Details for: ARF5
Gene ID: 381
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ARF5
Ensembl ID: ENSG00000004059
Description: ARF GTPase 5
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 47.34rCSI 49.48%PRS 20.17
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CSI 43.29rCSI 45.35%PRS 18.07
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CSI 38.96rCSI 57.01%PRS 20.51
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CSI 34.63rCSI 28.71%PRS 18.33
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CSI 33.85rCSI 26.08%PRS 17.9
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CSI 31.61rCSI 43.08%PRS 17.12
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CSI 29.79rCSI 24.97%PRS 23.09
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CSI 28.51rCSI 27.44%PRS 20.04
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CSI 25.65rCSI 25.23%PRS 20.95
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CSI 24.71rCSI 42.34%PRS 26.22
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CSI 24.59rCSI 16.34%PRS 23.19
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CSI 23rCSI 22.18%PRS 13.97
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CSI 19.68rCSI 17.77%PRS 17.39
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CSI 19.31rCSI 29.49%PRS 33.8
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CSI 17.97rCSI 39.24%PRS 37.52
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CSI 17.17rCSI 28.12%PRS 14.9
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CSI 16.23rCSI 37.47%PRS 15.62
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CSI 16.23rCSI 16.54%PRS 27.71
-
CSI 15.99rCSI 24.46%PRS 31.29
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CSI 15.22rCSI 22.29%PRS 22.24
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CSI 15.02rCSI 10.49%PRS 20.55
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CSI 15rCSI 20.5%PRS 21.46
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CSI 14.54rCSI 38.38%PRS 23.12
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CSI 13.85rCSI 12.18%PRS 14.08
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CSI 13.83rCSI 12.14%PRS 22.23
-
CSI 13.8rCSI 48.98%PRS 31.4
-
CSI 13.66rCSI 11.4%PRS 49.46
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CSI 13.43rCSI 17.97%PRS 62.08
-
CSI 12.77rCSI 29.96%PRS 27.89
-
CSI 12.6rCSI 12.57%PRS 16.52
-
CSI 12.44rCSI 13.63%PRS 21.85
-
CSI 12.37rCSI 24.67%PRS 32.18
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CSI 11.67rCSI 10.36%PRS 19.49
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CSI 11.67rCSI 12.4%PRS 33.23
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CSI 11.36rCSI 32.9%PRS 21.89
-
CSI 11.05rCSI 31.55%PRS 32.79
-
CSI 10.91rCSI 22.41%PRS 41.74
-
CSI 10.62rCSI 9.82%PRS 34.8
-
CSI 10.25rCSI 8.29%PRS 19.36
-
CSI 10.06rCSI 19.57%PRS 19.81
-
CSI 9.46rCSI 20.83%PRS 21.86
-
CSI 9.01rCSI 10.58%PRS 22.39
-
CSI 8.97rCSI 6.96%PRS 18.54
-
CSI 8.75rCSI 10.45%PRS 11.23
-
CSI 8.68rCSI 11.6%PRS 25.23
-
CSI 8.51rCSI 6.76%PRS 34.25
-
CSI 8.49rCSI 13.76%PRS 19.52
-
CSI 8.47rCSI 12.94%PRS 19.48
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CSI 8.44rCSI 17.12%PRS 9.66
-
CSI 8.38rCSI 6.37%PRS 25.57
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CSI 8.34rCSI 12.81%PRS 23.09
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CSI 8.32rCSI 6.25%PRS 20.5
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CSI 8.25rCSI 44.53%PRS 33.85
-
CSI 8.15rCSI 8.44%PRS 22.8
-
CSI 7.95rCSI 56.07%PRS 52.61
-
CSI 7.92rCSI 11.77%PRS 23.12
-
CSI 7.78rCSI 7.08%PRS 29.45
-
CSI 7.77rCSI 6.12%PRS 23.31
-
CSI 7.77rCSI 15.6%PRS 14.33
-
CSI 7.76rCSI 13.26%PRS 38.76
-
CSI 7.62rCSI 24.44%PRS 27.76
-
CSI 7.53rCSI 10.35%PRS 38.12
-
CSI 7.51rCSI 5.58%PRS 28.61
-
CSI 7.37rCSI 45.51%PRS 56.67
-
CSI 7.12rCSI 16.16%PRS 26.2
-
CSI 7.04rCSI 11.34%PRS 29.85
-
CSI 6.91rCSI 8.42%PRS 24.3
-
CSI 6.84rCSI 12.35%PRS 46.84
-
CSI 6.77rCSI 4.76%PRS 45.19
-
CSI 6.72rCSI 4.67%PRS 23.12
-
CSI 6.66rCSI 6.29%PRS 20.29
-
CSI 6.61rCSI 10.26%PRS 28.91
-
CSI 6.57rCSI 9.12%PRS 19.82
-
CSI 6.55rCSI 9.07%PRS 27.37
-
CSI 6.53rCSI 29.71%PRS 59.51
-
CSI 6.53rCSI 10.09%PRS 18.14
-
CSI 6.48rCSI 8.82%PRS 44.8
-
CSI 6.48rCSI 6.39%PRS 62.94
-
CSI 6.46rCSI 4.83%PRS 30.66
-
CSI 6.34rCSI 15.68%PRS 17.89
-
CSI 6.32rCSI 5.47%PRS 21.74
-
CSI 6.3rCSI 13%PRS 28.76
-
CSI 6.29rCSI 4.97%PRS 13.28
-
CSI 6.24rCSI 4.16%PRS 46.4
-
CSI 6.21rCSI 11.84%PRS 30.6
-
CSI 6.16rCSI 31.58%PRS 62.64
-
CSI 6.13rCSI 6.03%PRS 51.51
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CSI 6.11rCSI 5.06%PRS 19.62
-
CSI 6.08rCSI 9.35%PRS 26.61
-
CSI 6.05rCSI 13.56%PRS 11.96
-
CSI 6.04rCSI 8.96%PRS 80.16
-
CSI 5.99rCSI 7.67%PRS 63.89
-
CSI 5.97rCSI 7.98%PRS 36.65
-
CSI 5.84rCSI 11.57%PRS 51.46
-
CSI 5.83rCSI 10.92%PRS 13.9
-
CSI 5.69rCSI 9.12%PRS 52.12
-
CSI 5.49rCSI 25.36%PRS 39.83
-
CSI 5.44rCSI 7.4%PRS 29.26
-
CSI 5.39rCSI 12.29%PRS 19.97
-
CSI 5.37rCSI 12.8%PRS 48.85
-
CSI -3.4rCSI -4.2%PRS 10.7%
-
CSI 0.1rCSI 3.1%PRS 73.5%
-
CSI 0.2rCSI 4.7%PRS 52.5%
-
CSI 0.2rCSI 2.3%PRS 50.1%
-
CSI 0.3rCSI 1.8%PRS 29.1%
-
CSI 0.4rCSI 1.5%PRS 35.6%
-
CSI 0.4rCSI 3.9%PRS 36.7%
-
CSI 0.4rCSI 7.2%PRS 65.0%
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CSI 0.4rCSI 7.8%PRS 74.8%
-
CSI 0.5rCSI 2.3%PRS 42.9%
-
CSI 0.5rCSI 1.8%PRS 30.9%
-
CSI 0.5rCSI 0.7%PRS 12.0%
-
CSI 0.6rCSI 6.0%PRS 34.3%
-
CSI 0.6rCSI 3.0%PRS 37.5%
-
CSI 0.6rCSI 1.6%PRS 37.4%
-
CSI 0.6rCSI 2.4%PRS 33.1%
-
CSI 0.6rCSI 0.9%PRS 26.7%
-
CSI 0.7rCSI 2.3%PRS 56.4%
-
CSI 0.7rCSI 3.8%PRS 28.4%
-
CSI 0.7rCSI 1.0%PRS 19.5%
-
CSI 0.7rCSI 1.6%PRS 11.2%
-
CSI 0.7rCSI 1.2%PRS 14.8%
-
CSI 0.7rCSI 7.0%PRS 67.0%
-
CSI 0.8rCSI 2.9%PRS 11.8%
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CSI 0.8rCSI 7.6%PRS 49.6%
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CSI 0.8rCSI 3.5%PRS 35.6%
-
CSI 0.8rCSI 4.6%PRS 56.1%
-
CSI 0.8rCSI 2.2%PRS 25.1%
-
CSI 0.9rCSI 22.0%PRS 71.1%
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CSI 0.9rCSI 2.5%PRS 36.1%
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CSI 0.9rCSI 1.6%PRS 50.5%
-
CSI 0.9rCSI 1.3%PRS 18.0%
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CSI 0.9rCSI 1.2%PRS 30.3%
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CSI 0.9rCSI 6.0%PRS 37.4%
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CSI 0.9rCSI 2.5%PRS 31.7%
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CSI 0.9rCSI 3.4%PRS 10.8%
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CSI 1.0rCSI 2.2%PRS 13.9%
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CSI 1.0rCSI 1.8%PRS 25.4%
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CSI 1.1rCSI 3.4%PRS 13.1%
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CSI 1.1rCSI 5.2%PRS 47.8%
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CSI 1.2rCSI 3.2%PRS 30.0%
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CSI 1.2rCSI 6.7%PRS 28.7%
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CSI 1.2rCSI 2.1%PRS 17.9%
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CSI 1.2rCSI 3.6%PRS 12.2%
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CSI 1.2rCSI 2.8%PRS 28.9%
-
CSI 1.2rCSI 11.8%PRS 56.3%
-
CSI 1.2rCSI 1.5%PRS 33.7%
-
CSI 1.2rCSI 2.0%PRS 21.2%
-
CSI 1.3rCSI 1.6%PRS 25.1%
-
CSI 1.3rCSI 5.5%PRS 33.6%
-
CSI 1.3rCSI 3.8%PRS 44.1%
-
CSI 1.3rCSI 2.4%PRS 40.7%
-
CSI 1.3rCSI 2.5%PRS 43.2%
-
CSI 1.3rCSI 1.6%PRS 24.0%
-
CSI 1.3rCSI 1.5%PRS 14.2%
-
CSI 1.3rCSI 1.2%PRS 24.2%
-
CSI 1.3rCSI 2.3%PRS 37.5%
-
CSI 1.4rCSI 1.8%PRS 27.6%
-
CSI 1.4rCSI 2.0%PRS 29.1%
-
CSI 1.4rCSI 10.8%PRS 35.2%
-
CSI 1.4rCSI 4.2%PRS 41.2%
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CSI 1.5rCSI 3.8%PRS 25.0%
-
CSI 1.5rCSI 1.4%PRS 39.1%
-
CSI 1.5rCSI 46.2%PRS 42.4%
-
CSI 1.6rCSI 9.5%PRS 12.0%
-
CSI 1.6rCSI 1.5%PRS 22.6%
-
CSI 1.8rCSI 2.8%PRS 16.3%
-
CSI 1.8rCSI 8.1%PRS 18.3%
-
CSI 1.8rCSI 4.7%PRS 24.0%
-
CSI 1.8rCSI 4.1%PRS 17.9%
-
CSI 1.8rCSI 3.3%PRS 16.1%
-
CSI 1.9rCSI 9.3%PRS 25.6%
-
CSI 2.0rCSI 3.1%PRS 24.9%
-
CSI 2.0rCSI 2.8%PRS 21.8%
-
CSI 2.1rCSI 5.3%PRS 18.1%
-
CSI 2.1rCSI 3.1%PRS 17.8%
-
CSI 2.1rCSI 27.6%PRS 55.2%
-
CSI 2.1rCSI 5.1%PRS 34.4%
-
CSI 2.1rCSI 4.0%PRS 42.4%
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CSI 2.2rCSI 56.6%PRS 68.6%
-
CSI 2.2rCSI 3.2%PRS 22.1%
-
CSI 2.2rCSI 2.7%PRS 23.2%
-
CSI 2.2rCSI 5.4%PRS 19.0%
-
CSI 2.2rCSI 5.6%PRS 51.7%
-
CSI 2.3rCSI 2.6%PRS 26.4%
-
CSI 2.3rCSI 3.3%PRS 30.2%
-
CSI 2.3rCSI 10.0%PRS 19.0%
-
CSI 2.3rCSI 4.8%PRS 30.7%
-
CSI 2.3rCSI 3.4%PRS 25.4%
-
CSI 2.3rCSI 5.5%PRS 29.3%
-
CSI 2.4rCSI 3.0%PRS 22.4%
-
CSI 2.4rCSI 4.4%PRS 29.5%
-
CSI 2.4rCSI 2.0%PRS 20.4%
-
CSI 2.4rCSI 5.8%PRS 23.9%
-
CSI 2.4rCSI 4.3%PRS 11.4%
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CSI 2.5rCSI 2.6%PRS 52.4%
-
CSI 2.5rCSI 16.7%PRS 55.8%
-
CSI 2.5rCSI 6.4%PRS 14.7%
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CSI 2.6rCSI 3.2%PRS 20.6%
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CSI 2.6rCSI 5.8%PRS 29.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1154249174
Symbol: ARF5_HUMAN
Name: ADP-ribosylation factor 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1993656
Title: Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells.
PubMed ID: 1993656
PubMed ID: 9169151
Title: Localization and characterization of the human ADP-ribosylation factor 5 (ARF5) gene.
PubMed ID: 9169151
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10022920
Title: Identification of a new Pyk2 target protein with Arf-GAP activity.
PubMed ID: 10022920
PubMed ID: 11950392
Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.
PubMed ID: 11950392
DOI: 10.1042/bj20020428
PubMed ID: 17030804
Title: Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1.
PubMed ID: 17030804
PubMed ID: 17555535
Title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.
PubMed ID: 17555535
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25255805
Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
PubMed ID: 25255805
DOI: 10.1038/ncomms5919
Sequence Information:
- Length: 180
- Mass: 20530
- Checksum: 25EF3D4895408147
- Sequence:
MGLTVSALFS RIFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV QESADELQKM LQEDELRDAV LLVFANKQDM PNAMPVSELT DKLGLQHLRS RTWYVQATCA TQGTGLYDGL DWLSHELSKR