Details for: MED16

Gene ID: 37535

Symbol: MED16

Ensembl ID: FBgn0034707

Description: Mediator complex subunit 16

Associated with

  • Epigenetic regulation by wdr5-containing histone modifying complexes
    (R-DME-9917777)
  • Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
    (R-DME-9851695)
  • Epigenetic regulation of gene expression
    (R-DME-212165)
  • Epigenetic regulation of gene expression by mll3 and mll4 complexes
    (R-DME-9818564)
  • Gene expression (transcription)
    (R-DME-74160)
  • Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
    (R-DME-9841922)
  • Mediator complex
    (GO:0016592)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of transcription initiation by rna polymerase ii
    (GO:0060260)
  • Response to heat
    (GO:0009408)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Transcription coregulator activity
    (GO:0003712)

Other Information

Genular Protein ID: 1070360560

Symbol: MED16_DROME

Name: Mediator of RNA polymerase II transcription subunit 16

UniProtKB Accession Codes:

Q9W278 Q8MT57 Q9GYW8

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CTD 1 ComplexPortal 1 DNASU 1 EMBL 4 EnsemblMetazoa 1 FlyBase 1 GO 7 Gene3D 1 GeneTree 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 Pfam 3 PhylomeDB 1 Proteomes 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 15297616

Title: MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators.

PubMed ID: 15297616

DOI: 10.1073/pnas.0401985101

PubMed ID: 16751183

Title: Coactivator cross-talk specifies transcriptional output.

PubMed ID: 16751183

DOI: 10.1101/gad.1418806

Sequence Information:

  • Length: 818
  • Mass: 89979
  • Checksum: 9AC366D99948F4D5
  • Sequence:
    • MTILYKVEGK EFSKDSVFPH KKVLCSVSAR NIVAFSALQS AIFPASHGGD AGDGSLPGAG 
LAVGASNSHV YVCDIVTPWE YYKVCSSKSL ISVLQWSPNG EQLLLGYVGG RVEIWQPRNQ 
SINLWVLQYY ATVPSEDIIE AQFFQNGKGV IFNALKKDHT YYAEKFERVE QQRPTLSGFG 
GVASEGCVLL TSSGLLAAFS LPAIQKTSAA GADGPAHEVV ELTPALHSIG ISRSFIEHCS 
MTPSPSGALN IAFSCGWQQQ LVQCFKVSLS LEGELGLEQH LAIKSESQTS IFLGPLDGRR 
ISHLKWTRIA NEDVIFIAYA CPDGAGSQLE QWTLTRRHQS VHALLQGGGG ANNKPNEFVQ 
SESWEQVGKV QLNASLADIS VTRLSVSTPD SCQVYAILQD NSVQVLEPNS MKQLNHTQFD 
RLSDASGAVK FVSGDLTPSS QILLIFDSHA QLYAMQAPLP KQGGSGLLLL EYCIVTGCDA 
SDVLLLNLGN LEALVEKLTD NFTRQPSFVR HFYYANFLAL KSNICRMQQQ EFDNLIILHA 
ISTTFKSLLR PSDLGFQDKG PADNLAIKLA ESIPDVDTVM LNLDAKDFTV EPVMLQSLQQ 
LIQWVTDLAL NMLHRLPEEV MKTKLSGKRP SYDISRDIVA ISSLRELLVM IRIWGLLNTQ 
CLPVYTKTMD NIDVLVILFR LLTRLAQNPA EPDEMLLDEC SLLSKQLLIP QPTKFNPTTL 
LSAQGFAAVK SGQLQFTSME EPTCLQDMET EEVVFASSVK DGVSNLQLGA RPSHIRRCAR 
CGFVFVNNAS KVAKTSALKA WFSKWLHCHC GGFWKQVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.