Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 227.5223
Cell Significance Index: -35.3900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 174.0239
Cell Significance Index: -44.1400 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 136.1460
Cell Significance Index: -56.0900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 119.0625
Cell Significance Index: -48.3700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 101.1790
Cell Significance Index: -52.0500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 76.6145
Cell Significance Index: -51.4100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 51.9302
Cell Significance Index: -49.5800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 39.0849
Cell Significance Index: -48.1900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.9319
Cell Significance Index: -51.0300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.8473
Cell Significance Index: -39.4600 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 12.4646
Cell Significance Index: 37.0700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.9043
Cell Significance Index: -31.8900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.2930
Cell Significance Index: -18.1500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.2723
Cell Significance Index: 89.0700 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 3.0890
Cell Significance Index: 19.0100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.6683
Cell Significance Index: 47.1500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.4371
Cell Significance Index: 181.6400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.3096
Cell Significance Index: 108.5500 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.2983
Cell Significance Index: 296.9300 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 2.0951
Cell Significance Index: 5.6100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.0931
Cell Significance Index: 108.7300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.9517
Cell Significance Index: 57.3200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.9229
Cell Significance Index: 35.5400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.9024
Cell Significance Index: 233.9200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.7626
Cell Significance Index: 91.8100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.6278
Cell Significance Index: 14.9900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.4810
Cell Significance Index: 95.5500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.4133
Cell Significance Index: 254.7700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.3444
Cell Significance Index: 594.4000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.2754
Cell Significance Index: 36.5600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.1526
Cell Significance Index: 53.7400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.0539
Cell Significance Index: 47.7700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.0475
Cell Significance Index: 11.9000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0356
Cell Significance Index: 112.6400 - Cell Name: peg cell (CL4033014)
Fold Change: 1.0146
Cell Significance Index: 23.4400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9655
Cell Significance Index: 527.3000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.9505
Cell Significance Index: 67.2200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8517
Cell Significance Index: 100.4400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.7946
Cell Significance Index: 109.1200 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.7693
Cell Significance Index: 5.5300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.7355
Cell Significance Index: 25.5600 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.6828
Cell Significance Index: 17.9600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.6527
Cell Significance Index: 9.7800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6058
Cell Significance Index: 17.4600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.5421
Cell Significance Index: 13.5500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5041
Cell Significance Index: 13.4600 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.4987
Cell Significance Index: 63.9300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4171
Cell Significance Index: 376.6400 - Cell Name: theca cell (CL0000503)
Fold Change: 0.4098
Cell Significance Index: 2.4100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3938
Cell Significance Index: 23.6400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3102
Cell Significance Index: 59.0300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2906
Cell Significance Index: 6.3000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2486
Cell Significance Index: 6.6500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1623
Cell Significance Index: 32.2000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1090
Cell Significance Index: 3.8300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0994
Cell Significance Index: 16.9800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0844
Cell Significance Index: 13.7300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0645
Cell Significance Index: 1.3500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0390
Cell Significance Index: 0.8300 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.0030
Cell Significance Index: 0.0200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0015
Cell Significance Index: -1.1500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0093
Cell Significance Index: -6.8600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0163
Cell Significance Index: -3.2600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0168
Cell Significance Index: -12.3100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0199
Cell Significance Index: -37.4600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0295
Cell Significance Index: -3.0100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0301
Cell Significance Index: -2.9800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0331
Cell Significance Index: -61.0700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0342
Cell Significance Index: -21.3400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0355
Cell Significance Index: -20.0000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0393
Cell Significance Index: -60.4900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0441
Cell Significance Index: -59.9900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0542
Cell Significance Index: -19.4300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0645
Cell Significance Index: -44.5800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0667
Cell Significance Index: -42.3900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0923
Cell Significance Index: -2.5800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0992
Cell Significance Index: -1.6600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1084
Cell Significance Index: -49.1800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1150
Cell Significance Index: -7.2500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1214
Cell Significance Index: -25.5800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1371
Cell Significance Index: -15.6500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1548
Cell Significance Index: -44.5500 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.1877
Cell Significance Index: -3.2300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2331
Cell Significance Index: -3.1800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2347
Cell Significance Index: -26.8900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2644
Cell Significance Index: -30.8100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2741
Cell Significance Index: -8.7800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2970
Cell Significance Index: -15.6000 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2996
Cell Significance Index: -1.8100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3064
Cell Significance Index: -44.5400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4196
Cell Significance Index: -10.7200 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.4274
Cell Significance Index: -2.6500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4875
Cell Significance Index: -50.7700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5328
Cell Significance Index: -42.2000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.6387
Cell Significance Index: -49.0100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.6558
Cell Significance Index: -40.3100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6817
Cell Significance Index: -41.8000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6985
Cell Significance Index: -46.9700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.7408
Cell Significance Index: -41.5700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.7519
Cell Significance Index: -30.8100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 249932781
Symbol: ARF6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1993656
Title: Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells.
PubMed ID: 1993656
PubMed ID: 14659046
Title: Sequence, genomic organization, and expression of the human ADP-ribosylation factor 6 (ARF6) gene: a class III ARF.
PubMed ID: 14659046
PubMed ID: 9653160
Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.
PubMed ID: 9653160
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7589240
Title: Myristoylation is required for the intracellular localization and endocytic function of ARF6.
PubMed ID: 7589240
PubMed ID: 11062263
Title: ACAPs are arf6 GTPase-activating proteins that function in the cell periphery.
PubMed ID: 11062263
PubMed ID: 11950392
Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.
PubMed ID: 11950392
DOI: 10.1042/bj20020428
PubMed ID: 12847086
Title: ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma.
PubMed ID: 12847086
PubMed ID: 15509780
Title: The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.
PubMed ID: 15509780
PubMed ID: 14978216
Title: Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.
PubMed ID: 14978216
PubMed ID: 16148947
Title: Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis.
PubMed ID: 16148947
PubMed ID: 15642342
Title: Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins.
PubMed ID: 15642342
PubMed ID: 15793564
Title: Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics.
PubMed ID: 15793564
DOI: 10.1038/ncb1244
PubMed ID: 16737952
Title: Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4.
PubMed ID: 16737952
PubMed ID: 17030804
Title: Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1.
PubMed ID: 17030804
PubMed ID: 17398095
Title: The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.
PubMed ID: 17398095
PubMed ID: 17628206
Title: Molecular characterization of Rab11-FIP3 binding to ARF GTPases.
PubMed ID: 17628206
PubMed ID: 17555535
Title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.
PubMed ID: 17555535
PubMed ID: 18400762
Title: ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.
PubMed ID: 18400762
PubMed ID: 20727515
Title: TBC1D24, an ARF6-interacting protein, is mutated in familial infantile myoclonic epilepsy.
PubMed ID: 20727515
PubMed ID: 19948740
Title: AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling.
PubMed ID: 19948740
PubMed ID: 20682791
Title: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.
PubMed ID: 20682791
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21951725
Title: MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a.
PubMed ID: 21951725
PubMed ID: 23603394
Title: EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis.
PubMed ID: 23603394
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25255805
Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
PubMed ID: 25255805
DOI: 10.1038/ncomms5919
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 32103017
Title: NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle.
PubMed ID: 32103017
PubMed ID: 36017701
Title: AMPK promotes Arf6 activation in a kinase-independent manner upon glucose starvation.
PubMed ID: 36017701
DOI: 10.1242/jcs.259609
PubMed ID: 36250347
Title: Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signaling.
PubMed ID: 36250347
PubMed ID: 37417384
Title: Enterovirus 71 enters human brain microvascular endothelial cells through an ARF6-mediated endocytic pathway.
PubMed ID: 37417384
DOI: 10.1002/jmv.28915
PubMed ID: 37461827
Title: ARF6 plays a general role in targeting palmitoylated proteins from golgi to the plasma membrane.
PubMed ID: 37461827
DOI: 10.1242/jcs.261319
PubMed ID: 10881192
Title: Structure of Arf6-GDP suggests a basis for guanine nucleotide exchange factors specificity.
PubMed ID: 10881192
DOI: 10.1038/75863
PubMed ID: 11266366
Title: The structural GDP/GTP cycle of human Arf6.
PubMed ID: 11266366
PubMed ID: 16099990
Title: Structural basis for the activation of cholera toxin by human ARF6-GTP.
PubMed ID: 16099990
PubMed ID: 16839550
Title: NMR structural studies of the myristoylated N-terminus of ADP ribosylation factor 6 (Arf6).
PubMed ID: 16839550
PubMed ID: 19644450
Title: The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4.
PubMed ID: 19644450
PubMed ID: 20510928
Title: The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism.
PubMed ID: 20510928
PubMed ID: 21170023
Title: The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.
PubMed ID: 21170023
DOI: 10.1038/nature09593
PubMed ID: 22939626
Title: Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses.
PubMed ID: 22939626
PubMed ID: 23940353
Title: Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors.
PubMed ID: 23940353
Sequence Information:
- Length: 175
- Mass: 20082
- Checksum: 49E38E59AEA52B98
- Sequence:
MGKVLSKIFG NKEMRILMLG LDAAGKTTIL YKLKLGQSVT TIPTVGFNVE TVTYKNVKFN VWDVGGQDKI RPLWRHYYTG TQGLIFVVDC ADRDRIDEAR QELHRIINDR EMRDAIILIF ANKQDLPDAM KPHEIQEKLG LTRIRDRNWY VQPSCATSGD GLYEGLTWLT SNYKS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.