Details for: ARF4

Gene ID: 378

Symbol: ARF4

Ensembl ID: ENSG00000168374

Description: ADP ribosylation factor 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.74
    Marker Score: 2931
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.46
    Marker Score: 117762
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.28
    Marker Score: 8001.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.17
    Marker Score: 2702
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.91
    Marker Score: 4481.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.88
    Marker Score: 18720
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.86
    Marker Score: 2252
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.84
    Marker Score: 1184
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.74
    Marker Score: 36118
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.62
    Marker Score: 11293
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.58
    Marker Score: 9960
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.55
    Marker Score: 1148
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.53
    Marker Score: 1810
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.5
    Marker Score: 2131
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.48
    Marker Score: 3985
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.44
    Marker Score: 6390
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.44
    Marker Score: 5536
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.41
    Marker Score: 15390
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.41
    Marker Score: 6557
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.41
    Marker Score: 3311.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4
    Marker Score: 27038
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.4
    Marker Score: 1234
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.37
    Marker Score: 1380
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.37
    Marker Score: 2772
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.34
    Marker Score: 3720
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.31
    Marker Score: 19885
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.29
    Marker Score: 5211
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.27
    Marker Score: 770
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.27
    Marker Score: 78765
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.27
    Marker Score: 11155
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.27
    Marker Score: 564
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.26
    Marker Score: 2795
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.26
    Marker Score: 4722
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.26
    Marker Score: 5698
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.26
    Marker Score: 2396
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.25
    Marker Score: 564
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.24
    Marker Score: 3678
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.23
    Marker Score: 813
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.21
    Marker Score: 22224
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.2
    Marker Score: 781
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.19
    Marker Score: 2848
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.19
    Marker Score: 1950
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.18
    Marker Score: 2547
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.18
    Marker Score: 2086
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.17
    Marker Score: 3191
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.17
    Marker Score: 8510
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.15
    Marker Score: 610
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.15
    Marker Score: 2416
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.12
    Marker Score: 681
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.11
    Marker Score: 11091
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.1
    Marker Score: 13710
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.09
    Marker Score: 3557.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.09
    Marker Score: 990
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.07
    Marker Score: 1299
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.07
    Marker Score: 12286
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.07
    Marker Score: 3780
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.06
    Marker Score: 3413
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.05
    Marker Score: 2194
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.05
    Marker Score: 6427
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.04
    Marker Score: 3842
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.04
    Marker Score: 3621
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.03
    Marker Score: 2151
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.03
    Marker Score: 2189
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.03
    Marker Score: 1429
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.03
    Marker Score: 2132
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.02
    Marker Score: 482
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.02
    Marker Score: 1150
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.01
    Marker Score: 579
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2
    Marker Score: 2581
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2
    Marker Score: 9588
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2
    Marker Score: 1359
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.98
    Marker Score: 1323.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.97
    Marker Score: 2619
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.96
    Marker Score: 1237
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.96
    Marker Score: 4650.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.95
    Marker Score: 619
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.94
    Marker Score: 1972
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.94
    Marker Score: 2793
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.94
    Marker Score: 7188
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.94
    Marker Score: 812
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.94
    Marker Score: 1872
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.93
    Marker Score: 15040
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.9
    Marker Score: 470
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.9
    Marker Score: 774
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.89
    Marker Score: 2673
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.88
    Marker Score: 3763
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.87
    Marker Score: 1558
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.86
    Marker Score: 880.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.86
    Marker Score: 1023
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.85
    Marker Score: 1977
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.85
    Marker Score: 699
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.85
    Marker Score: 4344.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.83
    Marker Score: 710
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.83
    Marker Score: 1147
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.82
    Marker Score: 829
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.82
    Marker Score: 1710
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.82
    Marker Score: 2519
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.82
    Marker Score: 781
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.81
    Marker Score: 1193
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.81
    Marker Score: 892

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Other Information

## Summary ARF4 is a multifunctional protein that plays a crucial role in intracellular protein trafficking and cell signaling. It is involved in multiple pathways, including asparagine n-linked glycosylation, cargo trafficking, and Golgi-to-er retrograde transport. ## Key characteristics * ARF4 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including thyroid follicular cell, fibroblast of mammary gland, basal cell of prostate epithelium, fibroblast of connective tissue of nonglandular part of prostate, mesenchymal stem cell, interstitial cell of ovary, epithelial cell of urethra, and fibroblast of connective tissue of glandular part of prostate. * It is a key regulator of cell growth, differentiation, and migration. ## Pathways and functions * **Asparagine n-linked glycosylation:** ARF4 is responsible for the addition of a asparagine residue to specific proteins, which is crucial for their stability and function. * **Cargo trafficking to the periciliary membrane:** ARF4 is involved in the trafficking of proteins from the endoplasmic reticulum (ER) to the periciliary membrane. * **Cilia assembly:** ARF4 is essential for the assembly of cilia, which are hair-like structures that extend from the cell surface and are involved in various cellular processes, including cell migration and signaling. * **Copi-dependent golgi-to-er retrograde transport:** ARF4 is a key regulator of the Golgi-to-ER retrograde transport, which is a critical process for the recycling of proteins and organelles. * **Copi-mediated anterograde transport:** In addition to its role in the retrograde transport, ARF4 also plays a role in anterograde transport from the Golgi to the ER. * **Epidermal growth factor receptor binding:** ARF4 is a receptor for epidermal growth factor (EGF), a protein that is important for skin development and tumor growth. * **Er to golgi anterograde transport:** ARF4 is involved in the anterograde transport of proteins from the ER to the Golgi. * **Golgi-to-er retrograde transport:** ARF4 is also involved in the Golgi-to-ER retrograde transport, which is a process by which proteins are transported from the Golgi to the ER. * **Gtpase activity:** ARF4 is involved in the regulation of G protein-coupled receptors (GPCRs), which are a class of cell surface receptors that are involved in cell signaling. * **Gtp binding:** ARF4 is a binding partner for GTP, a second messenger molecule. * **Guanyl-nucleotide exchange factor activity:** ARF4 is involved in the regulation of guanosine nucleotide exchange factor (GNEF), another second messenger molecule. ## Clinical significance ARF4 mutations have been linked to a number of human diseases, including cancer and cardiovascular disease. These mutations can disrupt the normal function of ARF4, leading to cellular abnormalities and disease.

Genular Protein ID: 3237162662

Symbol: ARF4_HUMAN

Name: ADP-ribosylation factor 4

UniProtKB Accession Codes:

P18085 B2R7J7 P21371

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 13 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2107548

Title: Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin.

PubMed ID: 2107548

DOI: 10.1073/pnas.87.6.2206

PubMed ID: 1899243

Title: Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins.

PubMed ID: 1899243

DOI: 10.1016/s0021-9258(18)52288-2

PubMed ID: 10524252

Title: Cloning and characterization of the human ADP-ribosylation factor 4 gene.

PubMed ID: 10524252

DOI: 10.1016/s0378-1119(99)00290-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25673879

Title: The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting.

PubMed ID: 25673879

DOI: 10.1242/jcs.162925

PubMed ID: 26258637

Title: Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11.

PubMed ID: 26258637

DOI: 10.1038/nsmb.3065

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 180
  • Mass: 20511
  • Checksum: 3A43EB1F37A81BD9
  • Sequence:
    • MGLTISSLFS RLFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 
ICFTVWDVGG QDRIRPLWKH YFQNTQGLIF VVDSNDRERI QEVADELQKM LLVDELRDAV 
LLLFANKQDL PNAMAISEMT DKLGLQSLRN RTWYVQATCA TQGTGLYEGL DWLSNELSKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.