Gene AREG - ENSG00000109321 | NCBI Gene ID: 374

Details for: AREG

Gene ID: 374

Symbol: AREG

Ensembl ID: ENSG00000109321

Description: amphiregulin

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo concentration in the er
(R-HSA-5694530)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Copii-mediated vesicle transport
(R-HSA-204005)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Er to golgi anterograde transport
(R-HSA-199977)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
Grb2 events in egfr signaling
(R-HSA-179812)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nfe2l2 regulating tumorigenic genes
(R-HSA-9818030)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Raf/map kinase cascade
(R-HSA-5673001)
Shc1 events in egfr signaling
(R-HSA-180336)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Cell-cell signaling
(GO:0007267)
Cell surface
(GO:0009986)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Cytokine activity
(GO:0005125)
Dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
(GO:0060598)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum membrane
(GO:0005789)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Epithelial cell proliferation involved in mammary gland duct elongation
(GO:0060750)
Erbb2-egfr signaling pathway
(GO:0038134)
Er to golgi transport vesicle membrane
(GO:0012507)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glial cell proliferation
(GO:0014009)
G protein-coupled receptor signaling pathway
(GO:0007186)
Growth factor activity
(GO:0008083)
Mammary gland alveolus development
(GO:0060749)
Mammary gland branching involved in thelarche
(GO:0060744)
Negative regulation of osteoblast differentiation
(GO:0045668)
Neuron projection development
(GO:0031175)
Nucleus
(GO:0005634)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of keratinocyte proliferation
(GO:0010838)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Response to camp
(GO:0051591)
Response to estradiol
(GO:0032355)
Response to glucocorticoid
(GO:0051384)
Response to hydrogen peroxide
(GO:0042542)
Response to peptide hormone
(GO:0043434)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.55
Marker Score: 9794.5
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.94
Marker Score: 8588.5
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.93
Marker Score: 11279
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.69
Marker Score: 1161.5
Cell Name: early promyelocyte (CL0002154)
Fold Change: 2.68
Marker Score: 2148
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.6
Marker Score: 1297
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.56
Marker Score: 2698
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.45
Marker Score: 2807
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.41
Marker Score: 1895
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.34
Marker Score: 5721
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.3
Marker Score: 714
Cell Name: basophil (CL0000767)
Fold Change: 2.25
Marker Score: 1067
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.24
Marker Score: 760
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.17
Marker Score: 14117
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.12
Marker Score: 3124
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.99
Marker Score: 708.5
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.98
Marker Score: 5125
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.95
Marker Score: 1947
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.93
Marker Score: 1613
Cell Name: thymocyte (CL0000893)
Fold Change: 1.9
Marker Score: 1986
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.8
Marker Score: 11512
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.71
Marker Score: 8994.5
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.65
Marker Score: 542.5
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.61
Marker Score: 9778
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.57
Marker Score: 4923
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.55
Marker Score: 557
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.53
Marker Score: 1471
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.53
Marker Score: 11974
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.47
Marker Score: 3619
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167225
Cell Name: memory T cell (CL0000813)
Fold Change: 1.43
Marker Score: 616
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.41
Marker Score: 3191
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.37
Marker Score: 340
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.32
Marker Score: 380
Cell Name: ILC1, human (CL0001077)
Fold Change: 1.32
Marker Score: 334
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 1.25
Marker Score: 283
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.23
Marker Score: 10606.5
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.23
Marker Score: 600
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 1.23
Marker Score: 1006
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.19
Marker Score: 1893
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.18
Marker Score: 358
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 1.17
Marker Score: 600
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 1.16
Marker Score: 879
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1.15
Marker Score: 837
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.15
Marker Score: 1270
Cell Name: natural killer cell (CL0000623)
Fold Change: 1.14
Marker Score: 1473
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.14
Marker Score: 1826
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 1.11
Marker Score: 2317
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.08
Marker Score: 1081
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.07
Marker Score: 27480
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.07
Marker Score: 839
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 1.07
Marker Score: 449
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.06
Marker Score: 2568
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.06
Marker Score: 16643
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.06
Marker Score: 1786
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 1.04
Marker Score: 884
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.01
Marker Score: 1798
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71672.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47901
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.99
Marker Score: 247
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.98
Marker Score: 497
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30395
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.97
Marker Score: 2724
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 491
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.95
Marker Score: 1804
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2404
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 446
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.94
Marker Score: 627
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.94
Marker Score: 650
Cell Name: leukocyte (CL0000738)
Fold Change: 0.94
Marker Score: 539
Cell Name: memory B cell (CL0000787)
Fold Change: 0.94
Marker Score: 708
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.92
Marker Score: 632
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.91
Marker Score: 993
Cell Name: granulocyte (CL0000094)
Fold Change: 0.91
Marker Score: 409
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5190
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2717
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.91
Marker Score: 3760
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.9
Marker Score: 758
Cell Name: mature T cell (CL0002419)
Fold Change: 0.89
Marker Score: 8819
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 318
Cell Name: ionocyte (CL0005006)
Fold Change: 0.88
Marker Score: 268
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.88
Marker Score: 599
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5268
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.86
Marker Score: 229
Cell Name: basal cell (CL0000646)
Fold Change: 0.86
Marker Score: 1105.5
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.83
Marker Score: 324
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.83
Marker Score: 497
Cell Name: naive B cell (CL0000788)
Fold Change: 0.83
Marker Score: 738.5
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.82
Marker Score: 384
Cell Name: male germ cell (CL0000015)
Fold Change: 0.82
Marker Score: 236
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.81
Marker Score: 590
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.79
Marker Score: 1795.5
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.79
Marker Score: 154
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.78
Marker Score: 206
Cell Name: PP cell (CL0000696)
Fold Change: 0.78
Marker Score: 176
Cell Name: mast cell (CL0000097)
Fold Change: 0.78
Marker Score: 453
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 0.78
Marker Score: 354
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.78
Marker Score: 3813.5
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.78
Marker Score: 267
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1257

Hover over a box to see details here...

**Key characteristics:** - AREG is a secreted protein that is processed into a soluble form. - It is a glycoprotein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in tissues such as the skin, lungs, and immune cells. **Pathways and functions:** - AREG plays a critical role in cell growth and differentiation. - It is essential for the development and survival of epithelial cells. - It is involved in the regulation of immune cell function. - It is a key regulator of angiogenesis and tissue remodeling. - It is involved in the regulation of cell cycle progression and apoptosis. **Clinical significance:** - Mutations in the AREG gene have been linked to several human cancers, including breast cancer, lung cancer, and colorectal cancer. - Targeting AREG has emerged as a promising therapeutic strategy for cancer treatment. **Conclusion:** AREG is a critical protein that plays a crucial role in regulating cell growth, proliferation, and survival. Its overexpression is associated with various human cancers, underscoring its importance in maintaining tissue homeostasis and preventing cancer development. Targeting AREG has emerged as a promising therapeutic strategy for cancer treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

AREG_HUMAN

Genular Protein ID: 2786887089

Symbol: AREG_HUMAN

Name: N/A

UniProtKB Accession Codes:

P15514 Q5U026

Database IDs:

Citations:

PubMed ID: 2325643

Title: The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.

PubMed ID: 2325643

DOI: 10.1128/mcb.10.5.1969-1981.1990

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2466334

Title: Structure and function of human amphiregulin: a member of the epidermal growth factor family.

PubMed ID: 2466334

DOI: 10.1126/science.2466334

PubMed ID: 3413110

Title: Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7.

PubMed ID: 3413110

DOI: 10.1073/pnas.85.17.6528

PubMed ID: 2017164

Title: A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin.

PubMed ID: 2017164

DOI: 10.1128/mcb.11.5.2547-2557.1991

PubMed ID: 1333777

Title: Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family.

PubMed ID: 1333777

DOI: 10.3109/08977199209046924

PubMed ID: 22967896

Title: Clarification of the C-terminal proteolytic processing site of human Amphiregulin.

PubMed ID: 22967896

DOI: 10.1016/j.febslet.2012.07.078

PubMed ID: 7679104

Title: Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells.

PubMed ID: 7679104

DOI: 10.1016/s0021-9258(18)53862-x

PubMed ID: 17607000

Title: Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells.

PubMed ID: 17607000

DOI: 10.1242/jcs.004200

Sequence Information:

Length: 252
Mass: 27895
Checksum: 68C1FA6BCD4D2BED
Sequence:

MRAPLLPPAP VVLSLLILGS GHYAAGLDLN DTYSGKREPF SGDHSADGFE VTSRSEMSSG 
SEISPVSEMP SSSEPSSGAD YDYSEEYDNE PQIPGYIVDD SVRVEQVVKP PQNKTESENT 
SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER 
CGEKSMKTHS MIDSSLSKIA LAAIAAFMSA VILTAVAVIT VQLRRQYVRK YEGEAEERKK 
LRQENGNVHA IA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: AREG

Associated with

Cells (max top 100)

Other Information

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. PubMed ID: 2325643

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure and function of human amphiregulin: a member of the epidermal growth factor family. PubMed ID: 2466334

Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. PubMed ID: 3413110

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. PubMed ID: 2017164

Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. PubMed ID: 1333777

Clarification of the C-terminal proteolytic processing site of human Amphiregulin. PubMed ID: 22967896

Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells. PubMed ID: 7679104

Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells. PubMed ID: 17607000