Details for: KIFC1

Gene ID: 3833

Symbol: KIFC1

Ensembl ID: ENSG00000237649

Description: kinesin family member C1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 6.92
    Marker Score: 7247
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.58
    Marker Score: 5338
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.94
    Marker Score: 2785.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.63
    Marker Score: 1457
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.55
    Marker Score: 1454
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.48
    Marker Score: 4029
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.17
    Marker Score: 372
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.12
    Marker Score: 746
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1
    Marker Score: 3274
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.04
    Marker Score: 550
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.04
    Marker Score: 1111
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5203
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.89
    Marker Score: 288
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.88
    Marker Score: 1488
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.86
    Marker Score: 580
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1383
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.76
    Marker Score: 480
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 680
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.73
    Marker Score: 230
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 559.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.72
    Marker Score: 537
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.7
    Marker Score: 1650
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.67
    Marker Score: 887
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.65
    Marker Score: 1356
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.63
    Marker Score: 461
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.63
    Marker Score: 786
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.61
    Marker Score: 639
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.59
    Marker Score: 591
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.58
    Marker Score: 306
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.55
    Marker Score: 180
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 345
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.53
    Marker Score: 255
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.52
    Marker Score: 293
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.52
    Marker Score: 135
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.51
    Marker Score: 198
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.48
    Marker Score: 1137
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.46
    Marker Score: 436
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.46
    Marker Score: 1256
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.45
    Marker Score: 650
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.45
    Marker Score: 1766
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.41
    Marker Score: 271
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.4
    Marker Score: 247
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.39
    Marker Score: 196
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.39
    Marker Score: 194
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.39
    Marker Score: 224
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.39
    Marker Score: 246
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.37
    Marker Score: 109
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.36
    Marker Score: 96
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.36
    Marker Score: 2398
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.36
    Marker Score: 393
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.35
    Marker Score: 4672
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.35
    Marker Score: 100
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.35
    Marker Score: 172.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.35
    Marker Score: 82
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.35
    Marker Score: 337
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.34
    Marker Score: 267.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.33
    Marker Score: 96
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.33
    Marker Score: 1358
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.32
    Marker Score: 520
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.32
    Marker Score: 872
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.31
    Marker Score: 498
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.3
    Marker Score: 710
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.29
    Marker Score: 102
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.29
    Marker Score: 331
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.29
    Marker Score: 144
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.29
    Marker Score: 159
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.29
    Marker Score: 132
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.28
    Marker Score: 72
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.27
    Marker Score: 114
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.27
    Marker Score: 114
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.27
    Marker Score: 75
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.27
    Marker Score: 111
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.27
    Marker Score: 161
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.26
    Marker Score: 1526.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.26
    Marker Score: 182
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.26
    Marker Score: 50
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.25
    Marker Score: 102
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.25
    Marker Score: 166
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.25
    Marker Score: 137
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.24
    Marker Score: 225
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.23
    Marker Score: 129
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.23
    Marker Score: 566
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.23
    Marker Score: 138
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 153
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.23
    Marker Score: 56
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.22
    Marker Score: 163
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.22
    Marker Score: 77

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Other Information

**Key characteristics:** - KIFC1 is a large protein with a molecular weight of approximately 120 kDa. - It is a key regulator of cell cycle progression and is involved in the regulation of cell division and migration. - KIFC1 is also involved in the regulation of the formation of the primary ciliated process, which is responsible for the movement of secretory granules in the cell. **Pathways and functions:** - KIFC1 is involved in cell cycle progression by regulating the disassembly of the G1/S transition protein kinase complex. - It is also involved in the regulation of the formation of the primary ciliated process, which is responsible for the movement of secretory granules in the cell. - KIFC1 is also involved in the regulation of the sorting and transport of vesicles between the endoplasmic reticulum (ER) and the Golgi apparatus. - It is involved in the maintenance of nuclear integrity by preventing the aggregation of damaged or misfolded proteins. - KIFC1 also plays a role in the regulation of apoptosis by promoting the disassembly of the mitochondrial outer membrane potential protein, thus leading to the release of cytochrome c. **Clinical significance:** - Mutations in KIFC1 have been linked to a number of human diseases, including cancer and cardiovascular disease. - In cancer, mutations in KIFC1 are often associated with the activation of oncogenes and the development of tumors. - Targeting KIFC1 has been investigated as a therapeutic strategy for cancer, and several drugs that inhibit KIFC1 have been tested in clinical trials.

Genular Protein ID: 2165620451

Symbol: KIFC1_HUMAN

Name: Kinesin-like protein KIFC1

UniProtKB Accession Codes:

Q9BW19 O60887 Q14834 Q4KMP0 Q5SU09 Q6GMS7 Q6P4A5 Q9UQP7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10369922

Title: Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS).

PubMed ID: 10369922

DOI: 10.1007/s002510050660

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8276466

Title: Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region.

PubMed ID: 8276466

DOI: 10.1007/bf00241260

PubMed ID: 15843429

Title: Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.

PubMed ID: 15843429

DOI: 10.1091/mbc.e05-02-0167

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 673
  • Mass: 73748
  • Checksum: 9E99737665BF1E92
  • Sequence:
    • MDPQRSPLLE VKGNIELKRP LIKAPSQLPL SGSRLKRRPD QMEDGLEPEK KRTRGLGATT 
KITTSHPRVP SLTTVPQTQG QTTAQKVSKK TGPRCSTAIA TGLKNQKPVP AVPVQKSGTS 
GVPPMAGGKK PSKRPAWDLK GQLCDLNAEL KRCRERTQTL DQENQQLQDQ LRDAQQQVKA 
LGTERTTLEG HLAKVQAQAE QGQQELKNLR ACVLELEERL STQEGLVQEL QKKQVELQEE 
RRGLMSQLEE KERRLQTSEA ALSSSQAEVA SLRQETVAQA ALLTEREERL HGLEMERRRL 
HNQLQELKGN IRVFCRVRPV LPGEPTPPPG LLLFPSGPGG PSDPPTRLSL SRSDERRGTL 
SGAPAPPTRH DFSFDRVFPP GSGQDEVFEE IAMLVQSALD GYPVCIFAYG QTGSGKTFTM 
EGGPGGDPQL EGLIPRALRH LFSVAQELSG QGWTYSFVAS YVEIYNETVR DLLATGTRKG 
QGGECEIRRA GPGSEELTVT NARYVPVSCE KEVDALLHLA RQNRAVARTA QNERSSRSHS 
VFQLQISGEH SSRGLQCGAP LSLVDLAGSE RLDPGLALGP GERERLRETQ AINSSLSTLG 
LVIMALSNKE SHVPYRNSKL TYLLQNSLGG SAKMLMFVNI SPLEENVSES LNSLRFASKV 
NQCVIGTAQA NRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.