Details for: Usp47

Gene ID: 38644

Symbol: Usp47

Ensembl ID: FBgn0016756

Description: Ubiquitin specific protease 47

Associated with

  • Compound eye cone cell differentiation
    (GO:0042675)
  • Cysteine-type deubiquitinase activity
    (GO:0004843)
  • Cytosol
    (GO:0005829)
  • Negative regulation of proteasomal ubiquitin-dependent protein catabolic process
    (GO:0032435)
  • Nucleus
    (GO:0005634)
  • Positive regulation of canonical wnt signaling pathway
    (GO:0090263)
  • Positive regulation of epidermal growth factor receptor signaling pathway
    (GO:0045742)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of sevenless signaling pathway
    (GO:0045874)
  • Protein deubiquitination
    (GO:0016579)
  • Protein stabilization
    (GO:0050821)
  • Regulation of protein stability
    (GO:0031647)

Other Information

Genular Protein ID: 3331942121

Symbol: UBPE_DROME

Name: N/A

UniProtKB Accession Codes:

Q24574 A4V1I7 Q95TM9 Q9VRP1

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 EC 1 EMBL 6 EnsemblMetazoa 3 FlyBase 1 GO 13 Gene3D 1 GeneTree 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 8816485

Title: The dose of a putative ubiquitin-specific protease affects position-effect variegation in Drosophila melanogaster.

PubMed ID: 8816485

DOI: 10.1128/mcb.16.10.5717

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 10949024

Title: The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation.

PubMed ID: 10949024

DOI: 10.1016/s1097-2765(05)00008-0

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 18160715

Title: Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrack.

PubMed ID: 18160715

DOI: 10.1128/mcb.01567-07

PubMed ID: 26169834

Title: Deubiquitinase USP47/UBP64E regulates beta-Catenin ubiquitination and degradation and plays a positive role in wnt signaling.

PubMed ID: 26169834

DOI: 10.1128/mcb.00373-15

PubMed ID: 27552662

Title: The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.

PubMed ID: 27552662

DOI: 10.1371/journal.pbio.1002539

Sequence Information:

  • Length: 1556
  • Mass: 173794
  • Checksum: F70AE5BB2914E8BE
  • Sequence:
    • MTDKESEQCT VSVFDQTPGS EQKKINVVVR SHFTVKRVID LIGTQFSYEK FELLLQPHDN 
KDLVNLNALE SQLMYEVAGF EPQLKNHLIL LPSGSWDGDV TKRFELPIKR VVVKKVMKSD 
GEKAKSPATG EKKKRVVGEK TKKKPASGSS SPSKAKTTSE DSLAKTSISS ESSPEKTSKI 
KTTAAKISKP GSEKAPRASP EECPELSTEI NSKNTSSESP VAKKTAKVTS KPTLELLSPI 
KPSSPIKELD CEPVDTLSKQ QLSEQLQLYP QGRNLISPVD DAPSDLFISD AEQLSDDDLA 
LGASASPTML GPGYDYGAPT GDSDVEGVTG VTDPSTIGTD DGTYPALSNF YRRKYGGDEL 
RAWQRVNTTG ADFVSSATTE TEAEARQASL GPRGYVGLVN QAMTCYLNSL LQALFMTPEF 
RNALYRWEFD NDNEAKNIPY QLQKLFLNLQ TSPKAAVETT DLTRSFGWDS TEAWQQHDIQ 
ELCRVMFDAL EHKFKNTKQA NLISNLYEGK MNDYVKCLEC NTEKTREDTF LDIPLPVRPF 
GSSSAYGSIE EALRAFVQPE TLDGNNQYLC EKCKKKCDAH KGLHFKSFPY ILTLHLKRFD 
FDYQTMHRIK LNDRVTFPQT LNLNTFINRS GNSGEQNSQL NGTVDDCSTA DSGSAMEDDN 
LSSGVVTTAS SSQHENDLND EDEGIDMSSS TSKSAKQGSG PYLYELFAIM IHSGSASGGH 
YYAYIKDFDN NEWFCFNDQN VTSITQEDIQ RSFGGPNGSY YSSAYTSSTN AYMLMYRQVD 
AKRNELVAKV ADFPEHIKTL LPKLHSEEET RVSRLGRHIT VTDLALPDLY KPRVYFYNPS 
LKKMKITRVY VSQSFNINLV LMSAYEMLNV EQFAPLSRCR LVAYNSSMDT IIQSLESCTD 
PALTELRAAQ NYSLDFLLEY RAEDQEFEVY PPNGITWYVF KVDLSTMAMD GPFLVYSAAR 
EREASDVLRR SIALRLHISE QQFLLATVRA TVPKAFVSYD PHPTPEALQH LQNMANTQFK 
SITYFYLNVP NTDAATLEML GVPTVESVEC ASGGDVVDAA MMNGVAPGHM SSSNDYDWRR 
YKRDLVEPMS QPSPSHGHES NSEDSSLSDG DRTLVETDNM AHRGGGDSQV SSTSHSPQLS 
SPEDEAASHD AMMRVHAYCN GNGSYAAADV VDPLLLPTST NHFFYATKVE CVDVVGTGSS 
SGHQSDEEAQ LRKPTRAYKL LVGTHMRMGA FKKHIEQLIQ VPAAHFKLQR KHDNNLSNNQ 
NNSLVHLIEG ETLTVELGKT LEPDEFKAKI HFLRLADIDN ETSKLPCVCE WVYNANTTAE 
QAKKELVAKL HRIDAKYATL SVQNCRIWLK GGRIPIKILS DDETLYCDMR SSIAAEFIVQ 
ECEEEVDPQP KDDSLTLFVR RWCPAKLEFG KFQEITLDQD SEIRLSLSQI SDIPIDKLSY 
MKLNSNFPCT SISALSVNES SSWYSVPTTL DKYPLNSTQT GNIYLYKDRT VPARELTLEE 
RRLMNAREKA RLDRVGCVST TRYAQRRERA LKIYLDSPEK SSNVTASAPM DVHVNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.