Lis 1 | FBgn0015754 | NCBI 36791

Details for: Lis 1

Gene ID: 36791

Symbol: Lis 1

Ensembl ID: FBgn0015754

Description: Lissencephaly-1

Associated with

Copi-independent golgi-to-er retrograde traffic
(R-DME-6811436)
Golgi-to-er retrograde transport
(R-DME-8856688)
Intra-golgi and retrograde golgi-to-er traffic
(R-DME-6811442)
Membrane trafficking
(R-DME-199991)
Vesicle-mediated transport
(R-DME-5653656)
Axo-dendritic transport
(GO:0008088)
Axon
(GO:0030424)
Axonal transport
(GO:0098930)
Border follicle cell migration
(GO:0007298)
Brain morphogenesis
(GO:0048854)
Cell cortex
(GO:0005938)
Centrosome
(GO:0005813)
Centrosome localization
(GO:0051642)
Centrosome separation
(GO:0051299)
Chorion-containing eggshell pattern formation
(GO:0030381)
Clathrin-dependent endocytosis involved in vitellogenesis
(GO:0061883)
Cytoplasmic microtubule
(GO:0005881)
Dendrite
(GO:0030425)
Dendrite development
(GO:0016358)
Dendrite morphogenesis
(GO:0048813)
Dynactin complex
(GO:0005869)
Dynein complex
(GO:0030286)
Dynein complex binding
(GO:0070840)
Establishment of mitotic spindle orientation
(GO:0000132)
Female germ-line cyst formation
(GO:0048135)
Fusome organization
(GO:0045478)
Germarium-derived cystoblast division
(GO:0048142)
Germarium-derived oocyte differentiation
(GO:0030706)
Germarium-derived oocyte fate determination
(GO:0007294)
Germ cell development
(GO:0007281)
Growth cone
(GO:0030426)
Intracellular mrna localization
(GO:0008298)
Intracellular protein transport
(GO:0006886)
Kinetochore
(GO:0000776)
Kinetochore microtubule
(GO:0005828)
Kinetochore organization
(GO:0051383)
Microtubule associated complex
(GO:0005875)
Microtubule organizing center organization
(GO:0031023)
Microtubule plus-end binding
(GO:0051010)
Muscle cell cellular homeostasis
(GO:0046716)
Mushroom body development
(GO:0016319)
Neuroblast proliferation
(GO:0007405)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Nuclear envelope
(GO:0005635)
Nuclear migration
(GO:0007097)
Nuclear migration along microtubule
(GO:0030473)
Nucleus localization
(GO:0051647)
Oocyte fate determination
(GO:0030716)
Oocyte nucleus migration involved in oocyte dorsal/ventral axis specification
(GO:0007312)
Oogenesis
(GO:0048477)
Ovarian fusome organization
(GO:0030723)
Photoreceptor cell axon guidance
(GO:0072499)
Positive regulation of axonogenesis
(GO:0050772)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of mitotic metaphase/anaphase transition
(GO:0045842)
Protein localization
(GO:0008104)
Protein localization to kinetochore
(GO:0034501)
Regulation of dendrite morphogenesis
(GO:0048814)
Retrograde axonal transport
(GO:0008090)
Rhabdomere development
(GO:0042052)
Spermatogenesis
(GO:0007283)
Spindle assembly
(GO:0051225)
Spindle pole
(GO:0000922)
Spindle pole centrosome
(GO:0031616)
Stem cell population maintenance
(GO:0019827)
Transport along microtubule
(GO:0010970)
Vesicle transport along microtubule
(GO:0047496)

Other Information

Proteins

LIS1_DROME

Genular Protein ID: 585652562

Symbol: LIS1_DROME

Name: N/A

UniProtKB Accession Codes:

Q7KNS3 A4UZJ3 O96698 Q5BI20 Q8SXJ6

Database IDs:

Citations:

PubMed ID: 10498683

Title: Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation.

PubMed ID: 10498683

DOI: 10.1242/dev.126.20.4477

PubMed ID: 10559989

Title: Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning.

PubMed ID: 10559989

DOI: 10.1038/15680

PubMed ID: 10737922

Title: Homologs of the alpha- and beta-subunits of mammalian brain platelet-activating factor acetylhydrolase Ib in the Drosophila melanogaster genome.

PubMed ID: 10737922

DOI: 10.1002/(sici)1097-0134(20000401)39:1<1::aid-prot1>3.0.co;2-n

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 10993674

Title: The Drosophila Lissencephaly1 (DLis1) gene is required for nuclear migration.

PubMed ID: 10993674

DOI: 10.1006/dbio.2000.9848

PubMed ID: 11056531

Title: Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport.

PubMed ID: 11056531

DOI: 10.1038/35041011

PubMed ID: 16105886

Title: Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends.

PubMed ID: 16105886

DOI: 10.1242/jcs.02504

PubMed ID: 16107559

Title: Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control.

PubMed ID: 16107559

DOI: 10.1091/mbc.e05-04-0338

Sequence Information:

Length: 411
Mass: 46460
Checksum: 867D06C958B2D97F
Sequence:

MKMVLSQRQR EELNQAIADY LGSNGYADSL ETFRKEADLS TEVEKKFGGL LEKKWTSVIR 
LQKKVMELEA KLTEAEKEVI EGAPTKNKRT PGEWIPRPPE KFSLTGHRAS ITRVIFHPIF 
ALMVSASEDA TIRIWDFETG EYERSLKGHT DSVQDVAFDA QGKLLASCSA DLSIKLWDFQ 
QSYECIKTMH GHDHNVSSVA FVPAGDYVLS ASRDRTIKMW EVATGYCVKT YTGHREWVRM 
VRVHIEGSIF ATCSNDQTIR VWLTNSKDCK VELRDHEHTV ECIAWAPEAA ASAINEAAGA 
DNKKGHHQGP FLASGSRDKT IRIWDVSVGL CLLTLSGHDN WVRGLAFHPG GKYLVSASDD 
KTIRVWDLRN KRCMKTLYAH QHFCTSIDFH KAHPYVISGS VDQTVKVWEC R

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lis 1

Associated with

Other Information

Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation. PubMed ID: 10498683

Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning. PubMed ID: 10559989

Homologs of the alpha- and beta-subunits of mammalian brain platelet-activating factor acetylhydrolase Ib in the Drosophila melanogaster genome. PubMed ID: 10737922

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

The Drosophila Lissencephaly1 (DLis1) gene is required for nuclear migration. PubMed ID: 10993674

Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport. PubMed ID: 11056531

Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends. PubMed ID: 16105886

Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control. PubMed ID: 16107559