Gene ARF5 - ENSG00000004059 | NCBI Gene ID: 381

Details for: ARF5

Gene ID: 381

Symbol: ARF5

Ensembl ID: ENSG00000004059

Description: ADP ribosylation factor 5

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-mediated anterograde transport
(R-HSA-6807878)
Er to golgi anterograde transport
(R-HSA-199977)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Cytoplasm
(GO:0005737)
Extracellular exosome
(GO:0070062)
Golgi apparatus
(GO:0005794)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Intracellular protein transport
(GO:0006886)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Retrograde vesicle-mediated transport, golgi to endoplasmic reticulum
(GO:0006890)
Vesicle-mediated transport
(GO:0016192)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.85
Marker Score: 18515.5
Cell Name: neural cell (CL0002319)
Fold Change: 2.77
Marker Score: 1336
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.76
Marker Score: 154451.5
Cell Name: blood cell (CL0000081)
Fold Change: 2.72
Marker Score: 31616
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.7
Marker Score: 3258
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.68
Marker Score: 35295.5
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.59
Marker Score: 26022
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.58
Marker Score: 5025.5
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.55
Marker Score: 19000
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.55
Marker Score: 6930
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.52
Marker Score: 16138
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.31
Marker Score: 3786
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.29
Marker Score: 6788
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.28
Marker Score: 7205
Cell Name: Unknown (CL0002371)
Fold Change: 2.27
Marker Score: 2406.5
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.23
Marker Score: 19606
Cell Name: keratinocyte (CL0000312)
Fold Change: 2.21
Marker Score: 1850
Cell Name: oocyte (CL0000023)
Fold Change: 2.2
Marker Score: 545
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.16
Marker Score: 1563
Cell Name: decidual cell (CL2000002)
Fold Change: 2.15
Marker Score: 9283
Cell Name: mature T cell (CL0002419)
Fold Change: 2.15
Marker Score: 21295
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.14
Marker Score: 9162.5
Cell Name: oogonial cell (CL0000024)
Fold Change: 2.13
Marker Score: 3059
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.13
Marker Score: 12604
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.12
Marker Score: 5290
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.09
Marker Score: 2350
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.09
Marker Score: 2958
Cell Name: Leydig cell (CL0000178)
Fold Change: 2.09
Marker Score: 2251.5
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.05
Marker Score: 6428
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.04
Marker Score: 1789
Cell Name: centroblast (CL0009112)
Fold Change: 2.03
Marker Score: 1002
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.02
Marker Score: 2975
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 2.02
Marker Score: 1112
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.01
Marker Score: 1180
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.01
Marker Score: 4189
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2
Marker Score: 17218
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.99
Marker Score: 1878
Cell Name: Unknown (CL0000548)
Fold Change: 1.97
Marker Score: 1436
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 1.95
Marker Score: 4764
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.91
Marker Score: 3325
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.9
Marker Score: 1193
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.89
Marker Score: 653
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.89
Marker Score: 3218
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.89
Marker Score: 4621.5
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.89
Marker Score: 7421
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.88
Marker Score: 1820
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.86
Marker Score: 528
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.84
Marker Score: 971
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.84
Marker Score: 97100
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.83
Marker Score: 588
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.82
Marker Score: 2281
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.82
Marker Score: 1710
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.82
Marker Score: 3010
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.81
Marker Score: 2672
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 1.8
Marker Score: 1494
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.8
Marker Score: 1902
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.79
Marker Score: 6640
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.79
Marker Score: 1672
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.78
Marker Score: 599
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.78
Marker Score: 4904
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.77
Marker Score: 621
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.76
Marker Score: 4147.5
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.76
Marker Score: 1169.5
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.76
Marker Score: 3445
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.76
Marker Score: 3137.5
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.75
Marker Score: 60678
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 1.74
Marker Score: 1425.5
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.74
Marker Score: 2400
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.73
Marker Score: 1629
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.72
Marker Score: 4345
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.72
Marker Score: 611.5
Cell Name: plasmablast (CL0000980)
Fold Change: 1.72
Marker Score: 2285
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.72
Marker Score: 692
Cell Name: stem cell (CL0000034)
Fold Change: 1.71
Marker Score: 4068
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.71
Marker Score: 2720
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.71
Marker Score: 1741
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.7
Marker Score: 1710.5
Cell Name: kidney cell (CL1000497)
Fold Change: 1.69
Marker Score: 1128
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.69
Marker Score: 19008
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.68
Marker Score: 784
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.67
Marker Score: 6441
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.67
Marker Score: 1785
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.67
Marker Score: 1694
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.67
Marker Score: 959
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.66
Marker Score: 403
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.66
Marker Score: 971.5
Cell Name: motor neuron (CL0000100)
Fold Change: 1.66
Marker Score: 983
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.65
Marker Score: 778
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.64
Marker Score: 779
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 1.64
Marker Score: 712.5
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 1.62
Marker Score: 992
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.61
Marker Score: 1677
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 1.61
Marker Score: 1436
Cell Name: regulatory T cell (CL0000815)
Fold Change: 1.61
Marker Score: 1777
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.6
Marker Score: 1171.5
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.6
Marker Score: 1258.5
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.58
Marker Score: 814
Cell Name: male germ cell (CL0000015)
Fold Change: 1.58
Marker Score: 455.5
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 1.58
Marker Score: 2711
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.57
Marker Score: 1325

Hover over a box to see details here...

**Key characteristics:** * ARF5 is a protein of the ADP-ribosylation factor family. * It is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is localized to the cytoplasmic face of the Golgi apparatus. * It is a key regulator of the anterograde and retrograde transport of proteins between the ER and the Golgi. **Pathways and functions:** * ARF5 is involved in the regulation of protein trafficking between the ER and the Golgi apparatus. * It is a key regulator of the formation of the trans-Golgi intermediate compartment (TGC), which is a transient structure that forms during the retrograde transport of proteins from the ER to the Golgi. * ARF5 is also involved in the regulation of the sorting and trafficking of proteins to the plasma membrane. * It is a key regulator of the post-translational modification of proteins. **Clinical significance:** * Mutations in ARF5 have been linked to a number of human diseases, including cancer and neurodegenerative disorders. * ARF5 inhibitors are being investigated as potential treatments for these diseases. **Additional information:** * ARF5 is a highly conserved protein, with a similar protein being found in yeast and mice. * It is a member of the ADP-ribosylation factor family of proteins, which are involved in the regulation of protein translation. * It is a well-characterized protein that has been extensively studied in cell biology.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ADP-ribosylation factor 5

Genular Protein ID: 1154249174

Symbol: ARF5_HUMAN

Name: ADP-ribosylation factor 5

UniProtKB Accession Codes:

P84085 P26437

Database IDs:

Citations:

PubMed ID: 1993656

Title: Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells.

PubMed ID: 1993656

DOI: 10.1016/s0021-9258(18)49913-9

PubMed ID: 9169151

Title: Localization and characterization of the human ADP-ribosylation factor 5 (ARF5) gene.

PubMed ID: 9169151

DOI: 10.1006/geno.1997.4689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10022920

Title: Identification of a new Pyk2 target protein with Arf-GAP activity.

PubMed ID: 10022920

DOI: 10.1128/mcb.19.3.2338

PubMed ID: 11950392

Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.

PubMed ID: 11950392

DOI: 10.1042/bj20020428

PubMed ID: 17030804

Title: Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1.

PubMed ID: 17030804

DOI: 10.1073/pnas.0605357103

PubMed ID: 17555535

Title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.

PubMed ID: 17555535

DOI: 10.1111/j.1600-0854.2007.00594.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

Sequence Information:

Length: 180
Mass: 20530
Checksum: 25EF3D4895408147
Sequence:

MGLTVSALFS RIFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 
ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV QESADELQKM LQEDELRDAV 
LLVFANKQDM PNAMPVSELT DKLGLQHLRS RTWYVQATCA TQGTGLYDGL DWLSHELSKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ARF5

Associated with

Cells (max top 100)

Other Information

Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. PubMed ID: 1993656

Localization and characterization of the human ADP-ribosylation factor 5 (ARF5) gene. PubMed ID: 9169151

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a new Pyk2 target protein with Arf-GAP activity. PubMed ID: 10022920

GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. PubMed ID: 11950392

Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. PubMed ID: 17030804

Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta. PubMed ID: 17555535

Initial characterization of the human central proteome. PubMed ID: 21269460

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. PubMed ID: 25255805