Details for: Diap2

Gene ID: 36748

Symbol: Diap2

Ensembl ID: FBgn0015247

Description: Death-associated inhibitor of apoptosis 2

Associated with

  • Caspase binding
    (GO:0089720)
  • Chaeta development
    (GO:0022416)
  • Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
    (GO:0043027)
  • Cysteine-type endopeptidase regulator activity involved in apoptotic process
    (GO:0043028)
  • Cytoplasm
    (GO:0005737)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Nucleus
    (GO:0005634)
  • Peptidoglycan recognition protein signaling pathway
    (GO:0061057)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Positive regulation of biosynthetic process of antibacterial peptides active against gram-negative bacteria
    (GO:0006964)
  • Positive regulation of protein ubiquitination
    (GO:0031398)
  • Protein binding
    (GO:0005515)
  • Protein k48-linked ubiquitination
    (GO:0070936)
  • Protein k63-linked ubiquitination
    (GO:0070534)
  • Protein ubiquitination
    (GO:0016567)
  • Regulation of cell cycle
    (GO:0051726)
  • Ubiquitin-dependent protein catabolic process
    (GO:0006511)
  • Ubiquitin protein ligase activity
    (GO:0061630)
  • Ubiquitin protein ligase binding
    (GO:0031625)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 1520601398

Symbol: DIAP2_DROME

Name: Death-associated inhibitor of apoptosis 2

UniProtKB Accession Codes:

Q24307 A4UZI4 Q24115 Q24149 Q24177 Q960U3 Q9V7G1

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 4 DNASU 1 EMBL 8 EnsemblMetazoa 2 FlyBase 1 GO 24 Gene3D 2 GeneTree 1 Genevisible 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 Reactome 7 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 8548811

Title: Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death.

PubMed ID: 8548811

DOI: 10.1016/0092-8674(95)90150-7

PubMed ID: 8552191

Title: Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

PubMed ID: 8552191

DOI: 10.1038/379349a0

PubMed ID: 8654366

Title: A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.

PubMed ID: 8654366

DOI: 10.1002/j.1460-2075.1996.tb00629.x

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 8643514

Title: Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

PubMed ID: 8643514

DOI: 10.1073/pnas.93.10.4974

PubMed ID: 11550090

Title: STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2.

PubMed ID: 11550090

DOI: 10.1038/sj.cdd.4400864

PubMed ID: 16894030

Title: The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection.

PubMed ID: 16894030

DOI: 10.1128/mcb.00548-06

PubMed ID: 18166655

Title: DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.

PubMed ID: 18166655

DOI: 10.1083/jcb.200706027

PubMed ID: 17068333

Title: The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers.

PubMed ID: 17068333

DOI: 10.1074/jbc.m608051200

PubMed ID: 19217783

Title: Ubiquitin-mediated regulation of apoptosis.

PubMed ID: 19217783

DOI: 10.1016/j.tcb.2009.01.004

PubMed ID: 20888210

Title: To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death.

PubMed ID: 20888210

DOI: 10.1016/j.ceb.2010.08.025

PubMed ID: 22549468

Title: Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.

PubMed ID: 22549468

DOI: 10.1038/emboj.2012.121

PubMed ID: 24374974

Title: Epithelial immune response in Drosophila malpighian tubules: interplay between Diap2 and ion channels.

PubMed ID: 24374974

DOI: 10.1002/jcp.24541

Sequence Information:

  • Length: 498
  • Mass: 54538
  • Checksum: 0D0303DB2B26FA22
  • Sequence:
    • MTELGMELES VRLATFGEWP LNAPVSAEDL VANGFFATGN WLEAECHFCH VRIDRWEYGD 
QVAERHRRSS PICSMVLAPN HCGNVPRSQE SDNEGNSVVD SPESCSCPDL LLEANRLVTF 
KDWPNPNITP QALAKAGFYY LNRLDHVKCV WCNGVIAKWE KNDNAFEEHK RFFPQCPRVQ 
MGPLIEFATG KNLDELGIQP TTLPLRPKYA CVDARLRTFT DWPISNIQPA SALAQAGLYY 
QKIGDQVRCF HCNIGLRSWQ KEDEPWFEHA KWSPKCQFVL LAKGPAYVSE VLATTAANAS 
SQPATAPAPT LQADVLMDEA PAKEALALGI DGGVVRNAIQ RKLLSSGCAF STLDELLHDI 
FDDAGAGAAL EVREPPEPSA PFIEPCQATT SKAASVPIPV ADSIPAKPQA AEAVANISKI 
TDEIQKMSVA TPNGNLSLEE ENRQLKDARL CKVCLDEEVG VVFLPCGHLA TCNQCAPSVA 
NCPMCRADIK GFVRTFLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.