ARF4 | ENSG00000168374 | NCBI 378

Details for: ARF4

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo trafficking to the periciliary membrane
(R-HSA-5620920)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-mediated anterograde transport
(R-HSA-6807878)
Er to golgi anterograde transport
(R-HSA-199977)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Post-translational protein modification
(R-HSA-597592)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vxpx cargo-targeting to cilium
(R-HSA-5620916)
Apical protein localization
(GO:0045176)
Cell migration
(GO:0016477)
Cilium assembly
(GO:0060271)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendritic spine
(GO:0043197)
Dendritic spine development
(GO:0060996)
Endoplasmic reticulum to golgi vesicle-mediated transport
(GO:0006888)
Epidermal growth factor receptor binding
(GO:0005154)
Establishment or maintenance of epithelial cell apical/basal polarity
(GO:0045197)
Extracellular exosome
(GO:0070062)
Glutamatergic synapse
(GO:0098978)
Golgi membrane
(GO:0000139)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Intracellular protein transport
(GO:0006886)
Learning
(GO:0007612)
Membrane
(GO:0016020)
Nad+-protein-arginine adp-ribosyltransferase activity
(GO:0106274)
Negative regulation of apoptotic process
(GO:0043066)
Phospholipase d activator activity
(GO:1990583)
Plasma membrane
(GO:0005886)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein localization to cilium
(GO:0061512)
Regulation of cilium assembly
(GO:1902017)
Regulation of postsynapse organization
(GO:0099175)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Retrograde vesicle-mediated transport, golgi to endoplasmic reticulum
(GO:0006890)
Ruffle membrane
(GO:0032587)
Vesicle-mediated transport
(GO:0016192)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

plasmablast CL0000980

CSI 81.6

rCSI 64.19%

PRS 7.3
extravillous trophoblast CL0008036

CSI 68.1

rCSI 84.24%

PRS 5.37
intestinal epithelial cell CL0002563

CSI 64.71

rCSI 67.63%

PRS 6.45
placental villous trophoblast CL2000060

CSI 52.7

rCSI 81.43%

PRS 5.75
stem cell CL0000034

CSI 50.51

rCSI 48.71%

PRS 3.64
fallopian tube secretory epithelial cell CL4030006

CSI 48.76

rCSI 46.93%

PRS 6.36
colon epithelial cell CL0011108

CSI 48.33

rCSI 50.62%

PRS 5.71
mucous neck cell CL0000651

CSI 47.92

rCSI 69.07%

PRS 9.96
goblet cell CL0000160

CSI 45.74

rCSI 43.22%

PRS 6.42
pancreatic A cell CL0000171

CSI 44.85

rCSI 46.99%

PRS 6.54
intestine goblet cell CL0019031

CSI 41.95

rCSI 37.23%

PRS 6.14
epithelial cell of lower respiratory tract CL0002632

CSI 41.03

rCSI 31.81%

PRS 5.85
respiratory suprabasal cell CL4033048

CSI 38.61

rCSI 49.51%

PRS 7.08
epithelial cell of lung CL0000082

CSI 38.09

rCSI 31.58%

PRS 5.85
bronchus fibroblast of lung CL2000093

CSI 35.68

rCSI 28.99%

PRS 6.57
enteric smooth muscle cell CL0002504

CSI 35.43

rCSI 50.56%

PRS 6.95
M cell of gut CL0000682

CSI 33.55

rCSI 35.65%

PRS 11.01
small intestine goblet cell CL1000495

CSI 33.1

rCSI 72.5%

PRS 8.34
conjunctival epithelial cell CL1000432

CSI 33.1

rCSI 50.56%

PRS 6.15
pancreatic ductal cell CL0002079

CSI 30.77

rCSI 59.85%

PRS 6.26
peripheral nervous system neuron CL2000032

CSI 29.51

rCSI 40.22%

PRS 5.52
enterocyte CL0000584

CSI 27.41

rCSI 44.19%

PRS 9.92
plasma cell CL0000786

CSI 27.29

rCSI 35.77%

PRS 31.83
foveolar cell of stomach CL0002179

CSI 26.89

rCSI 57.23%

PRS 9.95
colon goblet cell CL0009039

CSI 24.92

rCSI 59.23%

PRS 9.23
syncytiotrophoblast cell CL0000525

CSI 23.98

rCSI 69.06%

PRS 12.41
pancreatic acinar cell CL0002064

CSI 22.95

rCSI 30.5%

PRS 6.66
glandular epithelial cell CL0000150

CSI 22.56

rCSI 59.38%

PRS 12
basal cell of prostate epithelium CL0002341

CSI 20.84

rCSI 60.28%

PRS 13.87
tendon cell CL0000388

CSI 20.49

rCSI 53.25%

PRS 18.68
keratinocyte CL0000312

CSI 20.49

rCSI 17.18%

PRS 7.35
epithelial cell CL0000066

CSI 19.26

rCSI 29.6%

PRS 8.85
stromal cell of ovary CL0002132

CSI 19.07

rCSI 52.4%

PRS 10.22
respiratory basal cell CL0002633

CSI 18.71

rCSI 19.38%

PRS 7.21
pancreatic D cell CL0000173

CSI 18.21

rCSI 17.91%

PRS 6.65
microcirculation associated smooth muscle cell CL0008035

CSI 18.17

rCSI 52.61%

PRS 6.97
acinar cell CL0000622

CSI 18.1

rCSI 26.54%

PRS 8.06
bronchial goblet cell CL1000312

CSI 18.09

rCSI 72.3%

PRS 13.61
luminal epithelial cell of mammary gland CL0002326

CSI 17.87

rCSI 32.47%

PRS 9.38
skin fibroblast CL0002620

CSI 17.58

rCSI 15.15%

PRS 10.17
adventitial cell CL0002503

CSI 17.3

rCSI 41.31%

PRS 9.94
ciliated epithelial cell CL0000067

CSI 17.22

rCSI 15.14%

PRS 4.43
club cell CL0000158

CSI 17.13

rCSI 25.09%

PRS 7.24
paneth cell of epithelium of small intestine CL1000343

CSI 16.68

rCSI 46.75%

PRS 9.57
secretory cell CL0000151

CSI 16.34

rCSI 17.05%

PRS 6.29
mesodermal cell CL0000222

CSI 15.94

rCSI 19.13%

PRS 6.1
mesenchymal cell CL0008019

CSI 15.78

rCSI 40.08%

PRS 6.28
alveolar adventitial fibroblast CL4028006

CSI 15.75

rCSI 24.88%

PRS 6.17
type B pancreatic cell CL0000169

CSI 15.32

rCSI 33.93%

PRS 5.71
transit amplifying cell of colon CL0009011

CSI 15.18

rCSI 17.83%

PRS 7.33
nasal mucosa goblet cell CL0002480

CSI 14.48

rCSI 16.79%

PRS 9.15
fibroblast of lung CL0002553

CSI 14.27

rCSI 13.28%

PRS 6.22
megakaryocyte-erythroid progenitor cell CL0000050

CSI 13.76

rCSI 12.43%

PRS 5.41
pancreatic stellate cell CL0002410

CSI 13.55

rCSI 78.85%

PRS 9.26
endothelial cell of placenta CL0009092

CSI 13.19

rCSI 65.03%

PRS 8.33
transit amplifying cell CL0009010

CSI 13.12

rCSI 20.06%

PRS 10.04
mammary gland epithelial cell CL0002327

CSI 12.76

rCSI 44.78%

PRS 11.23
kidney epithelial cell CL0002518

CSI 12.34

rCSI 23.55%

PRS 14.94
pulmonary alveolar type 2 cell CL0002063

CSI 12.32

rCSI 19.11%

PRS 9.67
tracheobronchial serous cell CL0019001

CSI 12.23

rCSI 52.83%

PRS 11.95
lung ciliated cell CL1000271

CSI 12.21

rCSI 14.12%

PRS 4.48
fibroblast of breast CL4006000

CSI 11.8

rCSI 49.61%

PRS 16.98
IgM plasma cell CL0000986

CSI 11.35

rCSI 51.07%

PRS 32.46
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 11.12

rCSI 19.02%

PRS 13.24
intrahepatic cholangiocyte CL0002538

CSI 11.12

rCSI 26.68%

PRS 11.56
Hofbauer cell CL3000001

CSI 11.08

rCSI 20.91%

PRS 7.63
keratocyte CL0002363

CSI 10.98

rCSI 26.39%

PRS 9.52
plasmacytoid dendritic cell, human CL0001058

CSI 10.9

rCSI 7.61%

PRS 6.45
perivascular cell CL4033054

CSI 10.76

rCSI 14.71%

PRS 6.97
intestinal crypt stem cell of small intestine CL0009017

CSI 10.48

rCSI 28.25%

PRS 7.93
IgA plasma cell CL0000987

CSI 10.2

rCSI 10.44%

PRS 11.63
myofibroblast cell CL0000186

CSI 9.9

rCSI 13.71%

PRS 8.86
mucus secreting cell CL0000319

CSI 9.88

rCSI 15.7%

PRS 7.98
enterocyte of epithelium of large intestine CL0002071

CSI 9.74

rCSI 51.17%

PRS 11.85
respiratory epithelial cell CL0002368

CSI 9.67

rCSI 59.72%

PRS 20.55
pancreatic PP cell CL0002275

CSI 9.66

rCSI 38.46%

PRS 10.89
radial glial cell CL0000681

CSI 9.57

rCSI 13.3%

PRS 6.39
cerebral cortex GABAergic interneuron CL0010011

CSI 9.34

rCSI 27.57%

PRS 7.73
duct epithelial cell CL0000068

CSI 9.26

rCSI 13.55%

PRS 6.5
corneal epithelial cell CL0000575

CSI 9.01

rCSI 25.78%

PRS 11.68
early lymphoid progenitor CL0000936

CSI 8.86

rCSI 7.78%

PRS 6.88
tracheal goblet cell CL1000329

CSI 8.85

rCSI 19.31%

PRS 12.55
eosinophil CL0000771

CSI 8.63

rCSI 56.63%

PRS 16.24
primitive red blood cell CL0002355

CSI 8.62

rCSI 46.53%

PRS 11.97
luminal cell of prostate epithelium CL0002340

CSI 8.53

rCSI 45.89%

PRS 11.2
activated type II NK T cell CL0000931

CSI 8.48

rCSI 9.54%

PRS 10.13
neuroblast (sensu Vertebrata) CL0000031

CSI 8.42

rCSI 10.81%

PRS 6.03
lung goblet cell CL1000143

CSI 8.07

rCSI 90.25%

PRS 21.63
respiratory goblet cell CL0002370

CSI 7.99

rCSI 86.95%

PRS 11.67
basal cell CL0000646

CSI 7.98

rCSI 10.67%

PRS 6.71
enteroendocrine cell CL0000164

CSI 7.86

rCSI 10.75%

PRS 6.78
helper T cell CL0000912

CSI 7.8

rCSI 11.03%

PRS 8.96
stromal cell CL0000499

CSI 7.68

rCSI 21.6%

PRS 8.95
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 7.53

rCSI 17.17%

PRS 6.41
brush cell of tracheobronchial tree CL0002075

CSI 7.29

rCSI 21.63%

PRS 10.1
IgG plasma cell CL0000985

CSI 6.81

rCSI 8.16%

PRS 10.69
lung secretory cell CL1000272

CSI 6.69

rCSI 16.55%

PRS 5.68
granulocyte CL0000094

CSI 6.63

rCSI 10.13%

PRS 7.7
peptic cell CL0000155

CSI 6.52

rCSI 64.09%

PRS 19.36
tissue-resident macrophage CL0000864

CSI 6.36

rCSI 29.78%

PRS 16

astrocyte of the cerebral cortex CL0002605

CSI -9.4

rCSI -21.1%

PRS 3.8%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -8.4

rCSI -26.3%

PRS 4.2%
renal alpha-intercalated cell CL0005011

CSI -7.5

rCSI -10.1%

PRS 8.2%
alternatively activated macrophage CL0000890

CSI -5.4

rCSI -6.8%

PRS 9.5%
parietal epithelial cell CL1000452

CSI -4.9

rCSI -13.1%

PRS 6.0%
T follicular helper cell CL0002038

CSI -4.6

rCSI -3.5%

PRS 10.0%
CD4-positive, alpha-beta memory T cell CL0000897

CSI -3.6

rCSI -2.6%

PRS 8.4%
regular ventricular cardiac myocyte CL0002131

CSI -2.6

rCSI -16.2%

PRS 5.0%
naive T cell CL0000898

CSI -2.1

rCSI -1.5%

PRS 8.9%
CD14-positive, CD16-positive monocyte CL0002397

CSI -2.0

rCSI -2.6%

PRS 8.6%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -1.7

rCSI -3.1%

PRS 5.6%
vascular leptomeningeal cell CL4023051

CSI -1.6

rCSI -2.9%

PRS 4.7%
lamp5 GABAergic cortical interneuron CL4023011

CSI -1.5

rCSI -2.5%

PRS 3.6%
effector CD4-positive, alpha-beta T cell CL0001044

CSI -1.4

rCSI -3.9%

PRS 8.9%
brush cell CL0002204

CSI -1.2

rCSI -2.4%

PRS 17.5%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -1.2

rCSI -4.3%

PRS 3.3%
sncg GABAergic cortical interneuron CL4023015

CSI -1.1

rCSI -1.8%

PRS 4.0%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -1.1

rCSI -2.7%

PRS 3.5%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -1.0

rCSI -5.9%

PRS 3.8%
near-projecting glutamatergic cortical neuron CL4023012

CSI -0.9

rCSI -3.5%

PRS 3.7%
fibroblast of cardiac tissue CL0002548

CSI -0.9

rCSI -4.1%

PRS 3.7%
L6b glutamatergic cortical neuron CL4023038

CSI -0.7

rCSI -2.2%

PRS 3.9%
pulmonary artery endothelial cell CL1001568

CSI -0.4

rCSI -0.5%

PRS 9.5%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI -0.3

rCSI -0.3%

PRS 10.7%
lung neuroendocrine cell CL1000223

CSI -0.2

rCSI -0.4%

PRS 7.1%
myelocyte CL0002193

CSI -0.2

rCSI -1.6%

PRS 21.2%
retinal ganglion cell CL0000740

CSI -0.1

rCSI -0.1%

PRS 4.4%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.0

rCSI 0.0%

PRS 10.2%
ventricular cardiac muscle cell CL2000046

CSI 0.0

rCSI 0.1%

PRS 26.9%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 0.0

rCSI 0.2%

PRS 30.5%
tracheobronchial smooth muscle cell CL0019019

CSI 0.1

rCSI 0.2%

PRS 8.2%
direct pathway medium spiny neuron CL4023026

CSI 0.1

rCSI 2.4%

PRS 2.6%
hair follicular keratinocyte CL2000092

CSI 0.1

rCSI 2.4%

PRS 25.9%
enteroglial cell CL4040002

CSI 0.2

rCSI 0.8%

PRS 13.8%
neural cell CL0002319

CSI 0.2

rCSI 0.6%

PRS 11.7%
megakaryocyte progenitor cell CL0000553

CSI 0.2

rCSI 3.3%

PRS 16.7%
parietal cell CL0000162

CSI 0.2

rCSI 1.6%

PRS 38.7%
enteroendocrine cell of colon CL0009042

CSI 0.2

rCSI 0.9%

PRS 16.9%
amacrine cell CL0000561

CSI 0.2

rCSI 0.7%

PRS 5.2%
pre-conventional dendritic cell CL0002010

CSI 0.2

rCSI 3.2%

PRS 21.6%
endocardial cell CL0002350

CSI 0.3

rCSI 1.2%

PRS 9.5%
basophil CL0000767

CSI 0.3

rCSI 0.5%

PRS 13.5%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.3

rCSI 1.6%

PRS 14.4%
blood vessel smooth muscle cell CL0019018

CSI 0.3

rCSI 2.2%

PRS 6.5%
renal interstitial pericyte CL1001318

CSI 0.3

rCSI 0.8%

PRS 6.6%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.3

rCSI 1.6%

PRS 8.0%
indirect pathway medium spiny neuron CL4023029

CSI 0.3

rCSI 8.0%

PRS 3.3%
retinal cone cell CL0000573

CSI 0.3

rCSI 0.6%

PRS 4.7%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.3

rCSI 0.4%

PRS 9.0%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 0.4

rCSI 1.1%

PRS 11.6%
thymocyte CL0000893

CSI 0.4

rCSI 1.3%

PRS 19.9%
group 2 innate lymphoid cell CL0001069

CSI 0.4

rCSI 2.3%

PRS 21.7%
neuroplacodal cell CL0000032

CSI 0.5

rCSI 4.3%

PRS 22.8%
smooth muscle cell of prostate CL1000487

CSI 0.5

rCSI 2.9%

PRS 32.4%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.5

rCSI 5.2%

PRS 9.8%
late pro-B cell CL0002048

CSI 0.5

rCSI 1.3%

PRS 20.0%
renal principal cell CL0005009

CSI 0.5

rCSI 1.3%

PRS 8.8%
retina horizontal cell CL0000745

CSI 0.5

rCSI 0.8%

PRS 5.8%
epicardial adipocyte CL1000309

CSI 0.5

rCSI 1.7%

PRS 8.8%
enterocyte of epithelium of small intestine CL1000334

CSI 0.5

rCSI 8.0%

PRS 15.7%
small pre-B-II cell CL0000954

CSI 0.5

rCSI 0.5%

PRS 13.3%
macroglial cell CL0000126

CSI 0.5

rCSI 1.4%

PRS 10.1%
lung microvascular endothelial cell CL2000016

CSI 0.5

rCSI 10.5%

PRS 22.0%
retinal rod cell CL0000604

CSI 0.6

rCSI 1.1%

PRS 6.4%
cytotoxic T cell CL0000910

CSI 0.6

rCSI 3.7%

PRS 9.4%
myeloid dendritic cell CL0000782

CSI 0.6

rCSI 0.9%

PRS 9.1%
retinal pigment epithelial cell CL0002586

CSI 0.7

rCSI 1.3%

PRS 6.7%
erythroblast CL0000765

CSI 0.7

rCSI 1.8%

PRS 10.4%
renal beta-intercalated cell CL0002201

CSI 0.7

rCSI 1.7%

PRS 7.8%
cardiac muscle cell CL0000746

CSI 0.7

rCSI 1.0%

PRS 4.9%
basophil mast progenitor cell CL0002028

CSI 0.7

rCSI 3.8%

PRS 21.8%
uterine smooth muscle cell CL0002601

CSI 0.7

rCSI 4.8%

PRS 43.4%
ON-bipolar cell CL0000749

CSI 0.8

rCSI 1.2%

PRS 7.8%
germinal center B cell CL0000844

CSI 0.9

rCSI 2.6%

PRS 16.3%
cerebellar granule cell CL0001031

CSI 0.9

rCSI 1.3%

PRS 6.1%
class switched memory B cell CL0000972

CSI 0.9

rCSI 0.7%

PRS 10.4%
myeloid dendritic cell, human CL0001057

CSI 0.9

rCSI 5.0%

PRS 20.1%
T-helper 1 cell CL0000545

CSI 0.9

rCSI 1.6%

PRS 18.1%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 0.9

rCSI 1.3%

PRS 13.2%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.9

rCSI 4.7%

PRS 12.3%
neural progenitor cell CL0011020

CSI 0.9

rCSI 4.0%

PRS 6.2%
periportal region hepatocyte CL0019026

CSI 0.9

rCSI 3.6%

PRS 9.8%
Schwann cell CL0002573

CSI 0.9

rCSI 2.7%

PRS 8.1%
epithelial cell of nephron CL1000449

CSI 0.9

rCSI 8.9%

PRS 27.3%
granulocyte monocyte progenitor cell CL0000557

CSI 1.0

rCSI 0.9%

PRS 6.8%
centrilobular region hepatocyte CL0019029

CSI 1.0

rCSI 2.6%

PRS 10.6%
alveolar macrophage CL0000583

CSI 1.1

rCSI 1.7%

PRS 7.2%
fraction A pre-pro B cell CL0002045

CSI 1.1

rCSI 1.3%

PRS 12.7%
Bergmann glial cell CL0000644

CSI 1.1

rCSI 1.6%

PRS 6.7%
dendritic cell, human CL0001056

CSI 1.2

rCSI 1.8%

PRS 7.1%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 1.2

rCSI 13.6%

PRS 26.0%
mature B cell CL0000785

CSI 1.2

rCSI 1.0%

PRS 7.6%
regular atrial cardiac myocyte CL0002129

CSI 1.2

rCSI 3.8%

PRS 7.1%
pulmonary alveolar type 1 cell CL0002062

CSI 1.2

rCSI 6.9%

PRS 9.0%
mesenchymal stem cell of adipose tissue CL0002570

CSI 1.2

rCSI 6.6%

PRS 22.0%
alpha-beta T cell CL0000789

CSI 1.2

rCSI 1.4%

PRS 9.4%
pro-T cell CL0000827

CSI 1.2

rCSI 28.6%

PRS 42.9%
kidney connecting tubule epithelial cell CL1000768

CSI 1.3

rCSI 3.2%

PRS 4.8%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.3

rCSI 2.6%

PRS 10.5%
innate lymphoid cell CL0001065

CSI 1.3

rCSI 2.7%

PRS 9.9%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [ARF4](/details-gene/378), or ADP-ribosylation factor 4, is a protein-coding gene located on chromosome 3p14.3. It encodes a member of the ARF family of small GTP-binding proteins, which are critical regulators of intracellular vesicular transport. As a GTPase, [ARF4](/details-gene/378) cycles between an active GTP-bound and an inactive GDP-bound state to control the assembly and disassembly of vesicle coat proteins, primarily at the Golgi apparatus. Functionally, it is integral to processes such as [Endoplasmic reticulum to golgi vesicle-mediated transport](/details-go/GO:0006888), [Cilium assembly](/details-go/GO:0060271), and the maintenance of cellular polarity. Its expression profile reflects this role, showing high significance in professional secretory cells such as [plasmablast](/details-cell/CL0000980)s, various trophoblast populations, and multiple types of intestinal and respiratory epithelial cells, suggesting it is a fundamental component of the cellular machinery required for high-volume protein and mucus secretion. An association with disease is noted in OMIM ([601177](https://omim.org/entry/601177)). ## Cellular Roles and Expression Landscape The expression landscape of [ARF4](/details-gene/378) strongly indicates its central role in cells with high secretory capacity and complex membrane trafficking requirements. **Overall**, the gene shows the highest significance in [plasmablast](/details-cell/CL0000980) (CSI: 81.60), the terminally differentiated B lymphocytes responsible for mass antibody production. This is complemented by high significance scores in placental cells, including [extravillous trophoblast](/details-cell/CL0008036) and [placental villous trophoblast](/details-cell/CL2000060), which are involved in extensive hormone and protein secretion to maintain pregnancy. A second major functional group where [ARF4](/details-gene/378) is highly significant comprises various epithelial cells that form mucosal barriers. This includes [intestinal epithelial cell](/details-cell/CL0002563), [colon epithelial cell](/details-cell/CL0011108), [goblet cell](/details-cell/CL0000160), and [epithelial cell of lower respiratory tract](/details-cell/CL0002632). In these cells, efficient Golgi transport is essential for the production and secretion of mucus, digestive enzymes, and other factors that maintain barrier integrity and function. Its high expression in [stem cell](/details-cell/CL0000034)s also suggests a role in the biogenesis of organelles required to support differentiation into these highly active cell types. Conversely, [ARF4](/details-gene/378) demonstrates low to negative significance in several neural cell types, such as [astrocyte of the cerebral cortex](/details-cell/CL0002605) and multiple GABAergic interneurons, as well as in various mature T cell subsets like [CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897) and [T follicular helper cell](/details-cell/CL0002038). This pattern suggests that while it is essential for the extreme secretory load of a [plasmablast](/details-cell/CL0000980), its role may be less prominent in other immune cells or in the central nervous system, highlighting its specialized function in high-flux secretory pathways rather than as a ubiquitous housekeeping gene. ## Pathways and Molecular Function The molecular functions and biological pathways associated with [ARF4](/details-gene/378) confirm its identity as a key regulator of intracellular trafficking. Its fundamental molecular activities are [Gtp binding](/details-go/GO:0005525) and [Gtpase activity](/details-go/GO:0003924), which enable it to act as a molecular switch in vesicle formation. This core function drives its participation in a wide array of transport-related processes. Analysis of Reactome pathways places [ARF4](/details-gene/378) at the heart of the secretory pathway, with significant involvement in [Membrane trafficking](/details-go/R-HSA-199991), [Er to golgi anterograde transport](/details-go/R-HSA-199977), and particularly in COPI-mediated transport, including [Copi-dependent golgi-to-er retrograde traffic](/details-go/R-HSA-6811434) and [Copi-mediated anterograde transport](/details-go/R-HSA-6807878). These pathways are essential for sorting and moving newly synthesized proteins and lipids from the endoplasmic reticulum through the Golgi complex, a process vital for the cells where [ARF4](/details-gene/378) is most prominently expressed. In addition to its canonical role in the Golgi, [ARF4](/details-gene/378) is also implicated in the specialized process of [Cilium assembly](/details-go/GO:0060271), as detailed in both GO annotations and Reactome pathways ([R-HSA-5617833](https://reactome.org/content/detail/R-HSA-5617833)). It participates in [Cargo trafficking to the periciliary membrane](/details-go/R-HSA-5620920), a critical step for building and maintaining the primary cilium, an organelle that functions as a cellular antenna. This function is consistent with its expression in polarized epithelial cells, where cilia play sensory and motility roles. The dual involvement in both general secretion and specific ciliary transport underscores its versatility as a trafficking regulator. ## Research Directions The well-defined role of [ARF4](/details-gene/378) in vesicle transport, combined with its specific expression pattern, suggests several avenues for future research into its function in health and disease. **Proposed Hypotheses:** 1. Given its top significance in [plasmablast](/details-cell/CL0000980)s and its fundamental role in Golgi trafficking, [ARF4](/details-gene/378) may be a rate-limiting factor for immunoglobulin secretion. Its functional impairment could lead to specific humoral immunodeficiencies characterized by defective antibody production, while its overexpression may be a feature of plasma cell dyscrasias like multiple myeloma. 2. The high expression of [ARF4](/details-gene/378) in placental trophoblasts suggests it is critical for establishing and maintaining a healthy pregnancy. Dysregulation of [ARF4](/details-gene/378)-mediated transport could disrupt the secretion of essential hormones (e.g., hCG) and growth factors, potentially contributing to placental insufficiency or pre-eclampsia. 3. Based on its role in [Cilium assembly](/details-go/GO:0060271) and high expression in respiratory and intestinal epithelia, defects in [ARF4](/details-gene/378) function could underlie certain ciliopathies or contribute to chronic inflammatory diseases of mucosal surfaces (e.g., inflammatory bowel disease, chronic obstructive pulmonary disease) by compromising mucosal barrier integrity and clearance mechanisms. **Key Experimental Approach:** To test the hypothesis that [ARF4](/details-gene/378) is a critical regulator of antibody secretion (Hypothesis 1), an *in vitro* model using human plasma cell lines or primary B cells differentiated into plasmablasts could be employed. CRISPR-Cas9-mediated knockout of [ARF4](/details-gene/378) would be performed, followed by stimulation to induce immunoglobulin production. The impact of [ARF4](/details-gene/378) loss would be assessed by quantifying secreted antibody levels via ELISA and analyzing intracellular immunoglobulin retention and Golgi apparatus morphology using immunofluorescence and electron microscopy. This would directly test whether [ARF4](/details-gene/378) is essential for the massive secretory output characteristic of [plasmablast](/details-cell/CL0000980)s. **Therapeutic Potential:** As an intracellular GTPase, [ARF4](/details-gene/378) presents a challenging therapeutic target. Direct systemic inhibition would likely cause significant toxicity due to its essential role in secretion in many vital tissues, such as the gut and placenta. However, in the context of pathologies driven by excessive protein secretion from a specific cell type, such as multiple myeloma, targeting [ARF4](/details-gene/378) or its regulatory partners could be a viable strategy. An inhibitory approach would be required. The development of highly specific, cell-type targeted delivery systems for an [ARF4](/details-gene/378) inhibitor would be necessary to exploit its therapeutic potential while minimizing off-target effects.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ADP-ribosylation factor 4

Genular Protein ID: 3237162662

Symbol: ARF4_HUMAN

Name: ADP-ribosylation factor 4

UniProtKB Accession Codes:

P18085 B2R7J7 P21371

Database IDs:

Citations:

PubMed ID: 2107548

Title: Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin.

PubMed ID: 2107548

DOI: 10.1073/pnas.87.6.2206

PubMed ID: 1899243

Title: Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins.

PubMed ID: 1899243

DOI: 10.1016/s0021-9258(18)52288-2

PubMed ID: 10524252

Title: Cloning and characterization of the human ADP-ribosylation factor 4 gene.

PubMed ID: 10524252

DOI: 10.1016/s0378-1119(99)00290-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25673879

Title: The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting.

PubMed ID: 25673879

DOI: 10.1242/jcs.162925

PubMed ID: 26258637

Title: Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11.

PubMed ID: 26258637

DOI: 10.1038/nsmb.3065

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

Length: 180
Mass: 20511
Checksum: 3A43EB1F37A81BD9
Sequence:

MGLTISSLFS RLFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 
ICFTVWDVGG QDRIRPLWKH YFQNTQGLIF VVDSNDRERI QEVADELQKM LLVDELRDAV 
LLLFANKQDL PNAMAISEMT DKLGLQSLRN RTWYVQATCA TQGTGLYEGL DWLSNELSKR

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Ascending colon UBERON0001156
	Atherosclerosis MONDO0005311
	Axilla UBERON0009472
	\|— Axilla Breast cancer UBERON0009472_MONDO0007254
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fallopian tube UBERON0003889
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Pancreas UBERON0001264
	\|— Pancreas Healthy UBERON0001264_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Small intestine UBERON0002108
	\|— Small intestine Healthy UBERON0002108_PATO0000461
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952

Details for: ARF4

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin. PubMed ID: 2107548

Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins. PubMed ID: 1899243

Cloning and characterization of the human ADP-ribosylation factor 4 gene. PubMed ID: 10524252

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. PubMed ID: 25255805

The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting. PubMed ID: 25673879

Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11. PubMed ID: 26258637

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712