Details for: ARL4D

Gene ID: 379

Symbol: ARL4D

Ensembl ID: ENSG00000175906

Description: ARF like GTPase 4D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 174.4830
    Cell Significance Index: -27.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.5132
    Cell Significance Index: -27.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.9389
    Cell Significance Index: -26.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.1338
    Cell Significance Index: -27.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 9.1933
    Cell Significance Index: 125.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7351
    Cell Significance Index: -23.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 8.0396
    Cell Significance Index: 506.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9639
    Cell Significance Index: -27.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 5.6142
    Cell Significance Index: 66.9300
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 4.0383
    Cell Significance Index: 12.0100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.7608
    Cell Significance Index: 21.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.2325
    Cell Significance Index: 31.7800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.6562
    Cell Significance Index: 9.7300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.4272
    Cell Significance Index: 9.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3549
    Cell Significance Index: 28.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2176
    Cell Significance Index: 28.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0466
    Cell Significance Index: 27.5200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0091
    Cell Significance Index: 10.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8928
    Cell Significance Index: 394.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8670
    Cell Significance Index: 45.0400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8660
    Cell Significance Index: 11.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7881
    Cell Significance Index: 77.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7685
    Cell Significance Index: 40.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7404
    Cell Significance Index: 20.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7169
    Cell Significance Index: 91.9000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.6607
    Cell Significance Index: 2.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5548
    Cell Significance Index: 19.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5333
    Cell Significance Index: 73.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4968
    Cell Significance Index: 61.0800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4621
    Cell Significance Index: 7.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3926
    Cell Significance Index: 354.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3537
    Cell Significance Index: 16.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3484
    Cell Significance Index: 66.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3429
    Cell Significance Index: 9.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3396
    Cell Significance Index: 25.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3102
    Cell Significance Index: 21.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3028
    Cell Significance Index: 165.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3013
    Cell Significance Index: 208.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2890
    Cell Significance Index: 52.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2620
    Cell Significance Index: 30.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2581
    Cell Significance Index: 41.9800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.2532
    Cell Significance Index: 1.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2401
    Cell Significance Index: 6.7100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1960
    Cell Significance Index: 1.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1904
    Cell Significance Index: 9.9200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1206
    Cell Significance Index: 1.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1094
    Cell Significance Index: 21.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1007
    Cell Significance Index: 2.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0842
    Cell Significance Index: 16.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0733
    Cell Significance Index: 7.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0496
    Cell Significance Index: 3.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0381
    Cell Significance Index: 1.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0261
    Cell Significance Index: 16.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0259
    Cell Significance Index: 1.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0209
    Cell Significance Index: 39.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0128
    Cell Significance Index: 9.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0120
    Cell Significance Index: 0.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0002
    Cell Significance Index: 0.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0107
    Cell Significance Index: -19.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0128
    Cell Significance Index: -7.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0136
    Cell Significance Index: -20.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0144
    Cell Significance Index: -9.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0175
    Cell Significance Index: -1.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0183
    Cell Significance Index: -24.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0200
    Cell Significance Index: -7.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0224
    Cell Significance Index: -0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0279
    Cell Significance Index: -21.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0397
    Cell Significance Index: -18.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0407
    Cell Significance Index: -8.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0530
    Cell Significance Index: -2.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0627
    Cell Significance Index: -18.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0644
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0699
    Cell Significance Index: -11.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0706
    Cell Significance Index: -3.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1239
    Cell Significance Index: -18.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1469
    Cell Significance Index: -18.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1729
    Cell Significance Index: -19.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1774
    Cell Significance Index: -20.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2016
    Cell Significance Index: -15.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2069
    Cell Significance Index: -13.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2117
    Cell Significance Index: -6.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2202
    Cell Significance Index: -25.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2540
    Cell Significance Index: -6.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2581
    Cell Significance Index: -26.8700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2622
    Cell Significance Index: -2.3100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2915
    Cell Significance Index: -1.7300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.2974
    Cell Significance Index: -1.5700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.3238
    Cell Significance Index: -0.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3371
    Cell Significance Index: -22.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3581
    Cell Significance Index: -27.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3687
    Cell Significance Index: -20.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3893
    Cell Significance Index: -8.2900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4046
    Cell Significance Index: -3.8500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4119
    Cell Significance Index: -2.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4388
    Cell Significance Index: -11.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4403
    Cell Significance Index: -12.9700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4785
    Cell Significance Index: -11.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4935
    Cell Significance Index: -11.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5072
    Cell Significance Index: -18.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ARL4D gene is a member of the ADP-ribosylation factor (ARF) family of GTPases, which are small GTP-binding proteins that regulate various cellular processes. ARL4D is characterized by its ability to bind to GTP and GDP, and its GTPase activity is essential for its function. The protein is also known to interact with other proteins, such as ARF6, to regulate vesicle-mediated transport and protein secretion. One of the key characteristics of ARL4D is its expression in multiple cell types, including those in the eye, kidney, and epithelial tissues. This widespread expression suggests that ARL4D plays a critical role in maintaining cellular homeostasis and function in these tissues. **Pathways and Functions** ARL4D is involved in several cellular pathways, including: 1. **Intracellular Protein Transport**: ARL4D regulates the transport of proteins within the cell by interacting with vesicle-mediated transport pathways. 2. **Vesicle-Mediated Transport**: ARL4D is involved in the regulation of vesicle-mediated transport, which is essential for the transport of proteins and lipids within the cell. 3. **Protein Secretion**: ARL4D regulates protein secretion by interacting with secretory pathways. 4. **GTPase Activity**: ARL4D's GTPase activity is essential for its function, as it regulates the hydrolysis of GTP to GDP. **Clinical Significance** Dysregulation of ARL4D has been implicated in various diseases, including: 1. **Retinal Disease**: Mutations in ARL4D have been associated with retinal disease, including retinitis pigmentosa. 2. **Neurodegenerative Disease**: ARL4D has also been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: ARL4D has been shown to play a role in cancer progression and metastasis. In summary, ARL4D is a critical gene involved in various cellular processes, including intracellular protein transport, vesicle-mediated transport, and protein secretion. Its dysregulation has been implicated in various diseases, highlighting the importance of ARL4D in maintaining cellular homeostasis and function.

Genular Protein ID: 1140363427

Symbol: ARL4D_HUMAN

Name: ADP-ribosylation factor-like protein 4D

UniProtKB Accession Codes:

P49703 B2RC59 D3DX43

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 7 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7590735

Title: Isolation and mapping of a gene encoding a novel human ADP-ribosylation factor on chromosome 17q12-q21.

PubMed ID: 7590735

DOI: 10.1006/geno.1995.1115

PubMed ID: 7581362

Title: Comparison of the positional cloning methods used to isolate the BRCA1 gene.

PubMed ID: 7581362

DOI: 10.1093/hmg/4.8.1259

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10831612

Title: ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.

PubMed ID: 10831612

DOI: 10.1083/jcb.149.5.1087

PubMed ID: 17398095

Title: The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.

PubMed ID: 17398095

DOI: 10.1016/j.cub.2007.03.007

Sequence Information:

  • Length: 201
  • Mass: 22156
  • Checksum: 18766BCF56A8127D
  • Sequence:
    • MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV PTKGFNTEKI 
RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV VDAAEAERLE EAKVELHRIS 
RASDNQGVPV LVLANKQDQP GALSAAEVEK RLAVRELAAA TLTHVQGCSA VDGLGLQQGL 
ERLYEMILKR KKAARGGKKR R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.