Details for: ARF1

Gene ID: 375

Symbol: ARF1

Ensembl ID: ENSG00000143761

Description: ADP ribosylation factor 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.52
    Marker Score: 119,724
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.3
    Marker Score: 10,412
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.24
    Marker Score: 37,627
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.14
    Marker Score: 31,106
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.13
    Marker Score: 4,536
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.13
    Marker Score: 8,640
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.13
    Marker Score: 41,250
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.06
    Marker Score: 171,124
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.97
    Marker Score: 19,341
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.93
    Marker Score: 7,451
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.89
    Marker Score: 8,439
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.89
    Marker Score: 2,571
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.83
    Marker Score: 12,136
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.83
    Marker Score: 2,483
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.82
    Marker Score: 149,023
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.82
    Marker Score: 2,722
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8
    Marker Score: 6,843
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.77
    Marker Score: 2,955
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.76
    Marker Score: 660
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.75
    Marker Score: 2,342
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.73
    Marker Score: 10,540
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.69
    Marker Score: 1,126
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.67
    Marker Score: 2,631
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.67
    Marker Score: 7,492
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.67
    Marker Score: 1,111
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.66
    Marker Score: 3,924
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.65
    Marker Score: 2,077
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.65
    Marker Score: 17,245
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.65
    Marker Score: 4,208
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.64
    Marker Score: 6,450
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.64
    Marker Score: 5,142
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.63
    Marker Score: 2,827
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.63
    Marker Score: 11,328
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.63
    Marker Score: 8,243
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.62
    Marker Score: 3,612
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.6
    Marker Score: 1,516
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.6
    Marker Score: 2,189
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.6
    Marker Score: 1,524
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.6
    Marker Score: 2,129
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.58
    Marker Score: 3,026
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.58
    Marker Score: 4,149
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.58
    Marker Score: 2,803
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.57
    Marker Score: 2,410
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.57
    Marker Score: 1,811
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.55
    Marker Score: 19,910
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.54
    Marker Score: 16,244
  • Cell Name: platelet (CL0000233)
    Fold Change: 2.52
    Marker Score: 1,142
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.52
    Marker Score: 16,063
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.51
    Marker Score: 4,491
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.5
    Marker Score: 2,865
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.5
    Marker Score: 13,130
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.49
    Marker Score: 10,397
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.49
    Marker Score: 1,421
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.48
    Marker Score: 2,381
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.48
    Marker Score: 1,957
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.48
    Marker Score: 2,930
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.48
    Marker Score: 1,805
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.47
    Marker Score: 1,125
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.47
    Marker Score: 2,214
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.46
    Marker Score: 5,157
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.46
    Marker Score: 4,620
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.45
    Marker Score: 1,475
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.45
    Marker Score: 1,646
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.44
    Marker Score: 3,017
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.44
    Marker Score: 84,650
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.44
    Marker Score: 4,008
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.44
    Marker Score: 1,661
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.44
    Marker Score: 4,126
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.43
    Marker Score: 20,978
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.43
    Marker Score: 2,349
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.43
    Marker Score: 32,620
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.43
    Marker Score: 3,434
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.43
    Marker Score: 11,913
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.41
    Marker Score: 27,200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.4
    Marker Score: 6,542
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.4
    Marker Score: 4,249
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.39
    Marker Score: 4,771
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.38
    Marker Score: 5,432
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.38
    Marker Score: 1,026
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.38
    Marker Score: 2,024
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.37
    Marker Score: 586
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.37
    Marker Score: 4,649
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.37
    Marker Score: 2,230
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.37
    Marker Score: 628
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.37
    Marker Score: 2,235
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.36
    Marker Score: 23,949
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.36
    Marker Score: 1,216
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.36
    Marker Score: 4,927
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.34
    Marker Score: 810
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.34
    Marker Score: 582
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.34
    Marker Score: 6,118
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.33
    Marker Score: 11,196
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.33
    Marker Score: 1,535
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.33
    Marker Score: 5,490
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.33
    Marker Score: 1,546
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.32
    Marker Score: 6,219
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.32
    Marker Score: 1,040
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.32
    Marker Score: 582
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.31
    Marker Score: 2,596
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.31
    Marker Score: 3,560

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ARF1 is a member of the ADP-ribosylation factor (ARF) family, which consists of six GTP-binding proteins that regulate various cellular processes. The primary characteristics of ARF1 include: 1. **GTP-binding activity**: ARF1 binds to GTP, which activates its GTPase activity, leading to the hydrolysis of GTP to GDP. 2. **Small size**: ARF1 is a small protein, consisting of approximately 160 amino acids. 3. **Membrane localization**: ARF1 is primarily localized to the Golgi apparatus and endoplasmic reticulum. 4. **Regulation of membrane trafficking**: ARF1 regulates the formation and movement of vesicles, which are essential for protein synthesis, modification, and transport. **Pathways and Functions** ARF1 is involved in various cellular pathways, including: 1. **Golgi-to-ER retrograde transport**: ARF1 regulates the transport of proteins and lipids from the Golgi apparatus to the endoplasmic reticulum. 2. **Anterograde transport**: ARF1 facilitates the transport of proteins and lipids from the endoplasmic reticulum to the Golgi apparatus and beyond. 3. **Vesicle-mediated transport**: ARF1 regulates the formation and movement of vesicles, which are essential for protein synthesis, modification, and transport. 4. **Cell signaling**: ARF1 is involved in various cell signaling pathways, including the regulation of cytokine signaling and immune responses. 5. **Immune system**: ARF1 plays a crucial role in the regulation of immune responses, including the presentation of antigens by MHC class II molecules. **Clinical Significance** ARF1 has been implicated in various diseases, including: 1. **HIV-1 infection**: ARF1 has been shown to interact with HIV-1 proteins, including Nef, which regulates the down-regulation of cell surface receptors. 2. **Cancer**: ARF1 has been implicated in the regulation of cancer cell metabolism and the transport of proteins and lipids. 3. **Neurological disorders**: ARF1 has been shown to play a role in the regulation of synaptic plasticity and the transport of proteins and lipids in neurons. 4. **Infectious diseases**: ARF1 has been implicated in the regulation of immune responses to viral infections, including HIV-1 and influenza virus. In conclusion, ARF1 is a critical regulator of cellular processes, including membrane trafficking, protein transport, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and mechanisms of action.

Genular Protein ID: 125910785

Symbol: ARF1_HUMAN

Name: ADP-ribosylation factor 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2474826

Title: Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.

PubMed ID: 2474826

DOI: 10.1073/pnas.86.16.6101

PubMed ID: 1899243

Title: Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins.

PubMed ID: 1899243

DOI: 10.1016/s0021-9258(18)52288-2

PubMed ID: 1577740

Title: Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin.

PubMed ID: 1577740

DOI: 10.1016/s0021-9258(19)50383-0

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8253837

Title: Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles.

PubMed ID: 8253837

DOI: 10.1083/jcb.123.6.1365

PubMed ID: 8861955

Title: p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.

PubMed ID: 8861955

DOI: 10.1002/j.1460-2075.1996.tb00801.x

PubMed ID: 10022920

Title: Identification of a new Pyk2 target protein with Arf-GAP activity.

PubMed ID: 10022920

DOI: 10.1128/mcb.19.3.2338

PubMed ID: 11950392

Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.

PubMed ID: 11950392

DOI: 10.1042/bj20020428

PubMed ID: 15107860

Title: FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.

PubMed ID: 15107860

DOI: 10.1038/ncb1119

PubMed ID: 17347647

Title: Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes.

PubMed ID: 17347647

DOI: 10.1038/sj.emboj.7601634

PubMed ID: 17555535

Title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.

PubMed ID: 17555535

DOI: 10.1111/j.1600-0854.2007.00594.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20213681

Title: Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.

PubMed ID: 20213681

DOI: 10.1002/pmic.200900783

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21454700

Title: Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain.

PubMed ID: 21454700

DOI: 10.1074/jbc.m111.233015

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23535599

Title: Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ.

PubMed ID: 23535599

DOI: 10.1038/nature12004

PubMed ID: 23889934

Title: The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity.

PubMed ID: 23889934

DOI: 10.1016/j.neuron.2013.05.003

PubMed ID: 24058294

Title: Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.

PubMed ID: 24058294

DOI: 10.1371/journal.pbio.1001652

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

PubMed ID: 28868155

Title: Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation.

PubMed ID: 28868155

DOI: 10.1038/npjgenmed.2016.36

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 7990966

Title: Structure of the human ADP-ribosylation factor 1 complexed with GDP.

PubMed ID: 7990966

DOI: 10.1038/372704a0

PubMed ID: 10102276

Title: Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis.

PubMed ID: 10102276

DOI: 10.1016/s0092-8674(00)80598-x

PubMed ID: 14690595

Title: Crystal structure of ARF1*Sec7 complexed with brefeldin A and its implications for the guanine nucleotide exchange mechanism.

PubMed ID: 14690595

DOI: 10.1016/s1097-2765(03)00475-1

PubMed ID: 15308674

Title: Conformational changes in human Arf1 on nucleotide exchange and deletion of membrane-binding elements.

PubMed ID: 15308674

DOI: 10.1074/jbc.m402109200

Sequence Information:

  • Length: 181
  • Mass: 20697
  • Checksum: AAC773D4A60186B6
  • Sequence:
  • MGNIFANLFK GLFGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 
    ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV 
    LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLSNQLRNQ 
    K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.