Details for: TRIM23

Gene ID: 373

Symbol: TRIM23

Ensembl ID: ENSG00000113595

Description: tripartite motif containing 23

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 182.5836
    Cell Significance Index: -28.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 112.5202
    Cell Significance Index: -28.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.8907
    Cell Significance Index: -29.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.3467
    Cell Significance Index: -22.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.5299
    Cell Significance Index: -22.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.1071
    Cell Significance Index: -28.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3701
    Cell Significance Index: -27.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.3846
    Cell Significance Index: -29.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2974
    Cell Significance Index: 437.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5335
    Cell Significance Index: 307.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1714
    Cell Significance Index: 115.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8055
    Cell Significance Index: 17.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7698
    Cell Significance Index: 276.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7389
    Cell Significance Index: 17.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6981
    Cell Significance Index: 42.9100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6591
    Cell Significance Index: 8.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6004
    Cell Significance Index: 97.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5717
    Cell Significance Index: 62.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5618
    Cell Significance Index: 507.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5554
    Cell Significance Index: 110.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4180
    Cell Significance Index: 15.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3992
    Cell Significance Index: 23.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3984
    Cell Significance Index: 17.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3922
    Cell Significance Index: 24.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3734
    Cell Significance Index: 25.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3459
    Cell Significance Index: 18.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3007
    Cell Significance Index: 41.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3002
    Cell Significance Index: 23.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2935
    Cell Significance Index: 202.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2874
    Cell Significance Index: 16.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2793
    Cell Significance Index: 3.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2760
    Cell Significance Index: 19.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2365
    Cell Significance Index: 42.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1704
    Cell Significance Index: 4.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1494
    Cell Significance Index: 66.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1343
    Cell Significance Index: 73.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1231
    Cell Significance Index: 5.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1223
    Cell Significance Index: 3.4900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1142
    Cell Significance Index: 0.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1053
    Cell Significance Index: 12.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0829
    Cell Significance Index: 1.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0816
    Cell Significance Index: 2.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0779
    Cell Significance Index: 9.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0461
    Cell Significance Index: 86.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0384
    Cell Significance Index: 6.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0315
    Cell Significance Index: 20.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0252
    Cell Significance Index: 0.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0166
    Cell Significance Index: 7.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0058
    Cell Significance Index: 10.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0044
    Cell Significance Index: 6.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0026
    Cell Significance Index: 0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0060
    Cell Significance Index: -8.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0089
    Cell Significance Index: -5.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0106
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0179
    Cell Significance Index: -2.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0179
    Cell Significance Index: -13.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0351
    Cell Significance Index: -26.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0362
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0416
    Cell Significance Index: -4.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0649
    Cell Significance Index: -13.6800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0817
    Cell Significance Index: -1.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0844
    Cell Significance Index: -24.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0954
    Cell Significance Index: -9.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0963
    Cell Significance Index: -11.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1075
    Cell Significance Index: -3.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1099
    Cell Significance Index: -2.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1183
    Cell Significance Index: -3.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1204
    Cell Significance Index: -14.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1276
    Cell Significance Index: -2.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1411
    Cell Significance Index: -9.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1543
    Cell Significance Index: -9.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1577
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1624
    Cell Significance Index: -18.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1645
    Cell Significance Index: -4.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1881
    Cell Significance Index: -24.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1931
    Cell Significance Index: -5.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2018
    Cell Significance Index: -10.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2117
    Cell Significance Index: -9.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2233
    Cell Significance Index: -4.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2308
    Cell Significance Index: -11.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2341
    Cell Significance Index: -12.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2430
    Cell Significance Index: -25.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2918
    Cell Significance Index: -21.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2924
    Cell Significance Index: -23.1600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3023
    Cell Significance Index: -6.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3133
    Cell Significance Index: -4.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3283
    Cell Significance Index: -8.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3412
    Cell Significance Index: -6.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3624
    Cell Significance Index: -22.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3699
    Cell Significance Index: -7.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3837
    Cell Significance Index: -10.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4084
    Cell Significance Index: -13.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4088
    Cell Significance Index: -13.0200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4199
    Cell Significance Index: -6.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4387
    Cell Significance Index: -15.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4438
    Cell Significance Index: -12.0800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4607
    Cell Significance Index: -3.8700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4818
    Cell Significance Index: -10.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5474
    Cell Significance Index: -11.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRIM23 is a member of the tripartite motif (TRIM) family, characterized by the presence of three conserved domains: a RING finger domain, a coiled-coil domain, and a zinc-binding domain. This unique combination of domains confers TRIM23's ability to interact with various proteins, regulate protein-protein interactions, and modulate cellular processes. TRIM23 is predominantly expressed in neurons, including GABAergic and glutamatergic neurons, as well as in pulmonary interstitial fibroblasts and germ cells. **Pathways and Functions:** TRIM23 is involved in multiple cellular pathways, including: 1. **Innate Immune Response:** TRIM23 regulates the expression of innate immune response genes, influencing the production of cytokines and type I interferons. 2. **Autophagy:** As an E3 ubiquitin-protein ligase, TRIM23 mediates the ubiquitination and degradation of autophagy-related proteins, modulating autophagy flux and cellular homeostasis. 3. **Protein Transport:** TRIM23 regulates the transport of proteins between the Golgi membrane, lysosomes, and the plasma membrane, influencing protein localization and degradation. 4. **GTP Binding and GTPase Activity:** TRIM23 interacts with GTP-binding proteins, regulating GTP hydrolysis and modulating cellular signaling pathways. **Clinical Significance:** Dysregulation of TRIM23 has been implicated in various disease states, including: 1. **Neurological Disorders:** TRIM23 has been associated with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Autoimmune Diseases:** TRIM23 has been implicated in autoimmune diseases, including multiple sclerosis and rheumatoid arthritis, where it regulates immune cell function and cytokine production. 3. **Cancer:** TRIM23 has been found to be overexpressed in certain types of cancer, including breast and lung cancer, where it regulates cell growth, proliferation, and apoptosis. In conclusion, TRIM23 is a multifunctional protein that plays a critical role in regulating immune responses, protein transport, and autophagy. Its dysregulation has been implicated in various disease states, highlighting the need for further research into the mechanisms underlying TRIM23's functions and the development of therapeutic strategies targeting this protein.

Genular Protein ID: 2813304776

Symbol: TRI23_HUMAN

Name: E3 ubiquitin-protein ligase TRIM23

UniProtKB Accession Codes:

P36406 Q9BZY4 Q9BZY5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 4 CORUM 1 CTD 1 ChEBI 3 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 18 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8473324

Title: ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain.

PubMed ID: 8473324

DOI: 10.1016/s0021-9258(18)52945-8

PubMed ID: 11331580

Title: The tripartite motif family identifies cell compartments.

PubMed ID: 11331580

DOI: 10.1093/emboj/20.9.2140

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9671726

Title: Localization of ADP-ribosylation factor domain protein 1 (ARD1) in lysosomes and Golgi apparatus.

PubMed ID: 9671726

DOI: 10.1073/pnas.95.15.8613

PubMed ID: 10748148

Title: Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1).

PubMed ID: 10748148

DOI: 10.1074/jbc.m909642199

PubMed ID: 15684077

Title: E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1).

PubMed ID: 15684077

DOI: 10.1073/pnas.0409800102

PubMed ID: 19176615

Title: Identification of TRIM23 as a cofactor involved in the regulation of NF-kappaB by human cytomegalovirus.

PubMed ID: 19176615

DOI: 10.1128/jvi.02072-08

PubMed ID: 28871090

Title: TRIM23 mediates virus-induced autophagy via activation of TBK1.

PubMed ID: 28871090

DOI: 10.1038/s41564-017-0017-2

PubMed ID: 28681414

Title: Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.

PubMed ID: 28681414

DOI: 10.1002/prot.25348

Sequence Information:

  • Length: 574
  • Mass: 64067
  • Checksum: CB85923B29BF0320
  • Sequence:
    • MATLVVNKLG AGVDSGRQGS RGTAVVKVLE CGVCEDVFSL QGDKVPRLLL CGHTVCHDCL 
TRLPLHGRAI RCPFDRQVTD LGDSGVWGLK KNFALLELLE RLQNGPIGQY GAAEESIGIS 
GESIIRCDED EAHLASVYCT VCATHLCSEC SQVTHSTKTL AKHRRVPLAD KPHEKTMCSQ 
HQVHAIEFVC LEEGCQTSPL MCCVCKEYGK HQGHKHSVLE PEANQIRASI LDMAHCIRTF 
TEEISDYSRK LVGIVQHIEG GEQIVEDGIG MAHTEHVPGT AENARSCIRA YFYDLHETLC 
RQEEMALSVV DAHVREKLIW LRQQQEDMTI LLSEVSAACL HCEKTLQQDD CRVVLAKQEI 
TRLLETLQKQ QQQFTEVADH IQLDASIPVT FTKDNRVHIG PKMEIRVVTL GLDGAGKTTI 
LFKLKQDEFM QPIPTIGFNV ETVEYKNLKF TIWDVGGKHK LRPLWKHYYL NTQAVVFVVD 
SSHRDRISEA HSELAKLLTE KELRDALLLI FANKQDVAGA LSVEEITELL SLHKLCCGRS 
WYIQGCDARS GMGLYEGLDW LSRQLVAAGV LDVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.