ARF1 | ENSG00000143761 | NCBI 375

Details for: ARF1

Gene ID: 375

Symbol: ARF1

Ensembl ID: ENSG00000143761

Description: ADP ribosylation factor 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Asparagine n-linked glycosylation
(R-HSA-446203)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-mediated anterograde transport
(R-HSA-6807878)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Er to golgi anterograde transport
(R-HSA-199977)
Gene and protein expression by jak-stat signaling after interleukin-12 stimulation
(R-HSA-8950505)
Glycosphingolipid transport
(R-HSA-9845576)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Golgi associated vesicle biogenesis
(R-HSA-432722)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Intra-golgi traffic
(R-HSA-6811438)
Lysosome vesicle biogenesis
(R-HSA-432720)
Membrane trafficking
(R-HSA-199991)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(R-HSA-164938)
Nef mediated cd4 down-regulation
(R-HSA-167590)
Phospholipid metabolism
(R-HSA-1483257)
Pi metabolism
(R-HSA-1483255)
Post-translational protein modification
(R-HSA-597592)
Signaling by interleukins
(R-HSA-449147)
Synthesis of pips at the golgi membrane
(R-HSA-1660514)
Synthesis of pips at the plasma membrane
(R-HSA-1660499)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Trans-golgi network vesicle budding
(R-HSA-199992)
Transport of small molecules
(R-HSA-382551)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Viral infection pathways
(R-HSA-9824446)
Cell leading edge
(GO:0031252)
Cellular response to virus
(GO:0098586)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendritic spine organization
(GO:0097061)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Golgi membrane
(GO:0000139)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Intracellular copper ion homeostasis
(GO:0006878)
Intracellular protein transport
(GO:0006886)
Long-term synaptic depression
(GO:0060292)
Magnesium ion binding
(GO:0000287)
Mitotic cleavage furrow ingression
(GO:1990386)
Neuron projection
(GO:0043005)
Plasma membrane
(GO:0005886)
Postsynaptic density
(GO:0014069)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of arp2/3 complex-mediated actin nucleation
(GO:0034315)
Regulation of receptor internalization
(GO:0002090)
Rna binding
(GO:0003723)
Sarcomere
(GO:0030017)
Vesicle-mediated transport
(GO:0016192)

Other Information

Proteins

ADP-ribosylation factor 1

Genular Protein ID: 125910785

Symbol: ARF1_HUMAN

Name: ADP-ribosylation factor 1

UniProtKB Accession Codes:

P84077 P10947 P32889

Database IDs:

Citations:

PubMed ID: 2474826

Title: Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.

PubMed ID: 2474826

DOI: 10.1073/pnas.86.16.6101

PubMed ID: 1899243

Title: Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins.

PubMed ID: 1899243

DOI: 10.1016/s0021-9258(18)52288-2

PubMed ID: 1577740

Title: Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin.

PubMed ID: 1577740

DOI: 10.1016/s0021-9258(19)50383-0

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8253837

Title: Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles.

PubMed ID: 8253837

DOI: 10.1083/jcb.123.6.1365

PubMed ID: 8861955

Title: p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.

PubMed ID: 8861955

DOI: 10.1002/j.1460-2075.1996.tb00801.x

PubMed ID: 10022920

Title: Identification of a new Pyk2 target protein with Arf-GAP activity.

PubMed ID: 10022920

DOI: 10.1128/mcb.19.3.2338

PubMed ID: 11950392

Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.

PubMed ID: 11950392

DOI: 10.1042/bj20020428

PubMed ID: 15107860

Title: FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.

PubMed ID: 15107860

DOI: 10.1038/ncb1119

PubMed ID: 17347647

Title: Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes.

PubMed ID: 17347647

DOI: 10.1038/sj.emboj.7601634

PubMed ID: 17555535

Title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.

PubMed ID: 17555535

DOI: 10.1111/j.1600-0854.2007.00594.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20213681

Title: Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.

PubMed ID: 20213681

DOI: 10.1002/pmic.200900783

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21454700

Title: Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain.

PubMed ID: 21454700

DOI: 10.1074/jbc.m111.233015

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23535599

Title: Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ.

PubMed ID: 23535599

DOI: 10.1038/nature12004

PubMed ID: 23889934

Title: The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity.

PubMed ID: 23889934

DOI: 10.1016/j.neuron.2013.05.003

PubMed ID: 24058294

Title: Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.

PubMed ID: 24058294

DOI: 10.1371/journal.pbio.1001652

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

PubMed ID: 28868155

Title: Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation.

PubMed ID: 28868155

DOI: 10.1038/npjgenmed.2016.36

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 7990966

Title: Structure of the human ADP-ribosylation factor 1 complexed with GDP.

PubMed ID: 7990966

DOI: 10.1038/372704a0

PubMed ID: 10102276

Title: Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis.

PubMed ID: 10102276

DOI: 10.1016/s0092-8674(00)80598-x

PubMed ID: 14690595

Title: Crystal structure of ARF1*Sec7 complexed with brefeldin A and its implications for the guanine nucleotide exchange mechanism.

PubMed ID: 14690595

DOI: 10.1016/s1097-2765(03)00475-1

PubMed ID: 15308674

Title: Conformational changes in human Arf1 on nucleotide exchange and deletion of membrane-binding elements.

PubMed ID: 15308674

DOI: 10.1074/jbc.m402109200

Sequence Information:

Length: 181
Mass: 20697
Checksum: AAC773D4A60186B6
Sequence:

MGNIFANLFK GLFGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV 
LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLSNQLRNQ 
K

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ARF1

Associated with

Other Information

Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin. PubMed ID: 2474826

Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins. PubMed ID: 1899243

Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin. PubMed ID: 1577740

Large-scale concatenation cDNA sequencing. PubMed ID: 9110174

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles. PubMed ID: 8253837

p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. PubMed ID: 8861955

Identification of a new Pyk2 target protein with Arf-GAP activity. PubMed ID: 10022920

GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. PubMed ID: 11950392

FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. PubMed ID: 15107860

Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. PubMed ID: 17347647

Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta. PubMed ID: 17555535

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system. PubMed ID: 20213681

Initial characterization of the human central proteome. PubMed ID: 21269460

Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain. PubMed ID: 21454700

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ. PubMed ID: 23535599

The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity. PubMed ID: 23889934

Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2. PubMed ID: 24058294

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. PubMed ID: 25255805

Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. PubMed ID: 25807930

Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation. PubMed ID: 28868155

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structure of the human ADP-ribosylation factor 1 complexed with GDP. PubMed ID: 7990966

Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis. PubMed ID: 10102276

Crystal structure of ARF1*Sec7 complexed with brefeldin A and its implications for the guanine nucleotide exchange mechanism. PubMed ID: 14690595

Conformational changes in human Arf1 on nucleotide exchange and deletion of membrane-binding elements. PubMed ID: 15308674