Details for: ARF3

Gene ID: 377

Symbol: ARF3

Ensembl ID: ENSG00000134287

Description: ADP ribosylation factor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.16
    Marker Score: 1918
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.38
    Marker Score: 1679
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.96
    Marker Score: 4815
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.84
    Marker Score: 3730.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.7
    Marker Score: 7071
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.64
    Marker Score: 2637
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.64
    Marker Score: 901
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.6
    Marker Score: 1796
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.49
    Marker Score: 51663
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.49
    Marker Score: 9053
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.48
    Marker Score: 5692
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.42
    Marker Score: 1418
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.41
    Marker Score: 413
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.41
    Marker Score: 317
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.41
    Marker Score: 700
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.4
    Marker Score: 4400.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.38
    Marker Score: 77329
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.38
    Marker Score: 11891
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.38
    Marker Score: 2030
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.38
    Marker Score: 11814
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.37
    Marker Score: 2427
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.35
    Marker Score: 6648
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.34
    Marker Score: 540.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.32
    Marker Score: 81446
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.32
    Marker Score: 33777
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.31
    Marker Score: 2994
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.31
    Marker Score: 441
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.31
    Marker Score: 10224
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.3
    Marker Score: 12349
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.3
    Marker Score: 1314
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.28
    Marker Score: 2680
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.27
    Marker Score: 1964
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.26
    Marker Score: 1306
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.23
    Marker Score: 1775
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.23
    Marker Score: 1411
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.23
    Marker Score: 819.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.23
    Marker Score: 5892
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.22
    Marker Score: 1295
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.22
    Marker Score: 4798
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.22
    Marker Score: 4996
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.2
    Marker Score: 6329
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2
    Marker Score: 5192
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.18
    Marker Score: 1237
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.15
    Marker Score: 430
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.15
    Marker Score: 723
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.14
    Marker Score: 563
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.14
    Marker Score: 328
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.14
    Marker Score: 1371
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.13
    Marker Score: 2819
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.13
    Marker Score: 10584
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.12
    Marker Score: 1058
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.12
    Marker Score: 7159
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.12
    Marker Score: 317
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.12
    Marker Score: 2900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.11
    Marker Score: 702
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.11
    Marker Score: 924
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.1
    Marker Score: 1877.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.1
    Marker Score: 2205
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1
    Marker Score: 1187
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.1
    Marker Score: 247
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.09
    Marker Score: 315
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.09
    Marker Score: 2929
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.09
    Marker Score: 1733
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.09
    Marker Score: 7101
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.08
    Marker Score: 604
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.08
    Marker Score: 1100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.08
    Marker Score: 9379.5
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.07
    Marker Score: 370
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.07
    Marker Score: 1518
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.07
    Marker Score: 1771
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.07
    Marker Score: 1339
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.06
    Marker Score: 270
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.06
    Marker Score: 548
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.05
    Marker Score: 991
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.04
    Marker Score: 262
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.04
    Marker Score: 2833
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.04
    Marker Score: 39426
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.04
    Marker Score: 492
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.03
    Marker Score: 704
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.03
    Marker Score: 987
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.02
    Marker Score: 240
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.02
    Marker Score: 1921
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.02
    Marker Score: 352
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.02
    Marker Score: 1669.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.02
    Marker Score: 475
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.02
    Marker Score: 579
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.01
    Marker Score: 258
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.01
    Marker Score: 1070
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.01
    Marker Score: 694
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.01
    Marker Score: 6414
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1
    Marker Score: 305
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1
    Marker Score: 730
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1
    Marker Score: 473
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1
    Marker Score: 36904
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1
    Marker Score: 3542
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1
    Marker Score: 246
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1
    Marker Score: 201
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1
    Marker Score: 1940
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71612
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.99
    Marker Score: 1201

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Other Information

**Key characteristics:** - ARF3 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in a variety of cell types, including myeloid dendritic cells, CD14-low and CD16-positive monocytes, glandular epithelial cells, and several types of immune cells. - It is a key regulator of the secretory pathway, which is responsible for the transport of proteins from the ER to the Golgi apparatus. **Pathways and functions:** - ARF3 is involved in the formation of lysosomes by promoting the sorting and trafficking of lysosomal precursors to the lysosome. - It also plays a role in the synthesis of membrane proteins by facilitating the transfer of newly synthesized polypeptide chains from the ER to the Golgi apparatus. - ARF3 is also involved in the regulation of inflammation by promoting the sorting and trafficking of inflammatory mediators to the cell surface. **Clinical significance:** - Mutations in ARF3 have been linked to a number of human diseases, including cancer and autoimmune disorders. - In cancer, ARF3 mutations can lead to the formation of tumors that are resistant to therapy. - Targeting ARF3 has been explored as a potential therapeutic strategy for cancer and other diseases that are characterized by abnormal protein trafficking.

Genular Protein ID: 3166562482

Symbol: ARF3_HUMAN

Name: ADP-ribosylation factor 3

UniProtKB Accession Codes:

P61204 A8K6G8 B7ZB63 P16587

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2474826

Title: Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.

PubMed ID: 2474826

DOI: 10.1073/pnas.86.16.6101

PubMed ID: 1744102

Title: Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding protein activator of cholera toxin.

PubMed ID: 1744102

DOI: 10.1016/s0021-9258(18)54462-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10623590

Title: Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.

PubMed ID: 10623590

DOI: 10.1006/bbrc.1999.1932

PubMed ID: 17555535

Title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.

PubMed ID: 17555535

DOI: 10.1111/j.1600-0854.2007.00594.x

Sequence Information:

  • Length: 181
  • Mass: 20601
  • Checksum: D6FA234DFAED3E5F
  • Sequence:
    • MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV 
LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLANQLKNK 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.