Details for: MALAT1

Gene ID: 378938

Symbol: MALAT1

Ensembl ID: ENSG00000251562

Description: metastasis associated lung adenocarcinoma transcript 1

Associated with

  • Cellular response to hypoxia
    (GO:0071456)
  • Lncrna-mediated post-transcriptional gene silencing
    (GO:0000512)
  • Mirna inhibitor activity via base-pairing
    (GO:0140869)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cardiac muscle myoblast proliferation
    (GO:0110024)
  • Positive regulation of cell motility
    (GO:2000147)
  • Positive regulation of mirna catabolic process
    (GO:2000627)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 15.17
    Marker Score: 269208
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 14.51
    Marker Score: 10920.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 12.95
    Marker Score: 77795
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 12.86
    Marker Score: 43127
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 12.56
    Marker Score: 52381
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 12.21
    Marker Score: 40016
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 12.12
    Marker Score: 50341
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 11.59
    Marker Score: 9520
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 11.38
    Marker Score: 18474.5
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 10.81
    Marker Score: 56734
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 10.57
    Marker Score: 14876
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 10.43
    Marker Score: 3771
  • Cell Name: granule cell (CL0000120)
    Fold Change: 9.82
    Marker Score: 74047
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 9.67
    Marker Score: 51971
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 8.9
    Marker Score: 20457
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 8.86
    Marker Score: 2926
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 8.83
    Marker Score: 5810.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 8.31
    Marker Score: 280579
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 8.31
    Marker Score: 7176
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 8
    Marker Score: 48511
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 7.66
    Marker Score: 4258
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 7.4
    Marker Score: 17714
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 7.16
    Marker Score: 8922
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 6.87
    Marker Score: 5224
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 6.52
    Marker Score: 3293
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 6.5
    Marker Score: 31911
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 6.43
    Marker Score: 6135
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 6.28
    Marker Score: 4429
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 6.1
    Marker Score: 47649
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.96
    Marker Score: 4325
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 5.88
    Marker Score: 1723
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.85
    Marker Score: 12258
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 5.79
    Marker Score: 37760
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.77
    Marker Score: 14665
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.75
    Marker Score: 2955
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.73
    Marker Score: 77050
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 5.71
    Marker Score: 4327
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 5.67
    Marker Score: 3870.5
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 5.65
    Marker Score: 2921
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 5.63
    Marker Score: 10839
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 5.63
    Marker Score: 5894.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 5.62
    Marker Score: 6061
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.61
    Marker Score: 2070
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 5.61
    Marker Score: 5496
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 5.55
    Marker Score: 124081
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 5.52
    Marker Score: 32757
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.52
    Marker Score: 16118
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 5.51
    Marker Score: 4693
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.5
    Marker Score: 7160
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 5.49
    Marker Score: 3534
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.37
    Marker Score: 53133.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 5.36
    Marker Score: 13355
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 5.34
    Marker Score: 7406
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 5.34
    Marker Score: 1538.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 5.31
    Marker Score: 4742
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.3
    Marker Score: 3741
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 5.27
    Marker Score: 9035
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.22
    Marker Score: 177750
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 5.17
    Marker Score: 1236
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.15
    Marker Score: 3691
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 5.08
    Marker Score: 3095
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 5.02
    Marker Score: 3360
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 5.02
    Marker Score: 26393
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 5
    Marker Score: 2824
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.99
    Marker Score: 23072
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.97
    Marker Score: 2138
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 4.95
    Marker Score: 1778
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.9
    Marker Score: 258867.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 4.87
    Marker Score: 8871
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.86
    Marker Score: 15335
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 4.84
    Marker Score: 1960
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 4.83
    Marker Score: 1686
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.83
    Marker Score: 2933
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 4.83
    Marker Score: 2321
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.83
    Marker Score: 12941.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 4.81
    Marker Score: 4087
  • Cell Name: podocyte (CL0000653)
    Fold Change: 4.81
    Marker Score: 1777
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 4.8
    Marker Score: 2727
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.71
    Marker Score: 30027
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 4.7
    Marker Score: 3198
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.67
    Marker Score: 5185
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.65
    Marker Score: 260250
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 4.63
    Marker Score: 4154
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 4.63
    Marker Score: 1062
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.63
    Marker Score: 1506
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.61
    Marker Score: 5567
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 4.57
    Marker Score: 1468
  • Cell Name: platelet (CL0000233)
    Fold Change: 4.57
    Marker Score: 2070
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 4.56
    Marker Score: 1160
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.55
    Marker Score: 4288.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.52
    Marker Score: 5441
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.51
    Marker Score: 59536
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 4.51
    Marker Score: 2815
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.51
    Marker Score: 6523
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.49
    Marker Score: 11332
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.47
    Marker Score: 10922.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 4.46
    Marker Score: 5226.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.44
    Marker Score: 26969
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 4.43
    Marker Score: 2204
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.43
    Marker Score: 3150

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Other Information

**Key Characteristics:** MALAT1 is a 3' untranslated region (UTR) lncRNA, meaning it is transcribed from a DNA sequence that does not encode a protein. It is approximately 7.1 kilobases in length and is expressed in a wide range of cell types, including cancer cells, immune cells, and cells of the cardiovascular system. MALAT1 is known for its ability to regulate gene expression through mechanisms such as lncRNA-mediated post-transcriptional gene silencing (lncRNA-mediated PTGS) and microRNA (miRNA) inhibition. It can also interact with RNA-binding proteins (RBPs) to modulate its own expression and that of other genes. **Pathways and Functions:** MALAT1 is involved in several key cellular pathways, including: 1. **Cellular response to hypoxia:** MALAT1 is upregulated in hypoxic conditions, which can promote tumor growth and metastasis. 2. **LncRNA-mediated post-transcriptional gene silencing:** MALAT1 can regulate gene expression by binding to RBPs and inhibiting the translation of target mRNAs. 3. **miRNA inhibition:** MALAT1 can inhibit the activity of miRNAs, which are small non-coding RNAs that regulate gene expression by binding to target mRNAs. 4. **Positive regulation of cardiac muscle myoblast proliferation:** MALAT1 can promote the proliferation of cardiac muscle cells, which can contribute to heart failure and other cardiovascular diseases. 5. **Positive regulation of cell motility:** MALAT1 can enhance cell migration and invasion, which are critical processes in cancer metastasis. **Clinical Significance:** MALAT1 has been implicated in various human diseases, including: 1. **Cancer:** MALAT1 is overexpressed in numerous types of cancer, including lung, breast, colon, and prostate cancer. It can promote tumor growth, metastasis, and resistance to therapy. 2. **Cardiovascular disease:** MALAT1 can contribute to the development of cardiovascular disease by promoting cardiac muscle cell proliferation and cell motility. 3. **Neurological disorders:** MALAT1 has been implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 4. **Immune system dysfunction:** MALAT1 can regulate immune cell function and contribute to immune system dysfunction in diseases such as multiple sclerosis and rheumatoid arthritis. In conclusion, MALAT1 is a critical regulator of cellular processes that can contribute to the development and progression of human disease. Further research is needed to fully understand the mechanisms by which MALAT1 regulates gene expression and to develop therapeutic strategies to target this lncRNA in cancer and other diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.