Details for: ARF4

Gene ID: 378

Symbol: ARF4

Ensembl ID: ENSG00000168374

Description: ARF GTPase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 502.4262
    Cell Significance Index: -78.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 332.0016
    Cell Significance Index: -84.2100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 224.2275
    Cell Significance Index: -92.3700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 198.8255
    Cell Significance Index: -93.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 194.1381
    Cell Significance Index: -78.8700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 174.2566
    Cell Significance Index: -89.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 140.2934
    Cell Significance Index: -94.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 82.7029
    Cell Significance Index: -78.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 65.5092
    Cell Significance Index: -80.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.0053
    Cell Significance Index: -80.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.4361
    Cell Significance Index: -92.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.2975
    Cell Significance Index: -56.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.5475
    Cell Significance Index: -29.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.0082
    Cell Significance Index: 104.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.7635
    Cell Significance Index: 98.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.7494
    Cell Significance Index: 107.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.5743
    Cell Significance Index: 167.9900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.5309
    Cell Significance Index: 21.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.4314
    Cell Significance Index: 159.9900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.1983
    Cell Significance Index: 18.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9082
    Cell Significance Index: 79.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.7382
    Cell Significance Index: 95.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7265
    Cell Significance Index: 374.4300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.7017
    Cell Significance Index: 34.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.6533
    Cell Significance Index: 197.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9788
    Cell Significance Index: 253.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7522
    Cell Significance Index: 956.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6868
    Cell Significance Index: 45.0400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6493
    Cell Significance Index: 17.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6449
    Cell Significance Index: 212.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5874
    Cell Significance Index: 82.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4573
    Cell Significance Index: 262.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3777
    Cell Significance Index: 169.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2498
    Cell Significance Index: 203.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.1268
    Cell Significance Index: 324.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0472
    Cell Significance Index: 463.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9265
    Cell Significance Index: 91.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8880
    Cell Significance Index: 176.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7512
    Cell Significance Index: 53.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7141
    Cell Significance Index: 143.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6771
    Cell Significance Index: 128.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5690
    Cell Significance Index: 5.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4431
    Cell Significance Index: 75.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3812
    Cell Significance Index: 44.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3675
    Cell Significance Index: 41.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2571
    Cell Significance Index: 194.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2477
    Cell Significance Index: 88.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1716
    Cell Significance Index: 154.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1326
    Cell Significance Index: 2.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1158
    Cell Significance Index: 3.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1093
    Cell Significance Index: 75.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0604
    Cell Significance Index: 3.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0385
    Cell Significance Index: 0.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0333
    Cell Significance Index: 62.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0100
    Cell Significance Index: -15.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0146
    Cell Significance Index: -9.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0191
    Cell Significance Index: -26.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0211
    Cell Significance Index: -38.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0371
    Cell Significance Index: -23.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0381
    Cell Significance Index: -28.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0464
    Cell Significance Index: -34.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0722
    Cell Significance Index: -7.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0773
    Cell Significance Index: -35.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1114
    Cell Significance Index: -62.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1667
    Cell Significance Index: -8.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1884
    Cell Significance Index: -39.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2275
    Cell Significance Index: -17.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2475
    Cell Significance Index: -28.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2746
    Cell Significance Index: -15.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2844
    Cell Significance Index: -12.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3737
    Cell Significance Index: -54.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3902
    Cell Significance Index: -10.4600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4060
    Cell Significance Index: -7.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4242
    Cell Significance Index: -49.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4991
    Cell Significance Index: -5.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5541
    Cell Significance Index: -7.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6072
    Cell Significance Index: -16.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6846
    Cell Significance Index: -42.0800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6918
    Cell Significance Index: -4.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7401
    Cell Significance Index: -23.7100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.7468
    Cell Significance Index: -4.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8335
    Cell Significance Index: -86.7900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.8586
    Cell Significance Index: -6.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8835
    Cell Significance Index: -15.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9035
    Cell Significance Index: -47.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9038
    Cell Significance Index: -23.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9292
    Cell Significance Index: -73.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9469
    Cell Significance Index: -24.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9738
    Cell Significance Index: -65.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0261
    Cell Significance Index: -25.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0745
    Cell Significance Index: -67.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1618
    Cell Significance Index: -34.2200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.2297
    Cell Significance Index: -12.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2300
    Cell Significance Index: -75.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.4507
    Cell Significance Index: -64.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.4592
    Cell Significance Index: -87.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.5294
    Cell Significance Index: -40.9100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.6058
    Cell Significance Index: -29.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.6277
    Cell Significance Index: -24.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.7421
    Cell Significance Index: -65.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARF4 is a member of the ADP-ribosylation factor (ARF) family, which consists of six small GTPases (ARF1-6). ARF4 shares similarities with other ARFs in terms of its GTP-binding and hydrolysis activities. However, its unique isoforms and post-translational modifications (PTMs) contribute to its distinct functional profile. ARF4 is characterized by its ability to bind guanine nucleotides, regulate protein trafficking, and modulate signaling pathways. **Pathways and Functions:** ARF4 is involved in various cellular processes, including: 1. **Cilium assembly and maintenance:** ARF4 regulates the formation and maintenance of cilia, which are essential for sensory perception and cell signaling. 2. **Protein trafficking:** ARF4 modulates the transport of proteins between the Golgi apparatus and the endoplasmic reticulum, influencing cell migration, differentiation, and survival. 3. **Cell migration:** ARF4 regulates cell migration by controlling the dynamics of protein trafficking and cytoskeletal rearrangement. 4. **Signaling pathways:** ARF4 interacts with various signaling molecules, including the epidermal growth factor receptor (EGFR) and the phospholipase D (PLD) pathway, to regulate cell growth, differentiation, and survival. 5. **Apoptosis regulation:** ARF4 acts as a negative regulator of the apoptotic process, influencing cell survival and death. **Clinical Significance:** The dysregulation of ARF4 has been implicated in various diseases, including: 1. **Cancer:** ARF4 is often downregulated in cancer cells, leading to impaired protein trafficking and increased cell migration and invasion. 2. **Neurodegenerative diseases:** ARF4 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation contributes to neuronal dysfunction and death. 3. **Inflammatory disorders:** ARF4 has been implicated in inflammatory disorders, such as atherosclerosis and arthritis, where its dysregulation contributes to immune cell activation and inflammation. In conclusion, ARF4 is a multifunctional protein that plays a critical role in various cellular processes, including cilium assembly, protein trafficking, cell migration, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and potential therapeutic targets.

Genular Protein ID: 3237162662

Symbol: ARF4_HUMAN

Name: ADP-ribosylation factor 4

UniProtKB Accession Codes:

P18085 B2R7J7 P21371

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 13 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2107548

Title: Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin.

PubMed ID: 2107548

DOI: 10.1073/pnas.87.6.2206

PubMed ID: 1899243

Title: Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins.

PubMed ID: 1899243

DOI: 10.1016/s0021-9258(18)52288-2

PubMed ID: 10524252

Title: Cloning and characterization of the human ADP-ribosylation factor 4 gene.

PubMed ID: 10524252

DOI: 10.1016/s0378-1119(99)00290-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25673879

Title: The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting.

PubMed ID: 25673879

DOI: 10.1242/jcs.162925

PubMed ID: 26258637

Title: Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11.

PubMed ID: 26258637

DOI: 10.1038/nsmb.3065

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 180
  • Mass: 20511
  • Checksum: 3A43EB1F37A81BD9
  • Sequence:
    • MGLTISSLFS RLFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 
ICFTVWDVGG QDRIRPLWKH YFQNTQGLIF VVDSNDRERI QEVADELQKM LLVDELRDAV 
LLLFANKQDL PNAMAISEMT DKLGLQSLRN RTWYVQATCA TQGTGLYEGL DWLSNELSKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.