Smurf | FBgn0029006 | NCBI 36999

Details for: Smurf

Gene ID: 36999

Symbol: Smurf

Ensembl ID: FBgn0029006

Description: SMAD specific E3 ubiquitin protein ligase

Associated with

Adaptive immune system
(R-DME-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-DME-983168)
Asymmetric localization of pcp proteins
(R-DME-4608870)
Beta-catenin independent wnt signaling
(R-DME-3858494)
Class i mhc mediated antigen processing & presentation
(R-DME-983169)
Degradation of axin
(R-DME-4641257)
Deubiquitination
(R-DME-5688426)
Downregulation of smad2/3:smad4 transcriptional activity
(R-DME-2173795)
Downregulation of tgf-beta receptor signaling
(R-DME-2173788)
Gene expression (transcription)
(R-DME-74160)
Generic transcription pathway
(R-DME-212436)
Hedgehog 'on' state
(R-DME-5632684)
Immune system
(R-DME-168256)
Metabolism of proteins
(R-DME-392499)
Pcp/ce pathway
(R-DME-4086400)
Post-translational protein modification
(R-DME-597592)
Regulation of runx3 expression and activity
(R-DME-8941858)
Rna polymerase ii transcription
(R-DME-73857)
Signaling by bmp
(R-DME-201451)
Signaling by hedgehog
(R-DME-5358351)
Signaling by tgf-beta receptor complex
(R-DME-170834)
Signaling by tgfb family members
(R-DME-9006936)
Signaling by wnt
(R-DME-195721)
Signal transduction
(R-DME-162582)
Tcf dependent signaling in response to wnt
(R-DME-201681)
Tgf-beta receptor signaling activates smads
(R-DME-2173789)
Tgf-beta receptor signaling in emt (epithelial to mesenchymal transition)
(R-DME-2173791)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-DME-2173793)
Transcriptional regulation by runx3
(R-DME-8878159)
Ub-specific processing proteases
(R-DME-5689880)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Embryonic development via the syncytial blastoderm
(GO:0001700)
Embryonic hindgut morphogenesis
(GO:0048619)
Germarium-derived egg chamber formation
(GO:0007293)
Male gamete generation
(GO:0048232)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of hippo signaling
(GO:0035331)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Regulation of growth
(GO:0040008)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

E3 ubiquitin-protein ligase Smurf1

Genular Protein ID: 2836759038

Symbol: SMUF1_DROME

Name: E3 ubiquitin-protein ligase Smurf1

UniProtKB Accession Codes:

Q9V853 Q9U3W2

Database IDs:

Citations:

PubMed ID: 11703946

Title: The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis.

PubMed ID: 11703946

DOI: 10.1016/s1534-5807(01)00057-0

PubMed ID: 12754252

Title: DSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development.

PubMed ID: 12754252

DOI: 10.1074/jbc.c300028200

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

Sequence Information:

Length: 1061
Mass: 115676
Checksum: 6BBCC550F5129163
Sequence:

MNKLDYPRRN GTHKVRITIL CARNLARKDL FRLPDPFAKV QVDGTGQVYS TEISKSSLDP 
KWNAHYDLFL GIGDAITITV WNQRKIHKGS GFLGCVRIPA FNIQSLKGAG FQRLDLGKLS 
PDDDELVRGQ IIISLLSKDG PSSGNPLAIV GPSGDVRGPS EDDSSEDSLP EGWEERRTDN 
GRVYYVNHAT KSTQWDRPRQ PGVVGSSHAT SPQQRHNTHN GNSGDRQAPA GPTRSTTCTN 
LMNNGHRSRD LSVTASDERR HSTEILSSVG KENTSPTTPV SATTTPGKKT SSSNSSSAGG 
RTLEQRPTNE PATPTSSTTS ASVRLHSNDN HVKTPKHQTN GHAPPESTPT SPTGQQNYVN 
GNAQNGSTSG NGSGQAAQPQ SASNGWTQED AATTTSPSTT TSPPRHSQSP PTPNISPPAS 
VTPSANGNVH SPNANSTPAG SGGGSRSYTA ATPGQRSQRR SSRQQGEESS TRRRSSRGTR 
NGGTSGGGGG GGSGQRYASA AIAAANQAAR PFLDLPPGYE MRTTQQGQVY FYHIPTGVST 
WHDPRIPRDF DTQHLTLDAI GPLPSGWEQR KTASGRVYFV DHNNRTTQFT DPRLSGSILQ 
MIRRGTVPPT SAANAGTPAP PSATPATPSA AAAVPPQATP ASNATPTTLT TTTNPPHRIV 
PDLPQGLLEG ADLLPKYRRD LVGKLRALRT ELQTMQPQSG HCRLEVSRNE IFEESYRLIM 
KMRAKDMRKR LMVKFKGEEG LDYGGVAREW LHLLSREMLN PQYGLFQYSR DDHYTLQINP 
DSGVNPDHLS YFHFVGRTLG IAVFHGHCLD GGFTTPFYKQ LLNKPITLGD IEGVDPDLHR 
SLTWMLESNI SGIIESTFSV ENNSFGALVV HELKPGGASI PVTEENKREY VKLYVNYRFM 
RGIEQQFLAL QKGFCELIPS HLLRPFDERE LELVIGGISS IDVNDWRNNT RLKHCTNETT 
QVLWFWQVVE SYSSEMRARL LQFVTGSSRV PLQGFRALQG STGAVGPRLF TIHLTADVPT 
QNLPKAHTCF NRIDLPPYET YQLLCDKLTQ AVEETCGFAV E

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smurf

Associated with

Other Information

The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis. PubMed ID: 11703946

DSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development. PubMed ID: 12754252

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132