Details for: ITGB3
Associated with
Other Information
Genular Protein ID: 1327102630
Symbol: ITB3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3494014
Title: Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to 'integrin'.
PubMed ID: 3494014
PubMed ID: 2452834
Title: Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors.
PubMed ID: 2452834
DOI: 10.1172/jci113478
PubMed ID: 2345548
Title: GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs.
PubMed ID: 2345548
DOI: 10.1007/bf00422712
PubMed ID: 9195946
Title: Cloning and characterization of a novel integrin beta3 subunit.
PubMed ID: 9195946
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8298129
Title: Isolation and characterization of a TATA-less promoter for the human beta 3 integrin gene.
PubMed ID: 8298129
PubMed ID: 3165296
Title: Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17.
PubMed ID: 3165296
PubMed ID: 1953640
Title: Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing.
PubMed ID: 1953640
DOI: 10.1042/bj2790419
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 2341395
Title: The genomic organization of platelet glycoprotein IIIa.
PubMed ID: 2341395
PubMed ID: 2145280
Title: Characterization of the human platelet glycoprotein IIIa gene. Comparison with the fibronectin receptor beta-subunit gene.
PubMed ID: 2145280
PubMed ID: 1382574
Title: The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1.
PubMed ID: 1382574
PubMed ID: 3801670
Title: Purification and partial amino acid sequence of human platelet membrane glycoproteins IIb and IIIa.
PubMed ID: 3801670
PubMed ID: 2787511
Title: An alternative cytoplasmic domain of the integrin beta 3 subunit.
PubMed ID: 2787511
PubMed ID: 2001252
Title: Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family.
PubMed ID: 2001252
DOI: 10.1042/bj2740063
PubMed ID: 7519807
Title: Entry of coxsackievirus A9 into host cells: specific interactions with alpha v beta 3 integrin, the vitronectin receptor.
PubMed ID: 7519807
PubMed ID: 8631894
Title: Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation.
PubMed ID: 8631894
PubMed ID: 9618541
Title: beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure.
PubMed ID: 9618541
PubMed ID: 10397733
Title: The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.
PubMed ID: 10397733
PubMed ID: 10896934
Title: Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.
PubMed ID: 10896934
PubMed ID: 11160695
PubMed ID: 11940607
Title: Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
PubMed ID: 11940607
PubMed ID: 11807098
Title: Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits.
PubMed ID: 11807098
PubMed ID: 12695522
Title: CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family.
PubMed ID: 12695522
PubMed ID: 12807887
Title: Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins.
PubMed ID: 12807887
PubMed ID: 15156152
Title: Myosin-X provides a motor-based link between integrins and the cytoskeleton.
PubMed ID: 15156152
DOI: 10.1038/ncb1136
PubMed ID: 15834425
Title: Integrin alphavbeta3 is a coreceptor for human cytomegalovirus.
PubMed ID: 15834425
DOI: 10.1038/nm1236
PubMed ID: 15466936
Title: A role for the thiol isomerase protein ERP5 in platelet function.
PubMed ID: 15466936
PubMed ID: 16216233
Title: Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium.
PubMed ID: 16216233
PubMed ID: 16051604
Title: Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins.
PubMed ID: 16051604
PubMed ID: 16322781
Title: Structure and function of the platelet integrin alphaIIbbeta3.
PubMed ID: 16322781
DOI: 10.1172/jci26989
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 16982628
Title: Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans.
PubMed ID: 16982628
PubMed ID: 16263699
Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.
PubMed ID: 16263699
PubMed ID: 17635696
Title: Platelet integrin alpha(IIb)beta(3): activation mechanisms.
PubMed ID: 17635696
PubMed ID: 18441324
Title: Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.
PubMed ID: 18441324
PubMed ID: 18317590
Title: Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.
PubMed ID: 18317590
DOI: 10.1172/jci33374
PubMed ID: 18635536
Title: Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.
PubMed ID: 18635536
PubMed ID: 18088087
PubMed ID: 18045938
Title: Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor.
PubMed ID: 18045938
DOI: 10.1128/jvi.01673-07
PubMed ID: 19494351
Title: Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101-positive antigen-presenting cells.
PubMed ID: 19494351
PubMed ID: 19141530
Title: Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta.
PubMed ID: 19141530
DOI: 10.1096/fj.08-117564
PubMed ID: 19578119
Title: The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.
PubMed ID: 19578119
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 20702409
Title: Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.
PubMed ID: 20702409
PubMed ID: 20682778
Title: Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.
PubMed ID: 20682778
PubMed ID: 22492581
Title: DICAM inhibits osteoclast differentiation through attenuation of the integrin alphaVbeta3 pathway.
PubMed ID: 22492581
DOI: 10.1002/jbmr.1632
PubMed ID: 23125415
Title: Integrins alphavbeta3 and alpha4beta1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.
PubMed ID: 23125415
PubMed ID: 23658209
Title: Integrins modulate the infection efficiency of West Nile virus into cells.
PubMed ID: 23658209
PubMed ID: 24478423
Title: Roles of the putative integrin-binding motif of the human metapneumovirus fusion (f) protein in cell-cell fusion, viral infectivity, and pathogenesis.
PubMed ID: 24478423
DOI: 10.1128/jvi.03491-13
PubMed ID: 24789099
Title: The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.
PubMed ID: 24789099
PubMed ID: 25398877
Title: Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins alphavbeta3, alpha4beta1, and alpha5beta1.
PubMed ID: 25398877
PubMed ID: 27993971
Title: The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin alphavbeta3.
PubMed ID: 27993971
DOI: 10.1042/bcj20160998
PubMed ID: 28302677
Title: The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis.
PubMed ID: 28302677
DOI: 10.1042/bsr20170173
PubMed ID: 29030430
Title: Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta.
PubMed ID: 29030430
PubMed ID: 28873464
Title: Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.
PubMed ID: 28873464
PubMed ID: 29301984
Title: Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4.
PubMed ID: 29301984
DOI: 10.1042/bcj20170867
PubMed ID: 31331973
Title: Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.
PubMed ID: 31331973
PubMed ID: 33436497
Title: Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications.
PubMed ID: 33436497
PubMed ID: 33436498
Title: Cytoplasmic short linear motifs in ACE2 and integrin beta3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy.
PubMed ID: 33436498
PubMed ID: 35687021
Title: PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.
PubMed ID: 35687021
PubMed ID: 11546839
Title: Crystal structure of the extracellular segment of integrin alpha Vbeta3.
PubMed ID: 11546839
PubMed ID: 15378069
Title: Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics.
PubMed ID: 15378069
DOI: 10.1038/nature02976
PubMed ID: 17583734
Title: Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity.
PubMed ID: 17583734
PubMed ID: 19111664
Title: Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
PubMed ID: 19111664
PubMed ID: 19704023
Title: Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.
PubMed ID: 19704023
PubMed ID: 7878622
Title: Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.
PubMed ID: 7878622
PubMed ID: 2565345
Title: The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing.
PubMed ID: 2565345
DOI: 10.1172/jci114082
PubMed ID: 1430225
Title: An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system.
PubMed ID: 1430225
DOI: 10.1172/jci116084
PubMed ID: 8093349
Title: Single point mutation in human glycoprotein IIIa is associated with a new platelet-specific alloantigen (Mo) involved in neonatal alloimmune thrombocytopenia.
PubMed ID: 8093349
PubMed ID: 7694683
Title: Amino acid 489 is encoded by a mutational 'hot spot' on the beta 3 integrin chain: the CA/TU human platelet alloantigen system.
PubMed ID: 7694683
PubMed ID: 8132570
Title: A point mutation leads to an unpaired cysteine residue and a molecular weight polymorphism of a functional platelet beta 3 integrin subunit. The Sra alloantigen system of GPIIIa.
PubMed ID: 8132570
PubMed ID: 2392682
Title: A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation.
PubMed ID: 2392682
PubMed ID: 1371279
Title: A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site.
PubMed ID: 1371279
PubMed ID: 1602006
Title: A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg-->214Trp mutation.
PubMed ID: 1602006
DOI: 10.1172/jci115808
PubMed ID: 1438206
Title: Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.
PubMed ID: 1438206
PubMed ID: 8781422
Title: A Cys374Tyr homozygous mutation of platelet glycoprotein IIIa (beta 3) in a Chinese patient with Glanzmann's thrombasthenia.
PubMed ID: 8781422
PubMed ID: 9376589
Title: A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface.
PubMed ID: 9376589
PubMed ID: 9215749
Title: Hematologically important mutations: Glanzmann thrombasthenia.
PubMed ID: 9215749
PubMed ID: 9790984
Title: Three novel integrin beta3 subunit missense mutations (H280P, C560F, and G579S) in thrombasthenia, including one (H280P) prevalent in Japanese patients.
PubMed ID: 9790984
PubMed ID: 9684783
Title: A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia.
PubMed ID: 9684783
PubMed ID: 10233432
Title: Homozygous Cys542-->Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann's thrombasthenia.
PubMed ID: 10233432
PubMed ID: 10391209
Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.
PubMed ID: 10391209
DOI: 10.1038/10290
PubMed ID: 11588040
Title: A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype.
PubMed ID: 11588040
PubMed ID: 12036875
Title: A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia.
PubMed ID: 12036875
PubMed ID: 11897046
Title: A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia.
PubMed ID: 11897046
PubMed ID: 12083483
Title: Glanzmann's thrombasthenia: identification of 19 new mutations in 30 patients.
PubMed ID: 12083483
PubMed ID: 12353082
Title: Two new beta3 integrin mutations in Indian patients with Glanzmann thrombasthenia: localization of mutations affecting cysteine residues in integrin beta3.
PubMed ID: 12353082
PubMed ID: 15583747
Title: A variant thrombasthenic phenotype associated with compound heterozygosity of integrin beta3-subunit: (Met124Val)beta3 alters the subunit dimerization rendering a decreased number of constitutive active alphaIIbbeta3 receptors.
PubMed ID: 15583747
DOI: 10.1160/th04-06-0380
PubMed ID: 15634267
Title: Double heterozygosity for a novel missense mutation of Ile304 to Asn in addition to the missense mutation His280 to Pro in the integrin beta3 gene as a cause of the absence of platelet alphaIIbbeta3 in Glanzmann's thrombasthenia.
PubMed ID: 15634267
PubMed ID: 15748237
Title: Mutations in GPIIIa molecule as a cause for Glanzmann thrombasthenia in Indian patients.
PubMed ID: 15748237
PubMed ID: 18065693
Title: A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia.
PubMed ID: 18065693
PubMed ID: 20020534
Title: AlphaIIbbeta3 integrin: new allelic variants in Glanzmann thrombasthenia, effects on ITGA2B and ITGB3 mRNA splicing, expression, and structure-function.
PubMed ID: 20020534
DOI: 10.1002/humu.21179
PubMed ID: 29084015
Title: Molecular characterization of Glanzmann's thrombasthenia in Iran: identification of three novel mutations.
PubMed ID: 29084015
PubMed ID: 29380037
Title: A novel heterozygous ITGB3 p.T720del inducing spontaneous activation of integrin alphaIIbbeta3 in autosomal dominant macrothrombocytopenia with aggregation dysfunction.
PubMed ID: 29380037
Sequence Information:
- Length: 788
- Mass: 87058
- Checksum: F246623608E05F9E
- Sequence:
MRARPRPRPL WATVLALGAL AGVGVGGPNI CTTRGVSSCQ QCLAVSPMCA WCSDEALPLG SPRCDLKENL LKDNCAPESI EFPVSEARVL EDRPLSDKGS GDSSQVTQVS PQRIALRLRP DDSKNFSIQV RQVEDYPVDI YYLMDLSYSM KDDLWSIQNL GTKLATQMRK LTSNLRIGFG AFVDKPVSPY MYISPPEALE NPCYDMKTTC LPMFGYKHVL TLTDQVTRFN EEVKKQSVSR NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVQPNDGQCH VGSDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VNLYQNYSEL IPGTTVGVLS MDSSNVLQLI VDAYGKIRSK VELEVRDLPE ELSLSFNATC LNNEVIPGLK SCMGLKIGDT VSFSIEAKVR GCPQEKEKSF TIKPVGFKDS LIVQVTFDCD CACQAQAEPN SHRCNNGNGT FECGVCRCGP GWLGSQCECS EEDYRPSQQD ECSPREGQPV CSQRGECLCG QCVCHSSDFG KITGKYCECD DFSCVRYKGE MCSGHGQCSC GDCLCDSDWT GYYCNCTTRT DTCMSSNGLL CSGRGKCECG SCVCIQPGSY GDTCEKCPTC PDACTFKKEC VECKKFDRGA LHDENTCNRY CRDEIESVKE LKDTGKDAVN CTYKNEDDCV VRFQYYEDSS GKSILYVVEE PECPKGPDIL VVLLSVMGAI LLIGLAALLI WKLLITIHDR KEFAKFEEER ARAKWDTANN PLYKEATSTF TNITYRGT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.