ARG1 | ENSG00000118520 | NCBI 383

Details for: ARG1

Gene ID: 383

Symbol: ARG1

Ensembl ID: ENSG00000118520

Description: arginase 1

Associated with

Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Neutrophil degranulation
(R-HSA-6798695)
Adaptive immune response
(GO:0002250)
Arginase activity
(GO:0004053)
Arginine catabolic process
(GO:0006527)
Arginine catabolic process to ornithine
(GO:0019547)
Azurophil granule lumen
(GO:0035578)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to protozoan
(GO:0042832)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Innate immune response
(GO:0045087)
Manganese ion binding
(GO:0030145)
Negative regulation of activated t cell proliferation
(GO:0046007)
Negative regulation of t-helper 2 cell cytokine production
(GO:2000552)
Negative regulation of t cell proliferation
(GO:0042130)
Negative regulation of type ii interferon-mediated signaling pathway
(GO:0060336)
Nucleus
(GO:0005634)
Positive regulation of neutrophil mediated killing of fungus
(GO:0070965)
Protein binding
(GO:0005515)
Specific granule lumen
(GO:0035580)
Urea cycle
(GO:0000050)

Other Information

Proteins

Arginase-1

Genular Protein ID: 271180517

Symbol: ARGI1_HUMAN

Name: Arginase-1

UniProtKB Accession Codes:

P05089 A6NEA0 Q5JWT5 Q5JWT6 Q8TE72 Q9BS50

Database IDs:

Citations:

PubMed ID: 3540966

Title: Molecular cloning and nucleotide sequence of cDNA for human liver arginase.

PubMed ID: 3540966

DOI: 10.1073/pnas.84.2.412

PubMed ID: 3174433

Title: Human liver-type arginase gene: structure of the gene and analysis of the promoter region.

PubMed ID: 3174433

DOI: 10.1093/nar/16.18.8789

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2241902

Title: Expression of human liver arginase in Escherichia coli. Purification and properties of the product.

PubMed ID: 2241902

DOI: 10.1042/bj2700697

PubMed ID: 15546957

Title: Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.

PubMed ID: 15546957

DOI: 10.1182/blood-2004-07-2521

PubMed ID: 16709924

Title: Suppression of T-cell functions by human granulocyte arginase.

PubMed ID: 16709924

DOI: 10.1182/blood-2006-11-010389

PubMed ID: 19380772

Title: Regulation of NK cell function by human granulocyte arginase.

PubMed ID: 19380772

DOI: 10.4049/jimmunol.0803523

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23749634

Title: Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms.

PubMed ID: 23749634

DOI: 10.4049/jimmunol.1300113

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27043409

Title: Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.

PubMed ID: 27043409

DOI: 10.1038/ni.3421

PubMed ID: 28813417

Title: CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

PubMed ID: 28813417

DOI: 10.1038/nature23643

PubMed ID: 16141327

Title: Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response.

PubMed ID: 16141327

DOI: 10.1073/pnas.0504027102

PubMed ID: 17562323

Title: Expression, purification, assay, and crystal structure of perdeuterated human arginase I.

PubMed ID: 17562323

DOI: 10.1016/j.abb.2007.04.036

PubMed ID: 17469833

Title: Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.

PubMed ID: 17469833

DOI: 10.1021/ja071567j

PubMed ID: 18802628

Title: Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I.

PubMed ID: 18802628

DOI: 10.1039/b811797g

PubMed ID: 21728378

Title: Binding of alpha,alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design.

PubMed ID: 21728378

DOI: 10.1021/jm200443b

PubMed ID: 1463019

Title: Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia.

PubMed ID: 1463019

PubMed ID: 1598908

Title: Molecular genetic study of human arginase deficiency.

PubMed ID: 1598908

PubMed ID: 7649538

Title: Molecular basis of phenotypic variation in patients with argininemia.

PubMed ID: 7649538

DOI: 10.1007/bf00210403

PubMed ID: 22959135

Title: Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes.

PubMed ID: 22959135

DOI: 10.1016/j.gene.2012.08.003

PubMed ID: 23859858

Title: Five novel mutations in ARG1 gene in Chinese patients of argininemia.

PubMed ID: 23859858

DOI: 10.1016/j.pediatrneurol.2013.04.026

Sequence Information:

Length: 322
Mass: 34735
Checksum: 8F3BE2652243F622
Sequence:

MSAKSRTIGI IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KEQECDVKDY GDLPFADIPN 
DSPFQIVKNP RSVGKASEQL AGKVAEVKKN GRISLVLGGD HSLAIGSISG HARVHPDLGV 
IWVDAHTDIN TPLTTTSGNL HGQPVSFLLK ELKGKIPDVP GFSWVTPCIS AKDIVYIGLR 
DVDPGEHYIL KTLGIKYFSM TEVDRLGIGK VMEETLSYLL GRKKRPIHLS FDVDGLDPSF 
TPATGTPVVG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVAIT 
LACFGLAREG NHKPIDYLNP PK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ARG1

Associated with

Other Information

Molecular cloning and nucleotide sequence of cDNA for human liver arginase. PubMed ID: 3540966

Human liver-type arginase gene: structure of the gene and analysis of the promoter region. PubMed ID: 3174433

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of human liver arginase in Escherichia coli. Purification and properties of the product. PubMed ID: 2241902

Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. PubMed ID: 15546957

Suppression of T-cell functions by human granulocyte arginase. PubMed ID: 16709924

Regulation of NK cell function by human granulocyte arginase. PubMed ID: 19380772

Initial characterization of the human central proteome. PubMed ID: 21269460

Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms. PubMed ID: 23749634

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. PubMed ID: 27043409

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. PubMed ID: 28813417

Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response. PubMed ID: 16141327

Expression, purification, assay, and crystal structure of perdeuterated human arginase I. PubMed ID: 17562323

Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster. PubMed ID: 17469833

Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I. PubMed ID: 18802628

Binding of alpha,alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design. PubMed ID: 21728378

Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia. PubMed ID: 1463019

Molecular genetic study of human arginase deficiency. PubMed ID: 1598908

Molecular basis of phenotypic variation in patients with argininemia. PubMed ID: 7649538

Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes. PubMed ID: 22959135

Five novel mutations in ARG1 gene in Chinese patients of argininemia. PubMed ID: 23859858