Details for: ARF1

Gene ID: 375

Symbol: ARF1

Ensembl ID: ENSG00000143761

Description: ARF GTPase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 534.2819
    Cell Significance Index: -83.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 330.5034
    Cell Significance Index: -83.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 244.3272
    Cell Significance Index: -100.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 221.1925
    Cell Significance Index: -104.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 199.2087
    Cell Significance Index: -102.4700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 155.8816
    Cell Significance Index: -104.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 77.0506
    Cell Significance Index: -95.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 28.7388
    Cell Significance Index: -88.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 26.4594
    Cell Significance Index: -104.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.3155
    Cell Significance Index: -59.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.7545
    Cell Significance Index: -34.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.6804
    Cell Significance Index: 105.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.3365
    Cell Significance Index: 156.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.2902
    Cell Significance Index: 68.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1428
    Cell Significance Index: 92.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.1237
    Cell Significance Index: 428.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.8356
    Cell Significance Index: 132.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.8238
    Cell Significance Index: 49.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7491
    Cell Significance Index: 204.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.5635
    Cell Significance Index: 47.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.4507
    Cell Significance Index: 31.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.2517
    Cell Significance Index: 290.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.1934
    Cell Significance Index: 76.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1604
    Cell Significance Index: 139.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1463
    Cell Significance Index: 58.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9661
    Cell Significance Index: 1073.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8848
    Cell Significance Index: 49.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8583
    Cell Significance Index: 219.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8219
    Cell Significance Index: 224.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8127
    Cell Significance Index: 326.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5576
    Cell Significance Index: 81.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5108
    Cell Significance Index: 40.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5077
    Cell Significance Index: 666.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4321
    Cell Significance Index: 287.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3429
    Cell Significance Index: 266.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2380
    Cell Significance Index: 158.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1734
    Cell Significance Index: 116.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1552
    Cell Significance Index: 26.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9613
    Cell Significance Index: 67.9900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9569
    Cell Significance Index: 7.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9237
    Cell Significance Index: 157.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7674
    Cell Significance Index: 34.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7476
    Cell Significance Index: 38.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7386
    Cell Significance Index: 8.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5380
    Cell Significance Index: 192.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4458
    Cell Significance Index: 4.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3836
    Cell Significance Index: 10.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3327
    Cell Significance Index: 3.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3265
    Cell Significance Index: 62.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2855
    Cell Significance Index: 8.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2632
    Cell Significance Index: 199.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1856
    Cell Significance Index: 4.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1429
    Cell Significance Index: 15.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0813
    Cell Significance Index: 1.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0111
    Cell Significance Index: 8.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0071
    Cell Significance Index: -1.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0075
    Cell Significance Index: -14.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0282
    Cell Significance Index: -2.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0314
    Cell Significance Index: -23.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0605
    Cell Significance Index: -111.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0664
    Cell Significance Index: -102.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0718
    Cell Significance Index: -8.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0720
    Cell Significance Index: -97.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0847
    Cell Significance Index: -52.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0990
    Cell Significance Index: -62.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1285
    Cell Significance Index: -3.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1305
    Cell Significance Index: -73.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1650
    Cell Significance Index: -74.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1967
    Cell Significance Index: -41.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2152
    Cell Significance Index: -1.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3070
    Cell Significance Index: -88.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3679
    Cell Significance Index: -24.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3789
    Cell Significance Index: -23.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4253
    Cell Significance Index: -48.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5524
    Cell Significance Index: -19.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5546
    Cell Significance Index: -80.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6002
    Cell Significance Index: -69.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6176
    Cell Significance Index: -37.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7637
    Cell Significance Index: -19.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8404
    Cell Significance Index: -22.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8998
    Cell Significance Index: -69.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9279
    Cell Significance Index: -29.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9754
    Cell Significance Index: -77.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9906
    Cell Significance Index: -103.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.0204
    Cell Significance Index: -15.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0444
    Cell Significance Index: -14.2500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.0822
    Cell Significance Index: -6.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0946
    Cell Significance Index: -61.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.2514
    Cell Significance Index: -21.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.2657
    Cell Significance Index: -36.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.5097
    Cell Significance Index: -104.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.5419
    Cell Significance Index: -18.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5523
    Cell Significance Index: -95.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.7545
    Cell Significance Index: -77.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.8819
    Cell Significance Index: -95.1100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.8982
    Cell Significance Index: -19.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0744
    Cell Significance Index: -61.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.1075
    Cell Significance Index: -79.8100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.1834
    Cell Significance Index: -18.3400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -2.2612
    Cell Significance Index: -14.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ARF1 is a member of the ADP-ribosylation factor (ARF) family, which consists of six GTP-binding proteins that regulate various cellular processes. The primary characteristics of ARF1 include: 1. **GTP-binding activity**: ARF1 binds to GTP, which activates its GTPase activity, leading to the hydrolysis of GTP to GDP. 2. **Small size**: ARF1 is a small protein, consisting of approximately 160 amino acids. 3. **Membrane localization**: ARF1 is primarily localized to the Golgi apparatus and endoplasmic reticulum. 4. **Regulation of membrane trafficking**: ARF1 regulates the formation and movement of vesicles, which are essential for protein synthesis, modification, and transport. **Pathways and Functions** ARF1 is involved in various cellular pathways, including: 1. **Golgi-to-ER retrograde transport**: ARF1 regulates the transport of proteins and lipids from the Golgi apparatus to the endoplasmic reticulum. 2. **Anterograde transport**: ARF1 facilitates the transport of proteins and lipids from the endoplasmic reticulum to the Golgi apparatus and beyond. 3. **Vesicle-mediated transport**: ARF1 regulates the formation and movement of vesicles, which are essential for protein synthesis, modification, and transport. 4. **Cell signaling**: ARF1 is involved in various cell signaling pathways, including the regulation of cytokine signaling and immune responses. 5. **Immune system**: ARF1 plays a crucial role in the regulation of immune responses, including the presentation of antigens by MHC class II molecules. **Clinical Significance** ARF1 has been implicated in various diseases, including: 1. **HIV-1 infection**: ARF1 has been shown to interact with HIV-1 proteins, including Nef, which regulates the down-regulation of cell surface receptors. 2. **Cancer**: ARF1 has been implicated in the regulation of cancer cell metabolism and the transport of proteins and lipids. 3. **Neurological disorders**: ARF1 has been shown to play a role in the regulation of synaptic plasticity and the transport of proteins and lipids in neurons. 4. **Infectious diseases**: ARF1 has been implicated in the regulation of immune responses to viral infections, including HIV-1 and influenza virus. In conclusion, ARF1 is a critical regulator of cellular processes, including membrane trafficking, protein transport, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and mechanisms of action.

Genular Protein ID: 125910785

Symbol: ARF1_HUMAN

Name: ADP-ribosylation factor 1

UniProtKB Accession Codes:

P84077 P10947 P32889

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 EC 1 ELM 1 EMBL 11 EMDB 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 12 RefSeq 4 Rhea 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2474826

Title: Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.

PubMed ID: 2474826

DOI: 10.1073/pnas.86.16.6101

PubMed ID: 1899243

Title: Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins.

PubMed ID: 1899243

DOI: 10.1016/s0021-9258(18)52288-2

PubMed ID: 1577740

Title: Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin.

PubMed ID: 1577740

DOI: 10.1016/s0021-9258(19)50383-0

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8253837

Title: Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles.

PubMed ID: 8253837

DOI: 10.1083/jcb.123.6.1365

PubMed ID: 8861955

Title: p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.

PubMed ID: 8861955

DOI: 10.1002/j.1460-2075.1996.tb00801.x

PubMed ID: 10022920

Title: Identification of a new Pyk2 target protein with Arf-GAP activity.

PubMed ID: 10022920

DOI: 10.1128/mcb.19.3.2338

PubMed ID: 11950392

Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.

PubMed ID: 11950392

DOI: 10.1042/bj20020428

PubMed ID: 15107860

Title: FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.

PubMed ID: 15107860

DOI: 10.1038/ncb1119

PubMed ID: 17347647

Title: Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes.

PubMed ID: 17347647

DOI: 10.1038/sj.emboj.7601634

PubMed ID: 17555535

Title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.

PubMed ID: 17555535

DOI: 10.1111/j.1600-0854.2007.00594.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20213681

Title: Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.

PubMed ID: 20213681

DOI: 10.1002/pmic.200900783

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21454700

Title: Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain.

PubMed ID: 21454700

DOI: 10.1074/jbc.m111.233015

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23535599

Title: Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ.

PubMed ID: 23535599

DOI: 10.1038/nature12004

PubMed ID: 23889934

Title: The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity.

PubMed ID: 23889934

DOI: 10.1016/j.neuron.2013.05.003

PubMed ID: 24058294

Title: Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.

PubMed ID: 24058294

DOI: 10.1371/journal.pbio.1001652

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

PubMed ID: 28868155

Title: Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation.

PubMed ID: 28868155

DOI: 10.1038/npjgenmed.2016.36

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 7990966

Title: Structure of the human ADP-ribosylation factor 1 complexed with GDP.

PubMed ID: 7990966

DOI: 10.1038/372704a0

PubMed ID: 10102276

Title: Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis.

PubMed ID: 10102276

DOI: 10.1016/s0092-8674(00)80598-x

PubMed ID: 14690595

Title: Crystal structure of ARF1*Sec7 complexed with brefeldin A and its implications for the guanine nucleotide exchange mechanism.

PubMed ID: 14690595

DOI: 10.1016/s1097-2765(03)00475-1

PubMed ID: 15308674

Title: Conformational changes in human Arf1 on nucleotide exchange and deletion of membrane-binding elements.

PubMed ID: 15308674

DOI: 10.1074/jbc.m402109200

Sequence Information:

  • Length: 181
  • Mass: 20697
  • Checksum: AAC773D4A60186B6
  • Sequence:
    • MGNIFANLFK GLFGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV 
LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLSNQLRNQ 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.