Details for: ARAF

Gene ID: 369

Symbol: ARAF

Ensembl ID: ENSG00000078061

Description: A-Raf proto-oncogene, serine/threonine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 103.8283
    Cell Significance Index: -16.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.5645
    Cell Significance Index: -16.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 50.6132
    Cell Significance Index: -20.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.0207
    Cell Significance Index: -18.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.4633
    Cell Significance Index: -20.5200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.5812
    Cell Significance Index: -20.3600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 30.6249
    Cell Significance Index: -20.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.2722
    Cell Significance Index: -18.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.1019
    Cell Significance Index: -18.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6629
    Cell Significance Index: -15.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9290
    Cell Significance Index: -19.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.7372
    Cell Significance Index: -14.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3263
    Cell Significance Index: -7.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5078
    Cell Significance Index: 175.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4161
    Cell Significance Index: 1278.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1207
    Cell Significance Index: 15.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0224
    Cell Significance Index: 111.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9692
    Cell Significance Index: 157.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9163
    Cell Significance Index: 55.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5729
    Cell Significance Index: 15.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5587
    Cell Significance Index: 38.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5408
    Cell Significance Index: 14.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5184
    Cell Significance Index: 24.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4364
    Cell Significance Index: 22.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4126
    Cell Significance Index: 18.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3739
    Cell Significance Index: 8.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3526
    Cell Significance Index: 9.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3286
    Cell Significance Index: 59.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2978
    Cell Significance Index: 8.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2798
    Cell Significance Index: 33.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2707
    Cell Significance Index: 7.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2449
    Cell Significance Index: 46.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2445
    Cell Significance Index: 33.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2337
    Cell Significance Index: 28.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2333
    Cell Significance Index: 127.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2160
    Cell Significance Index: 27.9100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1964
    Cell Significance Index: 3.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1803
    Cell Significance Index: 13.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1740
    Cell Significance Index: 76.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1721
    Cell Significance Index: 11.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1370
    Cell Significance Index: 27.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1280
    Cell Significance Index: 3.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1256
    Cell Significance Index: 25.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1208
    Cell Significance Index: 6.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1102
    Cell Significance Index: 10.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1055
    Cell Significance Index: 13.5300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0935
    Cell Significance Index: 0.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0932
    Cell Significance Index: 7.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0757
    Cell Significance Index: 2.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0690
    Cell Significance Index: 3.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0598
    Cell Significance Index: 10.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0531
    Cell Significance Index: 19.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0411
    Cell Significance Index: 1.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0277
    Cell Significance Index: 1.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0167
    Cell Significance Index: 11.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0151
    Cell Significance Index: 0.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0099
    Cell Significance Index: 18.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0097
    Cell Significance Index: 7.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0052
    Cell Significance Index: 0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0032
    Cell Significance Index: -5.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0034
    Cell Significance Index: -0.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -6.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0068
    Cell Significance Index: -4.3100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0080
    Cell Significance Index: -0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0089
    Cell Significance Index: -6.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0131
    Cell Significance Index: -17.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0145
    Cell Significance Index: -6.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0153
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0187
    Cell Significance Index: -2.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0198
    Cell Significance Index: -14.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0287
    Cell Significance Index: -0.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0322
    Cell Significance Index: -18.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0359
    Cell Significance Index: -22.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0476
    Cell Significance Index: -2.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0567
    Cell Significance Index: -0.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0590
    Cell Significance Index: -16.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0763
    Cell Significance Index: -11.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0955
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1028
    Cell Significance Index: -21.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1312
    Cell Significance Index: -1.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1662
    Cell Significance Index: -17.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1769
    Cell Significance Index: -1.4100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1846
    Cell Significance Index: -1.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1855
    Cell Significance Index: -4.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1873
    Cell Significance Index: -3.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2074
    Cell Significance Index: -16.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2226
    Cell Significance Index: -2.0500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2389
    Cell Significance Index: -5.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2433
    Cell Significance Index: -16.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2464
    Cell Significance Index: -15.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2502
    Cell Significance Index: -15.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2563
    Cell Significance Index: -4.2900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2574
    Cell Significance Index: -4.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2576
    Cell Significance Index: -13.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2864
    Cell Significance Index: -8.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2914
    Cell Significance Index: -7.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2930
    Cell Significance Index: -8.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3056
    Cell Significance Index: -7.6400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3154
    Cell Significance Index: -1.7200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3451
    Cell Significance Index: -2.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ARAF is a proto-oncogene that encodes a serine/threonine kinase, which is activated by phosphorylation. The ARAF protein is a key component of the MAPK signaling pathway, which is involved in regulating cell growth, differentiation, and survival. ARAF is specifically activated by the RAS protein, and its activation leads to the phosphorylation and activation of downstream targets, including MAPK kinases (MAP2K and MAPK) and other transcription factors. ARAF also interacts with other proteins, such as SHC2, to regulate the activity of the MAPK signaling pathway. **Pathways and Functions** ARAF is involved in several signaling pathways, including: 1. **MAPK signaling pathway**: ARAF is a downstream effector of RAS proteins and activates the MAPK signaling pathway, which regulates cell growth, differentiation, and survival. 2. **Regulation of apoptosis**: ARAF is involved in the regulation of apoptosis (programmed cell death) by interacting with pro-apoptotic and anti-apoptotic proteins. 3. **Regulation of proteasomal ubiquitin-dependent protein catabolic process**: ARAF regulates the activity of the proteasome, a protein complex involved in protein degradation. 4. **Regulation of TOR signaling**: ARAF regulates the activity of the TOR (Target of Rapamycin) signaling pathway, which is involved in regulating cell growth and metabolism. **Clinical Significance** Dysregulation of the ARAF gene has been implicated in various cancers and diseases, including: 1. **Cancer**: ARAF mutations have been identified in several types of cancer, including melanoma, colorectal cancer, and lung cancer. 2. **Neurodegenerative diseases**: ARAF has been implicated in the regulation of apoptosis and neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular disease**: ARAF has been implicated in the regulation of cardiac muscle cell growth and survival, and its dysregulation has been linked to cardiovascular disease. In conclusion, the ARAF gene is a critical component of the MAPK signaling pathway, and its dysregulation has significant implications for various diseases and cancers. Further research is needed to fully understand the mechanisms of ARAF in normal and diseased cells.

Genular Protein ID: 2570030779

Symbol: ARAF_HUMAN

Name: Serine/threonine-protein kinase A-Raf

UniProtKB Accession Codes:

P10398 P07557 Q5H9B2 Q5H9B3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 21 CPTC 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 11 RefSeq 4 Rhea 6 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3029685

Title: The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus.

PubMed ID: 3029685

DOI: 10.1093/nar/15.2.595

PubMed ID: 8020955

Title: The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1).

PubMed ID: 8020955

DOI: 10.1006/geno.1994.1125

PubMed ID: 17535970

Title: DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation.

PubMed ID: 17535970

DOI: 10.1083/jcb.200703195

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3529082

Title: Pks, a raf-related sequence in humans.

PubMed ID: 3529082

DOI: 10.1073/pnas.83.17.6312

PubMed ID: 11952167

Title: Identification of TH1 as an interaction partner of A-Raf kinase.

PubMed ID: 11952167

DOI: 10.1023/a:1014437024129

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22609986

Title: PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.

PubMed ID: 22609986

DOI: 10.1038/ncb2507

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 36402789

Title: BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy.

PubMed ID: 36402789

DOI: 10.1038/s41467-022-34907-0

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 606
  • Mass: 67585
  • Checksum: D23E5711304AA468
  • Sequence:
    • MEPPRGPPAN GAEPSRAVGT VKVYLPNKQR TVVTVRDGMS VYDSLDKALK VRGLNQDCCV 
VYRLIKGRKT VTAWDTAIAP LDGEELIVEV LEDVPLTMHN FVRKTFFSLA FCDFCLKFLF 
HGFRCQTCGY KFHQHCSSKV PTVCVDMSTN RQQFYHSVQD LSGGSRQHEA PSNRPLNELL 
TPQGPSPRTQ HCDPEHFPFP APANAPLQRI RSTSTPNVHM VSTTAPMDSN LIQLTGQSFS 
TDAAGSRGGS DGTPRGSPSP ASVSSGRKSP HSKSPAEQRE RKSLADDKKK VKNLGYRDSG 
YYWEVPPSEV QLLKRIGTGS FGTVFRGRWH GDVAVKVLKV SQPTAEQAQA FKNEMQVLRK 
TRHVNILLFM GFMTRPGFAI ITQWCEGSSL YHHLHVADTR FDMVQLIDVA RQTAQGMDYL 
HAKNIIHRDL KSNNIFLHEG LTVKIGDFGL ATVKTRWSGA QPLEQPSGSV LWMAAEVIRM 
QDPNPYSFQS DVYAYGVVLY ELMTGSLPYS HIGCRDQIIF MVGRGYLSPD LSKISSNCPK 
AMRRLLSDCL KFQREERPLF PQILATIELL QRSLPKIERS ASEPSLHRTQ ADELPACLLS 
AARLVP

Genular Protein ID: 4115044409

Symbol: Q96II5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96II5 A6NIT1

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 IntAct 1 InterPro 11 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 9 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 609
  • Mass: 67926
  • Checksum: 38B52E7C303E06CF
  • Sequence:
    • MEPPRGPPAN GAEPSRAVGT VKVYLPNKQR TVVTVRDGMS VYDSLDKALK VRGLNQDCCV 
VYRLIKGRKT VTAWDTAIAP LDGEELIVEV LEDVPLTMHN FVRKTFFSLA FCDFCLKFLF 
HGFRCQTCGY KFHQHCSSKV PTVCVDMSTN RQQPSRFYHS VQDLSGGSRQ HEAPSNRPLN 
ELLTPQGPSP RTQHCDPEHF PFPAPANAPL QRIRSTSTPN VHMVSTTAPM DSNLIQLTGQ 
SFSTDAAGSR GGSDGTPRGS PSPASVSSGR KSPHSKSPAE QRERKSLADD KKKVKNLGYR 
DSGYYWEVPP SEVQLLKRIG TGSFGTVFRG RWHGDVAVKV LKVSQPTAEQ AQAFKNEMQV 
LRKTRHVNIL LFMGFMTRPG FAIITQWCEG SSLYHHLHVA DTRFDMVQLI DVARQTAQGM 
DYLHAKNIIH RDLKSNNIFL HEGLTVKIGD FGLATVKTRW SGAQPLEQPS GSVLWMAAEV 
IRMQDPNPYS FQSDVYAYGV VLYELMTGSL PYSHIGCRDQ IIFMVGRGYL SPDLSKISSN 
CPKAMRRLLS DCLKFQREER PLFPQILATI ELLQRSLPKI ERSASEPSLH RTQADELPAC 
LLSAARLVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.