Details for: Egfr

Gene ID: 37455

Symbol: Egfr

Ensembl ID: FBgn0003731

Description: Epidermal growth factor receptor

Associated with

Other Information

Genular Protein ID: 2937799020

Symbol: EGFR_DROME

Name: Epidermal growth factor receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8070664

Title: Molecular analysis of the Drosophila EGF receptor homolog reveals that several genetically defined classes of alleles cluster in subdomains of the receptor protein.

PubMed ID: 8070664

DOI: 10.1093/genetics/137.2.531

PubMed ID: 2982499

Title: The Drosophila EGF receptor gene homolog: conservation of both hormone binding and kinase domains.

PubMed ID: 2982499

DOI: 10.1016/0092-8674(85)90208-9

PubMed ID: 3093080

Title: Alternative 5' exons and tissue-specific expression of the Drosophila EGF receptor homolog transcripts.

PubMed ID: 3093080

DOI: 10.1016/0092-8674(86)90709-9

PubMed ID: 9882502

Title: Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila.

PubMed ID: 9882502

DOI: 10.1006/dbio.1998.9121

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 2983232

Title: A Drosophila genomic sequence with homology to human epidermal growth factor receptor.

PubMed ID: 2983232

DOI: 10.1038/314178a0

PubMed ID: 9731193

Title: Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA.

PubMed ID: 9731193

DOI: 10.1006/bbrc.1998.9003

PubMed ID: 1936959

Title: Interallelic complementation among DER/flb alleles: implications for the mechanism of signal transduction by receptor-tyrosine kinases.

PubMed ID: 1936959

DOI: 10.1093/genetics/129.1.191

PubMed ID: 9094709

Title: There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor.

PubMed ID: 9094709

DOI: 10.1016/s0092-8674(00)80177-4

PubMed ID: 10781813

Title: Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav.

PubMed ID: 10781813

DOI: 10.1016/s0014-5793(00)01413-7

PubMed ID: 22140578

Title: Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila.

PubMed ID: 22140578

DOI: 10.1371/journal.pone.0028349

PubMed ID: 23579691

Title: Modulation of morphogenesis by Egfr during dorsal closure in Drosophila.

PubMed ID: 23579691

DOI: 10.1371/journal.pone.0060180

PubMed ID: 24855950

Title: Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration.

PubMed ID: 24855950

DOI: 10.1016/j.cell.2014.03.045

PubMed ID: 34411095

Title: EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis.

PubMed ID: 34411095

DOI: 10.1371/journal.pgen.1009738

PubMed ID: 19718021

Title: ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor.

PubMed ID: 19718021

DOI: 10.1038/nature08297

PubMed ID: 28993397

Title: Graf regulates hematopoiesis through GEEC endocytosis of EGFR.

PubMed ID: 28993397

DOI: 10.1242/dev.153288

PubMed ID: 20723758

Title: Structural basis for negative cooperativity in growth factor binding to an EGF receptor.

PubMed ID: 20723758

DOI: 10.1016/j.cell.2010.07.015

PubMed ID: 23029159

Title: Drosophila Zpr1 (Zinc finger protein 1) is required downstream of both EGFR and FGFR signaling in tracheal subcellular lumen formation.

PubMed ID: 23029159

DOI: 10.1371/journal.pone.0045649

Sequence Information:

  • Length: 1426
  • Mass: 159718
  • Checksum: 4D424C3C99DA4AF4
  • Sequence:
  • MLLRRRNGPC PFPLLLLLLA HCICIWPASA ARDRYARQNN RQRHQDIDRD RDRDRFLYRS 
    SSAQNRQRGG ANFALGLGAN GVTIPTSLED KNKNEFVKGK ICIGTKSRLS VPSNKEHHYR 
    NLRDRYTNCT YVDGNLKLTW LPNENLDLSF LDNIREVTGY ILISHVDVKK VVFPKLQIIR 
    GRTLFSLSVE EEKYALFVTY SKMYTLEIPD LRDVLNGQVG FHNNYNLCHM RTIQWSEIVS 
    NGTDAYYNYD FTAPERECPK CHESCTHGCW GEGPKNCQKF SKLTCSPQCA GGRCYGPKPR 
    ECCHLFCAGG CTGPTQKDCI ACKNFFDEAV SKEECPPMRK YNPTTYVLET NPEGKYAYGA 
    TCVKECPGHL LRDNGACVRS CPQDKMDKGG ECVPCNGPCP KTCPGVTVLH AGNIDSFRNC 
    TVIDGNIRIL DQTFSGFQDV YANYTMGPRY IPLDPERREV FSTVKEITGY LNIEGTHPQF 
    RNLSYFRNLE TIHGRQLMES MFAALAIVKS SLYSLEMRNL KQISSGSVVI QHNRDLCYVS 
    NIRWPAIQKE PEQKVWVNEN LRADLCEKNG TICSDQCNED GCWGAGTDQC LTCKNFNFNG 
    TCIADCGYIS NAYKFDNRTC KICHPECRTC NGAGADHCQE CVHVRDGQHC VSECPKNKYN 
    DRGVCRECHA TCDGCTGPKD TIGIGACTTC NLAIINNDAT VKRCLLKDDK CPDGYFWEYV 
    HPQEQGSLKP LAGRAVCRKC HPLCELCTNY GYHEQVCSKC THYKRREQCE TECPADHYTD 
    EEQRECFQRH PECNGCTGPG ADDCKSCRNF KLFDANETGP YVNSTMFNCT SKCPLEMRHV 
    NYQYTAIGPY CAASPPRSSK ITANLDVNMI FIITGAVLVP TICILCVVTY ICRQKQKAKK 
    ETVKMTMALS GCEDSEPLRP SNIGANLCKL RIVKDAELRK GGVLGMGAFG RVYKGVWVPE 
    GENVKIPVAI KELLKSTGAE SSEEFLREAY IMASEEHVNL LKLLAVCMSS QMMLITQLMP 
    LGCLLDYVRN NRDKIGSKAL LNWSTQIAKG MSYLEEKRLV HRDLAARNVL VQTPSLVKIT 
    DFGLAKLLSS DSNEYKAAGG KMPIKWLALE CIRNRVFTSK SDVWAFGVTI WELLTFGQRP 
    HENIPAKDIP DLIEVGLKLE QPEICSLDIY CTLLSCWHLD AAMRPTFKQL TTVFAEFARD 
    PGRYLAIPGD KFTRLPAYTS QDEKDLIRKL APTTDGSEAI AKPDDYLQPK AAPGPSHRTD 
    CTDEMPKLNR YCKDPSNKNS STGDDERDSS AREVGVGNLR LDLPVDEDDY LMPTCQPGPN 
    NNNNMNNPNQ NNMAAVGVAA GYMDLIGVPV SVDNPEYLLN AQTLGVGESP IPTQTIGIPV 
    MGGPGTMEVK VPMPGSEPTS SDHEYYNDTQ RELQPLHRNR NTETRV

Genular Protein ID: 832094362

Symbol: Q8MLW0_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 1377
  • Mass: 153602
  • Checksum: 38AFA4AEA9D5C954
  • Sequence:
  • MMIISMWMSI SRGLWDSSSI WSVLLILACM ASITTSSSVS NAGYVDNGNM KVCIGTKSRL 
    SVPSNKEHHY RNLRDRYTNC TYVDGNLELT WLPNENLDLS FLDNIREVTG YILISHVDVK 
    KVVFPKLQII RGRTLFSLSV EEEKYALFVT YSKMYTLEIP DLRDVLNGQV GFHNNYNLCH 
    MRTIQWSEIV SNGTDAYYNY DFTAPERECP KCHESCTHGC WGEGPKNCQK FSKLTCSPQC 
    AGGRCYGPKP RECCHLFCAG GCTGPTQKDC IACKNFFDEG VCKEECPPMR KYNPTTYVLE 
    TNPEGKYAYG ATCVKECPGH LLRDNGACVR SCPQDKMDKG GECVPCNGPC PKTCPGVTVL 
    HAGNIDSFRN CTVIDGNIRI LDQTFSGFQD VYANYTMGPR YIPLDPERLE VFSTVKEITG 
    YLNIEGTHPQ FRNLSYFRNL ETIHGRQLME SMFAALAIVK SSLYSLEMRN LKQISSGSVV 
    IQHNRDLCYV SNIRWPAIQK EPEQKVWVNE NLRADLCEKN GTICSDQCNE DGCWGAGTDQ 
    CLTCKNFNFN GTCIADCGYI SNAYKFDNRT CKICHPECRT CNGAGADHCQ ECVHVRDGQH 
    CVSECPKNKY NDRGVCRECH ATCDGCTGPK DTIGIGACTT CNLAIINNDA TVKRCLLKDD 
    KCPDGYFWEY VHPQEQGSLK PLAGRAVCRK CHPLCELCTN YGYHEQVCSK CTHYKRREQC 
    ETECPADHYT DEEQRECFQC HPECNGCTGP GADDCKSCRN FKLFDANETG PYVNSTMFNC 
    TSKCPLEMRH VNYQYTAIGP YCAASPPRSS KITANLDVNM IFIITGAVLV PTICILCVVT 
    YICRQKQKAK KETVKMTMAL SGCEDSEPLR PSNIGANLCK LRIVKDAELR KGGVLGMGAF 
    GRVYKGVWVP EGENVKIPVA IKELLKSTGA ESSEEFLREA YIMASVEHVN LLKLLAVCMS 
    SQMMLITQLM PLGCLLDYVR NNRDKIGSKA LLNWSTQIAK GMSYLEEKRL VHRDLAARNV 
    LVQTPSLVKI TDFGLAKLLS SDSNEYKAAG GKMPIKWLAL ECIRNRVFTS KSDVWAFGVT 
    IWELLTFGQR PHENIPAKDI PDLIEVGLKL EQPEICSLDI YCTLLSCWHL DAAMRPTFKQ 
    LTTVFAEFAR DPGRYLAIPG DKFTRLPAYT SQDEKDLIRK LAPTTDGSEA IAEPDDYLQP 
    KAAPGPSHRT DCTDEIPKLN RYCKDPSNKN SSTGDDETDS SAREVGVGNL RLDLPVDEDD 
    YLMPTCQPGP NNNNNINNPN QNNMAAVGVA AGYMDLIGVP VSVDNPEYLL NAQTLGVGES 
    PIPTQTIGIP VMGVPGTMEV KVPMPGSEPT SSDHEYYNDT QRELQPLHRN RNTETRV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.