Associated with
Other Information
Genular Protein ID: 233813695
Symbol: DCR2_DROME
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10731132
Title: The genome sequence of Drosophila melanogaster.
PubMed ID: 10731132
PubMed ID: 12537572
Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
PubMed ID: 12537572
PubMed ID: 15066283
Title: Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.
PubMed ID: 15066283
PubMed ID: 15550672
PubMed ID: 16554838
Title: Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila.
PubMed ID: 16554838
DOI: 10.1038/ni1335
PubMed ID: 18953338
Title: The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila.
PubMed ID: 18953338
DOI: 10.1038/ni.1664
PubMed ID: 19635780
Title: Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.
PubMed ID: 19635780
DOI: 10.1261/rna.1611309
PubMed ID: 21419681
Title: Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease.
PubMed ID: 21419681
PubMed ID: 21245036
Title: Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila.
PubMed ID: 21245036
DOI: 10.1093/nar/gkq1324
PubMed ID: 23063653
Title: Dicer partner proteins tune the length of mature miRNAs in flies and mammals.
PubMed ID: 23063653
PubMed ID: 24009507
Title: Functional specialization of the small interfering RNA pathway in response to virus infection.
PubMed ID: 24009507
PubMed ID: 24488111
Title: Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain.
PubMed ID: 24488111
PubMed ID: 25891075
Title: Drosophila dicer-2 cleavage is mediated by helicase- and dsRNA termini-dependent states that are modulated by Loquacious-PD.
PubMed ID: 25891075
PubMed ID: 26257286
Title: TAF11 Assembles the RISC Loading Complex to Enhance RNAi Efficiency.
PubMed ID: 26257286
PubMed ID: 26601278
Title: Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling.
PubMed ID: 26601278
PubMed ID: 27872309
Title: Phosphate-binding pocket in Dicer-2 PAZ domain for high-fidelity siRNA production.
PubMed ID: 27872309
PubMed ID: 29040648
Title: Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference.
PubMed ID: 29040648
DOI: 10.1093/nar/gkx886
PubMed ID: 28874570
Title: Loquacious-PD facilitates Drosophila Dicer-2 cleavage through interactions with the helicase domain and dsRNA.
PubMed ID: 28874570
PubMed ID: 28416567
Title: The C-terminal dsRNA-binding domain of Drosophila Dicer-2 is crucial for efficient and high-fidelity production of siRNA and loading of siRNA to Argonaute2.
PubMed ID: 28416567
PubMed ID: 29317541
Title: Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation.
PubMed ID: 29317541
PubMed ID: 29550490
Title: Loquacious-PD removes phosphate inhibition of Dicer-2 processing of hairpin RNAs into siRNAs.
PubMed ID: 29550490
PubMed ID: 32843367
Title: In vitro studies provide insight into effects of Dicer-2 helicase mutations in Drosophila melanogaster.
PubMed ID: 32843367
PubMed ID: 34590626
Title: Loquacious-PD regulates the terminus-dependent molecular recognition of Dicer-2 toward double-stranded RNA.
PubMed ID: 34590626
DOI: 10.1039/d1cc03843e
PubMed ID: 34257295
Title: Single-molecule analysis of processive double-stranded RNA cleavage by Drosophila Dicer-2.
PubMed ID: 34257295
PubMed ID: 29269422
Title: Dicer uses distinct modules for recognizing dsRNA termini.
PubMed ID: 29269422
PubMed ID: 35768503
Title: Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex.
PubMed ID: 35768503
PubMed ID: 35768513
Title: Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD.
PubMed ID: 35768513
Sequence Information:
- Length: 1722
- Mass: 197765
- Checksum: 73755021033C399A
- Sequence:
MEDVEIKPRG YQLRLVDHLT KSNGIVYLPT GSGKTFVAIL VLKRFSQDFD KPIESGGKRA LFMCNTVELA RQQAMAVRRC TNFKVGFYVG EQGVDDWTRG MWSDEIKKNQ VLVGTAQVFL DMVTQTYVAL SSLSVVIIDE CHHGTGHHPF REFMRLFTIA NQTKLPRVVG LTGVLIKGNE ITNVATKLKE LEITYRGNII TVSDTKEMEN VMLYATKPTE VMVSFPHQEQ VLTVTRLISA EIEKFYVSLD LMNIGVQPIR RSKSLQCLRD PSKKSFVKQL FNDFLYQMKE YGIYAASIAI ISLIVEFDIK RRQAETLSVK LMHRTALTLC EKIRHLLVQK LQDMTYDDDD DNVNTEEVIM NFSTPKVQRF LMSLKVSFAD KDPKDICCLV FVERRYTCKC IYGLLLNYIQ STPELRNVLT PQFMVGRNNI SPDFESVLER KWQKSAIQQF RDGNANLMIC SSVLEEGIDV QACNHVFILD PVKTFNMYVQ SKGRARTTEA KFVLFTADKE REKTIQQIYQ YRKAHNDIAE YLKDRVLEKT EPELYEIKGH FQDDIDPFTN ENGAVLLPNN ALAILHRYCQ TIPTDAFGFV IPWFHVLQED ERDRIFGVSA KGKHVISINM PVNCMLRDTI YSDPMDNVKT AKISAAFKAC KVLYSLGELN ERFVPKTLKE RVASIADVHF EHWNKYGDSV TATVNKADKS KDRTYKTECP LEFYDALPRV GEICYAYEIF LEPQFESCEY TEHMYLNLQT PRNYAILLRN KLPRLAEMPL FSNQGKLHVR VANAPLEVII QNSEQLELLH QFHGMVFRDI LKIWHPFFVL DRRSKENSYL VVPLILGAGE QKCFDWELMT NFRRLPQSHG SNVQQREQQP APRPEDFEGK IVTQWYANYD KPMLVTKVHR ELTPLSYMEK NQQDKTYYEF TMSKYGNRIG DVVHKDKFMI EVRDLTEQLT FYVHNRGKFN AKSKAKMKVI LIPELCFNFN FPGDLWLKLI FLPSILNRMY FLLHAEALRK RFNTYLNLHL LPFNGTDYMP RPLEIDYSLK RNVDPLGNVI PTEDIEEPKS LLEPMPTKSI EASVANLEIT EFENPWQKYM EPVDLSRNLL STYPVELDYY YHFSVGNVCE MNEMDFEDKE YWAKNQFHMP TGNIYGNRTP AKTNANVPAL MPSKPTVRGK VKPLLILQKT VSKEHITPAE QGEFLAAITA SSAADVFDME RLEILGDSFL KLSATLYLAS KYSDWNEGTL TEVKSKLVSN RNLLFCLIDA DIPKTLNTIQ FTPRYTWLPP GISLPHNVLA LWRENPEFAK IIGPHNLRDL ALGDEESLVK GNCSDINYNR FVEGCRANGQ SFYAGADFSS EVNFCVGLVT IPNKVIADTL EALLGVIVKN YGLQHAFKML EYFKICRADI DKPLTQLLNL ELGGKKMRAN VNTTEIDGFL INHYYLEKNL GYTFKDRRYL LQALTHPSYP TNRITGSYQE LEFIGDAILD FLISAYIFEN NTKMNPGALT DLRSALVNNT TLACICVRHR LHFFILAENA KLSEIISKFV NFQESQGHRV TNYVRILLEE ADVQPTPLDL DDELDMTELP HANKCISQEA EKGVPPKGEF NMSTNVDVPK ALGDVLEALI AAVYLDCRDL QRTWEVIFNL FEPELQEFTR KVPINHIRQL VEHKHAKPVF SSPIVEGETV MVSCQFTCME KTIKVYGFGS NKDQAKLSAA KHALQQLSKC DA
Genular Protein ID: 155083878
Symbol: A0A0B4LFK8_DROME
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10731132
Title: The genome sequence of Drosophila melanogaster.
PubMed ID: 10731132
PubMed ID: 12537568
Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.
PubMed ID: 12537568
PubMed ID: 12537572
Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
PubMed ID: 12537572
PubMed ID: 12537573
Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.
PubMed ID: 12537573
PubMed ID: 12537574
Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.
PubMed ID: 12537574
PubMed ID: 16110336
Title: Combined evidence annotation of transposable elements in genome sequences.
PubMed ID: 16110336
PubMed ID: 17569856
Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
PubMed ID: 17569856
PubMed ID: 17569867
Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
PubMed ID: 17569867
Sequence Information:
- Length: 1721
- Mass: 197710
- Checksum: 0E196ADE24E7AC77
- Sequence:
MEDVEIKPRG YQLRLVDHLT KSNGIVYLPT GSGKTFVAIL VLKRFSQDFD KPIESGGKRA LFMCNTVELA RQQAMAVRRC TNFKVGFYVG EQGVDDWTRG MWSDEIKKNQ VLVGTAQVFL DMVTQTYVAL SSLSVVIIDE CHHGTGHHPF REFMRLFTIA NQTKLPRVVG LTGVLIKGNE ITNVATKLKE LEITYRGNII TVSDTKEMEN VMLYATKPTE VMVSFPHQEQ VLTVTRLISA EIEKFYVSLD LMNIGVQPIR RSKSLQCLRD PSKKSFVKQL FNDFLYQMKE YGIYAASIAI ISLIVEFDIK RRQAETLSVK LMHRTALTLC EKIRHLLVQK LQDMTYDDDD DNVNTEEVIM NFSTPKVQRF LMSLKVSFAD KDPKDICCLV FVERRYTCKC IYGLLLNYIQ STPELRNVLT PQFMVGRNNI SPDFESVLER KWQKSAIQQF RDGNANLMIC SSVLEEGIDV QACNHVFILD PVKTFNMYVQ SKGRARTTEA KFVLFTADKE REKTIQQIYQ YRKAHNDIAE YLKDRVLEKT EPELYEIKGH FQDDIDPFTN ENGAVLLPNN ALAILHRYCQ TIPTDAFGFV IPWFHVLQED ERDRIFGVSA KGKHVISINM PVNCMLRDTI YSDPMDNVKT AKISAAFKAC KVLYSLGELN ERFVPKTLKE RVASIADVHF EHWNKYGDMT ATVNKADKSK DRTYKTECPL EFYDALPRVG EICYAYEIFL EPQFESCEYT EHMYLNLQTP RNYAILLRNK LPRLAEMPLF SNQGKLHVRV ANAPLEVIIQ NSEQLELLHQ FHGMVFRDIL KIWHPFFVLD RRSKENSYLV VPLILGAGEQ KCFDWELMTN FRRLPQSHGS NVQQREQQPA PRPEDFEGKI VTQWYANYDK PMLVTKVHRE LTPLSYMEKN QQDKTYYEFT MSKYGNRIGD VVHKDKFMIE VRDLTEQLTF YVHNRGKFNA KSKAKMKVIL IPELCFNFNF PGDLWLKLIF LPSILNRMYF LLHAEALRKR FNTYLNLHLL PFNGTDYMPR PLEIDYSLKR NVDPLGNVIP TEDIEEPKSL LEPMPTKSIE ASVANLEITE FENPWQKYME PVDLSRNLLS TYPVELDYYY HFSVGNVCEM NEMDFEDKEY WAKNQFHMPT GNIYGNRTPA KTNANVPALM PSKPTVRGKV KPLLILQKTV SKEHITPAEQ GEFLAAITAS SAADVFDMER LEILGDSFLK LSATLYLASK YSDWNEGTLT EVKSKLVSNR NLLFCLIDAD IPKTLNTIQF TPRYTWLPPG ISLPHNVLAL WRENPEFAKI IGPHNLRDLA LGDEESLVKG NCSDINYNRF VEGCRANGQS FYAGADFSSE VNFCVGLVTI PNKVIADTLE ALLGVIVKNY GLQHAFKMLE YFKICRADID KPLTQLLNLE LGGKKMRANV NTTEIDGFLI NHYYLEKNLG YTFKDRRYLL QALTHPSYPT NRITGSYQEL EFIGDAILDF LISAYIFENN TKMNPGALTD LRSALVNNTT LACICVRHRL HFFILAENAK LSEIISKFVN FQESQGHRVT NYVRILLEEA DVQPTPLDLD DELDMTELPH ANKCISQEAE KGVPPKGEFN MSTNVDVPKA LGDVLEALIA AVYLDCRDLQ RTWEVIFNLF EPELQEFTRK VPINHIRQLV EHKHAKPVFS SPIVEGETVM VSCQFTCMEK TIKVYGFGSN KDQAKLSAAK HALQQLSKCD A
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.