Details for: ARG1

Gene ID: 383

Symbol: ARG1

Ensembl ID: ENSG00000118520

Description: arginase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.37
    Marker Score: 15,663
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 4.1
    Marker Score: 12,171
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 3.82
    Marker Score: 3,659
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.58
    Marker Score: 30,261
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.29
    Marker Score: 4,563
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.07
    Marker Score: 8,745
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.65
    Marker Score: 7,610
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.46
    Marker Score: 8,049
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.28
    Marker Score: 12,284
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.98
    Marker Score: 12,762
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.95
    Marker Score: 8,405
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.05
    Marker Score: 7,001
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,816
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.03
    Marker Score: 2,612
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,058
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.95
    Marker Score: 1,016
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,356
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.92
    Marker Score: 626
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 655
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1,342
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1,196
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 379
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 470
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.57
    Marker Score: 214
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 129
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.46
    Marker Score: 7,192
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.45
    Marker Score: 3,834
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.44
    Marker Score: 676
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.43
    Marker Score: 428
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.41
    Marker Score: 128
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 391
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.4
    Marker Score: 251
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.39
    Marker Score: 167
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.36
    Marker Score: 220
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 308
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.29
    Marker Score: 190
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.28
    Marker Score: 586
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.28
    Marker Score: 97
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.28
    Marker Score: 76
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.27
    Marker Score: 133
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.26
    Marker Score: 2,505
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 114
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.24
    Marker Score: 88
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.23
    Marker Score: 14,344
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.23
    Marker Score: 51
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.22
    Marker Score: 346
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.2
    Marker Score: 69
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 83
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.2
    Marker Score: 98
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 0.2
    Marker Score: 83
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.19
    Marker Score: 87
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.19
    Marker Score: 109
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.18
    Marker Score: 1,674
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.17
    Marker Score: 176
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 73
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.16
    Marker Score: 142
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 138
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.14
    Marker Score: 62
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.14
    Marker Score: 114
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.13
    Marker Score: 55
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.13
    Marker Score: 53
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.12
    Marker Score: 64
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.1
    Marker Score: 102
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.1
    Marker Score: 77
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 49
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1
    Marker Score: 73
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: enucleate erythrocyte (CL0000595)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.09
    Marker Score: 3,162
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.09
    Marker Score: 111
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 80
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 85
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.08
    Marker Score: 43
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.07
    Marker Score: 444
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.07
    Marker Score: 971
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.07
    Marker Score: 262
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.07
    Marker Score: 278
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.07
    Marker Score: 89
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 17

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARG1 is a metalloenzyme, requiring manganese ions as a cofactor for its catalytic activity. It is primarily expressed in cells of the immune system, including neutrophils, macrophages, and T cells. The enzyme is also present in tissues such as the retina, liver, and kidney. ARG1 is a dimeric protein, consisting of two identical subunits, each with a molecular weight of approximately 240 kDa. **Pathways and Functions:** ARG1 is involved in several key pathways, including: 1. **Arginine catabolic process:** ARG1 catalyzes the conversion of arginine to ornithine and urea, regulating the availability of arginine for nitric oxide (NO) production and other cellular processes. 2. **Adaptive immune response:** ARG1 plays a crucial role in regulating T cell proliferation and cytokine production, particularly in the context of type II interferon-mediated signaling pathways. 3. **Innate immune response:** ARG1 is involved in the regulation of neutrophil degranulation and the killing of pathogens, including fungi. 4. **Metabolism:** ARG1 is also involved in the urea cycle, which is essential for the removal of excess nitrogen from the body. **Clinical Significance:** ARG1 has been implicated in various diseases, including: 1. **Autoimmune disorders:** ARG1 has been shown to play a role in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** ARG1 has been found to be overexpressed in certain types of cancer, including lung and breast cancer, where it may contribute to tumor growth and metastasis. 3. **Neurological disorders:** ARG1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Infectious diseases:** ARG1 has been shown to play a role in the regulation of immune responses to pathogens, including viruses and bacteria. In conclusion, ARG1 is a complex enzyme with a wide range of biological functions, from immune response regulation to metabolism. Further research is needed to fully understand the mechanisms by which ARG1 contributes to disease and to develop new therapeutic strategies targeting this enzyme. **References:** * [Insert relevant references] Note: This article is a summary of the provided information and is not intended to be a comprehensive review of the literature on ARG1.

Genular Protein ID: 271180517

Symbol: ARGI1_HUMAN

Name: Arginase-1

UniProtKB Accession Codes:

P05089 A6NEA0 Q5JWT5 Q5JWT6 Q8TE72 Q9BS50

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 13 EC 1 EMBL 16 EMDB 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 94 PDBsum 60 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3540966

Title: Molecular cloning and nucleotide sequence of cDNA for human liver arginase.

PubMed ID: 3540966

DOI: 10.1073/pnas.84.2.412

PubMed ID: 3174433

Title: Human liver-type arginase gene: structure of the gene and analysis of the promoter region.

PubMed ID: 3174433

DOI: 10.1093/nar/16.18.8789

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2241902

Title: Expression of human liver arginase in Escherichia coli. Purification and properties of the product.

PubMed ID: 2241902

DOI: 10.1042/bj2700697

PubMed ID: 15546957

Title: Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.

PubMed ID: 15546957

DOI: 10.1182/blood-2004-07-2521

PubMed ID: 16709924

Title: Suppression of T-cell functions by human granulocyte arginase.

PubMed ID: 16709924

DOI: 10.1182/blood-2006-11-010389

PubMed ID: 19380772

Title: Regulation of NK cell function by human granulocyte arginase.

PubMed ID: 19380772

DOI: 10.4049/jimmunol.0803523

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23749634

Title: Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms.

PubMed ID: 23749634

DOI: 10.4049/jimmunol.1300113

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27043409

Title: Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.

PubMed ID: 27043409

DOI: 10.1038/ni.3421

PubMed ID: 28813417

Title: CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

PubMed ID: 28813417

DOI: 10.1038/nature23643

PubMed ID: 16141327

Title: Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response.

PubMed ID: 16141327

DOI: 10.1073/pnas.0504027102

PubMed ID: 17562323

Title: Expression, purification, assay, and crystal structure of perdeuterated human arginase I.

PubMed ID: 17562323

DOI: 10.1016/j.abb.2007.04.036

PubMed ID: 17469833

Title: Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.

PubMed ID: 17469833

DOI: 10.1021/ja071567j

PubMed ID: 18802628

Title: Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I.

PubMed ID: 18802628

DOI: 10.1039/b811797g

PubMed ID: 21728378

Title: Binding of alpha,alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design.

PubMed ID: 21728378

DOI: 10.1021/jm200443b

PubMed ID: 1463019

Title: Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia.

PubMed ID: 1463019

PubMed ID: 1598908

Title: Molecular genetic study of human arginase deficiency.

PubMed ID: 1598908

PubMed ID: 7649538

Title: Molecular basis of phenotypic variation in patients with argininemia.

PubMed ID: 7649538

DOI: 10.1007/bf00210403

PubMed ID: 22959135

Title: Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes.

PubMed ID: 22959135

DOI: 10.1016/j.gene.2012.08.003

PubMed ID: 23859858

Title: Five novel mutations in ARG1 gene in Chinese patients of argininemia.

PubMed ID: 23859858

DOI: 10.1016/j.pediatrneurol.2013.04.026

Sequence Information:

  • Length: 322
  • Mass: 34735
  • Checksum: 8F3BE2652243F622
  • Sequence:
    • MSAKSRTIGI IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KEQECDVKDY GDLPFADIPN 
DSPFQIVKNP RSVGKASEQL AGKVAEVKKN GRISLVLGGD HSLAIGSISG HARVHPDLGV 
IWVDAHTDIN TPLTTTSGNL HGQPVSFLLK ELKGKIPDVP GFSWVTPCIS AKDIVYIGLR 
DVDPGEHYIL KTLGIKYFSM TEVDRLGIGK VMEETLSYLL GRKKRPIHLS FDVDGLDPSF 
TPATGTPVVG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVAIT 
LACFGLAREG NHKPIDYLNP PK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.