Details for: ITGB3

Gene ID: 3690

Symbol: ITGB3

Ensembl ID: ENSG00000259207

Description: integrin subunit beta 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.06
    Marker Score: 6341
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1991
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.55
    Marker Score: 650
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.54
    Marker Score: 2920
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.29
    Marker Score: 2623
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7678
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.02
    Marker Score: 579
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.92
    Marker Score: 5535
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.89
    Marker Score: 426
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.73
    Marker Score: 383
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.71
    Marker Score: 1676
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.68
    Marker Score: 339
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.65
    Marker Score: 205
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.61
    Marker Score: 196
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 393.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 353.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.58
    Marker Score: 566
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.57
    Marker Score: 283.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.51
    Marker Score: 227
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.41
    Marker Score: 130
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.39
    Marker Score: 142
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 220
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.37
    Marker Score: 166
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.35
    Marker Score: 151
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.34
    Marker Score: 11643
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.34
    Marker Score: 82
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.3
    Marker Score: 308
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 302
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3
    Marker Score: 315.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.29
    Marker Score: 113
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.23
    Marker Score: 830
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.22
    Marker Score: 121
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.21
    Marker Score: 91
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.21
    Marker Score: 55
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.2
    Marker Score: 248
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.2
    Marker Score: 284
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.19
    Marker Score: 222
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.19
    Marker Score: 71
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.19
    Marker Score: 190
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.17
    Marker Score: 135
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.16
    Marker Score: 188
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.16
    Marker Score: 383
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.16
    Marker Score: 278
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.16
    Marker Score: 90
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.15
    Marker Score: 72
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 0.14
    Marker Score: 52
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.14
    Marker Score: 174
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.14
    Marker Score: 86
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.13
    Marker Score: 528.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.13
    Marker Score: 83
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.12
    Marker Score: 191
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.12
    Marker Score: 41
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.11
    Marker Score: 174
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.11
    Marker Score: 176
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.11
    Marker Score: 67
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 24
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.1
    Marker Score: 500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.1
    Marker Score: 167.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1
    Marker Score: 170

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Other Information

**Key characteristics:** * ITGB3 is a glycoprotein with a molecular weight of approximately 120 kDa. * It is a transmembrane protein that is expressed in various tissues. * It is a key component of the vascular endothelium. * It is involved in cell adhesion, migration, and signaling. * It is a regulator of angiogenesis, cell migration, and tissue remodeling. **Pathways and functions:** * ITGB3 is involved in cell adhesion and migration by interacting with other integrins on the cell surface. * It is involved in cell signaling pathways, including the MAPK family signaling cascade and the TGF-beta receptor complex signaling pathway. * It is involved in tissue remodeling and wound healing. * It is also involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in ITGB3 have been linked to various human diseases, including cancer, cardiovascular disease, and diabetes. * ITGB3 is a potential target for cancer immunotherapy. * Targeting ITGB3 has been shown to be effective in inhibiting tumor growth and metastasis. **Additional notes:** * ITGB3 is a highly conserved protein, with similar sequences found in mammals. * It is a ubiquitin-dependent protein, meaning that it is degraded by the proteasome when it is no longer needed. * ITGB3 is a key regulator of the vascular endothelium, and its dysfunction can lead to vascular diseases such as atherosclerosis and cancer.

Genular Protein ID: 1327102630

Symbol: ITB3_HUMAN

Name: N/A

UniProtKB Accession Codes:

P05106 A0PJW2 D3DXJ8 O15495 Q12806 Q13413 Q14648 Q16499

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 14 ChEMBL 5 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 12 DrugCentral 1 ELM 1 EMBL 35 EMDB 8 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 97 PIR 5 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 20 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3494014

Title: Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to 'integrin'.

PubMed ID: 3494014

DOI: 10.1016/s0021-9258(18)61290-6

PubMed ID: 2452834

Title: Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors.

PubMed ID: 2452834

DOI: 10.1172/jci113478

PubMed ID: 2345548

Title: GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs.

PubMed ID: 2345548

DOI: 10.1007/bf00422712

PubMed ID: 9195946

Title: Cloning and characterization of a novel integrin beta3 subunit.

PubMed ID: 9195946

DOI: 10.1074/jbc.272.26.16390

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8298129

Title: Isolation and characterization of a TATA-less promoter for the human beta 3 integrin gene.

PubMed ID: 8298129

PubMed ID: 3165296

Title: Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17.

PubMed ID: 3165296

PubMed ID: 1953640

Title: Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing.

PubMed ID: 1953640

DOI: 10.1042/bj2790419

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 2341395

Title: The genomic organization of platelet glycoprotein IIIa.

PubMed ID: 2341395

DOI: 10.1016/s0021-9258(19)38928-8

PubMed ID: 2145280

Title: Characterization of the human platelet glycoprotein IIIa gene. Comparison with the fibronectin receptor beta-subunit gene.

PubMed ID: 2145280

DOI: 10.1016/s0021-9258(17)44722-3

PubMed ID: 1382574

Title: The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1.

PubMed ID: 1382574

DOI: 10.1093/intimm/4.9.1031

PubMed ID: 3801670

Title: Purification and partial amino acid sequence of human platelet membrane glycoproteins IIb and IIIa.

PubMed ID: 3801670

PubMed ID: 2787511

Title: An alternative cytoplasmic domain of the integrin beta 3 subunit.

PubMed ID: 2787511

DOI: 10.1073/pnas.86.14.5415

PubMed ID: 2001252

Title: Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family.

PubMed ID: 2001252

DOI: 10.1042/bj2740063

PubMed ID: 7519807

Title: Entry of coxsackievirus A9 into host cells: specific interactions with alpha v beta 3 integrin, the vitronectin receptor.

PubMed ID: 7519807

DOI: 10.1006/viro.1994.1494

PubMed ID: 8631894

Title: Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation.

PubMed ID: 8631894

DOI: 10.1074/jbc.271.18.10811

PubMed ID: 9618541

Title: beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure.

PubMed ID: 9618541

DOI: 10.1073/pnas.95.12.7074

PubMed ID: 10397733

Title: The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.

PubMed ID: 10397733

PubMed ID: 10896934

Title: Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.

PubMed ID: 10896934

DOI: 10.1074/jbc.m001908200

PubMed ID: 11160695

Title: Entry of human parechovirus 1.

PubMed ID: 11160695

DOI: 10.1128/jvi.75.4.1958-1967.2001

PubMed ID: 11940607

Title: Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.

PubMed ID: 11940607

DOI: 10.1083/jcb.200112113

PubMed ID: 11807098

Title: Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits.

PubMed ID: 11807098

DOI: 10.1083/jcb.200103037

PubMed ID: 12695522

Title: CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family.

PubMed ID: 12695522

DOI: 10.1074/jbc.m302028200

PubMed ID: 12807887

Title: Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins.

PubMed ID: 12807887

DOI: 10.1074/jbc.m303159200

PubMed ID: 15156152

Title: Myosin-X provides a motor-based link between integrins and the cytoskeleton.

PubMed ID: 15156152

DOI: 10.1038/ncb1136

PubMed ID: 15834425

Title: Integrin alphavbeta3 is a coreceptor for human cytomegalovirus.

PubMed ID: 15834425

DOI: 10.1038/nm1236

PubMed ID: 15466936

Title: A role for the thiol isomerase protein ERP5 in platelet function.

PubMed ID: 15466936

DOI: 10.1182/blood-2004-02-0608

PubMed ID: 16216233

Title: Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium.

PubMed ID: 16216233

DOI: 10.1016/j.ydbio.2005.09.003

PubMed ID: 16051604

Title: Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins.

PubMed ID: 16051604

DOI: 10.1074/jbc.m504778200

PubMed ID: 16322781

Title: Structure and function of the platelet integrin alphaIIbbeta3.

PubMed ID: 16322781

DOI: 10.1172/jci26989

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16982628

Title: Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans.

PubMed ID: 16982628

DOI: 10.1074/jbc.m605291200

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 17635696

Title: Platelet integrin alpha(IIb)beta(3): activation mechanisms.

PubMed ID: 17635696

DOI: 10.1111/j.1538-7836.2007.02537.x

PubMed ID: 18441324

Title: Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.

PubMed ID: 18441324

DOI: 10.1074/jbc.m801213200

PubMed ID: 18317590

Title: Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.

PubMed ID: 18317590

DOI: 10.1172/jci33374

PubMed ID: 18635536

Title: Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.

PubMed ID: 18635536

DOI: 10.1074/jbc.m804835200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18045938

Title: Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor.

PubMed ID: 18045938

DOI: 10.1128/jvi.01673-07

PubMed ID: 19494351

Title: Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101-positive antigen-presenting cells.

PubMed ID: 19494351

DOI: 10.1182/blood-2009-04-211839

PubMed ID: 19141530

Title: Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta.

PubMed ID: 19141530

DOI: 10.1096/fj.08-117564

PubMed ID: 19578119

Title: The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.

PubMed ID: 19578119

DOI: 10.1074/jbc.m109.013201

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20702409

Title: Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.

PubMed ID: 20702409

DOI: 10.1074/jbc.c110.134247

PubMed ID: 20682778

Title: Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.

PubMed ID: 20682778

DOI: 10.1074/jbc.m110.113878

PubMed ID: 22492581

Title: DICAM inhibits osteoclast differentiation through attenuation of the integrin alphaVbeta3 pathway.

PubMed ID: 22492581

DOI: 10.1002/jbmr.1632

PubMed ID: 23125415

Title: Integrins alphavbeta3 and alpha4beta1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.

PubMed ID: 23125415

DOI: 10.4049/jimmunol.1200889

PubMed ID: 23658209

Title: Integrins modulate the infection efficiency of West Nile virus into cells.

PubMed ID: 23658209

DOI: 10.1099/vir.0.052613-0

PubMed ID: 24478423

Title: Roles of the putative integrin-binding motif of the human metapneumovirus fusion (f) protein in cell-cell fusion, viral infectivity, and pathogenesis.

PubMed ID: 24478423

DOI: 10.1128/jvi.03491-13

PubMed ID: 24789099

Title: The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.

PubMed ID: 24789099

DOI: 10.1371/journal.pone.0096372

PubMed ID: 25398877

Title: Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins alphavbeta3, alpha4beta1, and alpha5beta1.

PubMed ID: 25398877

DOI: 10.1074/jbc.m114.579946

PubMed ID: 27993971

Title: The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin alphavbeta3.

PubMed ID: 27993971

DOI: 10.1042/bcj20160998

PubMed ID: 28302677

Title: The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis.

PubMed ID: 28302677

DOI: 10.1042/bsr20170173

PubMed ID: 29030430

Title: Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta.

PubMed ID: 29030430

DOI: 10.1074/jbc.m117.818302

PubMed ID: 28873464

Title: Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.

PubMed ID: 28873464

DOI: 10.1371/journal.pone.0184285

PubMed ID: 29301984

Title: Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4.

PubMed ID: 29301984

DOI: 10.1042/bcj20170867

PubMed ID: 31331973

Title: Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.

PubMed ID: 31331973

DOI: 10.4049/jimmunol.1801630

PubMed ID: 33436497

Title: Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications.

PubMed ID: 33436497

DOI: 10.1126/scisignal.abd0334

PubMed ID: 33436498

Title: Cytoplasmic short linear motifs in ACE2 and integrin beta3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy.

PubMed ID: 33436498

DOI: 10.1126/scisignal.abf1117

PubMed ID: 35687021

Title: PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.

PubMed ID: 35687021

DOI: 10.1083/jcb.202108027

PubMed ID: 11546839

Title: Crystal structure of the extracellular segment of integrin alpha Vbeta3.

PubMed ID: 11546839

DOI: 10.1126/science.1064535

PubMed ID: 15378069

Title: Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics.

PubMed ID: 15378069

DOI: 10.1038/nature02976

PubMed ID: 17583734

Title: Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity.

PubMed ID: 17583734

DOI: 10.1016/j.jmb.2007.05.025

PubMed ID: 19111664

Title: Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.

PubMed ID: 19111664

DOI: 10.1016/j.molcel.2008.11.018

PubMed ID: 19704023

Title: Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.

PubMed ID: 19704023

DOI: 10.1083/jcb.200905085

PubMed ID: 7878622

Title: Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.

PubMed ID: 7878622

PubMed ID: 2565345

Title: The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing.

PubMed ID: 2565345

DOI: 10.1172/jci114082

PubMed ID: 1430225

Title: An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system.

PubMed ID: 1430225

DOI: 10.1172/jci116084

PubMed ID: 8093349

Title: Single point mutation in human glycoprotein IIIa is associated with a new platelet-specific alloantigen (Mo) involved in neonatal alloimmune thrombocytopenia.

PubMed ID: 8093349

PubMed ID: 7694683

Title: Amino acid 489 is encoded by a mutational 'hot spot' on the beta 3 integrin chain: the CA/TU human platelet alloantigen system.

PubMed ID: 7694683

PubMed ID: 8132570

Title: A point mutation leads to an unpaired cysteine residue and a molecular weight polymorphism of a functional platelet beta 3 integrin subunit. The Sra alloantigen system of GPIIIa.

PubMed ID: 8132570

DOI: 10.1016/s0021-9258(17)37213-7

PubMed ID: 2392682

Title: A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation.

PubMed ID: 2392682

DOI: 10.1126/science.2392682

PubMed ID: 1371279

Title: A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site.

PubMed ID: 1371279

DOI: 10.1016/s0021-9258(19)50595-6

PubMed ID: 1602006

Title: A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg-->214Trp mutation.

PubMed ID: 1602006

DOI: 10.1172/jci115808

PubMed ID: 1438206

Title: Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.

PubMed ID: 1438206

DOI: 10.1073/pnas.89.21.10169

PubMed ID: 8781422

Title: A Cys374Tyr homozygous mutation of platelet glycoprotein IIIa (beta 3) in a Chinese patient with Glanzmann's thrombasthenia.

PubMed ID: 8781422

PubMed ID: 9376589

Title: A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface.

PubMed ID: 9376589

PubMed ID: 9215749

Title: Hematologically important mutations: Glanzmann thrombasthenia.

PubMed ID: 9215749

DOI: 10.1006/bcmd.1997.0117

PubMed ID: 9790984

Title: Three novel integrin beta3 subunit missense mutations (H280P, C560F, and G579S) in thrombasthenia, including one (H280P) prevalent in Japanese patients.

PubMed ID: 9790984

DOI: 10.1006/bbrc.1998.9526

PubMed ID: 9684783

Title: A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia.

PubMed ID: 9684783

PubMed ID: 10233432

Title: Homozygous Cys542-->Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann's thrombasthenia.

PubMed ID: 10233432

DOI: 10.1111/j.1365-2141.1999.01376.x

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 11588040

Title: A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype.

PubMed ID: 11588040

DOI: 10.1182/blood.v98.8.2432

PubMed ID: 12036875

Title: A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia.

PubMed ID: 12036875

DOI: 10.1182/blood.v99.12.4449

PubMed ID: 11897046

Title: A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia.

PubMed ID: 11897046

DOI: 10.1080/09537100220122466

PubMed ID: 12083483

Title: Glanzmann's thrombasthenia: identification of 19 new mutations in 30 patients.

PubMed ID: 12083483

PubMed ID: 12353082

Title: Two new beta3 integrin mutations in Indian patients with Glanzmann thrombasthenia: localization of mutations affecting cysteine residues in integrin beta3.

PubMed ID: 12353082

DOI: 10.1055/s-0037-1613244

PubMed ID: 15583747

Title: A variant thrombasthenic phenotype associated with compound heterozygosity of integrin beta3-subunit: (Met124Val)beta3 alters the subunit dimerization rendering a decreased number of constitutive active alphaIIbbeta3 receptors.

PubMed ID: 15583747

DOI: 10.1160/th04-06-0380

PubMed ID: 15634267

Title: Double heterozygosity for a novel missense mutation of Ile304 to Asn in addition to the missense mutation His280 to Pro in the integrin beta3 gene as a cause of the absence of platelet alphaIIbbeta3 in Glanzmann's thrombasthenia.

PubMed ID: 15634267

DOI: 10.1111/j.1538-7836.2004.00990.x

PubMed ID: 15748237

Title: Mutations in GPIIIa molecule as a cause for Glanzmann thrombasthenia in Indian patients.

PubMed ID: 15748237

DOI: 10.1111/j.1538-7836.2005.01159.x

PubMed ID: 18065693

Title: A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia.

PubMed ID: 18065693

DOI: 10.1182/blood-2007-09-112615

PubMed ID: 20020534

Title: AlphaIIbbeta3 integrin: new allelic variants in Glanzmann thrombasthenia, effects on ITGA2B and ITGB3 mRNA splicing, expression, and structure-function.

PubMed ID: 20020534

DOI: 10.1002/humu.21179

PubMed ID: 29084015

Title: Molecular characterization of Glanzmann's thrombasthenia in Iran: identification of three novel mutations.

PubMed ID: 29084015

DOI: 10.1097/mbc.0000000000000673

PubMed ID: 29380037

Title: A novel heterozygous ITGB3 p.T720del inducing spontaneous activation of integrin alphaIIbbeta3 in autosomal dominant macrothrombocytopenia with aggregation dysfunction.

PubMed ID: 29380037

DOI: 10.1007/s00277-017-3214-4

Sequence Information:

  • Length: 788
  • Mass: 87058
  • Checksum: F246623608E05F9E
  • Sequence:
    • MRARPRPRPL WATVLALGAL AGVGVGGPNI CTTRGVSSCQ QCLAVSPMCA WCSDEALPLG 
SPRCDLKENL LKDNCAPESI EFPVSEARVL EDRPLSDKGS GDSSQVTQVS PQRIALRLRP 
DDSKNFSIQV RQVEDYPVDI YYLMDLSYSM KDDLWSIQNL GTKLATQMRK LTSNLRIGFG 
AFVDKPVSPY MYISPPEALE NPCYDMKTTC LPMFGYKHVL TLTDQVTRFN EEVKKQSVSR 
NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVQPNDGQCH 
VGSDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VNLYQNYSEL IPGTTVGVLS 
MDSSNVLQLI VDAYGKIRSK VELEVRDLPE ELSLSFNATC LNNEVIPGLK SCMGLKIGDT 
VSFSIEAKVR GCPQEKEKSF TIKPVGFKDS LIVQVTFDCD CACQAQAEPN SHRCNNGNGT 
FECGVCRCGP GWLGSQCECS EEDYRPSQQD ECSPREGQPV CSQRGECLCG QCVCHSSDFG 
KITGKYCECD DFSCVRYKGE MCSGHGQCSC GDCLCDSDWT GYYCNCTTRT DTCMSSNGLL 
CSGRGKCECG SCVCIQPGSY GDTCEKCPTC PDACTFKKEC VECKKFDRGA LHDENTCNRY 
CRDEIESVKE LKDTGKDAVN CTYKNEDDCV VRFQYYEDSS GKSILYVVEE PECPKGPDIL 
VVLLSVMGAI LLIGLAALLI WKLLITIHDR KEFAKFEEER ARAKWDTANN PLYKEATSTF 
TNITYRGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.