Details for: ARL4D

Gene ID: 379

Symbol: ARL4D

Ensembl ID: ENSG00000175906

Description: ADP ribosylation factor like GTPase 4D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.72
    Marker Score: 812
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.67
    Marker Score: 7610
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.05
    Marker Score: 16021
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.99
    Marker Score: 3297
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.93
    Marker Score: 4856
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.75
    Marker Score: 13032
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.73
    Marker Score: 17454
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.63
    Marker Score: 1720
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.62
    Marker Score: 13930
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.56
    Marker Score: 501
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.51
    Marker Score: 512
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.49
    Marker Score: 6426
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168724
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.39
    Marker Score: 5151
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.3
    Marker Score: 1016
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.3
    Marker Score: 3189
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.29
    Marker Score: 2700.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.24
    Marker Score: 471
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.24
    Marker Score: 659
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.23
    Marker Score: 1358
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.22
    Marker Score: 1091.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.21
    Marker Score: 1567.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.16
    Marker Score: 1401
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.16
    Marker Score: 7545
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.13
    Marker Score: 1606
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.13
    Marker Score: 1928
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.1
    Marker Score: 265
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.08
    Marker Score: 853
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.08
    Marker Score: 2189
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.07
    Marker Score: 1012
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251743.5
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 1.03
    Marker Score: 1270
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1
    Marker Score: 234
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71764
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47988
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.96
    Marker Score: 687.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.94
    Marker Score: 994
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.94
    Marker Score: 1707
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.92
    Marker Score: 2166
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.91
    Marker Score: 177.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.91
    Marker Score: 756
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.91
    Marker Score: 466
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.89
    Marker Score: 2330
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.88
    Marker Score: 551
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4989
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5262
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.87
    Marker Score: 3404
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.86
    Marker Score: 911
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.85
    Marker Score: 1252
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.85
    Marker Score: 566
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.85
    Marker Score: 898
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.84
    Marker Score: 476.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.84
    Marker Score: 2289
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8
    Marker Score: 27373.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.8
    Marker Score: 1003
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8
    Marker Score: 183
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.78
    Marker Score: 764
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.77
    Marker Score: 516
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 307
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 688
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.75
    Marker Score: 360
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 569
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 473
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.73
    Marker Score: 495
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.72
    Marker Score: 179
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.72
    Marker Score: 204
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.72
    Marker Score: 228
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.71
    Marker Score: 9364
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.7
    Marker Score: 1085
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2934
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.69
    Marker Score: 7798
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.68
    Marker Score: 693.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.68
    Marker Score: 241
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.67
    Marker Score: 1796
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.67
    Marker Score: 2566
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.66
    Marker Score: 1087
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.65
    Marker Score: 346
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.65
    Marker Score: 279
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.65
    Marker Score: 3880
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.64
    Marker Score: 233
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.63
    Marker Score: 189
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.62
    Marker Score: 210
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.62
    Marker Score: 126
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1269
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.6
    Marker Score: 647
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.6
    Marker Score: 925
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.6
    Marker Score: 2943
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.6
    Marker Score: 281
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.59
    Marker Score: 568
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.58
    Marker Score: 383
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.58
    Marker Score: 365

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Other Information

## Summary The ARL4D gene encodes a protein that is involved in the regulation of protein translation. It is expressed in a variety of cell types, including eye photoreceptor cells, retinal rod cells, stratified epithelial cells, kidney collecting duct intercalated cells, kidney collecting duct principal cells, basal cells of the epithelium of the trachea, granulosa cells, conjunctival epithelial cells, epithelial cells of the esophagus, and mesothelial cells of the epicardium. ## Key characteristics * The ARL4D gene is a member of the ADP-ribosylation factor like GTPase family of proteins. * It is a protein that is involved in the cytoplasm, where it is found in association with ribosomes. * It is a GTP-binding protein that is involved in the regulation of protein translation. * It is significantly expressed in cells that are involved in protein synthesis, including eye photoreceptor cells, retinal rod cells, and stratified epithelial cells. ## Pathways and functions * The ARL4D protein is involved in the cytoplasm, where it is found in association with ribosomes. * It is a GTP-binding protein that is involved in the regulation of protein translation. * It is significantly expressed in cells that are involved in protein synthesis, including eye photoreceptor cells, retinal rod cells, and stratified epithelial cells. ## Clinical significance Mutations in the ARL4D gene have been linked to a number of human diseases, including retinal degenerative diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa. These diseases are characterized by the loss of vision, and mutations in ARL4D have been shown to be a cause of these conditions.

Genular Protein ID: 1140363427

Symbol: ARL4D_HUMAN

Name: ADP-ribosylation factor-like protein 4D

UniProtKB Accession Codes:

P49703 B2RC59 D3DX43

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7590735

Title: Isolation and mapping of a gene encoding a novel human ADP-ribosylation factor on chromosome 17q12-q21.

PubMed ID: 7590735

DOI: 10.1006/geno.1995.1115

PubMed ID: 7581362

Title: Comparison of the positional cloning methods used to isolate the BRCA1 gene.

PubMed ID: 7581362

DOI: 10.1093/hmg/4.8.1259

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10831612

Title: ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.

PubMed ID: 10831612

DOI: 10.1083/jcb.149.5.1087

PubMed ID: 17398095

Title: The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.

PubMed ID: 17398095

DOI: 10.1016/j.cub.2007.03.007

Sequence Information:

  • Length: 201
  • Mass: 22156
  • Checksum: 18766BCF56A8127D
  • Sequence:
    • MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV PTKGFNTEKI 
RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV VDAAEAERLE EAKVELHRIS 
RASDNQGVPV LVLANKQDQP GALSAAEVEK RLAVRELAAA TLTHVQGCSA VDGLGLQQGL 
ERLYEMILKR KKAARGGKKR R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.