Details for: ARF4

Gene ID: 378

Symbol: ARF4

Ensembl ID: ENSG00000168374

Description: ADP ribosylation factor 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.74
    Marker Score: 2,931
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.46
    Marker Score: 117,762
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.28
    Marker Score: 8,002
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.17
    Marker Score: 2,702
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.91
    Marker Score: 4,482
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.88
    Marker Score: 18,720
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.86
    Marker Score: 2,252
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.84
    Marker Score: 1,184
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.74
    Marker Score: 36,118
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.62
    Marker Score: 11,293
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.58
    Marker Score: 9,960
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.55
    Marker Score: 1,148
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.53
    Marker Score: 1,810
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.5
    Marker Score: 2,131
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.48
    Marker Score: 3,985
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.44
    Marker Score: 6,390
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.44
    Marker Score: 5,536
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.41
    Marker Score: 15,390
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.41
    Marker Score: 6,557
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.41
    Marker Score: 3,312
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4
    Marker Score: 27,038
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.4
    Marker Score: 1,234
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.37
    Marker Score: 1,380
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.37
    Marker Score: 2,772
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.34
    Marker Score: 3,720
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.31
    Marker Score: 19,885
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.29
    Marker Score: 5,211
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.27
    Marker Score: 770
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.27
    Marker Score: 78,765
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.27
    Marker Score: 11,155
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.27
    Marker Score: 564
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.26
    Marker Score: 2,795
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.26
    Marker Score: 4,722
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.26
    Marker Score: 5,698
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.26
    Marker Score: 2,396
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.25
    Marker Score: 564
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.24
    Marker Score: 3,678
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.23
    Marker Score: 813
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.21
    Marker Score: 22,224
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.2
    Marker Score: 781
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.19
    Marker Score: 2,848
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.19
    Marker Score: 1,950
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.18
    Marker Score: 2,547
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.18
    Marker Score: 2,086
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.17
    Marker Score: 3,191
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.17
    Marker Score: 8,510
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.15
    Marker Score: 610
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.15
    Marker Score: 2,416
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.12
    Marker Score: 681
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.11
    Marker Score: 11,091
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.1
    Marker Score: 13,710
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.09
    Marker Score: 3,558
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.09
    Marker Score: 990
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.07
    Marker Score: 1,299
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.07
    Marker Score: 12,286
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.07
    Marker Score: 3,780
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.06
    Marker Score: 3,413
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.05
    Marker Score: 2,194
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.05
    Marker Score: 6,427
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.04
    Marker Score: 3,842
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.04
    Marker Score: 3,621
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.03
    Marker Score: 2,151
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.03
    Marker Score: 2,189
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.03
    Marker Score: 1,429
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.03
    Marker Score: 2,132
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.02
    Marker Score: 482
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.02
    Marker Score: 1,150
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.01
    Marker Score: 579
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2
    Marker Score: 2,581
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2
    Marker Score: 9,588
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2
    Marker Score: 1,359
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.98
    Marker Score: 1,324
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.97
    Marker Score: 2,619
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.96
    Marker Score: 1,237
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.96
    Marker Score: 4,651
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.95
    Marker Score: 619
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.94
    Marker Score: 1,972
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.94
    Marker Score: 2,793
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.94
    Marker Score: 7,188
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.94
    Marker Score: 812
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.94
    Marker Score: 1,872
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.93
    Marker Score: 15,040
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.9
    Marker Score: 470
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.9
    Marker Score: 774
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.89
    Marker Score: 2,673
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.88
    Marker Score: 3,763
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.87
    Marker Score: 1,558
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.86
    Marker Score: 881
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.86
    Marker Score: 1,023
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.85
    Marker Score: 1,977
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.85
    Marker Score: 699
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.85
    Marker Score: 4,345
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.83
    Marker Score: 710
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.83
    Marker Score: 1,147
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.82
    Marker Score: 829
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.82
    Marker Score: 1,710
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.82
    Marker Score: 2,519
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.82
    Marker Score: 781
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.81
    Marker Score: 1,193
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.81
    Marker Score: 892

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARF4 is a member of the ADP-ribosylation factor (ARF) family, which consists of six small GTPases (ARF1-6). ARF4 shares similarities with other ARFs in terms of its GTP-binding and hydrolysis activities. However, its unique isoforms and post-translational modifications (PTMs) contribute to its distinct functional profile. ARF4 is characterized by its ability to bind guanine nucleotides, regulate protein trafficking, and modulate signaling pathways. **Pathways and Functions:** ARF4 is involved in various cellular processes, including: 1. **Cilium assembly and maintenance:** ARF4 regulates the formation and maintenance of cilia, which are essential for sensory perception and cell signaling. 2. **Protein trafficking:** ARF4 modulates the transport of proteins between the Golgi apparatus and the endoplasmic reticulum, influencing cell migration, differentiation, and survival. 3. **Cell migration:** ARF4 regulates cell migration by controlling the dynamics of protein trafficking and cytoskeletal rearrangement. 4. **Signaling pathways:** ARF4 interacts with various signaling molecules, including the epidermal growth factor receptor (EGFR) and the phospholipase D (PLD) pathway, to regulate cell growth, differentiation, and survival. 5. **Apoptosis regulation:** ARF4 acts as a negative regulator of the apoptotic process, influencing cell survival and death. **Clinical Significance:** The dysregulation of ARF4 has been implicated in various diseases, including: 1. **Cancer:** ARF4 is often downregulated in cancer cells, leading to impaired protein trafficking and increased cell migration and invasion. 2. **Neurodegenerative diseases:** ARF4 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation contributes to neuronal dysfunction and death. 3. **Inflammatory disorders:** ARF4 has been implicated in inflammatory disorders, such as atherosclerosis and arthritis, where its dysregulation contributes to immune cell activation and inflammation. In conclusion, ARF4 is a multifunctional protein that plays a critical role in various cellular processes, including cilium assembly, protein trafficking, cell migration, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and potential therapeutic targets.

Genular Protein ID: 3237162662

Symbol: ARF4_HUMAN

Name: ADP-ribosylation factor 4

UniProtKB Accession Codes:

P18085 B2R7J7 P21371

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 13 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2107548

Title: Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin.

PubMed ID: 2107548

DOI: 10.1073/pnas.87.6.2206

PubMed ID: 1899243

Title: Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins.

PubMed ID: 1899243

DOI: 10.1016/s0021-9258(18)52288-2

PubMed ID: 10524252

Title: Cloning and characterization of the human ADP-ribosylation factor 4 gene.

PubMed ID: 10524252

DOI: 10.1016/s0378-1119(99)00290-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25673879

Title: The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting.

PubMed ID: 25673879

DOI: 10.1242/jcs.162925

PubMed ID: 26258637

Title: Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11.

PubMed ID: 26258637

DOI: 10.1038/nsmb.3065

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 180
  • Mass: 20511
  • Checksum: 3A43EB1F37A81BD9
  • Sequence:
    • MGLTISSLFS RLFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 
ICFTVWDVGG QDRIRPLWKH YFQNTQGLIF VVDSNDRERI QEVADELQKM LLVDELRDAV 
LLLFANKQDL PNAMAISEMT DKLGLQSLRN RTWYVQATCA TQGTGLYEGL DWLSNELSKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.