AREG | ENSG00000109321 | NCBI 374

Details for: AREG

Gene ID: 374

Symbol: AREG

Ensembl ID: ENSG00000109321

Description: amphiregulin

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo concentration in the er
(R-HSA-5694530)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Copii-mediated vesicle transport
(R-HSA-204005)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Er to golgi anterograde transport
(R-HSA-199977)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
Grb2 events in egfr signaling
(R-HSA-179812)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nfe2l2 regulating tumorigenic genes
(R-HSA-9818030)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Raf/map kinase cascade
(R-HSA-5673001)
Shc1 events in egfr signaling
(R-HSA-180336)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Cell-cell signaling
(GO:0007267)
Cell surface
(GO:0009986)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Cytokine activity
(GO:0005125)
Dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
(GO:0060598)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum membrane
(GO:0005789)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Epithelial cell proliferation involved in mammary gland duct elongation
(GO:0060750)
Erbb2-egfr signaling pathway
(GO:0038134)
Er to golgi transport vesicle membrane
(GO:0012507)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glial cell proliferation
(GO:0014009)
G protein-coupled receptor signaling pathway
(GO:0007186)
Growth factor activity
(GO:0008083)
Mammary gland alveolus development
(GO:0060749)
Mammary gland branching involved in thelarche
(GO:0060744)
Negative regulation of osteoblast differentiation
(GO:0045668)
Neuron projection development
(GO:0031175)
Nucleus
(GO:0005634)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of keratinocyte proliferation
(GO:0010838)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Response to camp
(GO:0051591)
Response to estradiol
(GO:0032355)
Response to glucocorticoid
(GO:0051384)
Response to hydrogen peroxide
(GO:0042542)
Response to peptide hormone
(GO:0043434)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)

Other Information

Proteins

AREG_HUMAN

Genular Protein ID: 2786887089

Symbol: AREG_HUMAN

Name: N/A

UniProtKB Accession Codes:

P15514 Q5U026

Database IDs:

Citations:

PubMed ID: 2325643

Title: The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.

PubMed ID: 2325643

DOI: 10.1128/mcb.10.5.1969-1981.1990

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2466334

Title: Structure and function of human amphiregulin: a member of the epidermal growth factor family.

PubMed ID: 2466334

DOI: 10.1126/science.2466334

PubMed ID: 3413110

Title: Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7.

PubMed ID: 3413110

DOI: 10.1073/pnas.85.17.6528

PubMed ID: 2017164

Title: A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin.

PubMed ID: 2017164

DOI: 10.1128/mcb.11.5.2547-2557.1991

PubMed ID: 1333777

Title: Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family.

PubMed ID: 1333777

DOI: 10.3109/08977199209046924

PubMed ID: 22967896

Title: Clarification of the C-terminal proteolytic processing site of human Amphiregulin.

PubMed ID: 22967896

DOI: 10.1016/j.febslet.2012.07.078

PubMed ID: 7679104

Title: Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells.

PubMed ID: 7679104

DOI: 10.1016/s0021-9258(18)53862-x

PubMed ID: 17607000

Title: Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells.

PubMed ID: 17607000

DOI: 10.1242/jcs.004200

Sequence Information:

Length: 252
Mass: 27895
Checksum: 68C1FA6BCD4D2BED
Sequence:

MRAPLLPPAP VVLSLLILGS GHYAAGLDLN DTYSGKREPF SGDHSADGFE VTSRSEMSSG 
SEISPVSEMP SSSEPSSGAD YDYSEEYDNE PQIPGYIVDD SVRVEQVVKP PQNKTESENT 
SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER 
CGEKSMKTHS MIDSSLSKIA LAAIAAFMSA VILTAVAVIT VQLRRQYVRK YEGEAEERKK 
LRQENGNVHA IA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AREG

Associated with

Other Information

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. PubMed ID: 2325643

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure and function of human amphiregulin: a member of the epidermal growth factor family. PubMed ID: 2466334

Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. PubMed ID: 3413110

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. PubMed ID: 2017164

Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. PubMed ID: 1333777

Clarification of the C-terminal proteolytic processing site of human Amphiregulin. PubMed ID: 22967896

Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells. PubMed ID: 7679104

Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells. PubMed ID: 17607000