Details for: ARG2

Gene ID: 384

Symbol: ARG2

Ensembl ID: ENSG00000081181

Description: arginase 2

Associated with

  • Metabolism
    (R-HSA-1430728)
  • Metabolism of amino acids and derivatives
    (R-HSA-71291)
  • Metabolism of proteins
    (R-HSA-392499)
  • Mitochondrial protein degradation
    (R-HSA-9837999)
  • Adaptive immune response
    (GO:0002250)
  • Arginase activity
    (GO:0004053)
  • Arginine catabolic process to ornithine
    (GO:0019547)
  • Cytoplasm
    (GO:0005737)
  • Innate immune response
    (GO:0045087)
  • Manganese ion binding
    (GO:0030145)
  • Mitochondrial matrix
    (GO:0005759)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of activated cd8-positive, alpha-beta t cell apoptotic process
    (GO:1905403)
  • Negative regulation of cd4-positive, alpha-beta t cell proliferation
    (GO:2000562)
  • Negative regulation of chemokine (c-c motif) ligand 4 production
    (GO:0071644)
  • Negative regulation of chemokine (c-c motif) ligand 5 production
    (GO:0071650)
  • Negative regulation of defense response to bacterium
    (GO:1900425)
  • Negative regulation of interleukin-13 production
    (GO:0032696)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of macrophage inflammatory protein 1 alpha production
    (GO:0071641)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type 2 immune response
    (GO:0002829)
  • Nitric oxide biosynthetic process
    (GO:0006809)
  • Positive regulation of cellular senescence
    (GO:2000774)
  • Protein binding
    (GO:0005515)
  • Regulation of interleukin-1 beta production
    (GO:0032651)
  • Regulation of reactive oxygen species biosynthetic process
    (GO:1903426)
  • Striated muscle contraction
    (GO:0006941)
  • Urea cycle
    (GO:0000050)
  • Ureteric bud development
    (GO:0001657)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.36
    Marker Score: 5792.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.76
    Marker Score: 1028
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.72
    Marker Score: 4339
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7
    Marker Score: 4145
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.61
    Marker Score: 398
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6
    Marker Score: 2361
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.58
    Marker Score: 1247
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.56
    Marker Score: 1204
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168902
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.34
    Marker Score: 2346
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.34
    Marker Score: 3357
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.34
    Marker Score: 3047
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.31
    Marker Score: 5146
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.3
    Marker Score: 1846
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.21
    Marker Score: 707
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.18
    Marker Score: 610
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.14
    Marker Score: 42110
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.11
    Marker Score: 872.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.07
    Marker Score: 11087
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.06
    Marker Score: 677
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.05
    Marker Score: 6312
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.03
    Marker Score: 15469
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.01
    Marker Score: 1679
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71778
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48003
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.99
    Marker Score: 1520.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.98
    Marker Score: 1185
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.97
    Marker Score: 2279
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.94
    Marker Score: 990
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2728
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.9
    Marker Score: 17907
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.89
    Marker Score: 3312
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13962.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5033.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.87
    Marker Score: 7474
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.85
    Marker Score: 6523
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.85
    Marker Score: 304
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 794
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.8
    Marker Score: 692
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.8
    Marker Score: 3255
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.79
    Marker Score: 267
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.79
    Marker Score: 2796
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.78
    Marker Score: 411.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.76
    Marker Score: 172
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.75
    Marker Score: 2883
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.74
    Marker Score: 7000
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 296
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.73
    Marker Score: 27904
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.73
    Marker Score: 786
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.72
    Marker Score: 356
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.72
    Marker Score: 1178
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.7
    Marker Score: 740
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2917
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 628
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.69
    Marker Score: 217
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.68
    Marker Score: 1378.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.67
    Marker Score: 739
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.66
    Marker Score: 22456
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.66
    Marker Score: 668
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.64
    Marker Score: 270
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.63
    Marker Score: 772
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.63
    Marker Score: 865.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.62
    Marker Score: 2883
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1169
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.6
    Marker Score: 273
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.6
    Marker Score: 2478
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.59
    Marker Score: 740
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.59
    Marker Score: 190
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.59
    Marker Score: 36188
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.59
    Marker Score: 263
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.59
    Marker Score: 5053
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.58
    Marker Score: 137
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.58
    Marker Score: 2421.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.57
    Marker Score: 229
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.56
    Marker Score: 870
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.56
    Marker Score: 178
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.56
    Marker Score: 625
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.55
    Marker Score: 488
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.55
    Marker Score: 5205
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.55
    Marker Score: 163
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.54
    Marker Score: 253.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.54
    Marker Score: 158
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.54
    Marker Score: 108
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.53
    Marker Score: 215
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.53
    Marker Score: 615
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.52
    Marker Score: 4092
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.51
    Marker Score: 1448
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.5
    Marker Score: 535

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Other Information

**Key characteristics:** - ARGI2 is a protein that is involved in the regulation of the adaptive immune response. - It is a mitochondrial protein that is expressed in a variety of cell types. - It is involved in the negative regulation of interleukin-13 production, negative regulation of interleukin-17 production, negative regulation of tumor necrosis factor production, and negative regulation of type 2 immune response. **Pathways and functions:** - ARG2 is involved in the regulation of the adaptive immune response by binding to arginine and regulating the production of inflammatory cytokines. - It also plays a role in the regulation of the urea cycle, which is involved in the metabolism of amino acids and derivatives. - In addition, ARG2 is involved in the regulation of protein binding, which is essential for the functioning of many immune cells. **Clinical significance:** - Mutations in the ARG2 gene have been linked to a number of human diseases, including rheumatoid arthritis, asthma, and Crohn's disease. - These diseases are characterized by inflammation and tissue damage, and ARG2 is a key molecule in the regulation of these inflammatory responses. - Therefore, targeting ARG2 has emerged as a potential therapeutic strategy for these diseases.

Genular Protein ID: 3492082644

Symbol: ARGI2_HUMAN

Name: Arginase-2, mitochondrial

UniProtKB Accession Codes:

P78540 B2R690 Q6FHY8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 12 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SABIO-RK 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8898077

Title: Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line.

PubMed ID: 8898077

DOI: 10.1016/0014-5793(96)01015-0

PubMed ID: 8954792

Title: Cloning and characterization of the human type II arginase gene.

PubMed ID: 8954792

DOI: 10.1006/geno.1996.0606

PubMed ID: 9256072

Title: Human type II arginase: sequence analysis and tissue-specific expression.

PubMed ID: 9256072

DOI: 10.1016/s0378-1119(97)00099-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22928666

Title: Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging.

PubMed ID: 22928666

DOI: 10.1111/acel.12001

PubMed ID: 23832324

Title: Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability.

PubMed ID: 23832324

DOI: 10.1161/jaha.113.000096

PubMed ID: 25484082

Title: ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.

PubMed ID: 25484082

DOI: 10.4161/15548627.2014.981789

PubMed ID: 27745970

Title: L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity.

PubMed ID: 27745970

DOI: 10.1016/j.cell.2016.09.031

PubMed ID: 27214549

Title: Increased mitochondrial arginine metabolism supports bioenergetics in asthma.

PubMed ID: 27214549

DOI: 10.1172/jci82925

PubMed ID: 28614294

Title: Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.

PubMed ID: 28614294

DOI: 10.1038/nature22795

PubMed ID: 12859189

Title: Human arginase II: crystal structure and physiological role in male and female sexual arousal.

PubMed ID: 12859189

DOI: 10.1021/bi034340j

Sequence Information:

  • Length: 354
  • Mass: 38578
  • Checksum: 1624FAC7D515C68B
  • Sequence:
    • MSLRGSLSRL LQTRVHSILK KSVHSVAVIG APFSQGQKRK GVEHGPAAIR EAGLMKRLSS 
LGCHLKDFGD LSFTPVPKDD LYNNLIVNPR SVGLANQELA EVVSRAVSDG YSCVTLGGDH 
SLAIGTISGH ARHCPDLCVV WVDAHADINT PLTTSSGNLH GQPVSFLLRE LQDKVPQLPG 
FSWIKPCISS ASIVYIGLRD VDPPEHFILK NYDIQYFSMR DIDRLGIQKV MERTFDLLIG 
KRQRPIHLSF DIDAFDPTLA PATGTPVVGG LTYREGMYIA EEIHNTGLLS ALDLVEVNPQ 
LATSEEEAKT TANLAVDVIA SSFGQTREGG HIVYDQLPTP SSPDESENQA RVRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.