Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 193.5128
Cell Significance Index: -30.1000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 68.8910
Cell Significance Index: -32.5300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 48.0088
Cell Significance Index: -32.2200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 34.9204
Cell Significance Index: -33.3400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 24.5589
Cell Significance Index: -30.2800 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 22.3251
Cell Significance Index: 66.4000 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 18.7953
Cell Significance Index: 115.6700 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 16.6581
Cell Significance Index: 44.6300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.2851
Cell Significance Index: -32.9100 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 9.8047
Cell Significance Index: 62.5900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.7055
Cell Significance Index: -29.8100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 8.9311
Cell Significance Index: 665.6300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.8129
Cell Significance Index: -30.8300 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 7.4795
Cell Significance Index: 49.6200 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 6.1085
Cell Significance Index: 100.6600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.0894
Cell Significance Index: -8.9500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.9083
Cell Significance Index: 151.0800 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 2.5801
Cell Significance Index: 38.6600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.4729
Cell Significance Index: 288.1900 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.3183
Cell Significance Index: 299.5100 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.1086
Cell Significance Index: 13.0500 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.0694
Cell Significance Index: 26.6500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.8976
Cell Significance Index: 86.0100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.7822
Cell Significance Index: 83.7600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.4367
Cell Significance Index: 13.2300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0461
Cell Significance Index: 128.6300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.0074
Cell Significance Index: 29.0300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8136
Cell Significance Index: 734.5900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7945
Cell Significance Index: 143.2200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7156
Cell Significance Index: 70.7900 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.6656
Cell Significance Index: 2.7700 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.5652
Cell Significance Index: 8.0500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5010
Cell Significance Index: 81.4800 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.4725
Cell Significance Index: 4.0600 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.4332
Cell Significance Index: 7.6600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4093
Cell Significance Index: 44.5200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3482
Cell Significance Index: 153.9400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3331
Cell Significance Index: 8.9100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3323
Cell Significance Index: 11.6800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2617
Cell Significance Index: 18.5100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2140
Cell Significance Index: 116.8900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1503
Cell Significance Index: 10.4000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1487
Cell Significance Index: 17.5400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1244
Cell Significance Index: 3.1100 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.1163
Cell Significance Index: 1.8000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1017
Cell Significance Index: 19.3500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0959
Cell Significance Index: 72.6200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0262
Cell Significance Index: 1.2200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0151
Cell Significance Index: 3.0000 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.0140
Cell Significance Index: 0.1400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0157
Cell Significance Index: -29.4900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0220
Cell Significance Index: -40.5500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0227
Cell Significance Index: -1.1500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0261
Cell Significance Index: -40.1100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0270
Cell Significance Index: -1.1100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0300
Cell Significance Index: -40.7500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0437
Cell Significance Index: -32.0400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0455
Cell Significance Index: -28.8900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0470
Cell Significance Index: -34.8300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0597
Cell Significance Index: -33.6600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0777
Cell Significance Index: -35.2500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0861
Cell Significance Index: -8.8000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0871
Cell Significance Index: -2.3700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0891
Cell Significance Index: -31.9600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1109
Cell Significance Index: -12.7100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1446
Cell Significance Index: -3.0800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1499
Cell Significance Index: -20.5900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1571
Cell Significance Index: -31.5200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1666
Cell Significance Index: -35.0800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1754
Cell Significance Index: -25.5000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1770
Cell Significance Index: -5.6700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1873
Cell Significance Index: -31.9900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1898
Cell Significance Index: -2.5900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1944
Cell Significance Index: -5.1900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1966
Cell Significance Index: -4.2600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2341
Cell Significance Index: -15.1100 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.2354
Cell Significance Index: -3.9600 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2377
Cell Significance Index: -2.7000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2626
Cell Significance Index: -7.3400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2701
Cell Significance Index: -20.7300 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2735
Cell Significance Index: -35.0600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2914
Cell Significance Index: -7.4900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2934
Cell Significance Index: -30.5500 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3198
Cell Significance Index: -5.9100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4259
Cell Significance Index: -10.8800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4270
Cell Significance Index: -33.8200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4381
Cell Significance Index: -26.8600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4750
Cell Significance Index: -2.8700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4810
Cell Significance Index: -32.3500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5046
Cell Significance Index: -26.2900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5096
Cell Significance Index: -32.1200 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.5413
Cell Significance Index: -9.3000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.6012
Cell Significance Index: -36.9600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6446
Cell Significance Index: -36.1700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6538
Cell Significance Index: -24.0000 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.6730
Cell Significance Index: -16.8100 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.6733
Cell Significance Index: -5.4900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.6792
Cell Significance Index: -35.6600 - Cell Name: perivascular cell (CL4033054)
Fold Change: -0.6887
Cell Significance Index: -3.1800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.7797
Cell Significance Index: -22.3500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2786887089
Symbol: AREG_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2325643
Title: The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.
PubMed ID: 2325643
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2466334
Title: Structure and function of human amphiregulin: a member of the epidermal growth factor family.
PubMed ID: 2466334
PubMed ID: 3413110
Title: Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7.
PubMed ID: 3413110
PubMed ID: 2017164
Title: A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin.
PubMed ID: 2017164
PubMed ID: 1333777
Title: Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family.
PubMed ID: 1333777
PubMed ID: 22967896
Title: Clarification of the C-terminal proteolytic processing site of human Amphiregulin.
PubMed ID: 22967896
PubMed ID: 7679104
Title: Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells.
PubMed ID: 7679104
PubMed ID: 17607000
Title: Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells.
PubMed ID: 17607000
DOI: 10.1242/jcs.004200
Sequence Information:
- Length: 252
- Mass: 27895
- Checksum: 68C1FA6BCD4D2BED
- Sequence:
MRAPLLPPAP VVLSLLILGS GHYAAGLDLN DTYSGKREPF SGDHSADGFE VTSRSEMSSG SEISPVSEMP SSSEPSSGAD YDYSEEYDNE PQIPGYIVDD SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSKIA LAAIAAFMSA VILTAVAVIT VQLRRQYVRK YEGEAEERKK LRQENGNVHA IA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.