hpo | FBgn0261456 | NCBI 37247

Details for: hpo

Gene ID: 37247

Symbol: hpo

Ensembl ID: FBgn0261456

Description: hippo

Associated with

Apicomedial cortex
(GO:0106037)
Atp binding
(GO:0005524)
Border follicle cell migration
(GO:0007298)
Cell-cell junction
(GO:0005911)
Compound eye morphogenesis
(GO:0001745)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Eye development
(GO:0001654)
Hippo signaling
(GO:0035329)
Intracellular signal transduction
(GO:0035556)
Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
(GO:0042771)
Membrane
(GO:0016020)
Morphogenesis of an epithelial sheet
(GO:0002011)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of glial cell proliferation
(GO:0060253)
Negative regulation of neuroblast proliferation
(GO:0007406)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of ubiquitin-dependent protein catabolic process
(GO:2000059)
Organ growth
(GO:0035265)
Positive regulation of apoptotic process
(GO:0043065)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein tetramerization
(GO:0051262)
R8 cell fate specification
(GO:0045464)
Regulation of apoptotic signaling pathway
(GO:2001233)
Regulation of cell population proliferation
(GO:0042127)
Regulation of mapk cascade
(GO:0043408)
Regulation of protein processing
(GO:0070613)
Response to ionizing radiation
(GO:0010212)
Retinal cell programmed cell death
(GO:0046666)
Signal transduction
(GO:0007165)
Stem cell proliferation
(GO:0072089)

Other Information

Proteins

Serine/threonine-protein kinase hippo

Genular Protein ID: 852449989

Symbol: HIPPO_DROME

Name: Serine/threonine-protein kinase hippo

UniProtKB Accession Codes:

Q8T0S6 Q9V8W4

Database IDs:

Citations:

PubMed ID: 12941274

Title: The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.

PubMed ID: 12941274

DOI: 10.1016/s0092-8674(03)00557-9

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 11900973

Title: Identification of novel Drosophila neural precursor genes using a differential embryonic head cDNA screen.

PubMed ID: 11900973

DOI: 10.1016/s0925-4773(02)00010-2

PubMed ID: 12091301

Title: Gliogenesis in Drosophila: genome-wide analysis of downstream genes of glial cells missing in the embryonic nervous system.

PubMed ID: 12091301

DOI: 10.1242/dev.129.14.3295

PubMed ID: 12941273

Title: hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.

PubMed ID: 12941273

DOI: 10.1016/s0092-8674(03)00549-x

PubMed ID: 14561774

Title: The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis.

PubMed ID: 14561774

DOI: 10.1101/gad.1134003

PubMed ID: 14502294

Title: Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway.

PubMed ID: 14502294

DOI: 10.1038/ncb1050

PubMed ID: 14502295

Title: The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

PubMed ID: 14502295

DOI: 10.1038/ncb1051

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 20159598

Title: Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded.

PubMed ID: 20159598

DOI: 10.1016/j.devcel.2009.12.012

PubMed ID: 22075147

Title: Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway.

PubMed ID: 22075147

DOI: 10.1016/j.devcel.2011.08.028

PubMed ID: 26954546

Title: Drosophila Schip1 links Expanded and Tao-1 to regulate hippo signaling.

PubMed ID: 26954546

DOI: 10.1016/j.devcel.2016.02.004

Sequence Information:

Length: 669
Mass: 75110
Checksum: B3DDDFAF5F4E4EB3
Sequence:

MSEPEVTSVV DMKSPNISSS CSFFKLKKLS EESLLQPPEK VFDIMYKLGE GSYGSVYKAV 
HKESSSIVAI KLVPVESDLH EIIKEISIMQ QCDSPYVVRY YGSYFKQYDL WICMEYCGAG 
SVSDIMRLRK KTLTEDEIAT ILSDTLQGLV YLHLRRKIHR DIKAANILLN TEGYAKLADF 
GVAGQLTDTM AKRNTVIGTP FWMAPEVIEE IGYDCVADIW SLGITALEMA EGKPPYGEIH 
PMRAIFMIPQ KPPPSFREPD RWSTEFIDFV SKCLVKEPDD RATATELLEH EFIRNAKHRS 
ILKPMLEETC AIREQQRANR SFGGVLAASQ AKSLATQENG MQQHITDNAF MEDPGTLVPE 
KFGEYQQSSA SDATMIAHAE QGVDEGTLGP GGLRNLSKAA APAAASSAAS PLDMPAVDSG 
TMVELESNLG TMVINSDSDD STTAKNNDDQ KPRNRYRPQF LEHFDRKNAG DGRGDEKPIA 
TEYSPAAAEQ QQQQQQQQQQ QQQDEQHLAS GANDLNNWEH NMEMQFQQIS AINQYGLQQH 
QQQQQVLMAY PLMNEQLIAL NNQPNLLLSN AAPMGQQGIP AAAPAQPPPA YQNQHMHTQS 
HAYVEGEFEF LKFLTFDDLN QRLCNIDHEM ELEIEQLNKK YNAKRQPIVD AMNAKRKRQQ 
NINNNLIKI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: hpo

Associated with

Other Information

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. PubMed ID: 12941274

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

Identification of novel Drosophila neural precursor genes using a differential embryonic head cDNA screen. PubMed ID: 11900973

Gliogenesis in Drosophila: genome-wide analysis of downstream genes of glial cells missing in the embryonic nervous system. PubMed ID: 12091301

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. PubMed ID: 12941273

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. PubMed ID: 14561774

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. PubMed ID: 14502294

The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. PubMed ID: 14502295

Phosphoproteome analysis of Drosophila melanogaster embryos. PubMed ID: 18327897

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. PubMed ID: 20159598

Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. PubMed ID: 22075147

Drosophila Schip1 links Expanded and Tao-1 to regulate hippo signaling. PubMed ID: 26954546