Details for: ARCN1

Gene ID: 372

Symbol: ARCN1

Ensembl ID: ENSG00000095139

Description: archain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 241.9232
    Cell Significance Index: -37.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 146.2289
    Cell Significance Index: -37.0900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 92.8152
    Cell Significance Index: -38.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 92.0312
    Cell Significance Index: -43.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.7247
    Cell Significance Index: -34.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 64.9010
    Cell Significance Index: -43.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.2192
    Cell Significance Index: -34.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.2744
    Cell Significance Index: -38.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.5215
    Cell Significance Index: -41.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.8858
    Cell Significance Index: -39.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.3967
    Cell Significance Index: -25.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.9999
    Cell Significance Index: -15.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8397
    Cell Significance Index: 25.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7939
    Cell Significance Index: 195.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2941
    Cell Significance Index: 210.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0758
    Cell Significance Index: 50.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9662
    Cell Significance Index: 26.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8797
    Cell Significance Index: 108.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7838
    Cell Significance Index: 141.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6522
    Cell Significance Index: 89.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6005
    Cell Significance Index: 327.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5555
    Cell Significance Index: 110.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5518
    Cell Significance Index: 54.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5271
    Cell Significance Index: 105.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5221
    Cell Significance Index: 89.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5138
    Cell Significance Index: 14.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4269
    Cell Significance Index: 19.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3983
    Cell Significance Index: 20.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3921
    Cell Significance Index: 173.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3865
    Cell Significance Index: 73.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3393
    Cell Significance Index: 7.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3088
    Cell Significance Index: 6.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3025
    Cell Significance Index: 14.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2866
    Cell Significance Index: 20.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2493
    Cell Significance Index: 89.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1891
    Cell Significance Index: 9.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1889
    Cell Significance Index: 130.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1812
    Cell Significance Index: 5.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1475
    Cell Significance Index: 18.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1325
    Cell Significance Index: 15.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1245
    Cell Significance Index: 9.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1215
    Cell Significance Index: 13.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1081
    Cell Significance Index: 3.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0996
    Cell Significance Index: 6.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0691
    Cell Significance Index: 4.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0566
    Cell Significance Index: 51.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0401
    Cell Significance Index: 0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0115
    Cell Significance Index: 21.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0026
    Cell Significance Index: 1.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0001
    Cell Significance Index: 0.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0049
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0077
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0130
    Cell Significance Index: -9.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0173
    Cell Significance Index: -31.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0189
    Cell Significance Index: -8.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0203
    Cell Significance Index: -31.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0247
    Cell Significance Index: -0.5300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0301
    Cell Significance Index: -0.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0301
    Cell Significance Index: -40.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0434
    Cell Significance Index: -24.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0526
    Cell Significance Index: -5.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0564
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0586
    Cell Significance Index: -6.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0668
    Cell Significance Index: -8.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0766
    Cell Significance Index: -16.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0939
    Cell Significance Index: -0.8700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1067
    Cell Significance Index: -1.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1435
    Cell Significance Index: -41.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1441
    Cell Significance Index: -20.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1461
    Cell Significance Index: -8.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1619
    Cell Significance Index: -2.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1681
    Cell Significance Index: -19.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1936
    Cell Significance Index: -11.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2140
    Cell Significance Index: -5.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2899
    Cell Significance Index: -19.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3389
    Cell Significance Index: -10.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3475
    Cell Significance Index: -10.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3506
    Cell Significance Index: -9.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3576
    Cell Significance Index: -28.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3616
    Cell Significance Index: -37.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4273
    Cell Significance Index: -14.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4412
    Cell Significance Index: -11.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4417
    Cell Significance Index: -23.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4446
    Cell Significance Index: -22.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5107
    Cell Significance Index: -13.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5132
    Cell Significance Index: -4.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5275
    Cell Significance Index: -32.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5576
    Cell Significance Index: -24.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5710
    Cell Significance Index: -3.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5757
    Cell Significance Index: -10.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6033
    Cell Significance Index: -9.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6174
    Cell Significance Index: -10.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6578
    Cell Significance Index: -24.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6789
    Cell Significance Index: -16.9700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.7039
    Cell Significance Index: -11.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8827
    Cell Significance Index: -22.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8936
    Cell Significance Index: -19.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9206
    Cell Significance Index: -32.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ARCN1 gene is a small gene, approximately 1.5 kilobases in length, with a relatively low expression level. It is located on chromosome 12q21.3 and is highly conserved across species. The gene encodes for the Coatomer subunit delta (COPD) protein, which is a component of the COPI-coated vesicle, a type of retrograde transport vesicle involved in the transport of proteins from the Golgi apparatus to the endoplasmic reticulum. The COPD protein plays a crucial role in the regulation of protein transport and modification, and its dysregulation has been implicated in various diseases. **Pathways and Functions** The ARCN1 gene is involved in several cellular pathways, including: 1. **Protein transport**: The COPD protein is a key component of the COPI-coated vesicle, which is responsible for the retrograde transport of proteins from the Golgi apparatus to the endoplasmic reticulum. 2. **Endoplasmic reticulum-to-Golgi transport**: The COPD protein is also involved in the transport of proteins from the endoplasmic reticulum to the Golgi apparatus, a process that is essential for protein modification and secretion. 3. **Post-translational protein modification**: The COPD protein is involved in the regulation of post-translational protein modification, including glycosylation, phosphorylation, and ubiquitination. 4. **Cellular trafficking**: The COPD protein is involved in the regulation of cellular trafficking, including the transport of proteins and lipids within the cell. **Clinical Significance** Dysregulation of the ARCN1 gene has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in the ARCN1 gene have been associated with neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Metabolic disorders**: Dysregulation of the ARCN1 gene has been implicated in metabolic disorders, including diabetes and obesity. 3. **Cancer**: The COPD protein has been shown to play a role in the regulation of cell growth and survival, and its dysregulation has been implicated in cancer. 4. **Developmental disorders**: The ARCN1 gene is also involved in the regulation of cellular development, and its dysregulation has been implicated in developmental disorders, including Down syndrome. In conclusion, the ARCN1 gene is a critical regulator of protein transport, endoplasmic reticulum-to-Golgi transport, and post-translational protein modification. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, metabolic disorders, and cancer. Further research is needed to fully understand the role of the ARCN1 gene in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 2427256437

Symbol: COPD_HUMAN

Name: Coatomer subunit delta

UniProtKB Accession Codes:

P48444 B4E1X2 E9PEU4 Q52M80

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7782067

Title: The human archain gene, ARCN1, has highly conserved homologs in rice and Drosophila.

PubMed ID: 7782067

DOI: 10.1016/0888-7543(95)80087-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27476655

Title: ARCN1 mutations cause a recognizable craniofacial syndrome due to copi-mediated transport defects.

PubMed ID: 27476655

DOI: 10.1016/j.ajhg.2016.06.011

Sequence Information:

  • Length: 511
  • Mass: 57210
  • Checksum: 4ED1F7D2D12A7F75
  • Sequence:
    • MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE TESVRYVYQP 
MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN EISEHCFDLI FAFDEIVALG 
YRENVNLAQI RTFTEMDSHE EKVFRAVRET QEREAKAEMR RKAKELQQAR RDAERQGKKA 
PGFGGFGSSA VSGGSTAAMI TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD 
KLKSEGETIM SSSMGKRTSE ATKMHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM 
IMLRISDDKY GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE KSFPVNSDVG 
VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED NLELNDVVIT IPLPSGVGAP 
VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK SGSLEFSIAG QPNDFFPVQV SFVSKKNYCN 
IQVTKVTQVD GNSPVRFSTE TTFLVDKYEI L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.