with a de novo mutation of the androgen receptor gene detected by single strand conformation polymorphism.
PubMed ID: 8096390
PubMed ID: 8274409
Title: Androgen receptor gene mutations in human prostate cancer.
PubMed ID: 8274409
PubMed ID: 8446106
Title: Substitution of valine-865 by methionine or leucine in the human androgen receptor causes complete or partial androgen insensitivity, respectively with distinct androgen receptor phenotypes.
PubMed ID: 8446106
PubMed ID: 8145761
Title: Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.
PubMed ID: 8145761
PubMed ID: 7511268
Title: Androgen receptor gene mutations and p53 gene analysis in advanced prostate cancer.
PubMed ID: 7511268
PubMed ID: 8292051
Title: Microsatellite mutation (CAG24-->18) in the androgen receptor gene in human prostate cancer.
PubMed ID: 8292051
PubMed ID: 8187068
Title: Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers.
PubMed ID: 8187068
PubMed ID: 7910529
Title: Molecular prenatal diagnosis of partial androgen insensitivity syndrome based on the Hind III polymorphism of the androgen receptor gene.
PubMed ID: 7910529
PubMed ID: 7909256
Title: Molecular prenatal exclusion of familial partial androgen insensitivity (Reifenstein syndrome).
PubMed ID: 7909256
PubMed ID: 8205256
Title: Single amino acid substitution (840Arg-->His) in the hormone-binding domain of the androgen receptor leads to incomplete androgen insensitivity syndrome associated with a thermolabile androgen receptor.
PubMed ID: 8205256
PubMed ID: 8033918
Title: Molecular characterization of the androgen receptor gene in boys with hypospadias.
PubMed ID: 8033918
DOI: 10.1007/bf01956409
PubMed ID: 8162033
Title: Complete androgen insensitivity due to mutations in the probable alpha-helical segments of the DNA-binding domain in the human androgen receptor.
PubMed ID: 8162033
DOI: 10.1093/hmg/3.1.21
PubMed ID: 7981687
Title: Detection of point mutations in the androgen receptor gene using non-isotopic single strand conformation polymorphism analysis.
PubMed ID: 7981687
DOI: 10.1093/hmg/3.7.1163
PubMed ID: 7981689
Title: Two mutations causing complete androgen insensitivity: a frame-shift in the steroid binding domain and a Cys-->Phe substitution in the second zinc finger of the androgen receptor.
PubMed ID: 7981689
DOI: 10.1093/hmg/3.7.1169
PubMed ID: 8126121
Title: Characterization of mutant androgen receptors causing partial androgen insensitivity syndrome.
PubMed ID: 8126121
PubMed ID: 7962294
Title: An androgen receptor mutation causing androgen resistance in undervirilized male syndrome.
PubMed ID: 7962294
PubMed ID: 8040309
Title: Substitution of arginine-839 by cysteine or histidine in the androgen receptor causes different receptor phenotypes in cultured cells and coordinate degrees of clinical androgen resistance.
PubMed ID: 8040309
DOI: 10.1172/jci117368
PubMed ID: 7929841
Title: Amino acid substitutions in the hormone-binding domain of the human androgen receptor alter the stability of the hormone receptor complex.
PubMed ID: 7929841
DOI: 10.1172/jci117507
PubMed ID: 7993455
Title: Pregnancy after hormonal correction of severe spermatogenic defect due to mutation in androgen receptor gene.
PubMed ID: 7993455
PubMed ID: 7970939
Title: A practical approach to the detection of androgen receptor gene mutations and pedigree analysis in families with X-linked androgen insensitivity.
PubMed ID: 7970939
PubMed ID: 8830623
Title: A frame-shift mutation of the androgen receptor gene in a patient with receptor-negative complete testicular feminization: comparison with a single base substitution in a receptor-reduced incomplete form.
PubMed ID: 8830623
PubMed ID: 7712463
Title: Prevalence of androgen receptor gene mutations in latent prostatic carcinomas from Japanese men.
PubMed ID: 7712463
PubMed ID: 7641413
Title: Genetic counselling in complete androgen insensitivity syndrome: trinucleotide repeat polymorphisms, single-strand conformation polymorphism and direct detection of two novel mutations in the androgen receptor gene.
PubMed ID: 7641413
PubMed ID: 7671849
Title: Androgen receptor defects: historical, clinical, and molecular perspectives.
PubMed ID: 7671849
PubMed ID: 7633398
Title: Characterization of alternative amino acid substitutions at arginine 830 of the androgen receptor that cause complete androgen insensitivity in three families.
PubMed ID: 7633398
DOI: 10.1093/hmg/4.4.515
PubMed ID: 7537149
Title: Leu-676-Pro mutation of the androgen receptor causes complete androgen insensitivity syndrome in a large Hutterite kindred.
PubMed ID: 7537149
PubMed ID: 7581399
Title: Human androgen insensitivity due to point mutations encoding amino acid substitutions in the androgen receptor steroid-binding domain.
PubMed ID: 7581399
PubMed ID: 7591265
Title: Mutant androgen receptors in prostatic tumors distinguish between amino-acid-sequence requirements for transactivation and ligand binding.
PubMed ID: 7591265
PubMed ID: 7673412
Title: Mutations of the androgen receptor coding sequence are infrequent in patients with isolated hypospadias.
PubMed ID: 7673412
PubMed ID: 8530589
Title: Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol.
PubMed ID: 8530589
PubMed ID: 7649358
Title: A single amino acid exchange abolishes dimerization of the androgen receptor and causes Reifenstein syndrome.
PubMed ID: 7649358
PubMed ID: 7723794
Title: Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer.
PubMed ID: 7723794
PubMed ID: 8723113
Title: The clinical and molecular spectrum of androgen insensitivity syndromes.
PubMed ID: 8723113
DOI: 10.1002/(sici)1096-8628(19960503)63:1<218::aid-ajmg38>3.0.co;2-p
PubMed ID: 9816170
Title: Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.
PubMed ID: 9816170
PubMed ID: 9039340
Title: Clinical and biochemical investigations and molecular analysis of subjects with mutations in the androgen receptor gene.
PubMed ID: 9039340
PubMed ID: 9001799
Title: Rapid detection of a mutation hot-spot in the human androgen receptor.
PubMed ID: 9001799
PubMed ID: 8824883
Title: Functional analysis of six androgen receptor mutations identified in patients with partial androgen insensitivity syndrome.
PubMed ID: 8824883
DOI: 10.1093/hmg/5.2.265
PubMed ID: 8550758
Title: Partial androgen insensitivity caused by an androgen receptor mutation at amino acid 907 (Gly-->Arg) that results in decreased ligand binding affinity and reduced androgen receptor messenger ribonucleic acid levels.
PubMed ID: 8550758
PubMed ID: 8626869
Title: A novel substitution (Leu707Arg) in exon 4 of the androgen receptor gene causes complete androgen resistance.
PubMed ID: 8626869
PubMed ID: 8768864
Title: Different phenotypes in a family with androgen insensitivity caused by the same M780I point mutation in the androgen receptor gene.
PubMed ID: 8768864
PubMed ID: 8823308
Title: A novel missense mutation in the amino-terminal domain of the human androgen receptor gene in a family with partial androgen insensitivity syndrome causes reduced efficiency of protein translation.
PubMed ID: 8823308
DOI: 10.1172/jci118930
PubMed ID: 8918984
Title: Molecular basis of androgen insensitivity.
PubMed ID: 8918984
PubMed ID: 8683794
Title: Androgen receptor gene mutations are rarely associated with isolated penile hypospadias.
PubMed ID: 8683794
PubMed ID: 8647313
Title: Molecular modeling and in vitro investigations of the human androgen receptor DNA-binding domain: application for the study of two mutations.
PubMed ID: 8647313
PubMed ID: 8809734
Title: Androgen insensitivity syndrome due to new mutations in the DNA-binding domain of the androgen receptor.
PubMed ID: 8809734
PubMed ID: 8628719
Title: Low incidence of androgen receptor gene mutations in human prostatic tumors using single strand conformation polymorphism analysis.
PubMed ID: 8628719
DOI: 10.1002/(sici)1097-0045(199603)28:3<162::aid-pros3>3.0.co;2-h
PubMed ID: 8827083
Title: Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome.
PubMed ID: 8827083
DOI: 10.1002/1097-0045(199609)29:3<153::aid-pros2990290303>3.0.co;2-5
PubMed ID: 9106550
Title: Germ-line and somatic mosaicism in the androgen insensitivity syndrome: implications for genetic counseling.
PubMed ID: 9106550
PubMed ID: 9000575
Title: Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer.
PubMed ID: 9000575
PubMed ID: 9196614
Title: Correlation of clinical, endocrine and molecular abnormalities with in vivo responses to high-dose testosterone in patients with partial androgen insensitivity syndrome.
PubMed ID: 9196614
PubMed ID: 9160185
Title: Molecular analysis of androgen resistance syndromes in Egyptian patients.
PubMed ID: 9160185
PubMed ID: 9007482
Title: Functional assessment and clinical classification of androgen sensitivity in patients with mutations of the androgen receptor gene.
PubMed ID: 9007482
PubMed ID: 8990010
Title: Mutations of the androgen receptor gene in patients with complete androgen insensitivity.
PubMed ID: 8990010
DOI: 10.1002/(sici)1098-1004(1997)9:1<57::aid-humu10>3.0.co;2-o
PubMed ID: 9438000
Title: Genetic alterations of androgen receptor gene in Japanese human prostate cancer.
PubMed ID: 9438000
PubMed ID: 9184448
Title: Androgen receptor gene mutations in prostate cancer.
PubMed ID: 9184448
PubMed ID: 9255042
Title: DNA analysis of the androgen receptor gene in two cases with complete androgen insensitivity syndrome.
PubMed ID: 9255042
PubMed ID: 9329414
Title: Etiologic classification of severe hypospadias: implications for prognosis and management.
PubMed ID: 9329414
PubMed ID: 9252933
Title: Complete androgen insensitivity syndrome. Molecular characterization in two Chinese women.
PubMed ID: 9252933
PubMed ID: 9328206
Title: Wide variation in androgen receptor dysfunction in complete androgen insensitivity syndrome.
PubMed ID: 9328206
PubMed ID: 9302173
Title: Androgen receptor point mutations as the underlying molecular defect in 2 patients with androgen insensitivity syndrome.
PubMed ID: 9302173
PubMed ID: 9544375
Title: Molecular analysis of the androgen receptor gene in 4 patients with complete androgen insensitivity.
PubMed ID: 9544375
PubMed ID: 9698822
Title: Mutations of androgen receptor gene in Brazilian patients with male pseudohermaphroditism.
PubMed ID: 9698822
PubMed ID: 9788719
Title: Analysis of the transactivation domain of the androgen receptor in patients with male infertility.
PubMed ID: 9788719
PubMed ID: 9610419
Title: One additional mutation at exon A amplifies thermolability of androgen receptor in a case with complete androgen insensitivity syndrome.
PubMed ID: 9610419
PubMed ID: 9856504
Title: Functional characterisation of mutations in the ligand-binding domain of the androgen receptor gene in patients with androgen insensitivity syndrome.
PubMed ID: 9856504
PubMed ID: 9554754
Title: A new missense substitution at a mutational hot spot of the androgen receptor in siblings with complete androgen insensitivity syndrome.
PubMed ID: 9554754
PubMed ID: 9554755
Title: An androgen receptor gene mutation (A645D) in a boy with a normal phenotype.
PubMed ID: 9554755
PubMed ID: 9543136
Title: Response to androgen treatment in a patient with partial androgen insensitivity and a mutation in the deoxyribonucleic acid-binding domain of the androgen receptor.
PubMed ID: 9543136
PubMed ID: 9768671
Title: Trafficking of androgen receptor mutants fused to green fluorescent protein: a new investigation of partial androgen insensitivity syndrome.
PubMed ID: 9768671
PubMed ID: 9851768
Title: Azoospermia associated with a mutation in the ligand-binding domain of an androgen receptor displaying normal ligand binding, but defective trans-activation.
PubMed ID: 9851768
PubMed ID: 9627582
Title: Inherited and de novo androgen receptor gene mutations: investigation of single-case families.
PubMed ID: 9627582
PubMed ID: 9607727
Title: Partial androgen insensitivity and correlations with the predicted three dimensional structure of the androgen receptor ligand-binding domain.
PubMed ID: 9607727
PubMed ID: 10470409
Title: A new point mutation of the androgen receptor gene in a patient with partial androgen resistance and severe oligozoospermia.
PubMed ID: 10470409
PubMed ID: 10363963
Title: Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.
PubMed ID: 10363963
PubMed ID: 10502786
Title: A novel point mutation (R840S) in the androgen receptor in a Brazilian family with partial androgen insensitivity syndrome.
PubMed ID: 10502786
DOI: 10.1002/(sici)1098-1004(199910)14:4<353::aid-humu16>3.0.co;2-7
PubMed ID: 10571951
Title: Analysis of exon 1 mutations in the androgen receptor gene.
PubMed ID: 10571951
DOI: 10.1002/(sici)1098-1004(199912)14:6<527::aid-humu12>3.0.co;2-x
PubMed ID: 10221692
Title: Androgen receptor gene mutations in 46,XY females with germ cell tumours.
PubMed ID: 10221692
PubMed ID: 10404311
Title: A case of complete testicular feminization: laparoscopic orchiectomy and analysis of androgen receptor gene mutation.
PubMed ID: 10404311
PubMed ID: 10022458
Title: Discordant measures of androgen-binding kinetics in two mutant androgen receptors causing mild or partial androgen insensitivity, respectively.
PubMed ID: 10022458
PubMed ID: 10629558
Title: Androgen receptor gene mutations in hormone-refractory prostate cancer.
PubMed ID: 10629558
DOI: 10.1002/(sici)1096-9896(199912)189:4<559::aid-path471>3.0.co;2-y
PubMed ID: 10569618
Title: Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a.
PubMed ID: 10569618
PubMed ID: 10543676
Title: Directed pharmacological therapy of ambiguous genitalia due to an androgen receptor gene mutation.
PubMed ID: 10543676
PubMed ID: 10221770
Title: An androgen receptor mutation in the direct vicinity of the proposed C-terminal alpha-helix of the ligand binding domain containing the AF-2 transcriptional activating function core is associated with complete androgen insensitivity.
PubMed ID: 10221770
PubMed ID: 10598582
Title: A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1.
PubMed ID: 10598582
PubMed ID: 10590024
Title: Clinical and molecular spectrum of somatic mosaicism in androgen insensitivity syndrome.
PubMed ID: 10590024
PubMed ID: 10458483
Title: Point mutations in the steroid-binding domain of the androgen receptor gene of five Japanese patients with androgen insensitivity syndrome.
PubMed ID: 10458483
DOI: 10.1620/tjem.187.263
PubMed ID: 10092153
Title: Screening for mutations in candidate genes for hypospadias.
PubMed ID: 10092153
PubMed ID: 10706109
Title: Androgen receptor mutations in prostate cancer.
PubMed ID: 10706109
PubMed ID: 10690872
Title: Phenotypic features, androgen receptor binding, and mutational analysis in 278 clinical cases reported as androgen insensitivity syndrome.
PubMed ID: 10690872
PubMed ID: 11587068
Title: Eight novel mutations of the androgen receptor gene in patients with androgen insensitivity syndrome.
PubMed ID: 11587068
PubMed ID: 11231320
Title: Polymorphism of the androgen receptor gene is associated with male pattern baldness.
PubMed ID: 11231320
PubMed ID: 11744994
Title: Characterization of a novel receptor mutation A->T at exon 4 in complete androgen insensitivity syndrome and a carrier sibling via bidirectional polymorphism sequence analysis.
PubMed ID: 11744994
PubMed ID: 15902657
Title: Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia.
PubMed ID: 15902657
DOI: 10.1086/431425
PubMed ID: 15851746
Title: A family with early-onset and rapidly progressive X-linked spinal and bulbar muscular atrophy.
PubMed ID: 15851746
PubMed ID: 14756668
Title: Concordance of phenotypic expression and gender identity in a large kindred with a mutation in the androgen receptor.
PubMed ID: 14756668
PubMed ID: 16595706
Title: Human androgen receptor gene ligand-binding-domain mutations leading to disrupted interaction between the N- and C-terminal domains.
PubMed ID: 16595706
DOI: 10.1677/jme.1.01885
PubMed ID: 27535533
Title: Analysis of protein-coding genetic variation in 60,706 humans.
PubMed ID: 27535533
DOI: 10.1038/nature19057
PubMed ID: 33647767
Title: Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males.
PubMed ID: 33647767
Sequence Information:
- Length: 920
- Mass: 99188
- Checksum: A73432C55D39AE06
- Sequence:
MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP GASLLLLQQQ QQQQQQQQQQ QQQQQQQQQQ ETSPRQQQQQ QGEDGSPQAH RRGPTGYLVL DEEQQPSQPQ SALECHPERG CVPEPGAAVA ASKGLPQQLP APPDEDDSAA PSTLSLLGPT FPGLSSCSAD LKDILSEAST MQLLQQQQQE AVSEGSSSGR AREASGAPTS SKDNYLGGTS TISDNAKELC KAVSVSMGLG VEALEHLSPG EQLRGDCMYA PLLGVPPAVR PTPCAPLAEC KGSLLDDSAG KSTEDTAEYS PFKGGYTKGL EGESLGCSGS AAAGSSGTLE LPSTLSLYKS GALDEAAAYQ SRDYYNFPLA LAGPPPPPPP PHPHARIKLE NPLDYGSAWA AAAAQCRYGD LASLHGAGAA GPGSGSPSAA ASSSWHTLFT AEEGQLYGPC GGGGGGGGGG GGGGGGGGGG GGGEAGAVAP YGYTRPPQGL AGQESDFTAP DVWYPGGMVS RVPYPSPTCV KSEMGPWMDS YSGPYGDMRL ETARDHVLPI DYYFPPQKTC LICGDEASGC HYGALTCGSC KVFFKRAAEG KQKYLCASRN DCTIDKFRRK NCPSCRLRKC YEAGMTLGAR KLKKLGNLKL QEEGEASSTT SPTEETTQKL TVSHIEGYEC QPIFLNVLEA IEPGVVCAGH DNNQPDSFAA LLSSLNELGE RQLVHVVKWA KALPGFRNLH VDDQMAVIQY SWMGLMVFAM GWRSFTNVNS RMLYFAPDLV FNEYRMHKSR MYSQCVRMRH LSQEFGWLQI TPQEFLCMKA LLLFSIIPVD GLKNQKFFDE LRMNYIKELD RIIACKRKNP TSCSRRFYQL TKLLDSVQPI ARELHQFTFD LLIKSHMVSV DFPEMMAEII SVQVPKILSG KVKPIYFHTQ
Genular Protein ID: 2359757308
Symbol: F1D8N5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 388
- Mass: 44643
- Checksum: 495BAE974B4EFC75
- Sequence:
MILWLHSLET ARDHVLPIDY YFPPQKTCLI CGDEASGCHY GALTCGSCKV FFKRAAEGKQ KYLCASRNDC TIDKFRRKNC PSCRLRKCYE AGMTLGARKL KKLGNLKLQE EGEASSTTSP TEETTQKLTV SHIEGYECQP IFLNVLEAIE PGVVCAGHDN NQPDSFAALL SSLNELGERQ LVHVVKWAKA LPGFRNLHVD DQMAVIQYSW MGLMVFAMGW RSFTNVNSRM LYFAPDLVFN EYRMHKSRMY SQCVRMRHLS QEFGWLQITP QEFLCMKALL LFSIIPVDGL KNQKFFDELR MNYIKELDRI IACKRKNPTS CSRRFYQLTK LLDSVQPIAR ELHQFTFDLL IKSHMVSVDF PEMMAEIISV QVPKILSGKV KPIYFHTQ
Genular Protein ID: 3500293997
Symbol: G4VV16_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 21878636
Title: Novel Membrane-associated Androgen Receptor Splice Variant Potentiates Proliferative and Survival Responses in Prostate Cancer Cells.
PubMed ID: 21878636
Sequence Information:
- Length: 573
- Mass: 59863
- Checksum: 2A0FF3A289AC8975
- Sequence:
MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP GASLLLQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQETSPR QQQQQQGEDG SPQAHRRGPT GYLVLDEEQQ PSQPQSALEC HPERGCVPEP GAAVAASKGL PQQLPAPPDE DDSAAPSTLS LLGPTFPGLS SCSADLKDIL SEASTMQLLQ QQQQEAVSEG SSSGRAREAS GAPTSSKDNY LGGTSTISDN AKELCKAVSV SMGLGVEALE HLSPGEQLRG DCMYAPLLGV PPAVRPTPCA PLAECKGSLL DDSAGKSTED TAEYSPFKGG YTKGLEGESL GCSGSAAAGS SGTLELPSTL SLYKSGALDE AAAYQSRDYY NFPLALAGPP PPPPPPHPHA RIKLENPLDY GSAWAAAAAQ CRYGDLASLH GAGAAGPGSG SPSAAASSSW HTLFTAEEGQ LYGPCGGGGG GGGGGGGGGG GGGGEAGAVA PYGYTRPPQG LAGQESDFTA PDVWYPGGMV SRVPYPSPTC VKSEMGPWMD SYSGPYGDMR NTRRKRLWKL IIRSINSCIC SPRETEVPVR QQK
Genular Protein ID: 654034031
Symbol: A0A087WUX9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15772651
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 572
- Mass: 59436
- Checksum: E4FDB1BF20D0178E
- Sequence:
MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP GASLLLLQQQ QQQQQQQQQQ QQQQQQQQQQ ETSPRQQQQQ QGEDGSPQAH RRGPTGYLVL DEEQQPSQPQ SALECHPERG CVPEPGAAVA ASKGLPQQLP APPDEDDSAA PSTLSLLGPT FPGLSSCSAD LKDILSEAST MQLLQQQQQE AVSEGSSSGR AREASGAPTS SKDNYLGGTS TISDNAKELC KAVSVSMGLG VEALEHLSPG EQLRGDCMYA PLLGVPPAVR PTPCAPLAEC KGSLLDDSAG KSTEDTAEYS PFKGGYTKGL EGESLGCSGS AAAGSSGTLE LPSTLSLYKS GALDEAAAYQ SRDYYNFPLA LAGPPPPPPP PHPHARIKLE NPLDYGSAWA AAAAQCRYGD LASLHGAGAA GPGSGSPSAA ASSSWHTLFT AEEGQLYGPC GGGGGGGGGG GGGGGGGGGG GGGEAGAVAP YGYTRPPQGL AGQESDFTAP DVWYPGGMVS RVPYPSPTCV KSEMGPWMDS YSGPYGDMRN TRRKRLWKLI IRSINSCICS PRETEVPVRQ QK
Genular Protein ID: 1994014189
Symbol: Q9NUA2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12124798
Title: Characterization of androgen receptor and nuclear receptor co-regulator expression in human breast cancer cell lines exhibiting differential regulation of kallikreins 2 and 3.
PubMed ID: 12124798
DOI: 10.1002/ijc.10520
Sequence Information:
- Length: 539
- Mass: 55444
- Checksum: AB493953B89D869F
- Sequence:
MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP GASLLLLQQQ QQQQQQQQQQ QQQQQQQQQQ ETSPRQQQQQ QGEDGSPQAH RRGPTGYLVL DEEQQPSQPQ SALECHPERG CVPEPGAAVA ASKGLPQQLP APPDEDDSAA PSTLSLLGPT FPGLSSCSAD LKDILSEAST MQLLQQQQQE AVSEGSSSGR AREASGAPTS SKDNYLGGTS TISDNAKELC KAVSVSMGLG VEALEHLSPG EQLRGDCMYA PLLGVPPAVR PTPCAPLAEC KGSLLDDSAG KSTEDTAEYS PFKGGYTKGL EGESLGCSGS AAAGSSGTLE LPSTLSLYKS GALDEAAAYQ SRDYYNFPLA LAGPPPPPPP PHPHARIKLE NPLDYGSAWA AAAAQCRYGD LASLHGAGAA GPGSGSPSAA ASSSWHTLFT AEEGQLYGPC GGGGGGGGGG GGGGGGGGGG GGGEAGAVAP YGYTRPPQGL AGQESDFTAP DVWYPGGMVS RVPYPSPTCV KSEMGPWMDS YSGPYGDMR