Details for: ARG2

Gene ID: 384

Symbol: ARG2

Ensembl ID: ENSG00000081181

Description: arginase 2

Associated with

  • Metabolism
    (R-HSA-1430728)
  • Metabolism of amino acids and derivatives
    (R-HSA-71291)
  • Metabolism of proteins
    (R-HSA-392499)
  • Mitochondrial protein degradation
    (R-HSA-9837999)
  • Adaptive immune response
    (GO:0002250)
  • Arginase activity
    (GO:0004053)
  • Arginine catabolic process to ornithine
    (GO:0019547)
  • Cytoplasm
    (GO:0005737)
  • Innate immune response
    (GO:0045087)
  • Manganese ion binding
    (GO:0030145)
  • Mitochondrial matrix
    (GO:0005759)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of activated cd8-positive, alpha-beta t cell apoptotic process
    (GO:1905403)
  • Negative regulation of cd4-positive, alpha-beta t cell proliferation
    (GO:2000562)
  • Negative regulation of chemokine (c-c motif) ligand 4 production
    (GO:0071644)
  • Negative regulation of chemokine (c-c motif) ligand 5 production
    (GO:0071650)
  • Negative regulation of defense response to bacterium
    (GO:1900425)
  • Negative regulation of interleukin-13 production
    (GO:0032696)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of macrophage inflammatory protein 1 alpha production
    (GO:0071641)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type 2 immune response
    (GO:0002829)
  • Nitric oxide biosynthetic process
    (GO:0006809)
  • Positive regulation of cellular senescence
    (GO:2000774)
  • Protein binding
    (GO:0005515)
  • Regulation of interleukin-1 beta production
    (GO:0032651)
  • Regulation of reactive oxygen species biosynthetic process
    (GO:1903426)
  • Striated muscle contraction
    (GO:0006941)
  • Urea cycle
    (GO:0000050)
  • Ureteric bud development
    (GO:0001657)

Other Information

Genular Protein ID: 3492082644

Symbol: ARGI2_HUMAN

Name: Arginase-2, mitochondrial

UniProtKB Accession Codes:

P78540 B2R690 Q6FHY8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 12 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SABIO-RK 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8898077

Title: Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line.

PubMed ID: 8898077

DOI: 10.1016/0014-5793(96)01015-0

PubMed ID: 8954792

Title: Cloning and characterization of the human type II arginase gene.

PubMed ID: 8954792

DOI: 10.1006/geno.1996.0606

PubMed ID: 9256072

Title: Human type II arginase: sequence analysis and tissue-specific expression.

PubMed ID: 9256072

DOI: 10.1016/s0378-1119(97)00099-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22928666

Title: Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging.

PubMed ID: 22928666

DOI: 10.1111/acel.12001

PubMed ID: 23832324

Title: Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability.

PubMed ID: 23832324

DOI: 10.1161/jaha.113.000096

PubMed ID: 25484082

Title: ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.

PubMed ID: 25484082

DOI: 10.4161/15548627.2014.981789

PubMed ID: 27745970

Title: L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity.

PubMed ID: 27745970

DOI: 10.1016/j.cell.2016.09.031

PubMed ID: 27214549

Title: Increased mitochondrial arginine metabolism supports bioenergetics in asthma.

PubMed ID: 27214549

DOI: 10.1172/jci82925

PubMed ID: 28614294

Title: Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.

PubMed ID: 28614294

DOI: 10.1038/nature22795

PubMed ID: 12859189

Title: Human arginase II: crystal structure and physiological role in male and female sexual arousal.

PubMed ID: 12859189

DOI: 10.1021/bi034340j

Sequence Information:

  • Length: 354
  • Mass: 38578
  • Checksum: 1624FAC7D515C68B
  • Sequence:
    • MSLRGSLSRL LQTRVHSILK KSVHSVAVIG APFSQGQKRK GVEHGPAAIR EAGLMKRLSS 
LGCHLKDFGD LSFTPVPKDD LYNNLIVNPR SVGLANQELA EVVSRAVSDG YSCVTLGGDH 
SLAIGTISGH ARHCPDLCVV WVDAHADINT PLTTSSGNLH GQPVSFLLRE LQDKVPQLPG 
FSWIKPCISS ASIVYIGLRD VDPPEHFILK NYDIQYFSMR DIDRLGIQKV MERTFDLLIG 
KRQRPIHLSF DIDAFDPTLA PATGTPVVGG LTYREGMYIA EEIHNTGLLS ALDLVEVNPQ 
LATSEEEAKT TANLAVDVIA SSFGQTREGG HIVYDQLPTP SSPDESENQA RVRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.