Details for: ACADVL

Gene ID: 37

Symbol: ACADVL

Ensembl ID: ENSG00000072778

Description: acyl-CoA dehydrogenase very long chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 341.7013
    Cell Significance Index: -53.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 233.0043
    Cell Significance Index: -59.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 154.1142
    Cell Significance Index: -62.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 147.6099
    Cell Significance Index: -69.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 135.7348
    Cell Significance Index: -69.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 65.8711
    Cell Significance Index: -62.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.1673
    Cell Significance Index: -64.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.8638
    Cell Significance Index: -58.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.7838
    Cell Significance Index: -41.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.9233
    Cell Significance Index: -66.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.7022
    Cell Significance Index: -51.3000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.7464
    Cell Significance Index: 91.4100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.7405
    Cell Significance Index: 23.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.7272
    Cell Significance Index: 99.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 3.2711
    Cell Significance Index: 196.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.1788
    Cell Significance Index: 84.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.0619
    Cell Significance Index: 228.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.0248
    Cell Significance Index: 141.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.6668
    Cell Significance Index: 36.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.5731
    Cell Significance Index: 74.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.5649
    Cell Significance Index: 120.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5266
    Cell Significance Index: 131.2500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.4414
    Cell Significance Index: 41.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3417
    Cell Significance Index: 63.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.3296
    Cell Significance Index: 300.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.1235
    Cell Significance Index: 19.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1215
    Cell Significance Index: 96.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1001
    Cell Significance Index: 60.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.9569
    Cell Significance Index: 54.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.9264
    Cell Significance Index: 28.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9184
    Cell Significance Index: 135.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6205
    Cell Significance Index: 885.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.5001
    Cell Significance Index: 25.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4670
    Cell Significance Index: 264.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3018
    Cell Significance Index: 178.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2616
    Cell Significance Index: 250.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2258
    Cell Significance Index: 36.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2243
    Cell Significance Index: 121.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1967
    Cell Significance Index: 147.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1440
    Cell Significance Index: 87.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1244
    Cell Significance Index: 191.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9369
    Cell Significance Index: 414.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8839
    Cell Significance Index: 113.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8783
    Cell Significance Index: 176.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8528
    Cell Significance Index: 138.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8285
    Cell Significance Index: 21.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8279
    Cell Significance Index: 53.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8233
    Cell Significance Index: 743.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5693
    Cell Significance Index: 20.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4775
    Cell Significance Index: 7.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3468
    Cell Significance Index: 124.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2342
    Cell Significance Index: 162.0100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.1587
    Cell Significance Index: 3.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1300
    Cell Significance Index: 24.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1193
    Cell Significance Index: 14.0700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1186
    Cell Significance Index: 1.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0955
    Cell Significance Index: 69.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0728
    Cell Significance Index: 3.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0628
    Cell Significance Index: 1.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0476
    Cell Significance Index: 36.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0057
    Cell Significance Index: -10.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0118
    Cell Significance Index: -21.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0268
    Cell Significance Index: -41.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0299
    Cell Significance Index: -22.1400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0345
    Cell Significance Index: -0.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0352
    Cell Significance Index: -22.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0371
    Cell Significance Index: -50.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0399
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0568
    Cell Significance Index: -35.4600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0773
    Cell Significance Index: -0.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0819
    Cell Significance Index: -11.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0888
    Cell Significance Index: -50.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1037
    Cell Significance Index: -1.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1087
    Cell Significance Index: -49.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1117
    Cell Significance Index: -12.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1474
    Cell Significance Index: -31.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1993
    Cell Significance Index: -57.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2667
    Cell Significance Index: -30.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3087
    Cell Significance Index: -16.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3219
    Cell Significance Index: -8.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3347
    Cell Significance Index: -11.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3599
    Cell Significance Index: -24.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3822
    Cell Significance Index: -12.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3855
    Cell Significance Index: -44.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4625
    Cell Significance Index: -9.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5377
    Cell Significance Index: -11.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5611
    Cell Significance Index: -10.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5644
    Cell Significance Index: -44.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5684
    Cell Significance Index: -14.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6251
    Cell Significance Index: -65.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6474
    Cell Significance Index: -16.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6537
    Cell Significance Index: -40.1800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.6793
    Cell Significance Index: -10.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7061
    Cell Significance Index: -20.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7844
    Cell Significance Index: -15.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8014
    Cell Significance Index: -50.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8210
    Cell Significance Index: -14.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0274
    Cell Significance Index: -57.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0348
    Cell Significance Index: -63.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1351
    Cell Significance Index: -50.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics** 1. **Function**: ACADVL is a mitochondrial enzyme that catalyzes the first step in the beta-oxidation of very-long-chain fatty acids, converting them into acyl-CoA, which is then further processed by other enzymes. 2. **Subcellular localization**: The ACADVL protein is localized to the mitochondrial inner membrane, where it is embedded in the mitochondrial membrane. 3. **Expression**: ACADVL is highly expressed in various tissues, including the liver, adrenal gland, kidney, and heart, where it plays a crucial role in energy production and fatty acid metabolism. 4. **Structural features**: The ACADVL protein has a characteristic FAD-binding domain, which is essential for its enzymatic activity. **Pathways and functions** ACADVL is involved in several key pathways, including: 1. **Beta-oxidation of fatty acids**: ACADVL catalyzes the first step in the beta-oxidation of very-long-chain fatty acids, converting them into acyl-CoA. 2. **Mitochondrial fatty acid beta-oxidation**: ACADVL is a key enzyme in the mitochondrial fatty acid beta-oxidation pathway, which is essential for energy production in the mitochondria. 3. **Fatty acid metabolism**: ACADVL is involved in the regulation of fatty acid metabolism, particularly in the breakdown of fatty acids. 4. **Energy derivation by oxidation of organic compounds**: ACADVL plays a crucial role in the energy derivation by oxidation of organic compounds, particularly fatty acids. **Clinical significance** Mutations in the ACADVL gene have been associated with various disorders, including: 1. **Fatty acid oxidation deficiencies**: ACADVL mutations can lead to fatty acid oxidation deficiencies, which can cause serious health complications, including hypoglycemia, lactic acidosis, and cardiac arrhythmias. 2. **Neonatal adrenoleukodystrophy**: Mutations in the ACADVL gene have been associated with neonatal adrenoleukodystrophy, a rare genetic disorder characterized by progressive neurological and adrenal gland dysfunction. 3. **Adrenal insufficiency**: ACADVL mutations can also lead to adrenal insufficiency, particularly in individuals with adrenal gland abnormalities. In conclusion, the ACADVL gene plays a critical role in fatty acid metabolism and energy production in the mitochondria. Mutations in this gene can lead to various disorders, highlighting the importance of understanding the function and regulation of this enzyme.

Genular Protein ID: 1016093399

Symbol: ACADV_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49748 B4DEB6 F5H2A9 O76056 Q8WUL0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 85 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 64 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 2 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7668252

Title: Cloning of human very-long-chain acyl-coenzyme A dehydrogenase and molecular characterization of its deficiency in two patients.

PubMed ID: 7668252

PubMed ID: 8845838

Title: Cloning and characterization of human very-long-chain acyl-CoA dehydrogenase cDNA, chromosomal assignment of the gene and identification in four patients of nine different mutations within the VLCAD gene.

PubMed ID: 8845838

DOI: 10.1093/hmg/5.4.461

PubMed ID: 8554625

Title: Genomic DNA organization of human mitochondrial very-long-chain acyl-CoA dehydrogenase and mutation analysis.

PubMed ID: 8554625

DOI: 10.1006/bbrc.1995.2867

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7769092

Title: Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients.

PubMed ID: 7769092

DOI: 10.1172/jci117947

PubMed ID: 9461620

Title: Catalytic and FAD-binding residues of mitochondrial very long chain acyl-coenzyme A dehydrogenase.

PubMed ID: 9461620

DOI: 10.1074/jbc.273.7.4227

PubMed ID: 9973285

Title: Clear correlation of genotype with disease phenotype in very-long-chain acyl-CoA dehydrogenase deficiency.

PubMed ID: 9973285

DOI: 10.1086/302261

PubMed ID: 17374501

Title: Expression and characterization of mutations in human very long-chain acyl-CoA dehydrogenase using a prokaryotic system.

PubMed ID: 17374501

DOI: 10.1016/j.ymgme.2007.01.013

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21237683

Title: Identification and characterization of new long chain acyl-CoA dehydrogenases.

PubMed ID: 21237683

DOI: 10.1016/j.ymgme.2010.12.005

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 18227065

Title: Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase.

PubMed ID: 18227065

DOI: 10.1074/jbc.m709135200

PubMed ID: 8554073

Title: Mutation analysis of very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) deficiency: identification and characterization of mutant VLCAD cDNAs from four patients.

PubMed ID: 8554073

PubMed ID: 9546340

Title: Very long chain acyl-coenzyme A dehydrogenase deficiency with adult onset.

PubMed ID: 9546340

DOI: 10.1002/ana.410430422

PubMed ID: 9839948

Title: Relationship between structure and substrate-chain-length specificity of mitochondrial very-long-chain acyl-coenzyme A dehydrogenase.

PubMed ID: 9839948

DOI: 10.1046/j.1432-1327.1998.2570592.x

PubMed ID: 9599005

Title: Very-long-chain acyl-CoA dehydrogenase subunit assembles to the dimer form on mitochondrial inner membrane.

PubMed ID: 9599005

DOI: 10.1016/s0014-5793(98)00343-3

PubMed ID: 10077518

Title: Molecular heterogeneity in very-long-chain acyl-CoA dehydrogenase deficiency causing pediatric cardiomyopathy and sudden death.

PubMed ID: 10077518

DOI: 10.1161/01.cir.99.10.1337

Sequence Information:

  • Length: 655
  • Mass: 70390
  • Checksum: A5594D1EA7911D19
  • Sequence:
    • MQAARMAASL GRQLLRLGGG SSRLTALLGQ PRPGPARRPY AGGAAQLALD KSDSHPSDAL 
TRKKPAKAES KSFAVGMFKG QLTTDQVFPY PSVLNEEQTQ FLKELVEPVS RFFEEVNDPA 
KNDALEMVEE TTWQGLKELG AFGLQVPSEL GGVGLCNTQY ARLVEIVGMH DLGVGITLGA 
HQSIGFKGIL LFGTKAQKEK YLPKLASGET VAAFCLTEPS SGSDAASIRT SAVPSPCGKY 
YTLNGSKLWI SNGGLADIFT VFAKTPVTDP ATGAVKEKIT AFVVERGFGG ITHGPPEKKM 
GIKASNTAEV FFDGVRVPSE NVLGEVGSGF KVAMHILNNG RFGMAAALAG TMRGIIAKAV 
DHATNRTQFG EKIHNFGLIQ EKLARMVMLQ YVTESMAYMV SANMDQGATD FQIEAAISKI 
FGSEAAWKVT DECIQIMGGM GFMKEPGVER VLRDLRIFRI FEGTNDILRL FVALQGCMDK 
GKELSGLGSA LKNPFGNAGL LLGEAGKQLR RRAGLGSGLS LSGLVHPELS RSGELAVRAL 
EQFATVVEAK LIKHKKGIVN EQFLLQRLAD GAIDLYAMVV VLSRASRSLS EGHPTAQHEK 
MLCDTWCIEA AARIREGMAA LQSDPWQQEL YRNFKSISKA LVERGGVVTS NPLGF

Genular Protein ID: 1807849729

Symbol: B3KPA6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KPA6

Database IDs:

ARBA 23 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 36 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 GO 4 Gene3D 3 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 8 RefSeq 1 Rhea 28 RuleBase 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 579
  • Mass: 62582
  • Checksum: F354E18C74751AE8
  • Sequence:
    • MFKGQLTTDQ VFPYPSVLNE EQTQFLKELV EPVSRFFEEV NDPAKNDALE MVEETTWQGL 
KELGAFGLQV PSELGGVGLC NTQYARLVEI VGMHDLGVGI TLGAHQSIGF KGILLFGTKA 
QKEKYLPKLA SGETVAAFCL TEPSSGSDAA SIRTSAVPSP CGKYYTLNGS KLWISNGGLA 
DIFTVFAKTP VTDPATGAVK EKITAFVVER GFGGITHGPP EKKMGIKASN TAEVFFDGVR 
VPSENVLGEV GSGFKVAMHI LNNGRFGMAA ALAGTMRGII AKAVDHATNR TQFGEKIHNF 
GLIQEKLARM VMLQYVTESM AYMVSANMDQ GATDFQIEAA ISKIFGSEAA WKVTDECIQI 
MGGMGFMKEP GVERVLRDLR IFRIFEGTND ILRLFVALQG CMDKGKELSG LGSALKNPFG 
NAGLLLGEAG KQLRRRAGLG SGLSLSGLVH PELSRSGELA VRALEQFATV VEAKLIKHKK 
GIVNEQFLLQ RLADGAIDLY AMVVVLSRAS RSLSEGHPTA QHEKMLCDTW CIEAAARIRE 
GMAALQSDPW QQELYRNFKS ISKALVERGG VVTSNPLGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.