Details for: ACADVL
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 65.58rCSI 69.68%PRS 21.71
-
CSI 55.36rCSI 57.99%PRS 11.39
-
CSI 54.81rCSI 52.85%PRS 8.35
-
CSI 53.08rCSI 52.98%PRS 10.46
-
CSI 49.88rCSI 58.58%PRS 14.42
-
CSI 42.43rCSI 65.56%PRS 11.46
-
CSI 40.46rCSI 42.28%PRS 12.87
-
CSI 36.62rCSI 59.05%PRS 19.55
-
CSI 32.24rCSI 42.84%PRS 13.37
-
CSI 31.28rCSI 44.84%PRS 16.78
-
CSI 30.85rCSI 60%PRS 12.49
-
CSI 29.15rCSI 69.96%PRS 22.32
-
CSI 28.55rCSI 29.91%PRS 13.05
-
CSI 23.56rCSI 29.14%PRS 10.73
-
CSI 22.63rCSI 32.62%PRS 19.72
-
CSI 22.48rCSI 64.77%PRS 23.78
-
CSI 21.44rCSI 50.96%PRS 18.44
-
CSI 20.81rCSI 70.35%PRS 20.56
-
CSI 20.6rCSI 43.86%PRS 19.75
-
CSI 20.04rCSI 16.61%PRS 11.54
-
CSI 18.58rCSI 16.49%PRS 12.25
-
CSI 17.07rCSI 44.53%PRS 19.67
-
CSI 16.68rCSI 39.15%PRS 18.68
-
CSI 16.07rCSI 46.54%PRS 13.84
-
CSI 15.5rCSI 19.87%PRS 14.13
-
CSI 14.9rCSI 15.97%PRS 11.25
-
CSI 13.66rCSI 29.82%PRS 24.69
-
CSI 13.47rCSI 10.59%PRS 14.52
-
CSI 12.84rCSI 35.98%PRS 18.91
-
CSI 12.35rCSI 15.36%PRS 12.92
-
CSI 12.27rCSI 33.07%PRS 15.76
-
CSI 12.23rCSI 18.71%PRS 19.89
-
CSI 12.05rCSI 21.89%PRS 18.71
-
CSI 11.53rCSI 45.91%PRS 21.48
-
CSI 11.24rCSI 10.62%PRS 12.78
-
CSI 11.19rCSI 9.38%PRS 14.66
-
CSI 10.86rCSI 20.74%PRS 28.9
-
CSI 10.44rCSI 10.27%PRS 13.27
-
CSI 10.26rCSI 41%PRS 26.84
-
CSI 10.09rCSI 43.58%PRS 23.42
-
CSI 9.63rCSI 50.6%PRS 21.86
-
CSI 9.43rCSI 43.98%PRS 29.13
-
CSI 9.25rCSI 40.63%PRS 22.8
-
CSI 9.17rCSI 43%PRS 32.81
-
CSI 9.04rCSI 52.61%PRS 18.39
-
CSI 8.88rCSI 6.89%PRS 11.65
-
CSI 8.7rCSI 8.37%PRS 12.66
-
CSI 8.62rCSI 30.58%PRS 20.07
-
CSI 8.58rCSI 7.88%PRS 13.96
-
CSI 8.19rCSI 61.5%PRS 22.54
-
CSI 7.27rCSI 10.65%PRS 14.3
-
CSI 6.76rCSI 17.55%PRS 16.41
-
CSI 6.66rCSI 54.2%PRS 12.65
-
CSI 6.56rCSI 12.39%PRS 15.18
-
CSI 6.48rCSI 35.27%PRS 30.21
-
CSI 6.33rCSI 5.48%PRS 13.62
-
CSI 6.24rCSI 8.18%PRS 51.89
-
CSI 6.16rCSI 4.28%PRS 14.32
-
CSI 5.75rCSI 62.55%PRS 23.64
-
CSI 5.71rCSI 10.22%PRS 11.39
-
CSI 5.62rCSI 24.99%PRS 12.05
-
CSI 5.57rCSI 6.27%PRS 19.58
-
CSI 5.33rCSI 24.43%PRS 34.21
-
CSI 5.23rCSI 6.74%PRS 7.48
-
CSI 5.22rCSI 36.86%PRS 37.58
-
CSI 5.14rCSI 7.9%PRS 17.47
-
CSI 5.01rCSI 30.04%PRS 19.23
-
CSI 4.97rCSI 6.89%PRS 17.63
-
CSI 4.96rCSI 52.51%PRS 17.23
-
CSI 4.95rCSI 6.15%PRS 6.63
-
CSI 4.94rCSI 42.67%PRS 22.23
-
CSI 4.86rCSI 4.52%PRS 12.27
-
CSI 4.84rCSI 6.95%PRS 9.56
-
CSI 4.8rCSI 5%PRS 12.56
-
CSI 4.77rCSI 4.01%PRS 19.7
-
CSI 4.74rCSI 10.49%PRS 11.35
-
CSI 4.68rCSI 3.56%PRS 15.99
-
CSI 4.65rCSI 5.1%PRS 13.98
-
CSI 4.65rCSI 7.94%PRS 24.65
-
CSI 4.62rCSI 45.4%PRS 34.76
-
CSI 4.59rCSI 6.78%PRS 19.25
-
CSI 4.54rCSI 50.73%PRS 40
-
CSI 4.51rCSI 16.31%PRS 20.98
-
CSI 4.46rCSI 17.34%PRS 17.19
-
CSI 4.44rCSI 12.84%PRS 27.21
-
CSI 4.42rCSI 3.81%PRS 19.84
-
CSI 4.29rCSI 5.86%PRS 13.56
-
CSI 4.28rCSI 3.48%PRS 12.94
-
CSI 4.11rCSI 6.49%PRS 12.23
-
CSI 4.03rCSI 4.15%PRS 19.92
-
CSI 4rCSI 5.02%PRS 15.57
-
CSI 3.97rCSI 39.07%PRS 36
-
CSI 3.97rCSI 11.78%PRS 18.15
-
CSI 3.95rCSI 9.43%PRS 19.07
-
CSI 3.91rCSI 5.74%PRS 16.03
-
CSI 3.81rCSI 6.18%PRS 12.47
-
CSI 3.8rCSI 3.32%PRS 16.2
-
CSI 3.75rCSI 9.7%PRS 11.4
-
CSI 3.72rCSI 3.81%PRS 22.7
-
CSI 3.61rCSI 4.6%PRS 14.21
-
CSI -12.3rCSI -14.7%PRS 21.2%
-
CSI -5.8rCSI -9.2%PRS 13.4%
-
CSI -4.9rCSI -12.0%PRS 7.0%
-
CSI -2.2rCSI -3.5%PRS 7.9%
-
CSI -1.4rCSI -4.4%PRS 7.7%
-
CSI -0.9rCSI -0.9%PRS 17.5%
-
CSI -0.9rCSI -1.3%PRS 14.1%
-
CSI -0.5rCSI -1.4%PRS 17.7%
-
CSI -0.5rCSI -1.5%PRS 8.7%
-
CSI -0.1rCSI -0.3%PRS 8.2%
-
CSI -0.1rCSI -0.1%PRS 12.3%
-
CSI 0.0rCSI 0.1%PRS 22.1%
-
CSI 0.1rCSI 0.3%PRS 20.1%
-
CSI 0.1rCSI 0.3%PRS 20.2%
-
CSI 0.1rCSI 3.3%PRS 69.6%
-
CSI 0.2rCSI 0.9%PRS 44.3%
-
CSI 0.2rCSI 3.7%PRS 41.4%
-
CSI 0.2rCSI 0.8%PRS 8.1%
-
CSI 0.2rCSI 1.4%PRS 48.5%
-
CSI 0.2rCSI 1.1%PRS 17.9%
-
CSI 0.2rCSI 1.1%PRS 4.8%
-
CSI 0.2rCSI 0.2%PRS 15.1%
-
CSI 0.2rCSI 0.3%PRS 12.1%
-
CSI 0.2rCSI 0.3%PRS 20.1%
-
CSI 0.2rCSI 0.9%PRS 30.1%
-
CSI 0.2rCSI 2.9%PRS 39.6%
-
CSI 0.2rCSI 4.0%PRS 47.8%
-
CSI 0.2rCSI 0.8%PRS 18.0%
-
CSI 0.3rCSI 0.4%PRS 9.4%
-
CSI 0.3rCSI 0.3%PRS 7.0%
-
CSI 0.3rCSI 2.1%PRS 65.7%
-
CSI 0.3rCSI 1.6%PRS 24.0%
-
CSI 0.3rCSI 0.3%PRS 20.5%
-
CSI 0.3rCSI 2.0%PRS 7.5%
-
CSI 0.3rCSI 2.1%PRS 27.3%
-
CSI 0.4rCSI 1.8%PRS 15.9%
-
CSI 0.4rCSI 1.0%PRS 11.5%
-
CSI 0.4rCSI 7.5%PRS 38.4%
-
CSI 0.4rCSI 0.6%PRS 29.6%
-
CSI 0.4rCSI 1.1%PRS 20.2%
-
CSI 0.4rCSI 2.3%PRS 22.9%
-
CSI 0.4rCSI 0.9%PRS 18.8%
-
CSI 0.4rCSI 1.5%PRS 38.0%
-
CSI 0.4rCSI 0.6%PRS 10.9%
-
CSI 0.4rCSI 0.7%PRS 12.1%
-
CSI 0.4rCSI 2.0%PRS 25.4%
-
CSI 0.4rCSI 2.3%PRS 48.8%
-
CSI 0.5rCSI 2.5%PRS 44.1%
-
CSI 0.5rCSI 2.7%PRS 38.4%
-
CSI 0.5rCSI 0.9%PRS 8.8%
-
CSI 0.5rCSI 7.1%PRS 62.7%
-
CSI 0.5rCSI 5.5%PRS 47.2%
-
CSI 0.5rCSI 1.4%PRS 10.5%
-
CSI 0.5rCSI 1.3%PRS 11.3%
-
CSI 0.5rCSI 2.6%PRS 16.6%
-
CSI 0.5rCSI 2.5%PRS 44.2%
-
CSI 0.6rCSI 1.0%PRS 24.4%
-
CSI 0.6rCSI 1.6%PRS 22.1%
-
CSI 0.6rCSI 2.0%PRS 6.6%
-
CSI 0.6rCSI 0.5%PRS 18.5%
-
CSI 0.6rCSI 4.4%PRS 44.6%
-
CSI 0.6rCSI 6.8%PRS 59.8%
-
CSI 0.7rCSI 0.9%PRS 23.3%
-
CSI 0.7rCSI 1.2%PRS 16.1%
-
CSI 0.7rCSI 1.0%PRS 14.3%
-
CSI 0.7rCSI 12.4%PRS 34.9%
-
CSI 0.7rCSI 1.0%PRS 17.1%
-
CSI 0.7rCSI 2.8%PRS 25.1%
-
CSI 0.7rCSI 1.6%PRS 8.8%
-
CSI 0.8rCSI 3.3%PRS 22.0%
-
CSI 0.8rCSI 5.2%PRS 31.7%
-
CSI 0.8rCSI 1.9%PRS 19.4%
-
CSI 0.8rCSI 1.3%PRS 9.4%
-
CSI 0.8rCSI 1.2%PRS 25.2%
-
CSI 0.8rCSI 1.2%PRS 12.5%
-
CSI 0.9rCSI 0.7%PRS 17.6%
-
CSI 0.9rCSI 1.9%PRS 16.3%
-
CSI 0.9rCSI 3.6%PRS 26.3%
-
CSI 0.9rCSI 4.2%PRS 15.8%
-
CSI 0.9rCSI 1.2%PRS 12.4%
-
CSI 0.9rCSI 4.1%PRS 11.9%
-
CSI 1.0rCSI 1.4%PRS 17.0%
-
CSI 1.0rCSI 2.1%PRS 7.5%
-
CSI 1.0rCSI 1.5%PRS 11.4%
-
CSI 1.0rCSI 1.2%PRS 18.7%
-
CSI 1.0rCSI 6.9%PRS 24.0%
-
CSI 1.0rCSI 5.9%PRS 16.3%
-
CSI 1.0rCSI 1.5%PRS 11.2%
-
CSI 1.1rCSI 2.7%PRS 15.2%
-
CSI 1.1rCSI 1.7%PRS 10.5%
-
CSI 1.1rCSI 0.8%PRS 16.9%
-
CSI 1.1rCSI 0.8%PRS 11.1%
-
CSI 1.1rCSI 6.2%PRS 45.6%
-
CSI 1.1rCSI 2.4%PRS 13.5%
-
CSI 1.1rCSI 2.9%PRS 11.3%
-
CSI 1.1rCSI 2.9%PRS 33.2%
-
CSI 1.1rCSI 0.8%PRS 18.1%
-
CSI 1.1rCSI 1.6%PRS 11.4%
-
CSI 1.1rCSI 2.9%PRS 9.3%
-
CSI 1.2rCSI 0.9%PRS 21.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1016093399
Symbol: ACADV_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7668252
Title: Cloning of human very-long-chain acyl-coenzyme A dehydrogenase and molecular characterization of its deficiency in two patients.
PubMed ID: 7668252
PubMed ID: 8845838
Title: Cloning and characterization of human very-long-chain acyl-CoA dehydrogenase cDNA, chromosomal assignment of the gene and identification in four patients of nine different mutations within the VLCAD gene.
PubMed ID: 8845838
DOI: 10.1093/hmg/5.4.461
PubMed ID: 8554625
Title: Genomic DNA organization of human mitochondrial very-long-chain acyl-CoA dehydrogenase and mutation analysis.
PubMed ID: 8554625
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7769092
Title: Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients.
PubMed ID: 7769092
DOI: 10.1172/jci117947
PubMed ID: 9461620
Title: Catalytic and FAD-binding residues of mitochondrial very long chain acyl-coenzyme A dehydrogenase.
PubMed ID: 9461620
PubMed ID: 9973285
Title: Clear correlation of genotype with disease phenotype in very-long-chain acyl-CoA dehydrogenase deficiency.
PubMed ID: 9973285
DOI: 10.1086/302261
PubMed ID: 17374501
Title: Expression and characterization of mutations in human very long-chain acyl-CoA dehydrogenase using a prokaryotic system.
PubMed ID: 17374501
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21237683
Title: Identification and characterization of new long chain acyl-CoA dehydrogenases.
PubMed ID: 21237683
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 18227065
Title: Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase.
PubMed ID: 18227065
PubMed ID: 8554073
Title: Mutation analysis of very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) deficiency: identification and characterization of mutant VLCAD cDNAs from four patients.
PubMed ID: 8554073
PubMed ID: 9546340
Title: Very long chain acyl-coenzyme A dehydrogenase deficiency with adult onset.
PubMed ID: 9546340
PubMed ID: 9839948
Title: Relationship between structure and substrate-chain-length specificity of mitochondrial very-long-chain acyl-coenzyme A dehydrogenase.
PubMed ID: 9839948
PubMed ID: 9599005
Title: Very-long-chain acyl-CoA dehydrogenase subunit assembles to the dimer form on mitochondrial inner membrane.
PubMed ID: 9599005
PubMed ID: 10077518
Title: Molecular heterogeneity in very-long-chain acyl-CoA dehydrogenase deficiency causing pediatric cardiomyopathy and sudden death.
PubMed ID: 10077518
Sequence Information:
- Length: 655
- Mass: 70390
- Checksum: A5594D1EA7911D19
- Sequence:
MQAARMAASL GRQLLRLGGG SSRLTALLGQ PRPGPARRPY AGGAAQLALD KSDSHPSDAL TRKKPAKAES KSFAVGMFKG QLTTDQVFPY PSVLNEEQTQ FLKELVEPVS RFFEEVNDPA KNDALEMVEE TTWQGLKELG AFGLQVPSEL GGVGLCNTQY ARLVEIVGMH DLGVGITLGA HQSIGFKGIL LFGTKAQKEK YLPKLASGET VAAFCLTEPS SGSDAASIRT SAVPSPCGKY YTLNGSKLWI SNGGLADIFT VFAKTPVTDP ATGAVKEKIT AFVVERGFGG ITHGPPEKKM GIKASNTAEV FFDGVRVPSE NVLGEVGSGF KVAMHILNNG RFGMAAALAG TMRGIIAKAV DHATNRTQFG EKIHNFGLIQ EKLARMVMLQ YVTESMAYMV SANMDQGATD FQIEAAISKI FGSEAAWKVT DECIQIMGGM GFMKEPGVER VLRDLRIFRI FEGTNDILRL FVALQGCMDK GKELSGLGSA LKNPFGNAGL LLGEAGKQLR RRAGLGSGLS LSGLVHPELS RSGELAVRAL EQFATVVEAK LIKHKKGIVN EQFLLQRLAD GAIDLYAMVV VLSRASRSLS EGHPTAQHEK MLCDTWCIEA AARIREGMAA LQSDPWQQEL YRNFKSISKA LVERGGVVTS NPLGF
Genular Protein ID: 1807849729
Symbol: B3KPA6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 579
- Mass: 62582
- Checksum: F354E18C74751AE8
- Sequence:
MFKGQLTTDQ VFPYPSVLNE EQTQFLKELV EPVSRFFEEV NDPAKNDALE MVEETTWQGL KELGAFGLQV PSELGGVGLC NTQYARLVEI VGMHDLGVGI TLGAHQSIGF KGILLFGTKA QKEKYLPKLA SGETVAAFCL TEPSSGSDAA SIRTSAVPSP CGKYYTLNGS KLWISNGGLA DIFTVFAKTP VTDPATGAVK EKITAFVVER GFGGITHGPP EKKMGIKASN TAEVFFDGVR VPSENVLGEV GSGFKVAMHI LNNGRFGMAA ALAGTMRGII AKAVDHATNR TQFGEKIHNF GLIQEKLARM VMLQYVTESM AYMVSANMDQ GATDFQIEAA ISKIFGSEAA WKVTDECIQI MGGMGFMKEP GVERVLRDLR IFRIFEGTND ILRLFVALQG CMDKGKELSG LGSALKNPFG NAGLLLGEAG KQLRRRAGLG SGLSLSGLVH PELSRSGELA VRALEQFATV VEAKLIKHKK GIVNEQFLLQ RLADGAIDLY AMVVVLSRAS RSLSEGHPTA QHEKMLCDTW CIEAAARIRE GMAALQSDPW QQELYRNFKS ISKALVERGG VVTSNPLGF