Details for: ARG1

Gene ID: 383

Symbol: ARG1

Ensembl ID: ENSG00000118520

Description: arginase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 15.7771
    Cell Significance Index: 265.3600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 10.9614
    Cell Significance Index: -1.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.3295
    Cell Significance Index: -2.6200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 9.5150
    Cell Significance Index: 25.1000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.9006
    Cell Significance Index: 149.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6201
    Cell Significance Index: 321.5100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.4802
    Cell Significance Index: 5.5800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.1979
    Cell Significance Index: 2.7000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.8031
    Cell Significance Index: 4.6300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.7976
    Cell Significance Index: 19.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.6665
    Cell Significance Index: -2.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6084
    Cell Significance Index: 8.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3857
    Cell Significance Index: 8.4500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3657
    Cell Significance Index: 5.2400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2337
    Cell Significance Index: 7.3900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2088
    Cell Significance Index: 3.2300
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1824
    Cell Significance Index: 1.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1745
    Cell Significance Index: 2.0800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.1195
    Cell Significance Index: 0.3200
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.0774
    Cell Significance Index: 0.6000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0633
    Cell Significance Index: 1.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0354
    Cell Significance Index: 7.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0342
    Cell Significance Index: 12.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0292
    Cell Significance Index: 5.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0156
    Cell Significance Index: 0.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0100
    Cell Significance Index: 0.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0083
    Cell Significance Index: 0.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0044
    Cell Significance Index: 6.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0033
    Cell Significance Index: 5.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0023
    Cell Significance Index: 4.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0020
    Cell Significance Index: 3.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0003
    Cell Significance Index: 0.0400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0015
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0038
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0039
    Cell Significance Index: -2.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0044
    Cell Significance Index: -0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0044
    Cell Significance Index: -2.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0045
    Cell Significance Index: -2.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0051
    Cell Significance Index: -2.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0063
    Cell Significance Index: -0.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0070
    Cell Significance Index: -0.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0073
    Cell Significance Index: -0.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0087
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0149
    Cell Significance Index: -3.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0166
    Cell Significance Index: -2.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0172
    Cell Significance Index: -2.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0178
    Cell Significance Index: -1.2000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0203
    Cell Significance Index: -0.1600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0205
    Cell Significance Index: -0.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0206
    Cell Significance Index: -0.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0221
    Cell Significance Index: -2.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0228
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0233
    Cell Significance Index: -2.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0241
    Cell Significance Index: -2.8100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0247
    Cell Significance Index: -0.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0255
    Cell Significance Index: -2.6000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0255
    Cell Significance Index: -0.4400
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0270
    Cell Significance Index: -0.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0290
    Cell Significance Index: -1.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0329
    Cell Significance Index: -3.8800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0346
    Cell Significance Index: -0.2300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0358
    Cell Significance Index: -0.3400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0408
    Cell Significance Index: -0.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0464
    Cell Significance Index: -1.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0467
    Cell Significance Index: -1.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0475
    Cell Significance Index: -2.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0475
    Cell Significance Index: -1.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0482
    Cell Significance Index: -3.1100
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0489
    Cell Significance Index: -0.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0499
    Cell Significance Index: -2.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0522
    Cell Significance Index: -2.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0564
    Cell Significance Index: -1.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0571
    Cell Significance Index: -1.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0612
    Cell Significance Index: -1.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0620
    Cell Significance Index: -2.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0620
    Cell Significance Index: -1.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0639
    Cell Significance Index: -2.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0641
    Cell Significance Index: -2.6300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0647
    Cell Significance Index: -0.7700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0694
    Cell Significance Index: -1.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0700
    Cell Significance Index: -1.2000
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: -0.0735
    Cell Significance Index: -0.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0751
    Cell Significance Index: -2.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0816
    Cell Significance Index: -2.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0823
    Cell Significance Index: -2.3500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0827
    Cell Significance Index: -1.2000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0829
    Cell Significance Index: -1.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0831
    Cell Significance Index: -3.0500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0850
    Cell Significance Index: -2.1200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0850
    Cell Significance Index: -1.7300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0863
    Cell Significance Index: -0.7900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0870
    Cell Significance Index: -1.1000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0872
    Cell Significance Index: -0.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0881
    Cell Significance Index: -2.6000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0895
    Cell Significance Index: -2.2800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0895
    Cell Significance Index: -1.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0903
    Cell Significance Index: -1.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0934
    Cell Significance Index: -2.4600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0944
    Cell Significance Index: -1.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARG1 is a metalloenzyme, requiring manganese ions as a cofactor for its catalytic activity. It is primarily expressed in cells of the immune system, including neutrophils, macrophages, and T cells. The enzyme is also present in tissues such as the retina, liver, and kidney. ARG1 is a dimeric protein, consisting of two identical subunits, each with a molecular weight of approximately 240 kDa. **Pathways and Functions:** ARG1 is involved in several key pathways, including: 1. **Arginine catabolic process:** ARG1 catalyzes the conversion of arginine to ornithine and urea, regulating the availability of arginine for nitric oxide (NO) production and other cellular processes. 2. **Adaptive immune response:** ARG1 plays a crucial role in regulating T cell proliferation and cytokine production, particularly in the context of type II interferon-mediated signaling pathways. 3. **Innate immune response:** ARG1 is involved in the regulation of neutrophil degranulation and the killing of pathogens, including fungi. 4. **Metabolism:** ARG1 is also involved in the urea cycle, which is essential for the removal of excess nitrogen from the body. **Clinical Significance:** ARG1 has been implicated in various diseases, including: 1. **Autoimmune disorders:** ARG1 has been shown to play a role in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** ARG1 has been found to be overexpressed in certain types of cancer, including lung and breast cancer, where it may contribute to tumor growth and metastasis. 3. **Neurological disorders:** ARG1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Infectious diseases:** ARG1 has been shown to play a role in the regulation of immune responses to pathogens, including viruses and bacteria. In conclusion, ARG1 is a complex enzyme with a wide range of biological functions, from immune response regulation to metabolism. Further research is needed to fully understand the mechanisms by which ARG1 contributes to disease and to develop new therapeutic strategies targeting this enzyme. **References:** * [Insert relevant references] Note: This article is a summary of the provided information and is not intended to be a comprehensive review of the literature on ARG1.

Genular Protein ID: 271180517

Symbol: ARGI1_HUMAN

Name: Arginase-1

UniProtKB Accession Codes:

P05089 A6NEA0 Q5JWT5 Q5JWT6 Q8TE72 Q9BS50

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 13 EC 1 EMBL 16 EMDB 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 60 PDBsum 60 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3540966

Title: Molecular cloning and nucleotide sequence of cDNA for human liver arginase.

PubMed ID: 3540966

DOI: 10.1073/pnas.84.2.412

PubMed ID: 3174433

Title: Human liver-type arginase gene: structure of the gene and analysis of the promoter region.

PubMed ID: 3174433

DOI: 10.1093/nar/16.18.8789

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2241902

Title: Expression of human liver arginase in Escherichia coli. Purification and properties of the product.

PubMed ID: 2241902

DOI: 10.1042/bj2700697

PubMed ID: 15546957

Title: Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.

PubMed ID: 15546957

DOI: 10.1182/blood-2004-07-2521

PubMed ID: 16709924

Title: Suppression of T-cell functions by human granulocyte arginase.

PubMed ID: 16709924

DOI: 10.1182/blood-2006-11-010389

PubMed ID: 19380772

Title: Regulation of NK cell function by human granulocyte arginase.

PubMed ID: 19380772

DOI: 10.4049/jimmunol.0803523

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23749634

Title: Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms.

PubMed ID: 23749634

DOI: 10.4049/jimmunol.1300113

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27043409

Title: Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.

PubMed ID: 27043409

DOI: 10.1038/ni.3421

PubMed ID: 28813417

Title: CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

PubMed ID: 28813417

DOI: 10.1038/nature23643

PubMed ID: 16141327

Title: Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response.

PubMed ID: 16141327

DOI: 10.1073/pnas.0504027102

PubMed ID: 17562323

Title: Expression, purification, assay, and crystal structure of perdeuterated human arginase I.

PubMed ID: 17562323

DOI: 10.1016/j.abb.2007.04.036

PubMed ID: 17469833

Title: Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.

PubMed ID: 17469833

DOI: 10.1021/ja071567j

PubMed ID: 18802628

Title: Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I.

PubMed ID: 18802628

DOI: 10.1039/b811797g

PubMed ID: 21728378

Title: Binding of alpha,alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design.

PubMed ID: 21728378

DOI: 10.1021/jm200443b

PubMed ID: 1463019

Title: Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia.

PubMed ID: 1463019

PubMed ID: 1598908

Title: Molecular genetic study of human arginase deficiency.

PubMed ID: 1598908

PubMed ID: 7649538

Title: Molecular basis of phenotypic variation in patients with argininemia.

PubMed ID: 7649538

DOI: 10.1007/bf00210403

PubMed ID: 22959135

Title: Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes.

PubMed ID: 22959135

DOI: 10.1016/j.gene.2012.08.003

PubMed ID: 23859858

Title: Five novel mutations in ARG1 gene in Chinese patients of argininemia.

PubMed ID: 23859858

DOI: 10.1016/j.pediatrneurol.2013.04.026

Sequence Information:

  • Length: 322
  • Mass: 34735
  • Checksum: 8F3BE2652243F622
  • Sequence:
    • MSAKSRTIGI IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KEQECDVKDY GDLPFADIPN 
DSPFQIVKNP RSVGKASEQL AGKVAEVKKN GRISLVLGGD HSLAIGSISG HARVHPDLGV 
IWVDAHTDIN TPLTTTSGNL HGQPVSFLLK ELKGKIPDVP GFSWVTPCIS AKDIVYIGLR 
DVDPGEHYIL KTLGIKYFSM TEVDRLGIGK VMEETLSYLL GRKKRPIHLS FDVDGLDPSF 
TPATGTPVVG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVAIT 
LACFGLAREG NHKPIDYLNP PK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.