Details for: ARF5

Gene ID: 381

Symbol: ARF5

Ensembl ID: ENSG00000004059

Description: ADP ribosylation factor 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.85
    Marker Score: 18,516
  • Cell Name: neural cell (CL0002319)
    Fold Change: 2.77
    Marker Score: 1,336
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.76
    Marker Score: 154,452
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.72
    Marker Score: 31,616
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.7
    Marker Score: 3,258
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.68
    Marker Score: 35,296
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.59
    Marker Score: 26,022
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.58
    Marker Score: 5,026
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.55
    Marker Score: 19,000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.55
    Marker Score: 6,930
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.52
    Marker Score: 16,138
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.31
    Marker Score: 3,786
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.29
    Marker Score: 6,788
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.28
    Marker Score: 7,205
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.27
    Marker Score: 2,407
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.23
    Marker Score: 19,606
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.21
    Marker Score: 1,850
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.2
    Marker Score: 545
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.16
    Marker Score: 1,563
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.15
    Marker Score: 9,283
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.15
    Marker Score: 21,295
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.14
    Marker Score: 9,163
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.13
    Marker Score: 3,059
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.13
    Marker Score: 12,604
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.12
    Marker Score: 5,290
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.09
    Marker Score: 2,350
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.09
    Marker Score: 2,958
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.09
    Marker Score: 2,252
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.05
    Marker Score: 6,428
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.04
    Marker Score: 1,789
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.03
    Marker Score: 1,002
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.02
    Marker Score: 2,975
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.02
    Marker Score: 1,112
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.01
    Marker Score: 1,180
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.01
    Marker Score: 4,189
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2
    Marker Score: 17,218
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.99
    Marker Score: 1,878
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.97
    Marker Score: 1,436
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.95
    Marker Score: 4,764
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.91
    Marker Score: 3,325
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.9
    Marker Score: 1,193
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.89
    Marker Score: 653
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.89
    Marker Score: 3,218
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.89
    Marker Score: 4,622
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.89
    Marker Score: 7,421
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.88
    Marker Score: 1,820
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.86
    Marker Score: 528
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.84
    Marker Score: 971
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.84
    Marker Score: 97,100
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.83
    Marker Score: 588
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.82
    Marker Score: 2,281
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.82
    Marker Score: 1,710
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.82
    Marker Score: 3,010
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.81
    Marker Score: 2,672
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.8
    Marker Score: 1,494
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.8
    Marker Score: 1,902
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.79
    Marker Score: 6,640
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.79
    Marker Score: 1,672
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.78
    Marker Score: 599
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.78
    Marker Score: 4,904
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.77
    Marker Score: 621
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.76
    Marker Score: 4,148
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.76
    Marker Score: 1,170
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.76
    Marker Score: 3,445
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.76
    Marker Score: 3,138
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.75
    Marker Score: 60,678
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.74
    Marker Score: 1,426
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.74
    Marker Score: 2,400
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.73
    Marker Score: 1,629
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.72
    Marker Score: 4,345
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.72
    Marker Score: 612
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.72
    Marker Score: 2,285
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.72
    Marker Score: 692
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.71
    Marker Score: 4,068
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.71
    Marker Score: 2,720
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.71
    Marker Score: 1,741
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.7
    Marker Score: 1,711
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.69
    Marker Score: 1,128
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.69
    Marker Score: 19,008
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.68
    Marker Score: 784
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.67
    Marker Score: 6,441
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.67
    Marker Score: 1,785
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.67
    Marker Score: 1,694
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.67
    Marker Score: 959
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.66
    Marker Score: 403
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.66
    Marker Score: 972
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.66
    Marker Score: 983
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.65
    Marker Score: 778
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.64
    Marker Score: 779
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.64
    Marker Score: 713
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.62
    Marker Score: 992
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.61
    Marker Score: 1,677
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.61
    Marker Score: 1,436
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.61
    Marker Score: 1,777
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.6
    Marker Score: 1,172
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.6
    Marker Score: 1,259
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.58
    Marker Score: 814
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.58
    Marker Score: 456
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.58
    Marker Score: 2,711
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.57
    Marker Score: 1,325

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ARF5 is a small GTPase protein that belongs to the ADP-ribosylation factor family. It is characterized by its ability to bind GTP, which triggers a conformational change that activates its effector proteins. ARF5 is involved in regulating various cellular processes, including: * Protein transport: ARF5 regulates the transport of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus and vice versa. * Vesicle-mediated transport: ARF5 is involved in the regulation of vesicle trafficking pathways, including anterograde and retrograde transport. * Post-translational protein modification: ARF5 regulates the modification of proteins by glycosylation and other post-translational modifications. ARF5 is also characterized by its ability to interact with various proteins, including SNARE proteins, which are involved in vesicle fusion and transport. **Pathways and Functions** ARF5 is involved in various cellular pathways, including: * **Golgi-to-ER retrograde transport**: ARF5 regulates the transport of proteins from the Golgi apparatus to the ER. * **Copi-dependent Golgi-to-ER retrograde transport**: ARF5 is involved in the regulation of the Copi-dependent retrograde transport pathway, which is essential for the transport of proteins from the Golgi apparatus to the ER. * **Copi-mediated anterograde transport**: ARF5 regulates the transport of proteins from the ER to the Golgi apparatus. * **Intra-golgi and retrograde Golgi-to-ER traffic**: ARF5 is involved in regulating the intra-golgi and retrograde Golgi-to-ER transport pathways. * **Protein binding**: ARF5 interacts with various proteins, including SNARE proteins, which are involved in vesicle fusion and transport. **Clinical Significance** Dysregulation of ARF5 has been implicated in various diseases, including: * **Immunological disorders**: ARF5 has been implicated in the regulation of immune cell function and has been associated with various immunological disorders, including multiple sclerosis and rheumatoid arthritis. * **Cancer**: ARF5 has been implicated in the regulation of cancer cell growth and migration, and has been associated with various types of cancer, including breast cancer and lung cancer. * **Neurological disorders**: ARF5 has been implicated in the regulation of neuronal function and has been associated with various neurological disorders, including Alzheimer's disease and Parkinson's disease. * **Ovarian cancer**: ARF5 has been implicated in the regulation of ovarian cancer cell growth and migration, and has been associated with ovarian cancer. In conclusion, ARF5 is a small GTPase protein that plays a crucial role in regulating various cellular processes, including protein transport, modification, and vesicle-mediated transport. Its dysregulation has been implicated in various diseases, highlighting its clinical significance. Further research is needed to fully understand the mechanisms by which ARF5 regulates cellular processes and its role in disease.

Genular Protein ID: 1154249174

Symbol: ARF5_HUMAN

Name: ADP-ribosylation factor 5

UniProtKB Accession Codes:

P84085 P26437

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1993656

Title: Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells.

PubMed ID: 1993656

DOI: 10.1016/s0021-9258(18)49913-9

PubMed ID: 9169151

Title: Localization and characterization of the human ADP-ribosylation factor 5 (ARF5) gene.

PubMed ID: 9169151

DOI: 10.1006/geno.1997.4689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10022920

Title: Identification of a new Pyk2 target protein with Arf-GAP activity.

PubMed ID: 10022920

DOI: 10.1128/mcb.19.3.2338

PubMed ID: 11950392

Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.

PubMed ID: 11950392

DOI: 10.1042/bj20020428

PubMed ID: 17030804

Title: Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1.

PubMed ID: 17030804

DOI: 10.1073/pnas.0605357103

PubMed ID: 17555535

Title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.

PubMed ID: 17555535

DOI: 10.1111/j.1600-0854.2007.00594.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

Sequence Information:

  • Length: 180
  • Mass: 20530
  • Checksum: 25EF3D4895408147
  • Sequence:
    • MGLTVSALFS RIFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 
ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV QESADELQKM LQEDELRDAV 
LLVFANKQDM PNAMPVSELT DKLGLQHLRS RTWYVQATCA TQGTGLYDGL DWLSHELSKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.