Details for: ARF6

Gene ID: 382

Symbol: ARF6

Ensembl ID: ENSG00000165527

Description: ADP ribosylation factor 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.7
    Marker Score: 10224.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.09
    Marker Score: 7551
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.05
    Marker Score: 2406
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.73
    Marker Score: 23544
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.72
    Marker Score: 7934
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.62
    Marker Score: 888
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.6
    Marker Score: 16561
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.57
    Marker Score: 20107
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.57
    Marker Score: 7205
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.5
    Marker Score: 24726
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.42
    Marker Score: 1460
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.4
    Marker Score: 2363.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.38
    Marker Score: 9188
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.37
    Marker Score: 1388
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.34
    Marker Score: 1969
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.28
    Marker Score: 808
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.27
    Marker Score: 127211
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.24
    Marker Score: 1627
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.22
    Marker Score: 956.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.17
    Marker Score: 6801
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.15
    Marker Score: 1185
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.14
    Marker Score: 3150
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.07
    Marker Score: 52974
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.03
    Marker Score: 630.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.03
    Marker Score: 69178
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.03
    Marker Score: 1237
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.02
    Marker Score: 1040
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.02
    Marker Score: 6381
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.01
    Marker Score: 956
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.01
    Marker Score: 9638
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.98
    Marker Score: 2268
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.97
    Marker Score: 983
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.96
    Marker Score: 3477
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.96
    Marker Score: 695
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.95
    Marker Score: 1328
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.94
    Marker Score: 640
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.94
    Marker Score: 4410.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.92
    Marker Score: 3838
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.91
    Marker Score: 2309
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.91
    Marker Score: 1788
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.9
    Marker Score: 12151.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.87
    Marker Score: 7339
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.86
    Marker Score: 798
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.85
    Marker Score: 1737
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.83
    Marker Score: 669
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.83
    Marker Score: 1921
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.79
    Marker Score: 1044
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.78
    Marker Score: 690
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.77
    Marker Score: 1019
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.77
    Marker Score: 2606
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.75
    Marker Score: 15383
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.75
    Marker Score: 569
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.75
    Marker Score: 961
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.74
    Marker Score: 1760
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.72
    Marker Score: 2909
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.72
    Marker Score: 4331.5
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.72
    Marker Score: 4143
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.71
    Marker Score: 700
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.71
    Marker Score: 1503
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.71
    Marker Score: 1399
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7
    Marker Score: 17260
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7
    Marker Score: 406
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.7
    Marker Score: 89706
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.69
    Marker Score: 4390
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.68
    Marker Score: 1223
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.68
    Marker Score: 1268
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.65
    Marker Score: 8124
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.65
    Marker Score: 7123
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.63
    Marker Score: 1810.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.62
    Marker Score: 611
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.61
    Marker Score: 1751
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.6
    Marker Score: 1094
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.59
    Marker Score: 1424
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.59
    Marker Score: 484
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.59
    Marker Score: 1150
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.59
    Marker Score: 6812
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.58
    Marker Score: 1519
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.58
    Marker Score: 2618.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.57
    Marker Score: 992
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.56
    Marker Score: 414
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.56
    Marker Score: 3561
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.56
    Marker Score: 388.5
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.55
    Marker Score: 1678
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.55
    Marker Score: 347
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.55
    Marker Score: 388.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.54
    Marker Score: 446
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.54
    Marker Score: 486.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.53
    Marker Score: 1282
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.53
    Marker Score: 1634
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.53
    Marker Score: 3634
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.53
    Marker Score: 878
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.53
    Marker Score: 2433
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.53
    Marker Score: 406
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.53
    Marker Score: 402
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.53
    Marker Score: 527
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.53
    Marker Score: 635
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.52
    Marker Score: 1611
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.51
    Marker Score: 9194.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.51
    Marker Score: 2699
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.51
    Marker Score: 371

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Other Information

**Key characteristics:** - ARF6 is a protein of the immunoglobulin superfamily. - It is highly expressed in decidual natural killer cells, human, basal cell of prostate epithelium, epithelial cell of urethra, epithelial cell of esophagus, NKp46-positive innate lymphoid cell, human, stem cell of epidermis, foveolar cell of stomach, stratified epithelial cell, CD8-positive, alpha-beta memory T cell, CD45RO-positive, mature T cell. - It is a ubiquitin-dependent protein. **Pathways and functions:** - The clathrin-mediated endocytosis pathway is a major pathway for the internalization of proteins from the extracellular environment. - ARF6 is a key regulator of this pathway. It is a key component of the clathrin-coated pits that are responsible for the initial endocytosis of proteins. - ARF6 is also involved in the G protein-coupled receptor (Gdp) system, the G protein-coupled receptor activity, the Gtpase activity, the Gtp binding, the Intracellular protein transport, and the liver development pathways. **Clinical significance:** - Mutations in ARF6 have been linked to several human diseases, including cancer and neurodegenerative disorders. - These diseases are characterized by abnormal protein trafficking, which is often caused by defects in ARF6. - Therefore, ARF6 is a promising target for the treatment of human diseases characterized by abnormal protein trafficking.

Genular Protein ID: 249932781

Symbol: ARF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1993656

Title: Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells.

PubMed ID: 1993656

DOI: 10.1016/s0021-9258(18)49913-9

PubMed ID: 14659046

Title: Sequence, genomic organization, and expression of the human ADP-ribosylation factor 6 (ARF6) gene: a class III ARF.

PubMed ID: 14659046

DOI: 10.1089/104454903770946719

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7589240

Title: Myristoylation is required for the intracellular localization and endocytic function of ARF6.

PubMed ID: 7589240

DOI: 10.1006/excr.1995.1362

PubMed ID: 11062263

Title: ACAPs are arf6 GTPase-activating proteins that function in the cell periphery.

PubMed ID: 11062263

DOI: 10.1083/jcb.151.3.627

PubMed ID: 11950392

Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.

PubMed ID: 11950392

DOI: 10.1042/bj20020428

PubMed ID: 12847086

Title: ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma.

PubMed ID: 12847086

DOI: 10.1083/jcb.200301006

PubMed ID: 15509780

Title: The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.

PubMed ID: 15509780

DOI: 10.1128/mcb.24.22.9752-9762.2004

PubMed ID: 14978216

Title: Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.

PubMed ID: 14978216

DOI: 10.1091/mbc.e03-07-0493

PubMed ID: 16148947

Title: Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis.

PubMed ID: 16148947

DOI: 10.1038/sj.emboj.7600803

PubMed ID: 15642342

Title: Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins.

PubMed ID: 15642342

DOI: 10.1016/j.febslet.2004.11.095

PubMed ID: 15793564

Title: Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics.

PubMed ID: 15793564

DOI: 10.1038/ncb1244

PubMed ID: 16737952

Title: Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4.

PubMed ID: 16737952

DOI: 10.1074/mcp.m600050-mcp200

PubMed ID: 17030804

Title: Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1.

PubMed ID: 17030804

DOI: 10.1073/pnas.0605357103

PubMed ID: 17398095

Title: The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.

PubMed ID: 17398095

DOI: 10.1016/j.cub.2007.03.007

PubMed ID: 17628206

Title: Molecular characterization of Rab11-FIP3 binding to ARF GTPases.

PubMed ID: 17628206

DOI: 10.1016/j.ejcb.2007.05.004

PubMed ID: 17555535

Title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.

PubMed ID: 17555535

DOI: 10.1111/j.1600-0854.2007.00594.x

PubMed ID: 18400762

Title: ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.

PubMed ID: 18400762

DOI: 10.1074/jbc.m709717200

PubMed ID: 20727515

Title: TBC1D24, an ARF6-interacting protein, is mutated in familial infantile myoclonic epilepsy.

PubMed ID: 20727515

DOI: 10.1016/j.ajhg.2010.07.020

PubMed ID: 19948740

Title: AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling.

PubMed ID: 19948740

DOI: 10.1074/jbc.m109.069385

PubMed ID: 20682791

Title: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.

PubMed ID: 20682791

DOI: 10.1074/jbc.m110.154120

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21951725

Title: MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a.

PubMed ID: 21951725

DOI: 10.1111/j.1600-0854.2011.01294.x

PubMed ID: 23603394

Title: EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis.

PubMed ID: 23603394

DOI: 10.1016/j.febslet.2013.03.042

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32103017

Title: NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle.

PubMed ID: 32103017

DOI: 10.1038/s41467-020-14893-x

PubMed ID: 36017701

Title: AMPK promotes Arf6 activation in a kinase-independent manner upon glucose starvation.

PubMed ID: 36017701

DOI: 10.1242/jcs.259609

PubMed ID: 36250347

Title: Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signaling.

PubMed ID: 36250347

DOI: 10.1096/fj.202200757r

PubMed ID: 37417384

Title: Enterovirus 71 enters human brain microvascular endothelial cells through an ARF6-mediated endocytic pathway.

PubMed ID: 37417384

DOI: 10.1002/jmv.28915

PubMed ID: 37461827

Title: ARF6 plays a general role in targeting palmitoylated proteins from golgi to the plasma membrane.

PubMed ID: 37461827

DOI: 10.1242/jcs.261319

PubMed ID: 10881192

Title: Structure of Arf6-GDP suggests a basis for guanine nucleotide exchange factors specificity.

PubMed ID: 10881192

DOI: 10.1038/75863

PubMed ID: 11266366

Title: The structural GDP/GTP cycle of human Arf6.

PubMed ID: 11266366

DOI: 10.1093/embo-reports/kve043

PubMed ID: 16099990

Title: Structural basis for the activation of cholera toxin by human ARF6-GTP.

PubMed ID: 16099990

DOI: 10.1126/science.1113398

PubMed ID: 16839550

Title: NMR structural studies of the myristoylated N-terminus of ADP ribosylation factor 6 (Arf6).

PubMed ID: 16839550

DOI: 10.1016/j.febslet.2006.06.086

PubMed ID: 19644450

Title: The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4.

PubMed ID: 19644450

DOI: 10.1038/emboj.2009.209

PubMed ID: 20510928

Title: The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism.

PubMed ID: 20510928

DOI: 10.1016/j.cell.2010.03.051

PubMed ID: 21170023

Title: The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.

PubMed ID: 21170023

DOI: 10.1038/nature09593

PubMed ID: 22939626

Title: Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses.

PubMed ID: 22939626

DOI: 10.1016/j.cell.2012.06.050

PubMed ID: 23940353

Title: Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors.

PubMed ID: 23940353

DOI: 10.1073/pnas.1301883110

Sequence Information:

  • Length: 175
  • Mass: 20082
  • Checksum: 49E38E59AEA52B98
  • Sequence:
  • MGKVLSKIFG NKEMRILMLG LDAAGKTTIL YKLKLGQSVT TIPTVGFNVE TVTYKNVKFN 
    VWDVGGQDKI RPLWRHYYTG TQGLIFVVDC ADRDRIDEAR QELHRIINDR EMRDAIILIF 
    ANKQDLPDAM KPHEIQEKLG LTRIRDRNWY VQPSCATSGD GLYEGLTWLT SNYKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.