Details for: ARF3

Gene ID: 377

Symbol: ARF3

Ensembl ID: ENSG00000134287

Description: ARF GTPase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 218.2002
    Cell Significance Index: -33.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.9074
    Cell Significance Index: -27.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 90.1814
    Cell Significance Index: -37.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 78.6448
    Cell Significance Index: -31.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.0306
    Cell Significance Index: -36.8400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 69.5588
    Cell Significance Index: -35.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.8101
    Cell Significance Index: -32.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.8842
    Cell Significance Index: -34.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5813
    Cell Significance Index: -32.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.4018
    Cell Significance Index: -27.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7987
    Cell Significance Index: -34.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6482
    Cell Significance Index: 330.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3270
    Cell Significance Index: 36.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1229
    Cell Significance Index: 10.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0143
    Cell Significance Index: 75.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9888
    Cell Significance Index: 540.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9377
    Cell Significance Index: 169.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9314
    Cell Significance Index: 114.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8602
    Cell Significance Index: 22.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8231
    Cell Significance Index: 236.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8206
    Cell Significance Index: 42.6300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8143
    Cell Significance Index: 6.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7661
    Cell Significance Index: 35.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7131
    Cell Significance Index: 13.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6943
    Cell Significance Index: 306.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6369
    Cell Significance Index: 33.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5507
    Cell Significance Index: 38.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5441
    Cell Significance Index: 25.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5027
    Cell Significance Index: 14.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4955
    Cell Significance Index: 177.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4948
    Cell Significance Index: 67.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4752
    Cell Significance Index: 13.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4480
    Cell Significance Index: 5.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4343
    Cell Significance Index: 392.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4190
    Cell Significance Index: 9.6800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4030
    Cell Significance Index: 2.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3871
    Cell Significance Index: 45.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3739
    Cell Significance Index: 22.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3736
    Cell Significance Index: 36.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3478
    Cell Significance Index: 44.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3167
    Cell Significance Index: 8.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2774
    Cell Significance Index: 17.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2629
    Cell Significance Index: 11.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2572
    Cell Significance Index: 32.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2440
    Cell Significance Index: 46.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1962
    Cell Significance Index: 2.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1777
    Cell Significance Index: 11.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1676
    Cell Significance Index: 6.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1423
    Cell Significance Index: 7.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1347
    Cell Significance Index: 23.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1279
    Cell Significance Index: 6.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0942
    Cell Significance Index: 4.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0771
    Cell Significance Index: 12.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0736
    Cell Significance Index: 55.7000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0539
    Cell Significance Index: 0.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0504
    Cell Significance Index: 1.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0139
    Cell Significance Index: 0.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0092
    Cell Significance Index: 0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0036
    Cell Significance Index: 2.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0086
    Cell Significance Index: -5.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0104
    Cell Significance Index: -7.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0182
    Cell Significance Index: -34.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0225
    Cell Significance Index: -41.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0241
    Cell Significance Index: -2.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0270
    Cell Significance Index: -41.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0310
    Cell Significance Index: -0.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0310
    Cell Significance Index: -42.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0336
    Cell Significance Index: -23.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0451
    Cell Significance Index: -25.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0454
    Cell Significance Index: -0.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0533
    Cell Significance Index: -33.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0657
    Cell Significance Index: -13.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0681
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0720
    Cell Significance Index: -8.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0808
    Cell Significance Index: -36.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1122
    Cell Significance Index: -13.0700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1424
    Cell Significance Index: -16.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1521
    Cell Significance Index: -4.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1534
    Cell Significance Index: -30.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1788
    Cell Significance Index: -2.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1910
    Cell Significance Index: -4.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2441
    Cell Significance Index: -35.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2750
    Cell Significance Index: -4.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2787
    Cell Significance Index: -7.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3139
    Cell Significance Index: -24.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3207
    Cell Significance Index: -25.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3347
    Cell Significance Index: -13.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3378
    Cell Significance Index: -35.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3415
    Cell Significance Index: -9.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3418
    Cell Significance Index: -19.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3696
    Cell Significance Index: -10.3300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.3881
    Cell Significance Index: -2.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4128
    Cell Significance Index: -8.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4366
    Cell Significance Index: -9.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4993
    Cell Significance Index: -30.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4994
    Cell Significance Index: -10.8200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5164
    Cell Significance Index: -3.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5308
    Cell Significance Index: -5.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5361
    Cell Significance Index: -36.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5743
    Cell Significance Index: -16.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARF3 is a small GTPase that belongs to the ADP-ribosylation factor (ARF) family. It is characterized by its ability to bind GTP and hydrolyze it to GDP, regulating its activity. ARF3 is predominantly expressed in cells of the immune system, including myeloid dendritic cells, classical monocytes, and macrophages. It is also found in epithelial cells, neurons, and cells of the peripheral nervous system. ARF3 is involved in various cellular processes, including: * Vesicle-mediated transport: ARF3 regulates the formation and transport of vesicles between the Golgi apparatus and the endoplasmic reticulum (ER). * Golgi-to-ER retrograde transport: ARF3 is involved in the transport of proteins and lipids from the Golgi apparatus to the ER. * Anterograde transport: ARF3 regulates the transport of proteins and lipids from the ER to the Golgi apparatus and the plasma membrane. **Pathways and Functions:** ARF3 is involved in various signaling pathways, including: * Asparagine n-linked glycosylation: ARF3 regulates the formation of glycoproteins in the Golgi apparatus. * Copi-dependent golgi-to-er retrograde traffic: ARF3 is involved in the transport of proteins and lipids from the Golgi apparatus to the ER. * Copi-mediated anterograde transport: ARF3 regulates the transport of proteins and lipids from the ER to the Golgi apparatus and the plasma membrane. * Intra-golgi and retrograde golgi-to-er traffic: ARF3 is involved in the transport of proteins and lipids within the Golgi apparatus and between the Golgi apparatus and the ER. * Intracellular protein transport: ARF3 regulates the transport of proteins within the cell. **Clinical Significance:** Dysregulation of ARF3 has been implicated in various diseases, including: * Cancer: ARF3 is involved in the regulation of cell growth and proliferation, and its dysregulation has been implicated in various types of cancer. * Inflammatory disorders: ARF3 is involved in the regulation of immune responses, and its dysregulation has been implicated in inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. * Neurodegenerative diseases: ARF3 is involved in the regulation of protein synthesis and transport, and its dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, ARF3 is a crucial regulator of membrane trafficking and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of ARF3 regulation and its role in human disease.

Genular Protein ID: 3166562482

Symbol: ARF3_HUMAN

Name: ADP-ribosylation factor 3

UniProtKB Accession Codes:

P61204 A8K6G8 B7ZB63 P16587

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EMDB 1 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2474826

Title: Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.

PubMed ID: 2474826

DOI: 10.1073/pnas.86.16.6101

PubMed ID: 1744102

Title: Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding protein activator of cholera toxin.

PubMed ID: 1744102

DOI: 10.1016/s0021-9258(18)54462-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10623590

Title: Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.

PubMed ID: 10623590

DOI: 10.1006/bbrc.1999.1932

PubMed ID: 17555535

Title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.

PubMed ID: 17555535

DOI: 10.1111/j.1600-0854.2007.00594.x

Sequence Information:

  • Length: 181
  • Mass: 20601
  • Checksum: D6FA234DFAED3E5F
  • Sequence:
    • MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV 
LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLANQLKNK 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.