Details for: botv

Gene ID: 37198

Symbol: botv

Ensembl ID: FBgn0027535

Description: brother of tout-velu

Associated with

  • Acetylglucosaminyltransferase activity
    (GO:0008375)
  • Endoplasmic reticulum
    (GO:0005783)
  • Glucuronyl-galactosyl-proteoglycan 4-alpha-n-acetylglucosaminyltransferase activity
    (GO:0001888)
  • Glycosaminoglycan biosynthetic process
    (GO:0006024)
  • Glycosyltransferase activity
    (GO:0016757)
  • Golgi apparatus
    (GO:0005794)
  • Heparan sulfate proteoglycan biosynthetic process
    (GO:0015012)
  • Heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
    (GO:0015014)
  • Heparan sulfate proteoglycan metabolic process
    (GO:0030201)
  • Heparin biosynthetic process
    (GO:0030210)
  • Membrane
    (GO:0016020)
  • N-acetylglucosamine metabolic process
    (GO:0006044)
  • Protein glycosylation
    (GO:0006486)

Other Information

Genular Protein ID: 4012645805

Symbol: EXT3_DROME

Name: Exostosin-3

UniProtKB Accession Codes:

Q9XZ08

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CAZy 2 CTD 1 ChEBI 17 DNASU 1 EC 1 EMBL 3 EnsemblMetazoa 1 FlyBase 1 GO 17 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 RefSeq 1 Rhea 3 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 11832488

Title: Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation.

PubMed ID: 11832488

DOI: 10.1074/jbc.m111630200

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 10731138

Title: A Drosophila complementary DNA resource.

PubMed ID: 10731138

DOI: 10.1126/science.287.5461.2222

PubMed ID: 14645127

Title: Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans.

PubMed ID: 14645127

DOI: 10.1242/dev.00913

PubMed ID: 14998928

Title: Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation.

PubMed ID: 14998928

DOI: 10.1242/dev.01051

PubMed ID: 15056609

Title: Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways.

PubMed ID: 15056609

DOI: 10.1242/dev.01061

PubMed ID: 23720043

Title: The Drosophila GOLPH3 homolog regulates the biosynthesis of heparan sulfate proteoglycans by modulating the retrograde trafficking of exostosins.

PubMed ID: 23720043

DOI: 10.1242/dev.087171

Sequence Information:

  • Length: 972
  • Mass: 111000
  • Checksum: 2A111BD6912FFCCA
  • Sequence:
    • MPPAYDLGHS GEAYQPLDTG SGGGNEACAP NSSSAQIRHS MGFRTSWMRQ FRRYKLPMVL 
LMLLFLVSCL AYRILSVEQD APPLDLHRSS PLLDAYEDFS AMRAGDLKMR IEEMVRIKST 
VSVELRELES RRQKLQSDIS QYNQKIEELK QELLREQTEL ERLKISVEQA QVAQREAVQR 
NTPDLALPRS LLPNTLPRKS NPITGGMAAS CEMHNCFNHS RCSLTSGFPV YLYDPDEHSV 
QRKGYDIDGF LKTTLKQTLG YNAHIVKDPK HACIYLVLVG EALLEQDLLR NNRYAAQEAE 
HQQPSTPTLE NDCPVDMEKL YSLPYWGGDG RNHVLLNLAR RDLTSHRTNP LYRQNTMRAI 
VVQSAFEREQ FRPGYDLIVP PILGPPGGDV WQECAEMVPA RRKYLLTYQG ELRPKQSSLN 
PLDAFILEHL ADMAKGATQD QFVLQFQCVP ATEQQEGDSL PDWTLCGSDS SRRQLLKDST 
FSLILPPLNG RVSSTLMLAR IYEALRSGAV PVILGADELR LPYAETVDWR RTALLLPKAR 
ITELHFLLRA VQDADLLLLR RQGRLIWERY LSSVQATVDT VIASLRDRLG IPPRPVPSVI 
AQSVFNSTFI PLKSDPPVGL DTEPEESLGP IEPPYPSPAF RRNYTILRMQ AKEAWNDWLD 
PFYLYPQLPF DPALPSEAKF MGSHTGFRPI GKGLGGAGKE FGESLGGNYP REQFTIVMLT 
YEREQVLMDS LGRLYGLPYL HKVVVVWNSP KPPLDDLRWP DIGVPVAVLR APRNSLNNRF 
LPFDVIETEA VLSVDDDAHL RHDEILFGFR VWREHRDRVV GFPGRYHAWD LGNPNGQWHY 
NSNYSCELSM VLTGAAFVHK YYLYLYTYHL PQAIRDKVDE YMNCEDIAMN FLVSHITRKP 
PVKVTSRWTF RCPGCPVSLS EDDTHFQERH KCINFFSRVF GYTPLLNTQY RADSILFKTR 
IPHDKQKCFK YI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.