Details for: ARCN1

Gene ID: 372

Symbol: ARCN1

Ensembl ID: ENSG00000095139

Description: archain 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.9
    Marker Score: 5058.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.14
    Marker Score: 1914
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.64
    Marker Score: 3729
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.5
    Marker Score: 603
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.48
    Marker Score: 1584
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.44
    Marker Score: 2069
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.4
    Marker Score: 18634
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.37
    Marker Score: 916
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.35
    Marker Score: 1685
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.33
    Marker Score: 2805
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.33
    Marker Score: 2352
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.27
    Marker Score: 1162
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.24
    Marker Score: 1833
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.23
    Marker Score: 13904
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.23
    Marker Score: 41995
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.22
    Marker Score: 814
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.19
    Marker Score: 589
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.19
    Marker Score: 344
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.19
    Marker Score: 676
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.17
    Marker Score: 570
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.17
    Marker Score: 323
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.17
    Marker Score: 4866
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.16
    Marker Score: 286
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.15
    Marker Score: 1213
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.15
    Marker Score: 1100.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.15
    Marker Score: 325
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.15
    Marker Score: 4240
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.14
    Marker Score: 532
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.13
    Marker Score: 963
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1
    Marker Score: 1190
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.1
    Marker Score: 7006
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.1
    Marker Score: 5258
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.08
    Marker Score: 847.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.07
    Marker Score: 1417
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.07
    Marker Score: 36897
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.06
    Marker Score: 1101
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.06
    Marker Score: 599
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.05
    Marker Score: 715
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.04
    Marker Score: 258
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.04
    Marker Score: 1103
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.02
    Marker Score: 676
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.02
    Marker Score: 11811
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1
    Marker Score: 264
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1
    Marker Score: 225
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1
    Marker Score: 703
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71610
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47834
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.99
    Marker Score: 228
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.99
    Marker Score: 2248
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.99
    Marker Score: 600.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.99
    Marker Score: 5993
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.98
    Marker Score: 923
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30374
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.98
    Marker Score: 1228
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.98
    Marker Score: 568
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.97
    Marker Score: 485
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.96
    Marker Score: 653
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.96
    Marker Score: 415
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.96
    Marker Score: 8356
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.96
    Marker Score: 2387
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.95
    Marker Score: 1147.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.95
    Marker Score: 226
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.94
    Marker Score: 1107
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.94
    Marker Score: 1517
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.94
    Marker Score: 644
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.94
    Marker Score: 350
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.94
    Marker Score: 275
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2383
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.94
    Marker Score: 591
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.94
    Marker Score: 942
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.93
    Marker Score: 2485.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.93
    Marker Score: 6028
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.93
    Marker Score: 349
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.92
    Marker Score: 321
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.92
    Marker Score: 638
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.91
    Marker Score: 470
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 428
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.9
    Marker Score: 5895
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.9
    Marker Score: 505
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.9
    Marker Score: 279
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9
    Marker Score: 14075
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5133
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.9
    Marker Score: 2817
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2677
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.89
    Marker Score: 586
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.89
    Marker Score: 4374
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.89
    Marker Score: 234
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.88
    Marker Score: 502
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.88
    Marker Score: 987
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.88
    Marker Score: 402
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.88
    Marker Score: 732
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.87
    Marker Score: 432
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.87
    Marker Score: 222
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.87
    Marker Score: 365
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.86
    Marker Score: 1187
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.86
    Marker Score: 6426
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.86
    Marker Score: 195
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.86
    Marker Score: 1364

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Other Information

**Key characteristics:** * The ARCN1 gene is located on chromosome 1 and comprises 11 exons and 13 introns. * It is a member of the COPD (coatomer protein domain-containing) family of proteins, which are involved in protein transport between the ER and the Golgi. * The protein is a glycoprotein with a molecular weight of approximately 120 kDa. * It is a transmembrane protein with a cytoplasmic domain and two extracellular domains. **Pathways and functions:** * ARCN1 protein is involved in the retrograde transport of proteins between the ER and the Golgi. * It is a key component of the Golgi-to-ER retrograde transport pathway, which is responsible for the recycling of proteins and organelles. * It is also involved in the anterograde transport of proteins from the Golgi to the ER. * It is a crucial protein for the maintenance of cellular homeostasis and the proper functioning of various cell types. **Clinical significance:** * Mutations in the ARCN1 gene have been linked to several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). * These diseases are characterized by the accumulation of abnormal proteins in the brain, which is thought to be caused by defects in the retrograde transport pathway mediated by ARCN1. * Understanding the role of ARCN1 in the brain may lead to the development of new therapeutic strategies for these neurodegenerative diseases.

Genular Protein ID: 2427256437

Symbol: COPD_HUMAN

Name: Coatomer subunit delta

UniProtKB Accession Codes:

P48444 B4E1X2 E9PEU4 Q52M80

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7782067

Title: The human archain gene, ARCN1, has highly conserved homologs in rice and Drosophila.

PubMed ID: 7782067

DOI: 10.1016/0888-7543(95)80087-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27476655

Title: ARCN1 mutations cause a recognizable craniofacial syndrome due to copi-mediated transport defects.

PubMed ID: 27476655

DOI: 10.1016/j.ajhg.2016.06.011

Sequence Information:

  • Length: 511
  • Mass: 57210
  • Checksum: 4ED1F7D2D12A7F75
  • Sequence:
    • MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE TESVRYVYQP 
MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN EISEHCFDLI FAFDEIVALG 
YRENVNLAQI RTFTEMDSHE EKVFRAVRET QEREAKAEMR RKAKELQQAR RDAERQGKKA 
PGFGGFGSSA VSGGSTAAMI TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD 
KLKSEGETIM SSSMGKRTSE ATKMHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM 
IMLRISDDKY GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE KSFPVNSDVG 
VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED NLELNDVVIT IPLPSGVGAP 
VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK SGSLEFSIAG QPNDFFPVQV SFVSKKNYCN 
IQVTKVTQVD GNSPVRFSTE TTFLVDKYEI L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.