Details for: ARF1

Gene ID: 375

Symbol: ARF1

Ensembl ID: ENSG00000143761

Description: ADP ribosylation factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.52
    Marker Score: 119724
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.3
    Marker Score: 10412
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.24
    Marker Score: 37627
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.14
    Marker Score: 31106
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.13
    Marker Score: 4536
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.13
    Marker Score: 8639.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.13
    Marker Score: 41250
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.06
    Marker Score: 171124
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.97
    Marker Score: 19341
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.93
    Marker Score: 7451
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.89
    Marker Score: 8439
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.89
    Marker Score: 2571
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.83
    Marker Score: 12136
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.83
    Marker Score: 2483
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.82
    Marker Score: 149023
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.82
    Marker Score: 2722
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8
    Marker Score: 6843
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.77
    Marker Score: 2955
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.76
    Marker Score: 660
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.75
    Marker Score: 2342
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.73
    Marker Score: 10540
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.69
    Marker Score: 1126
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.67
    Marker Score: 2631
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.67
    Marker Score: 7491.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.67
    Marker Score: 1110.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.66
    Marker Score: 3924
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.65
    Marker Score: 2077
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.65
    Marker Score: 17245
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.65
    Marker Score: 4208
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.64
    Marker Score: 6449.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.64
    Marker Score: 5142
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.63
    Marker Score: 2827
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.63
    Marker Score: 11328
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.63
    Marker Score: 8243
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.62
    Marker Score: 3612
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.6
    Marker Score: 1516
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.6
    Marker Score: 2189
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.6
    Marker Score: 1524
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.6
    Marker Score: 2129
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.58
    Marker Score: 3026
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.58
    Marker Score: 4149
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.58
    Marker Score: 2803
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.57
    Marker Score: 2409.5
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.57
    Marker Score: 1811
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.55
    Marker Score: 19910
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.54
    Marker Score: 16244
  • Cell Name: platelet (CL0000233)
    Fold Change: 2.52
    Marker Score: 1142
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.52
    Marker Score: 16063
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.51
    Marker Score: 4491
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.5
    Marker Score: 2865
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.5
    Marker Score: 13130
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.49
    Marker Score: 10396.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.49
    Marker Score: 1421
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.48
    Marker Score: 2381
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.48
    Marker Score: 1957
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.48
    Marker Score: 2930
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.48
    Marker Score: 1804.5
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.47
    Marker Score: 1125
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.47
    Marker Score: 2214
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.46
    Marker Score: 5157
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.46
    Marker Score: 4620
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.45
    Marker Score: 1475
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.45
    Marker Score: 1646
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.44
    Marker Score: 3017
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.44
    Marker Score: 84650
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.44
    Marker Score: 4007.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.44
    Marker Score: 1661
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.44
    Marker Score: 4126
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.43
    Marker Score: 20977.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.43
    Marker Score: 2348.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.43
    Marker Score: 32620
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.43
    Marker Score: 3434
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.43
    Marker Score: 11913
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.41
    Marker Score: 27200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.4
    Marker Score: 6542
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.4
    Marker Score: 4248.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.39
    Marker Score: 4771
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.38
    Marker Score: 5431.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.38
    Marker Score: 1026
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.38
    Marker Score: 2024
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.37
    Marker Score: 586
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.37
    Marker Score: 4649
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.37
    Marker Score: 2230
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.37
    Marker Score: 628
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.37
    Marker Score: 2235
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.36
    Marker Score: 23949
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.36
    Marker Score: 1216
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.36
    Marker Score: 4927
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.34
    Marker Score: 810
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.34
    Marker Score: 582
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.34
    Marker Score: 6118
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.33
    Marker Score: 11196
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.33
    Marker Score: 1535
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.33
    Marker Score: 5490
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.33
    Marker Score: 1546
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.32
    Marker Score: 6219
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.32
    Marker Score: 1040
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.32
    Marker Score: 582
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.31
    Marker Score: 2596
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.31
    Marker Score: 3560

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Other Information

**Key characteristics:** - ARF1 is a transmembrane protein that is expressed in a variety of cell types. - It is a key regulator of the adaptive immune system, and it is involved in the processing, sorting, and trafficking of proteins in the endoplasmic reticulum. - It is also involved in the regulation of innate immunity, and it has been shown to play a role in the development of autoimmune diseases. **Pathways and functions:** - ARF1 is involved in the processing of proteins in the endoplasmic reticulum. - It is also involved in the sorting and trafficking of proteins in the ER. - It is involved in the regulation of innate immunity, and it has been shown to play a role in the development of autoimmune diseases. - ARF1 is also involved in the regulation of cell migration and differentiation. **Clinical significance:** - Mutations in the ARF1 gene have been linked to a number of human diseases, including rheumatoid arthritis, Crohn's disease, and multiple sclerosis. - ARF1 is a potential therapeutic target for these diseases, as it is involved in the development of autoimmune diseases. **Additional information:** - ARF1 is a member of the ADP-ribosylation factor family of proteins. - It is expressed in high levels in cells that are involved in the immune response, such as macrophages, dendritic cells, and T cells. - It is a highly conserved protein, with a similar sequence in mice and humans.

Genular Protein ID: 125910785

Symbol: ARF1_HUMAN

Name: ADP-ribosylation factor 1

UniProtKB Accession Codes:

P84077 P10947 P32889

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 EC 1 ELM 1 EMBL 11 EMDB 9 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 34 PDBsum 26 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 11 RefSeq 4 Rhea 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2474826

Title: Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.

PubMed ID: 2474826

DOI: 10.1073/pnas.86.16.6101

PubMed ID: 1899243

Title: Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins.

PubMed ID: 1899243

DOI: 10.1016/s0021-9258(18)52288-2

PubMed ID: 1577740

Title: Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin.

PubMed ID: 1577740

DOI: 10.1016/s0021-9258(19)50383-0

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8253837

Title: Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles.

PubMed ID: 8253837

DOI: 10.1083/jcb.123.6.1365

PubMed ID: 8861955

Title: p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.

PubMed ID: 8861955

DOI: 10.1002/j.1460-2075.1996.tb00801.x

PubMed ID: 10022920

Title: Identification of a new Pyk2 target protein with Arf-GAP activity.

PubMed ID: 10022920

DOI: 10.1128/mcb.19.3.2338

PubMed ID: 11950392

Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.

PubMed ID: 11950392

DOI: 10.1042/bj20020428

PubMed ID: 15107860

Title: FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.

PubMed ID: 15107860

DOI: 10.1038/ncb1119

PubMed ID: 17347647

Title: Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes.

PubMed ID: 17347647

DOI: 10.1038/sj.emboj.7601634

PubMed ID: 17555535

Title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.

PubMed ID: 17555535

DOI: 10.1111/j.1600-0854.2007.00594.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20213681

Title: Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.

PubMed ID: 20213681

DOI: 10.1002/pmic.200900783

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21454700

Title: Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain.

PubMed ID: 21454700

DOI: 10.1074/jbc.m111.233015

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23535599

Title: Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ.

PubMed ID: 23535599

DOI: 10.1038/nature12004

PubMed ID: 23889934

Title: The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity.

PubMed ID: 23889934

DOI: 10.1016/j.neuron.2013.05.003

PubMed ID: 24058294

Title: Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.

PubMed ID: 24058294

DOI: 10.1371/journal.pbio.1001652

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

PubMed ID: 28868155

Title: Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation.

PubMed ID: 28868155

DOI: 10.1038/npjgenmed.2016.36

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 7990966

Title: Structure of the human ADP-ribosylation factor 1 complexed with GDP.

PubMed ID: 7990966

DOI: 10.1038/372704a0

PubMed ID: 10102276

Title: Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis.

PubMed ID: 10102276

DOI: 10.1016/s0092-8674(00)80598-x

PubMed ID: 14690595

Title: Crystal structure of ARF1*Sec7 complexed with brefeldin A and its implications for the guanine nucleotide exchange mechanism.

PubMed ID: 14690595

DOI: 10.1016/s1097-2765(03)00475-1

PubMed ID: 15308674

Title: Conformational changes in human Arf1 on nucleotide exchange and deletion of membrane-binding elements.

PubMed ID: 15308674

DOI: 10.1074/jbc.m402109200

Sequence Information:

  • Length: 181
  • Mass: 20697
  • Checksum: AAC773D4A60186B6
  • Sequence:
    • MGNIFANLFK GLFGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV 
LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLSNQLRNQ 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.