dos | FBgn0016794 | NCBI 38321

Details for: dos

Gene ID: 38321

Symbol: dos

Ensembl ID: FBgn0016794

Description: daughter of sevenless

Associated with

Axon guidance
(R-DME-422475)
Cytokine signaling in immune system
(R-DME-1280215)
Developmental biology
(R-DME-1266738)
Downstream signaling of activated fgfr1
(R-DME-5654687)
Downstream signaling of activated fgfr2
(R-DME-5654696)
Downstream signaling of activated fgfr3
(R-DME-5654708)
Downstream signaling of activated fgfr4
(R-DME-5654716)
Erythropoietin activates phosphoinositide-3-kinase (pi3k)
(R-DME-9027276)
Fc epsilon receptor (fceri) signaling
(R-DME-2454202)
Gab1 signalosome
(R-DME-180292)
Igf1r signaling cascade
(R-DME-2428924)
Immune system
(R-DME-168256)
Innate immune system
(R-DME-168249)
Insulin receptor signalling cascade
(R-DME-74751)
Intracellular signaling by second messengers
(R-DME-9006925)
Irs-mediated signalling
(R-DME-112399)
Irs-related events triggered by igf1r
(R-DME-2428928)
Negative regulation of the pi3k/akt network
(R-DME-199418)
Nervous system development
(R-DME-9675108)
Pi-3k cascade:fgfr1
(R-DME-5654689)
Pi-3k cascade:fgfr2
(R-DME-5654695)
Pi-3k cascade:fgfr3
(R-DME-5654710)
Pi-3k cascade:fgfr4
(R-DME-5654720)
Pi3k cascade
(R-DME-109704)
Pi3k events in erbb2 signaling
(R-DME-1963642)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-DME-6811558)
Pip3 activates akt signaling
(R-DME-1257604)
Ret signaling
(R-DME-8853659)
Role of lat2/ntal/lab on calcium mobilization
(R-DME-2730905)
Signaling by csf3 (g-csf)
(R-DME-9674555)
Signaling by egfr
(R-DME-177929)
Signaling by erbb2
(R-DME-1227986)
Signaling by erythropoietin
(R-DME-9006335)
Signaling by fgfr
(R-DME-190236)
Signaling by fgfr1
(R-DME-5654736)
Signaling by fgfr2
(R-DME-5654738)
Signaling by fgfr3
(R-DME-5654741)
Signaling by fgfr4
(R-DME-5654743)
Signaling by insulin receptor
(R-DME-74752)
Signaling by receptor tyrosine kinases
(R-DME-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-DME-2404192)
Anterior/posterior axis specification, embryo
(GO:0008595)
Cytoplasm
(GO:0005737)
Photoreceptor cell development
(GO:0042461)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
R7 cell fate commitment
(GO:0007465)
Regulation of ras protein signal transduction
(GO:0046578)
Sevenless signaling pathway
(GO:0045500)
Sh2 domain binding
(GO:0042169)
Signaling adaptor activity
(GO:0035591)
Signal transduction
(GO:0007165)
Torso signaling pathway
(GO:0008293)

Other Information

Proteins

Protein daughter of sevenless

Genular Protein ID: 3953531031

Symbol: DOS_DROME

Name: Protein daughter of sevenless

UniProtKB Accession Codes:

Q9VZZ9 Q24452 Q9W000

Database IDs:

Citations:

PubMed ID: 8681385

Title: Dos, a novel PH domain containing protein required for signal transduction between Sevenless and Ras1 in Drosophila.

PubMed ID: 8681385

DOI: 10.1016/s0092-8674(00)81274-x

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 8681384

Title: Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling.

PubMed ID: 8681384

DOI: 10.1016/s0092-8674(00)81273-8

PubMed ID: 10601017

Title: Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase.

PubMed ID: 10601017

DOI: 10.1093/emboj/18.24.6950

PubMed ID: 10640704

Title: In vivo functional analysis of the daughter of sevenless protein in receptor tyrosine kinase signaling.

PubMed ID: 10640704

DOI: 10.1016/s0925-4773(99)00252-x

PubMed ID: 12128212

Title: SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases.

PubMed ID: 12128212

DOI: 10.1016/s0925-4773(02)00147-8

PubMed ID: 17372656

Title: An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells.

PubMed ID: 17372656

DOI: 10.1039/b617545g

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

Sequence Information:

Length: 878
Mass: 95536
Checksum: 5BE89F16EA5E6177
Sequence:

MDRTFYEGWL IKSPPTKRIW RARWRRRYFT LKQGEIPEQF CLEYYTDHNC RKLKGVIDLD 
QCEQVDCGLR LENRKQKFQY MFDIKTPKRT YYLAAETEAD MRDWVNCICQ VCHLHDTKQS 
NELPLGAVGA DENRTQHTSS SGGLSNSTQN TTTTSLHSSA GTTAPQASVP NAGGSAQLRR 
PAVIEEQPMP SNAGNNNSDS VYVNTEYSNR ETMLCDANFD QQELLSAAQQ QPPPSPATAL 
YLNHSALIQA QAAAAAAEQL QQQQQQAARL AVSANGVVRK LPEHLVLTQQ TLAEAAAQQH 
SSVQASPALS TASGPYIPIS ECFSGSPRFL PGVPLPGADL AIPNNPTTPL NNLDPKFYDT 
PRSHNNIGLN LTNDQSYSPK ITNLSLQQLA NNNASKQRSD SDSESVFTDD DEWAHPLPLR 
ENVDRSTRPS DSSIENESFV LTYSQRFSKM PEEGGAIVPP AEKSSKLAGA ASLPEAGDQG 
TLDKLAKVLK NKNNLILDFK ENEKIPRDLP QLSDTENTSP AIVARRNAHS AFIEESYDIP 
RSHQQPYYNV NQLLGERPVT SPHNSNPIAA STPNLMAADL GAVAAISAAA NPGLMGEAQA 
VASSPTSART LPRHCYTNAA PTKMEGNVFR YDFMEQADCP PVNRKLKPKV AGGLPVVEDK 
PPEEFPAKPP VGVDQLTNKL GAAQLQQPIG PPSVDRKCKP NAYKLGNSAT MSPATRRSSG 
APLSMVLPHE TDVHSPAAAN AFFHETRTLP RQQHRHHPNS PGSMSVQHQR TASAAAAMMS 
LTAAAAPKQQ AAAQTEHKLQ YFDLDVTNKP PLLNRSSMSV GNLYSQGGNG ASGMRFAGVE 
AGGARAPVPS SVVYRSVDFV KTEAFKRIRE ERESSGNK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: dos

Associated with

Other Information

Dos, a novel PH domain containing protein required for signal transduction between Sevenless and Ras1 in Drosophila. PubMed ID: 8681385

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. PubMed ID: 8681384

Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase. PubMed ID: 10601017

In vivo functional analysis of the daughter of sevenless protein in receptor tyrosine kinase signaling. PubMed ID: 10640704

SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases. PubMed ID: 12128212

An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells. PubMed ID: 17372656

Phosphoproteome analysis of Drosophila melanogaster embryos. PubMed ID: 18327897